ATE365169T1 - Regioselektive synthese von cci-779 - Google Patents
Regioselektive synthese von cci-779Info
- Publication number
- ATE365169T1 ATE365169T1 AT04778398T AT04778398T ATE365169T1 AT E365169 T1 ATE365169 T1 AT E365169T1 AT 04778398 T AT04778398 T AT 04778398T AT 04778398 T AT04778398 T AT 04778398T AT E365169 T1 ATE365169 T1 AT E365169T1
- Authority
- AT
- Austria
- Prior art keywords
- cci
- regioselective synthesis
- regioselective
- synthesis
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960000235 temsirolimus Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49324903P | 2003-08-07 | 2003-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365169T1 true ATE365169T1 (de) | 2007-07-15 |
Family
ID=34193170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04778398T ATE365169T1 (de) | 2003-08-07 | 2004-07-15 | Regioselektive synthese von cci-779 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7153957B2 (de) |
| EP (1) | EP1658295B1 (de) |
| JP (1) | JP4227649B2 (de) |
| KR (1) | KR20060057605A (de) |
| CN (1) | CN1829722B (de) |
| AR (1) | AR045217A1 (de) |
| AT (1) | ATE365169T1 (de) |
| AU (1) | AU2004265267A1 (de) |
| BR (1) | BRPI0412667A (de) |
| CA (1) | CA2532988A1 (de) |
| CO (1) | CO5650251A2 (de) |
| CR (1) | CR8189A (de) |
| DE (1) | DE602004007145T2 (de) |
| DK (1) | DK1658295T3 (de) |
| EC (1) | ECSP066413A (de) |
| ES (1) | ES2287772T3 (de) |
| IL (1) | IL173134A0 (de) |
| MX (1) | MXPA06000951A (de) |
| NO (1) | NO20060494L (de) |
| PL (1) | PL1658295T3 (de) |
| PT (1) | PT1658295E (de) |
| RU (1) | RU2339639C2 (de) |
| TW (1) | TW200508241A (de) |
| UA (1) | UA83245C2 (de) |
| WO (1) | WO2005016935A2 (de) |
| ZA (1) | ZA200601055B (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE427948T1 (de) * | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| EP1504010B1 (de) * | 2002-05-15 | 2009-03-25 | Endocyte, Inc. | Vitamin-mitomycin-konjugate |
| PT1553940E (pt) | 2002-07-30 | 2008-05-09 | Wyeth Corp | Formulações parentéricas contendo um hidroxi-éster de rapamicina |
| EP2517730A3 (de) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate |
| WO2005023254A1 (en) * | 2003-09-03 | 2005-03-17 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same |
| PL1701698T3 (pl) * | 2004-01-08 | 2008-03-31 | Wyeth Corp | Prasowana bezpośrednio kompozycja farmaceutyczna do podawania doustnego CCI-779 |
| US7445916B2 (en) * | 2004-04-14 | 2008-11-04 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| CA2562952A1 (en) | 2004-04-14 | 2005-11-10 | Wyeth | Regiospecific synthesis of rapamycin 42-ester derivatives |
| CA2564811A1 (en) | 2004-04-14 | 2005-10-27 | Wyeth | Proline cci-779 (proline-rapamycin 42-ester with 2,2-bis (hydroxymethyl) propionic acid) and two-step enzymatic synthesis of proline cci-779 and cci-779 using microbial lipase |
| BRPI0510277A (pt) * | 2004-04-27 | 2007-10-30 | Wyeth Corp | método para marcar especificamente uma rapamicina, rapamicina especificamente marcada, composição, e, kit |
| US8288557B2 (en) * | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| AR050452A1 (es) * | 2004-08-10 | 2006-10-25 | Wyeth Corp | Derivados de cci-779 |
| CA2585840A1 (en) | 2004-10-28 | 2006-05-11 | Wyeth | Use of an mtor inhibitor in treatment of uterine leiomyoma |
| AU2006213061A1 (en) | 2005-02-09 | 2006-08-17 | Wyeth | CCI-779 polymorph and use thereof |
| MX2007010716A (es) * | 2005-03-02 | 2008-01-16 | Wyeth Corp | Purificacion de rapamicina. |
| EP1853611A1 (de) | 2005-03-02 | 2007-11-14 | Wyeth | Wiederherstellung von cci-779 aus mutterlaugen |
| JP5289935B2 (ja) | 2005-03-16 | 2013-09-11 | エンドサイト，インコーポレイテッド | プテロイン酸およびその結合体の合成と精製 |
| US8465724B2 (en) | 2005-08-19 | 2013-06-18 | Endocyte, Inc. | Multi-drug ligand conjugates |
| EP2382995A3 (de) * | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligandenkonjugate von Vincaalkaloiden, Analoga und Derivaten |
| KR101354828B1 (ko) | 2005-11-04 | 2014-02-18 | 와이어쓰 엘엘씨 | ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합 |
| WO2007056175A2 (en) * | 2005-11-04 | 2007-05-18 | Wyeth | 41-methoxy isotope labeled rapamycin 42-ester |
| TW200736603A (en) * | 2005-12-07 | 2007-10-01 | Wyeth Corp | Methods for preparing crystalline rapamycin and measuring crystallinity of rapamycin compounds using differential scanning calorimetry |
| TW200804399A (en) | 2005-12-07 | 2008-01-16 | Wyeth Corp | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
| WO2007067565A1 (en) * | 2005-12-07 | 2007-06-14 | Wyeth | Process for the preparation of purified crystalline cci-779 |
