ATE458726T1 - Exo- und diastereoselektive synthese von himbacin-analoga - Google Patents

Exo- und diastereoselektive synthese von himbacin-analoga

Info

Publication number: ATE458726T1
Authority: AT; Austria
Prior art keywords: exo; diastereoselective synthesis; himbacin; analogs; himbacin analogs
Prior art date: 2005-01-14

Application number

AT06718069T

Other languages

English (en)

Inventor

George Wu

Anantha Sudhakar

Tao Wang

Ji Xie

Frank Chen

Marc Poirier

Mingsheng Huang

Vijay Sabesan

Daw-Long Kwok

Jian Cui

Xiaojing Yang

Tiruvettipuram Thiruvengadam

Jing Liao

Ilia Zavialov

Hoa Nguyen

Ngiap Kie Lim

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-14

Filing date

2006-01-12

Publication date

2010-03-15

2006-01-12 Application filed by Schering Corp filed Critical Schering Corp

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458726T1 publication Critical patent/ATE458726T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
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- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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- C07D277/62—Benzothiazoles
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Pharmacology & Pharmacy (AREA)
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Animal Behavior & Ethology (AREA)
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Molecular Biology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT06718069T 2005-01-14 2006-01-12 Exo- und diastereoselektive synthese von himbacin-analoga ATE458726T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64446405P	2005-01-14	2005-01-14
PCT/US2006/000954 WO2006076415A2 (en)	2005-01-14	2006-01-12	Exo- and diastereo- selective syntheses of himbacine analogs

Publications (1)

Publication Number	Publication Date
ATE458726T1 true ATE458726T1 (de)	2010-03-15

Family

ID=36168544

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT10001844T ATE530516T1 (de)	2005-01-14	2006-01-12	Exo- und diastereoselektive synthese von himbacin-analoga
AT06718069T ATE458726T1 (de)	2005-01-14	2006-01-12	Exo- und diastereoselektive synthese von himbacin-analoga

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT10001844T ATE530516T1 (de)	2005-01-14	2006-01-12	Exo- und diastereoselektive synthese von himbacin-analoga

Country Status (21)

Country	Link
US (4)	US7605275B2 (de)
EP (4)	EP2206697B1 (de)
JP (3)	JP4681616B2 (de)
CN (2)	CN101193880B (de)
AR (1)	AR056919A1 (de)
AT (2)	ATE530516T1 (de)
CA (2)	CA2875768C (de)
CY (2)	CY1109896T1 (de)
DE (1)	DE602006012450D1 (de)
DK (2)	DK1848705T3 (de)
ES (3)	ES2339696T3 (de)
HR (2)	HRP20100218T1 (de)
ME (1)	ME01967B (de)
MX (1)	MX2007008665A (de)
PL (2)	PL1848705T3 (de)
PT (2)	PT1848705E (de)
RS (2)	RS52117B (de)
SG (2)	SG192505A1 (de)
SI (2)	SI2206697T1 (de)
WO (1)	WO2006076415A2 (de)
ZA (1)	ZA200706711B (de)

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DK1848705T3 (da)	2005-01-14	2010-06-14	Schering Corp	EXO- og diastereoselektive synteser af himbacin-analoger
AR052871A1 (es) *	2005-01-14	2007-04-11	Schering Corp	Una sintesis exo-selectiva de analogos de himbacina
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2006
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Also Published As

Publication number	Publication date
EP2206697A1 (de)	2010-07-14
DE602006012450D1 (de)	2010-04-08
ES2412981T3 (es)	2013-07-15
ES2374379T3 (es)	2012-02-16
AR056919A1 (es)	2007-11-07
EP2206697B1 (de)	2011-10-26
CA2594871C (en)	2015-04-07
HK1108893A1 (en)	2008-05-23
JP2013177407A (ja)	2013-09-09
DK1848705T3 (da)	2010-06-14
CA2875768C (en)	2018-03-06
CY1112371T1 (el)	2015-12-09
SG192505A1 (en)	2013-08-30
ATE530516T1 (de)	2011-11-15
SI1848705T1 (sl)	2010-06-30
CN102757423B (zh)	2016-04-20
EP2196454B1 (de)	2014-08-27
US20060247450A1 (en)	2006-11-02
CA2875768A1 (en)	2006-07-20
SI2206697T1 (sl)	2012-02-29
EP2196454A2 (de)	2010-06-16
US20120296093A1 (en)	2012-11-22
RS52117B (sr)	2012-08-31
DK2206697T3 (da)	2012-02-13
HRP20100218T1 (hr)	2010-05-31
HRP20110963T1 (hr)	2012-01-31
PL1848705T3 (pl)	2010-07-30
ZA200706711B (en)	2014-01-29
WO2006076415A2 (en)	2006-07-20
US20090281321A1 (en)	2009-11-12
PT1848705E (pt)	2010-05-10
EP2196454A3 (de)	2010-09-22
ME01967B (me)	2012-08-31
JP4681616B2 (ja)	2011-05-11
RS51315B (sr)	2010-12-31
US7989653B2 (en)	2011-08-02
JP2008526972A (ja)	2008-07-24
US8618314B2 (en)	2013-12-31
PT2206697E (pt)	2012-01-10
ES2339696T3 (es)	2010-05-24
EP2196468B1 (de)	2013-04-10
US20110251392A1 (en)	2011-10-13
PL2206697T3 (pl)	2012-03-30
MX2007008665A (es)	2008-03-04
CN101193880B (zh)	2012-08-22
WO2006076415A3 (en)	2006-11-16
CN102757423A (zh)	2012-10-31
SG158888A1 (en)	2010-02-26
EP2196468A1 (de)	2010-06-16
JP5388231B2 (ja)	2014-01-15
US8258319B2 (en)	2012-09-04
EP1848705A2 (de)	2007-10-31
CA2594871A1 (en)	2006-07-20
JP5911447B2 (ja)	2016-04-27
CY1109896T1 (el)	2014-09-10
CN101193880A (zh)	2008-06-04
US7605275B2 (en)	2009-10-20
EP1848705B1 (de)	2010-02-24
JP2011098967A (ja)	2011-05-19

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