MEP2908A - Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation - Google Patents

Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Info

Publication number: MEP2908A
Authority: ME; Montenegro
Prior art keywords: preparation; polymorphic forms; novel crystalline; lercanidipine hydrochloride; crystalline polymorphic
Prior art date: 2001-08-06

Application number

MEP-29/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Fausto Bonifacio

Francesco Campana

Iasi Gianluca De

Amedeo Leonardi

Original Assignee

Recordati Ireland Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-06

Filing date

2002-08-05

Publication date

2010-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP2908(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-08-05 Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd

2010-10-10 Publication of MEP2908A publication Critical patent/MEP2908A/xx

Links

WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title abstract 2
229960002162 lercanidipine hydrochloride Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
229960004294 lercanidipine Drugs 0.000 abstract 1
ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

MEP-29/08A 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation MEP2908A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI001726A ITMI20011726A1 (it)	2001-08-06	2001-08-06	Forme polimorfe della lercanidipina cloridrato
PCT/EP2002/008699 WO2003014084A1 (en)	2001-08-06	2002-08-05	Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Publications (1)

Publication Number	Publication Date
MEP2908A true MEP2908A (en)	2010-10-10

Family

ID=11448245

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MEP-29/08A MEP2908A (en)	2001-08-06	2002-08-05	Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
MEP-2008-29A ME01525B (de)	2001-08-06	2002-08-05	Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
MEP-2008-29A ME01525B (de)	2001-08-06	2002-08-05	Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung

Country Status (35)

Country	Link
EP (4)	EP1432683B9 (de)
JP (1)	JP2005504045A (de)
KR (3)	KR100626819B1 (de)
CN (2)	CN100448847C (de)
AP (1)	AP1766A (de)
AR (1)	AR037139A1 (de)
AT (2)	ATE453624T1 (de)
AU (1)	AU2002327924C1 (de)
BR (1)	BR0211739A (de)
CY (2)	CY1109711T1 (de)
DE (2)	DE60206787T2 (de)
DK (3)	DK1600441T3 (de)
EA (1)	EA005673B1 (de)
EC (1)	ECSP044973A (de)
ES (3)	ES2212759T3 (de)
HR (1)	HRP20040156B1 (de)
HU (1)	HU229563B1 (de)
IL (3)	IL153917A (de)
IT (1)	ITMI20011726A1 (de)
MA (1)	MA27133A1 (de)
ME (2)	MEP2908A (de)
MX (1)	MXPA04001069A (de)
NO (2)	NO325541B1 (de)
NZ (2)	NZ531558A (de)
OA (1)	OA12648A (de)
PE (1)	PE20030328A1 (de)
PL (1)	PL216066B1 (de)
PT (2)	PT2157083E (de)
RS (1)	RS52161B (de)
SI (3)	SI1600441T1 (de)
TN (1)	TNSN04024A1 (de)
UA (1)	UA82988C2 (de)
UY (1)	UY27410A1 (de)
WO (1)	WO2003014084A1 (de)
ZA (1)	ZA200401806B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20011726A1 (it)	2001-08-06	2003-02-06	Recordati Ind Chimica E Farma	Forme polimorfe della lercanidipina cloridrato
AR043395A1 (es) *	2003-02-28	2005-07-27	Recordati Ireland Ltd	Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii
DE04801160T1 (de) *	2003-12-01	2007-08-09	Lifecycle Pharma A/S	Pharmazeutische zusammensetzungen mit lercanidipin
AR052918A1 (es)	2005-02-25	2007-04-11	Recordati Ireland Ltd	Clorhidrato de lercanidipina amorfo
EP1940790B1 (de)	2005-09-16	2015-09-02	Glenmark Pharmaceuticals Limited	Polymorphe form von lercanidipin-hydrochlorid und verfahren zu ihrer herstellung
KR100821165B1 (ko) *	2006-03-10	2008-04-14	동우신테크 주식회사	레르카니디핀 염산염의 제조 방법
US20110040097A1 (en) *	2006-12-29	2011-02-17	Dongwoo Syntech Co., Ltd	Process for preparing lercanidipine hydrochloride
US20100104649A1 (en) *	2007-03-05	2010-04-29	Actavis Group Ptc Ehf	Lercanidipine Hydrochloride Polymorphs and an Improved Process for Preparation of 1,1,N-Trimethyl-N-(3,3-Diphenylpropyl)-2-Aminoethyl Acetoacetate
SI2585051T2 (sl)	2010-06-23	2020-07-31	Krka, D.D., Novo Mesto	Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli
EP2444394A1 (de)	2010-10-21	2012-04-25	Alembic Pharmaceuticals Limited	Verfahren zur Herstellung amorpher Formen von Lercanidipin HCl
WO2012085249A2 (en)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
EP2700632A4 (de) *	2011-04-18	2014-09-03	Hefei Beini Medical Technology Company Ltd	Verfahren zur reinigung von dihydropyridin-calciumkanalblockern und herstellung von nanopartikeln dafür
CN102531999B (zh) *	2011-12-16	2014-02-26	华润赛科药业有限责任公司	无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) *	2011-12-16	2014-02-26	华润赛科药业有限责任公司	一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) *	2011-12-31	2012-07-18	苏州二叶制药有限公司	盐酸乐卡地平的制备方法
CN103497075B (zh) *	2013-09-25	2016-03-23	山西北化关铝化工有限公司	水悬浮延期药造型粉
CN109232389B (zh) *	2018-05-15	2021-10-08	迪嘉药业集团有限公司	一种小粒度硝苯地平的结晶制备方法
CN115353485B (zh) *	2022-07-26	2024-04-19	山西双雁药业有限公司	从硝苯地平母液中回收硝苯地平的方法及应用
CN115671066B (zh) *	2022-11-21	2024-07-02	安徽宏业药业有限公司	一种盐酸乐卡地平片及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US596139A (en) *		1897-12-28		Process of generating acetylene gas
GB8403866D0 (en)	1984-02-14	1984-03-21	Recordati Chem Pharm	Diphenylalkylaminoalkyl esters
US5767136A (en) *	1995-05-12	1998-06-16	Recordati, S.A. Chemical And Pharmaceutical Company	1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
IT1274480B (it) *	1995-05-12	1997-07-17	Recordati Chem Pharm	Procedimento migliorato per la preparazione della lercanidipina cloridrato
IT1275532B (it) *	1995-07-14	1997-08-07	Recordati Chem Pharm	Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
US5696139A (en) *	1995-05-12	1997-12-09	Recordati S.A., Chemical And Pharmaceutical Company	Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
AP2002002620A0 (en)	2000-02-16	2002-09-30	Neurogen Corp	Substituted arylpyrazines
ITMI20011726A1 (it)	2001-08-06	2003-02-06	Recordati Ind Chimica E Farma	Forme polimorfe della lercanidipina cloridrato
US20040198789A1 (en)	2003-02-28	2004-10-07	Recordati Ireland Limited	Lercanidipine/ARB/diuretic therapeutic combinations

2001
- 2001-08-06 IT IT2001MI001726A patent/ITMI20011726A1/it unknown
2002
- 2002-05-08 UA UA2004031657A patent/UA82988C2/uk unknown
- 2002-08-02 AR ARP020102958A patent/AR037139A1/es unknown
- 2002-08-05 WO PCT/EP2002/008699 patent/WO2003014084A1/en not_active Ceased
- 2002-08-05 DE DE60206787T patent/DE60206787T2/de not_active Expired - Lifetime
- 2002-08-05 AU AU2002327924A patent/AU2002327924C1/en not_active Expired
- 2002-08-05 NZ NZ531558A patent/NZ531558A/en not_active IP Right Cessation
- 2002-08-05 EP EP02762428A patent/EP1432683B9/de not_active Expired - Lifetime
- 2002-08-05 PT PT91746099T patent/PT2157083E/pt unknown
- 2002-08-05 DE DE60234961T patent/DE60234961D1/de not_active Expired - Lifetime
- 2002-08-05 SI SI200230871T patent/SI1600441T1/sl unknown
- 2002-08-05 DK DK05106264.4T patent/DK1600441T3/da active
- 2002-08-05 MX MXPA04001069A patent/MXPA04001069A/es active IP Right Grant
- 2002-08-05 AP APAP/P/2004/002989A patent/AP1766A/en active
- 2002-08-05 ES ES02762428T patent/ES2212759T3/es not_active Expired - Lifetime
- 2002-08-05 ES ES05106264T patent/ES2334678T3/es not_active Expired - Lifetime
- 2002-08-05 RS YU11304A patent/RS52161B/sr unknown
- 2002-08-05 HR HR20040156A patent/HRP20040156B1/xx not_active IP Right Cessation
- 2002-08-05 BR BR0211739-8A patent/BR0211739A/pt not_active Application Discontinuation
- 2002-08-05 NZ NZ541341A patent/NZ541341A/en not_active IP Right Cessation
- 2002-08-05 SI SI200231065T patent/SI2157083T1/sl unknown
- 2002-08-05 HU HU0401163A patent/HU229563B1/hu unknown
- 2002-08-05 AT AT05106264T patent/ATE453624T1/de active
- 2002-08-05 PL PL369522A patent/PL216066B1/pl unknown
- 2002-08-05 EP EP05106264A patent/EP1600441B1/de not_active Expired - Lifetime
- 2002-08-05 KR KR1020057021508A patent/KR100626819B1/ko not_active Expired - Fee Related
- 2002-08-05 JP JP2003519034A patent/JP2005504045A/ja active Pending
- 2002-08-05 ME MEP-29/08A patent/MEP2908A/xx unknown
- 2002-08-05 CN CNB028154134A patent/CN100448847C/zh not_active Expired - Lifetime
- 2002-08-05 EA EA200400280A patent/EA005673B1/ru unknown
- 2002-08-05 AT AT02762428T patent/ATE307114T1/de active
- 2002-08-05 KR KR1020047001558A patent/KR100667687B1/ko not_active Expired - Fee Related
- 2002-08-05 EP EP08019093A patent/EP2036890A1/de not_active Withdrawn
- 2002-08-05 EP EP09174609.9A patent/EP2157083B1/de not_active Expired - Lifetime
- 2002-08-05 DK DK09174609.9T patent/DK2157083T3/en active
- 2002-08-05 CN CN2008101812364A patent/CN101475524B/zh not_active Expired - Lifetime
- 2002-08-05 IL IL15391702A patent/IL153917A/xx active IP Right Grant
- 2002-08-05 OA OA1200400033A patent/OA12648A/en unknown
- 2002-08-05 ES ES09174609.9T patent/ES2555213T3/es not_active Expired - Lifetime
- 2002-08-05 PT PT05106264T patent/PT1600441E/pt unknown
- 2002-08-05 DK DK02762428T patent/DK1432683T3/da active
- 2002-08-05 SI SI200230250T patent/SI1432683T1/sl unknown
- 2002-08-05 ME MEP-2008-29A patent/ME01525B/de unknown
- 2002-08-05 IL IL16464802A patent/IL164648A0/xx active IP Right Grant
- 2002-08-05 KR KR1020057006786A patent/KR20050043992A/ko not_active Ceased
- 2002-08-06 PE PE2002000715A patent/PE20030328A1/es not_active Application Discontinuation
- 2002-08-06 UY UY27410A patent/UY27410A1/es unknown
2004
- 2004-01-20 NO NO20040266A patent/NO325541B1/no not_active IP Right Cessation
- 2004-02-05 TN TNP2004000024A patent/TNSN04024A1/en unknown
- 2004-02-06 MA MA27517A patent/MA27133A1/fr unknown
- 2004-02-06 EC EC2004004973A patent/ECSP044973A/es unknown
- 2004-03-04 ZA ZA2004/01806A patent/ZA200401806B/en unknown
- 2004-10-17 IL IL164648A patent/IL164648A/en not_active IP Right Cessation
2008
- 2008-05-22 NO NO20082330A patent/NO335651B1/no not_active IP Right Cessation
2010
- 2010-01-05 CY CY20101100011T patent/CY1109711T1/el unknown
2015
- 2015-12-10 CY CY20151101129T patent/CY1117051T1/el unknown

Also Published As

Publication number	Publication date
AP2004002989A0 (en)	2004-03-31
ES2334678T3 (es)	2010-03-15
ECSP044973A (es)	2004-06-28
EP2157083A3 (de)	2010-03-24
EP1432683A1 (de)	2004-06-30
CN101475524B (zh)	2012-08-29
NO20040266L (no)	2004-03-24
KR100667687B1 (ko)	2007-01-12
HK1067123A1 (en)	2005-04-01
KR20050111799A (ko)	2005-11-28
ME01525B (de)	2011-02-10
SI1432683T1 (sl)	2006-04-30
EP2157083A2 (de)	2010-02-24
HUP0401163A3 (en)	2009-04-28
RS52161B (sr)	2012-08-31
PL216066B1 (pl)	2014-02-28
HUP0401163A2 (hu)	2004-09-28
EP2157083B1 (de)	2015-09-30
ATE307114T1 (de)	2005-11-15
MXPA04001069A (es)	2005-02-17
NO335651B1 (no)	2015-01-19
PT2157083E (pt)	2016-01-22
PL369522A1 (en)	2005-05-02
NZ541341A (en)	2007-02-23
HK1140487A1 (en)	2010-10-15
ATE453624T1 (de)	2010-01-15
ITMI20011726A1 (it)	2003-02-06
NO325541B1 (no)	2008-06-16
IL153917A (en)	2005-11-20
DK2157083T3 (en)	2015-11-02
EA200400280A1 (ru)	2004-08-26
KR100626819B1 (ko)	2006-09-20
DE60234961D1 (de)	2010-02-11
HRP20040156B1 (en)	2012-03-31
DK1600441T3 (da)	2010-02-08
WO2003014084A1 (en)	2003-02-20
ES2212759T1 (es)	2004-08-01
NO20082330L (no)	2004-03-24
IL164648A0 (en)	2005-12-18
AR037139A1 (es)	2004-10-27
OA12648A (en)	2006-06-16
EP1600441A3 (de)	2005-12-07
UY27410A1 (es)	2003-03-31
NZ531558A (en)	2005-12-23
CN1538957A (zh)	2004-10-20
CY1117051T1 (el)	2017-04-05
ITMI20011726A0 (it)	2001-08-06
HRP20040156A2 (en)	2004-08-31
EP1432683B1 (de)	2005-10-19
DE60206787T2 (de)	2006-07-13
SI1600441T1 (sl)	2010-02-26
IL153917A0 (en)	2003-07-31
KR20040030903A (ko)	2004-04-09
ZA200401806B (en)	2005-06-29
MA27133A1 (fr)	2005-01-03
DK1432683T3 (da)	2006-03-06
CY1109711T1 (el)	2014-08-13
ES2555213T3 (es)	2015-12-29
KR20050043992A (ko)	2005-05-11
BR0211739A (pt)	2004-09-28
EP2036890A1 (de)	2009-03-18
ES2212759T3 (es)	2006-04-16
PE20030328A1 (es)	2003-05-09
EA005673B1 (ru)	2005-04-28
JP2005504045A (ja)	2005-02-10
PT1600441E (pt)	2010-01-20
SI2157083T1 (sl)	2016-01-29
EP1600441A2 (de)	2005-11-30
RS11304A (sr)	2007-02-05
UA82988C2 (uk)	2008-06-10
AU2002327924B2 (en)	2008-04-24
AP1766A (en)	2007-08-10
AU2002327924C1 (en)	2009-12-10
HU229563B1 (en)	2014-02-28
DE60206787D1 (de)	2006-03-02
CN100448847C (zh)	2009-01-07
CN101475524A (zh)	2009-07-08
IL164648A (en)	2007-02-11
HK1086263A1 (en)	2006-09-15
EP1600441B1 (de)	2009-12-30
TNSN04024A1 (en)	2006-06-01
EP1432683B9 (de)	2006-01-18

Publication	Publication Date	Title
MEP2908A (en)	2010-10-10	Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
HUP0001539A2 (hu)	2000-11-28	2-(1-Imino-etil-amino)-etil-homocisztein, eljárás előállítására és az ezt tartalmazó gyógyszerkészítmények
HUP0302793A3 (en)	2006-01-30	N-substituted aniline derivatives useful as phosphodiesterase 4 inhibitors, pharmaceutical compositions containing them and process for their preparations
AP1830A (en)	2008-02-22	Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same.
NO20042298L (no)	2004-09-06	Farmasoytiske preparater og deres anvendelser
MA26995A1 (fr)	2004-12-20	Derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
HUP0203559A3 (en)	2008-01-28	Polymorphic forms of sertraline hydrochloride, process for their preparation and pharmaceutical compositions containing them
NO20020282L (no)	2002-03-21	Nytt difenyl-piperidinderivat
NO20023643L (no)	2002-09-30	Forbindelser som har antitumoraktivitet, fremgangsmåte for deres fremstilling og farmasöytiske sammensetninger som inneholderdem
DK0579681T3 (da)	1999-11-15	Krystallinsk tiagabin-hydrochlorid-monohydrat, dets fremstilling og dets anvendelse
PA8527401A1 (es)	2002-07-30	7-oxo-piridopirimidinas (ii)
NO20025015L (no)	2002-12-16	Et pyridin-1-oksidderivat, og fremgangsmåte for dets overföring til farmasöytisk effektive forbindelser
IL157540A (en)	2010-11-30	Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
ATE276262T1 (de)	2004-10-15	Oxazinochinolone für die behandlung viraler infektionen
IL164903A0 (en)	2005-12-18	Processes for preparation of polymorphic form II of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
IL182340A0 (en)	2007-07-24	Method for the isolation of haptoglobin
NO20061575L (no)	2006-06-09	Fremgangsmate for fremstilling av renzapride og mellomprodukter derav
NO20031643D0 (no)	2003-04-10	Nye aminotriazolonforbindelser, fremgangsmåte for deres fremstilling og farmasöytiske sammensetninger inneholdende dem
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