| AU2006331874A1 (en) * | 2005-12-20 | 2007-07-05 | Wyeth | Control of CCI-779 dosage form stability through control of drug substance impurities |
| US20070203169A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same |
| TW200824713A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| TW200901989A (en) * | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN101784565B (zh) * | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CA2703491C (en) | 2007-10-25 | 2017-06-13 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| WO2011051960A2 (en) | 2009-09-25 | 2011-05-05 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| EP2528906A2 (de) * | 2010-01-28 | 2012-12-05 | Fresenius Kabi Oncology Ltd | Verfahren zur herstellung von temsirolimus und seinen zwischenprodukten |
| CN102020661B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔合成方法 |
| CN102020662B (zh) | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| RU2603261C2 (ru) * | 2011-04-01 | 2016-11-27 | Сандоз Аг | Региоселективное ацилирование рапамицина в положении с-42 |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| AU2013331440A1 (en) | 2012-10-16 | 2015-04-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| CN104086564B (zh) * | 2014-07-30 | 2019-02-05 | 江苏奥赛康药业股份有限公司 | 一种高纯度坦罗莫司的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| DE19857765A1 (de) | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
-
2004
- 2004-07-15 RU RU2006106910/04A patent/RU2339639C2/ru not_active IP Right Cessation
- 2004-07-15 CN CN2004800217944A patent/CN1829722B/zh not_active Expired - Fee Related
- 2004-07-15 BR BRPI0412667-0A patent/BRPI0412667A/pt not_active IP Right Cessation
- 2004-07-15 JP JP2006522574A patent/JP4227649B2/ja not_active Expired - Fee Related
- 2004-07-15 DE DE602004007145T patent/DE602004007145T2/de not_active Expired - Fee Related
- 2004-07-15 DK DK04778398T patent/DK1658295T3/da active
- 2004-07-15 AU AU2004265267A patent/AU2004265267A1/en not_active Abandoned
- 2004-07-15 PL PL04778398T patent/PL1658295T3/pl unknown
- 2004-07-15 AT AT04778398T patent/ATE365169T1/de not_active IP Right Cessation
- 2004-07-15 CA CA002532988A patent/CA2532988A1/en not_active Abandoned
- 2004-07-15 PT PT04778398T patent/PT1658295E/pt unknown
- 2004-07-15 WO PCT/US2004/022860 patent/WO2005016935A2/en not_active Ceased
- 2004-07-15 UA UAA200602447A patent/UA83245C2/ru unknown
- 2004-07-15 EP EP04778398A patent/EP1658295B1/de not_active Expired - Lifetime
- 2004-07-15 ES ES04778398T patent/ES2287772T3/es not_active Expired - Lifetime
- 2004-07-15 MX MXPA06000951A patent/MXPA06000951A/es active IP Right Grant
- 2004-07-15 KR KR1020067002610A patent/KR20060057605A/ko not_active Ceased
- 2004-07-30 US US10/903,062 patent/US7153957B2/en not_active Expired - Fee Related
- 2004-08-04 AR ARP040102778A patent/AR045217A1/es unknown
- 2004-08-05 TW TW093123422A patent/TW200508241A/zh unknown
-
2006
- 2006-01-12 IL IL173134A patent/IL173134A0/en unknown
- 2006-01-13 CR CR8189A patent/CR8189A/es not_active Application Discontinuation
- 2006-01-31 NO NO20060494A patent/NO20060494L/no not_active Application Discontinuation
- 2006-02-06 ZA ZA200601055A patent/ZA200601055B/en unknown
- 2006-02-28 CO CO06019898A patent/CO5650251A2/es unknown
- 2006-03-07 EC EC2006006413A patent/ECSP066413A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1658295T3 (pl) | 2007-11-30 |
| TW200508241A (en) | 2005-03-01 |
| AR045217A1 (es) | 2005-10-19 |
| KR20060057605A (ko) | 2006-05-26 |
| US20050033046A1 (en) | 2005-02-10 |
| ZA200601055B (en) | 2008-07-30 |
| CO5650251A2 (es) | 2006-06-30 |
| DE602004007145T2 (de) | 2008-02-28 |
| MXPA06000951A (es) | 2006-03-30 |
| CA2532988A1 (en) | 2005-02-24 |
| PT1658295E (pt) | 2007-09-25 |
| CR8189A (es) | 2006-10-04 |
| BRPI0412667A (pt) | 2006-09-26 |
| UA83245C2 (en) | 2008-06-25 |
| EP1658295A2 (de) | 2006-05-24 |
| RU2339639C2 (ru) | 2008-11-27 |
| EP1658295B1 (de) | 2007-06-20 |
| US7153957B2 (en) | 2006-12-26 |
| IL173134A0 (en) | 2006-06-11 |
| RU2006106910A (ru) | 2007-09-20 |
| WO2005016935A2 (en) | 2005-02-24 |
| DE602004007145D1 (de) | 2007-08-02 |
| CN1829722B (zh) | 2010-10-27 |
| WO2005016935A3 (en) | 2005-04-07 |
| CN1829722A (zh) | 2006-09-06 |
| JP2007501783A (ja) | 2007-02-01 |
| NO20060494L (no) | 2006-03-06 |
| ECSP066413A (es) | 2006-09-18 |
| HK1085482A1 (en) | 2006-08-25 |
| ES2287772T3 (es) | 2007-12-16 |
| DK1658295T3 (da) | 2007-09-24 |
| AU2004265267A1 (en) | 2005-02-24 |
| JP4227649B2 (ja) | 2009-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1658295 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |