ATE365169T1 - Regioselektive synthese von cci-779 - Google Patents
Regioselektive synthese von cci-779Info
- Publication number
- ATE365169T1 ATE365169T1 AT04778398T AT04778398T ATE365169T1 AT E365169 T1 ATE365169 T1 AT E365169T1 AT 04778398 T AT04778398 T AT 04778398T AT 04778398 T AT04778398 T AT 04778398T AT E365169 T1 ATE365169 T1 AT E365169T1
- Authority
- AT
- Austria
- Prior art keywords
- cci
- regioselective synthesis
- regioselective
- synthesis
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960000235 temsirolimus Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49324903P | 2003-08-07 | 2003-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365169T1 true ATE365169T1 (de) | 2007-07-15 |
Family
ID=34193170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04778398T ATE365169T1 (de) | 2003-08-07 | 2004-07-15 | Regioselektive synthese von cci-779 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7153957B2 (de) |
| EP (1) | EP1658295B1 (de) |
| JP (1) | JP4227649B2 (de) |
| KR (1) | KR20060057605A (de) |
| CN (1) | CN1829722B (de) |
| AR (1) | AR045217A1 (de) |
| AT (1) | ATE365169T1 (de) |
| AU (1) | AU2004265267A1 (de) |
| BR (1) | BRPI0412667A (de) |
| CA (1) | CA2532988A1 (de) |
| CO (1) | CO5650251A2 (de) |
| CR (1) | CR8189A (de) |
| DE (1) | DE602004007145T2 (de) |
| DK (1) | DK1658295T3 (de) |
| EC (1) | ECSP066413A (de) |
| ES (1) | ES2287772T3 (de) |
| IL (1) | IL173134A0 (de) |
| MX (1) | MXPA06000951A (de) |
| NO (1) | NO20060494L (de) |
| PL (1) | PL1658295T3 (de) |
| PT (1) | PT1658295E (de) |
| RU (1) | RU2339639C2 (de) |
| TW (1) | TW200508241A (de) |
| UA (1) | UA83245C2 (de) |
| WO (1) | WO2005016935A2 (de) |
| ZA (1) | ZA200601055B (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1389209B1 (de) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| KR20040106547A (ko) * | 2002-05-15 | 2004-12-17 | 엔도사이트, 인코포레이티드 | 비타민-마이토마이신 공액체 |
| RU2344821C2 (ru) * | 2002-07-30 | 2009-01-27 | Уайт | Парентеральные композиции, содержащие гидроксиэфиры рапамицина |
| US7601332B2 (en) | 2003-01-27 | 2009-10-13 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| EP1660081A1 (de) * | 2003-09-03 | 2006-05-31 | Wyeth | Amorphe rapamycin 42-ester mit 3-hydroxy-2-(hydroxymethyl)-2-methylpropionsäure und diese enthaltende pharmazeutische zusammensetzungen |
| DE602004011398T2 (de) * | 2004-01-08 | 2009-01-15 | Wyeth | Direkt komprimierbare pharmazeutische zusammensetzung für die orale verabreichung von cci-779 |
| KR20070015544A (ko) | 2004-04-14 | 2007-02-05 | 와이어쓰 | 라파마이신 42-에스테르 유도체의 위치특이성 합성 |
| PL1735321T3 (pl) | 2004-04-14 | 2009-04-30 | Wyeth Corp | Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała |
| EP1751168A1 (de) | 2004-04-14 | 2007-02-14 | Wyeth | Prolin cci-779 (prolin-rapamycin 42-ester mit 2,2-bis(hydroxymethyl)propionsäure) und zweistufige enzymatische synthese von prolin cci-779 und cci-779 mit mikrobieller lipase |
| CN1946852A (zh) * | 2004-04-27 | 2007-04-11 | 惠氏公司 | 利用雷帕霉素特异性甲基化酶标记雷帕霉素 |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| TW200616633A (en) * | 2004-08-10 | 2006-06-01 | Wyeth Corp | CCI-779 derivatives and methods of making same |
| EP1804779A1 (de) | 2004-10-28 | 2007-07-11 | Wyeth | Verwendung eines mto-inhibitors bei der behandlung von gebärmutter-leiomyomen |
| JP2008530090A (ja) * | 2005-02-09 | 2008-08-07 | ワイス | Ｃｃｉ−７７９多形及びその使用 |
| BRPI0607390A2 (pt) | 2005-03-02 | 2017-08-22 | Wyeth Corp | Processo para recuperar cci-779 de licores mâe |
| AU2006218918A1 (en) * | 2005-03-02 | 2006-09-08 | Wyeth | Purification of rapamycin |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| RU2470668C2 (ru) | 2005-08-19 | 2012-12-27 | Эндосайт, Инк. | Конъюгаты лиганда с несколькими лекарственными средствами |
| JP2009504783A (ja) * | 2005-08-19 | 2009-02-05 | エンドサイト，インコーポレイテッド | ビンカアルカロイド、類似体および誘導体のリガンド結合体 |
| US7538119B2 (en) * | 2005-11-04 | 2009-05-26 | Wyeth | 41-Methoxy isotope labeled rapamycin 42-ester |
| EP3488866A1 (de) | 2005-11-04 | 2019-05-29 | Wyeth LLC | Antineoplastische kombinationen mit mtor-inhibitor, herceptin und/oder hki-272 |
| AR058282A1 (es) * | 2005-12-07 | 2008-01-30 | Wyeth Corp | Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| PE20070748A1 (es) | 2005-12-07 | 2007-08-08 | Wyeth Corp | Proceso ajustable a escala para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina |
| JP2009518648A (ja) * | 2005-12-07 | 2009-05-07 | ワイス | 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法 |
| JP2009520818A (ja) * | 2005-12-20 | 2009-05-28 | ワイス | 薬物物質不純物の制御によるｃｃｉ−７７９製剤安定性の制御 |
| US20070203169A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same |
| TW200824713A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN104127878A (zh) * | 2007-03-14 | 2014-11-05 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| TW200901989A (en) | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| BRPI0812970A2 (pt) * | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| EP2209374B1 (de) | 2007-10-25 | 2014-12-03 | Endocyte, Inc. | Tubulysine und verfahren zu ihrer herstellung |
| US8754207B2 (en) | 2009-09-25 | 2014-06-17 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| AU2011210227A1 (en) * | 2010-01-28 | 2012-08-30 | Fresenius Kabi Oncology Ltd. | Process for the preparation of Temsirolimus and its intermediates |
| CN102020662B (zh) | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| CN102020661B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔合成方法 |
| RU2603261C2 (ru) * | 2011-04-01 | 2016-11-27 | Сандоз Аг | Региоселективное ацилирование рапамицина в положении с-42 |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| EA201590622A1 (ru) | 2012-10-16 | 2015-10-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения |
| CN104086564B (zh) * | 2014-07-30 | 2019-02-05 | 江苏奥赛康药业股份有限公司 | 一种高纯度坦罗莫司的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| DE19857765A1 (de) * | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
-
2004
- 2004-07-15 JP JP2006522574A patent/JP4227649B2/ja not_active Expired - Fee Related
- 2004-07-15 PT PT04778398T patent/PT1658295E/pt unknown
- 2004-07-15 MX MXPA06000951A patent/MXPA06000951A/es active IP Right Grant
- 2004-07-15 PL PL04778398T patent/PL1658295T3/pl unknown
- 2004-07-15 CA CA002532988A patent/CA2532988A1/en not_active Abandoned
- 2004-07-15 UA UAA200602447A patent/UA83245C2/ru unknown
- 2004-07-15 DK DK04778398T patent/DK1658295T3/da active
- 2004-07-15 RU RU2006106910/04A patent/RU2339639C2/ru not_active IP Right Cessation
- 2004-07-15 DE DE602004007145T patent/DE602004007145T2/de not_active Expired - Fee Related
- 2004-07-15 WO PCT/US2004/022860 patent/WO2005016935A2/en not_active Ceased
- 2004-07-15 CN CN2004800217944A patent/CN1829722B/zh not_active Expired - Fee Related
- 2004-07-15 ES ES04778398T patent/ES2287772T3/es not_active Expired - Lifetime
- 2004-07-15 AU AU2004265267A patent/AU2004265267A1/en not_active Abandoned
- 2004-07-15 BR BRPI0412667-0A patent/BRPI0412667A/pt not_active IP Right Cessation
- 2004-07-15 KR KR1020067002610A patent/KR20060057605A/ko not_active Ceased
- 2004-07-15 AT AT04778398T patent/ATE365169T1/de not_active IP Right Cessation
- 2004-07-15 EP EP04778398A patent/EP1658295B1/de not_active Expired - Lifetime
- 2004-07-30 US US10/903,062 patent/US7153957B2/en not_active Expired - Fee Related
- 2004-08-04 AR ARP040102778A patent/AR045217A1/es unknown
- 2004-08-05 TW TW093123422A patent/TW200508241A/zh unknown
-
2006
- 2006-01-12 IL IL173134A patent/IL173134A0/en unknown
- 2006-01-13 CR CR8189A patent/CR8189A/es not_active Application Discontinuation
- 2006-01-31 NO NO20060494A patent/NO20060494L/no not_active Application Discontinuation
- 2006-02-06 ZA ZA200601055A patent/ZA200601055B/en unknown
- 2006-02-28 CO CO06019898A patent/CO5650251A2/es unknown
- 2006-03-07 EC EC2006006413A patent/ECSP066413A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004007145T2 (de) | 2008-02-28 |
| NO20060494L (no) | 2006-03-06 |
| BRPI0412667A (pt) | 2006-09-26 |
| HK1085482A1 (en) | 2006-08-25 |
| DK1658295T3 (da) | 2007-09-24 |
| JP2007501783A (ja) | 2007-02-01 |
| DE602004007145D1 (de) | 2007-08-02 |
| CN1829722A (zh) | 2006-09-06 |
| EP1658295B1 (de) | 2007-06-20 |
| WO2005016935A3 (en) | 2005-04-07 |
| TW200508241A (en) | 2005-03-01 |
| CR8189A (es) | 2006-10-04 |
| AR045217A1 (es) | 2005-10-19 |
| ES2287772T3 (es) | 2007-12-16 |
| WO2005016935A2 (en) | 2005-02-24 |
| KR20060057605A (ko) | 2006-05-26 |
| AU2004265267A1 (en) | 2005-02-24 |
| PT1658295E (pt) | 2007-09-25 |
| RU2339639C2 (ru) | 2008-11-27 |
| US20050033046A1 (en) | 2005-02-10 |
| CA2532988A1 (en) | 2005-02-24 |
| MXPA06000951A (es) | 2006-03-30 |
| JP4227649B2 (ja) | 2009-02-18 |
| EP1658295A2 (de) | 2006-05-24 |
| ECSP066413A (es) | 2006-09-18 |
| CN1829722B (zh) | 2010-10-27 |
| CO5650251A2 (es) | 2006-06-30 |
| PL1658295T3 (pl) | 2007-11-30 |
| IL173134A0 (en) | 2006-06-11 |
| ZA200601055B (en) | 2008-07-30 |
| UA83245C2 (en) | 2008-06-25 |
| US7153957B2 (en) | 2006-12-26 |
| RU2006106910A (ru) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1658295 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |