ATE491021T1 - Verfahren zur produktion eines zytotoxischen lymphozyten - Google Patents

Verfahren zur produktion eines zytotoxischen lymphozyten

Info

Publication number
ATE491021T1
ATE491021T1 AT03712887T AT03712887T ATE491021T1 AT E491021 T1 ATE491021 T1 AT E491021T1 AT 03712887 T AT03712887 T AT 03712887T AT 03712887 T AT03712887 T AT 03712887T AT E491021 T1 ATE491021 T1 AT E491021T1
Authority
AT
Austria
Prior art keywords
cytotoxic lymphocyte
producing
cytotoxic
lymphocyte
fibronectin
Prior art date
Application number
AT03712887T
Other languages
English (en)
Inventor
Hiroaki Sagawa
Mitsuko Ideno
Ikunoshin Kato
Original Assignee
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc filed Critical Takara Bio Inc
Application granted granted Critical
Publication of ATE491021T1 publication Critical patent/ATE491021T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT03712887T 2002-03-25 2003-03-25 Verfahren zur produktion eines zytotoxischen lymphozyten ATE491021T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002084414 2002-03-25
PCT/JP2003/003575 WO2003080817A1 (fr) 2002-03-25 2003-03-25 Procede de production de lymphocyte cytotoxique

Publications (1)

Publication Number Publication Date
ATE491021T1 true ATE491021T1 (de) 2010-12-15

Family

ID=28449211

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03712887T ATE491021T1 (de) 2002-03-25 2003-03-25 Verfahren zur produktion eines zytotoxischen lymphozyten

Country Status (14)

Country Link
US (3) US8728811B2 (de)
EP (3) EP2305796B1 (de)
JP (1) JP4406566B2 (de)
KR (2) KR100786054B1 (de)
CN (3) CN102321579A (de)
AT (1) ATE491021T1 (de)
AU (2) AU2003221073B2 (de)
CA (1) CA2479288C (de)
DE (1) DE60335253D1 (de)
EA (1) EA010434B1 (de)
ES (3) ES2396447T3 (de)
MX (1) MXPA04009287A (de)
TW (2) TW201043699A (de)
WO (1) WO2003080817A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE429486T1 (de) 2001-08-15 2009-05-15 Takara Bio Inc Expansionskulturverfahren für antigenspezifische zytotoxische t-lymphozyten
TW201043699A (en) 2002-03-25 2010-12-16 Takara Bio Inc Process for producing cytotoxic lymphocyte
US8927273B2 (en) * 2003-08-22 2015-01-06 Takara Bio Inc. Process for producing cytotoxic lymphocytes
GB0409775D0 (en) * 2004-04-30 2004-06-09 Mabtech Ab Assay
WO2007020880A1 (ja) 2005-08-17 2007-02-22 Takara Bio Inc. リンパ球の製造方法
JP4741906B2 (ja) * 2005-08-31 2011-08-10 タカラバイオ株式会社 リンパ球の製造方法
KR101408565B1 (ko) * 2005-09-30 2014-06-17 다카라 바이오 가부시키가이샤 Ｔ 세포 집단의 제조 방법
EP2028266A4 (de) * 2006-06-09 2010-08-11 Takara Bio Inc Verfahren zur herstellung von lymphozyten
US8715718B2 (en) * 2006-07-14 2014-05-06 Rutgers, The State University Of New Jersey Extracellular matrix production from nanoscale substrate
US20110158954A1 (en) * 2007-03-09 2011-06-30 Mitsuko Ideno Method for producing gamma delta t cell population
JPWO2008143014A1 (ja) * 2007-05-11 2010-08-05 タカラバイオ株式会社 がん治療剤
US8470966B2 (en) * 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US20110027242A1 (en) * 2008-03-27 2011-02-03 Takara Bio Inc. Method for production of transfected cell
EP2471901A4 (de) 2009-08-25 2013-06-26 Takara Bio Inc Verfahren zur herstellung einer t-zellen-population unter verwendung von retinsäure
CN102597223B (zh) 2009-09-11 2017-05-10 宝生物工程株式会社 生产天然杀伤细胞的方法
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
JP2013512694A (ja) * 2009-12-08 2013-04-18 ウィルソン ウォルフ マニュファクチャリング コーポレイション 養子細胞療法のための細胞を培養する方法
CN103547278B (zh) 2011-05-19 2015-11-25 东丽株式会社 免疫诱导剂
JP6987390B2 (ja) 2016-04-08 2021-12-22 エモリー ユニバーシティー 細胞ベースの治療法を用いて癌および感染性疾患を処置する方法
JP7023228B2 (ja) 2016-07-29 2022-02-21 タカラバイオ株式会社 幹細胞の製造に用いられるフィブロネクチンフラグメント
US12006512B2 (en) 2017-01-20 2024-06-11 Kyoto University Method for producing CD8alpha+beta+ cytotoxic t cells
KR20200112868A (ko) 2018-01-25 2020-10-05 다카라 바이오 가부시키가이샤 림프구의 제조방법
WO2019157597A1 (en) 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
JPWO2021200901A1 (de) 2020-03-31 2021-10-07
JPWO2024248141A1 (de) 2023-06-02 2024-12-05

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516421D0 (en) 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
CA1324098C (en) 1986-10-20 1993-11-09 Frederick J. Darfler Serum-free medium for the proliferation of lymphokine-activated killer cells
US5019646A (en) * 1987-08-25 1991-05-28 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
JP2561131B2 (ja) 1988-06-30 1996-12-04 寳酒造株式会社 細胞接着活性ポリペプチド
GB8909916D0 (en) 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
US5198423A (en) 1989-05-26 1993-03-30 Takara Shuzo Co., Ltd. Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
GR1001034B (el) 1989-07-21 1993-03-31 Ortho Pharma Corp Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.
US5188959A (en) 1989-09-28 1993-02-23 Trustees Of Tufts College Extracellular matrix protein adherent t cells
JP3104178B2 (ja) 1990-03-30 2000-10-30 寶酒造株式会社 機能性ポリペプチド
JPH04297494A (ja) * 1991-03-26 1992-10-21 Fuji Photo Film Co Ltd ペプチド誘導体とその用途
JP2729712B2 (ja) 1991-04-23 1998-03-18 寳酒造株式会社 機能性ポリペプチド
JPH07102131B2 (ja) 1991-07-15 1995-11-08 日本石油株式会社 ヒトリンパ球の癌細胞に対する傷害活性を高める方法
JPH06172203A (ja) 1992-12-02 1994-06-21 Takara Shuzo Co Ltd フィブロネクチンレセプター産生異常細胞抑制剤
JPH06306096A (ja) * 1993-02-26 1994-11-01 Fuji Photo Film Co Ltd ペプチド誘導体及びその用途
GB9315810D0 (en) 1993-07-30 1993-09-15 Univ London Stabilised materials
DE4336399A1 (de) 1993-10-26 1995-04-27 Augustinus Dr Med Bader Verfahren zur Verbesserung der Matrixbedingungen bipolar adhärierter Hepatozyten und zur Herstellung eines entsprechend konfigurierten Zellkulturkits
US6821778B1 (en) 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
DE4412794A1 (de) 1994-04-14 1995-12-14 Univ Ludwigs Albert Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens
GB9413029D0 (en) 1994-06-29 1994-08-17 Common Services Agency Stem cell immobilisation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5824547A (en) * 1994-11-29 1998-10-20 Takara Shuzo Co., Ltd. Method for production of transfected cells
CA2206449A1 (en) 1994-12-01 1996-06-06 Beth Israel Deaconess Medical Center, Inc. In vitro t-lymphopoiesis system
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
EP0824594B1 (de) 1995-05-04 2005-04-06 The United States of America as Representend by The Secretary of the Navy Verbesserte verfahren zur transfektion der t-zellen
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
JP3391941B2 (ja) 1995-06-15 2003-03-31 アサヒビール株式会社 余剰汚泥の処理方法
DE19624887A1 (de) 1995-06-21 1997-01-02 Fraunhofer Ges Forschung Elektrochemisches Festelektrolyt-Zellsystem
JPH0925299A (ja) 1995-07-13 1997-01-28 Sumitomo Electric Ind Ltd Ｃｄ４４リガンド
CA2227327A1 (en) 1995-07-25 1997-02-13 Celltherapy, Inc. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
DE19537494C2 (de) 1995-09-25 1997-10-02 Desitin Arzneimittel Gmbh Kreatin zum Schutz von neuralem Gewebe
EP0873049B1 (de) 1995-09-29 2006-05-10 Indiana University Research and Technology Corporation Verfahren zum verbesserten virusvermittelten dns-transfer unter verwendung von molekülen mit virus- und zellbindenden domänen
WO1997018318A1 (fr) 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Procede d'introduction de genes dans des cellules cibles au moyen de retrovirus
US6734014B1 (en) 1996-02-08 2004-05-11 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for transforming dendritic cells and activating T cells
WO1997032970A1 (en) 1996-03-04 1997-09-12 Targeted Genetics Corporation Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes
JP2002516562A (ja) 1996-03-04 2002-06-04 ターゲティッド ジェネティックス コーポレイション Ｔリンパ球のインビトロ増殖のための改変された迅速な拡大方法（「改変ｒｅｍ」）
JPH1029952A (ja) 1996-07-16 1998-02-03 Takara Shuzo Co Ltd ヒト免疫不全ウイルス感染の制御用組成物および制御方法
CA2267288A1 (en) 1996-09-23 1998-03-26 Ontogeny, Inc. Hematopoietic stem cells and methods for generating such cells
JP2001509677A (ja) 1997-01-31 2001-07-24 エピミューン，インコーポレイティド Ｃｔｌを活性化するためのペプチドおよびペプチド担持抗原提示細胞
JP3591286B2 (ja) 1997-04-24 2004-11-17 セイコーエプソン株式会社 タイミング調整方法、印字装置及び調整パターン作成方法
TWI239352B (en) 1997-07-23 2005-09-11 Takara Bio Inc Gene transfer method with the use of serum-free medium
AU2010699A (en) 1997-12-24 1999-07-19 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for theiruse
DE69838490T2 (de) 1997-12-24 2008-02-07 Bracco International B.V. Peptide chelatoren die nach der koordination mit einem metall zu einem vorherrschenden einzel-stereoisomeren führen
AU8780198A (en) 1998-08-11 2000-03-06 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A method of transducing mammalian cells, and products related thereto
EP1163912B1 (de) 1999-03-23 2007-10-31 Takara Bio Inc. Gentherapeutika
BR0108545A (pt) 2000-02-24 2004-06-29 Xcyte Therapies Inc Estimulação e concentração simultâneas das células
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
JP3904374B2 (ja) * 2000-02-29 2007-04-11 独立行政法人科学技術振興機構 キラー活性を増強したリンパ球
WO2002014481A1 (en) 2000-08-16 2002-02-21 Takara Bio Inc. Method of extensive culture of antigen-specific cytotoxic t cells
KR20040048379A (ko) 2001-06-01 2004-06-09 싸이트 테라피스 인코포레이티드 Ｔ 세포 유도된 조직 복구 및 재생
ATE429486T1 (de) * 2001-08-15 2009-05-15 Takara Bio Inc Expansionskulturverfahren für antigenspezifische zytotoxische t-lymphozyten
JP4759890B2 (ja) 2001-09-12 2011-08-31 大日本印刷株式会社 パール調印刷物の印刷濃度管理方法
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
TW201043699A (en) 2002-03-25 2010-12-16 Takara Bio Inc Process for producing cytotoxic lymphocyte
AU2003254950A1 (en) 2002-08-26 2004-03-11 Kirin Beer Kabushiki Kaisha Peptides and drugs containing the same
US8927273B2 (en) 2003-08-22 2015-01-06 Takara Bio Inc. Process for producing cytotoxic lymphocytes

Also Published As

Publication number Publication date
JP4406566B2 (ja) 2010-01-27
US8975070B2 (en) 2015-03-10
ES2397319T3 (es) 2013-03-06
EP1496109A4 (de) 2006-07-19
ES2356814T3 (es) 2011-04-13
MXPA04009287A (es) 2005-01-25
EP1496109B1 (de) 2010-12-08
HK1079543A1 (zh) 2006-04-07
CN101735981A (zh) 2010-06-16
TW201043699A (en) 2010-12-16
CN100591760C (zh) 2010-02-24
EP2305796B1 (de) 2012-10-24
KR100895231B1 (ko) 2009-05-04
EP1496109A1 (de) 2005-01-12
ES2396447T3 (es) 2013-02-21
CA2479288A1 (en) 2003-10-02
EP2305793A1 (de) 2011-04-06
JPWO2003080817A1 (ja) 2005-07-28
KR100786054B1 (ko) 2007-12-17
TWI334442B (en) 2010-12-11
KR20040099352A (ko) 2004-11-26
EA200401242A1 (ru) 2005-04-28
US20140212972A1 (en) 2014-07-31
EA010434B1 (ru) 2008-08-29
WO2003080817A1 (fr) 2003-10-02
US20050227354A1 (en) 2005-10-13
AU2008243221A1 (en) 2008-12-04
US8728811B2 (en) 2014-05-20
AU2003221073A1 (en) 2003-10-08
KR20070015620A (ko) 2007-02-05
CA2479288C (en) 2015-02-24
TW200400265A (en) 2004-01-01
CN101735981B (zh) 2013-01-02
AU2003221073B2 (en) 2008-08-21
US20080227204A1 (en) 2008-09-18
AU2008243221B2 (en) 2011-10-27
EP2305796A1 (de) 2011-04-06
EP2305793B1 (de) 2012-10-17
DE60335253D1 (de) 2011-01-20
HK1144105A1 (en) 2011-01-28
CN102321579A (zh) 2012-01-18
CN1656215A (zh) 2005-08-17

Similar Documents

Publication Publication Date Title
DE60335253D1 (de) Verfahren zur produktion eines zytotoxischen lymphozyten
DE60328492D1 (de) Verfahren zur erzeugung von nanoteilchen
ATE331695T1 (de) Verfahren und vorrichtung zur herstellung von mineralwolle und so hergestellte mineralwolleprodukte
ATE544754T1 (de) Verfahren zur herstellung von ivabradinhydrochlorid
DE60308525D1 (de) Verfahren zur herstellung einer rasch erstarrten legierung für magnete
DE60223032D1 (de) Vorrichtung zur herstellung von verbundkonstruktionen und verfahren zur herstellung derselben
ATE453648T1 (de) Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol
DE50113774D1 (de) Fahrzeugverbundbauteil sowie Verfahren und Vorrichtung zur Herstellung des Fahrzeugverbundbauteils
DE502004003625D1 (de) Verfahren zur herstellung von polyisobutenen
ATE458046T1 (de) Verfahren zur herstellung zytotoxischer lymphozyten
TW200741000A (en) Method of producing lymphocytes
DE60311990D1 (de) Verfahren zur herstellung eines virus inaktivierten thrombin präparates
ATE486841T1 (de) Verfahren zur herstellung von pregabalin und salzen daraus
DE602004026253D1 (de) Verfahren zur Herstellung von Stahlbrammen mit ultra-geringem Kohlenstoffgehalt
EP1848580A4 (de) Vorrichtung und verfahren zur herstellung von wellpappe und kaschiertem karton sowie darauf beruhende zusammensetzungen
ATE506351T1 (de) Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
EP1441978A4 (de) Verfahren und vorrichtung zur erzeugung von wasserstoffgas
ATE323677T1 (de) Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen
DE60234002D1 (de) Verfahren zur Herstellung von Verbundmaterial
DE60229198D1 (de) Verfahren zur Herstellung eines Verbundwerkstoffes
DE60334180D1 (de) Verfahren zur Herstellung einer Radlaufschale und damit hergestellte Radlaufschale
ATE437879T1 (de) Verfahren zur herstellung von imipenem
DE60332739D1 (de) Rekombinante typ-ii-restriktionsendonukleasen, mme i und verwandte endonukleasen sowie verfahren zur herstellung davon
ATE374755T1 (de) Verfahren zur herstellung von 1,3,5- triazincarbamaten und -harnstoffen
ATE325794T1 (de) Verfahren zur herstellung und zwischenprodukte von pyridin-2-yl-amin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties