ATE458817T1 - Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend - Google Patents

Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend

Info

Publication number
ATE458817T1
ATE458817T1 AT05017821T AT05017821T ATE458817T1 AT E458817 T1 ATE458817 T1 AT E458817T1 AT 05017821 T AT05017821 T AT 05017821T AT 05017821 T AT05017821 T AT 05017821T AT E458817 T1 ATE458817 T1 AT E458817T1
Authority
AT
Austria
Prior art keywords
phospholipase
nucleic acids
recombinant
vespidae
cloning
Prior art date
Application number
AT05017821T
Other languages
English (en)
Inventor
Te Piao King
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of ATE458817T1 publication Critical patent/ATE458817T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT05017821T 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend ATE458817T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3140093A 1993-03-11 1993-03-11
US08/180,209 US5593877A (en) 1993-03-11 1994-01-11 Nucleic acid and recombinant production of vespid venom hyaluronidase

Publications (1)

Publication Number Publication Date
ATE458817T1 true ATE458817T1 (de) 2010-03-15

Family

ID=21859247

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05017821T ATE458817T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend
AT94911550T ATE347601T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94911550T ATE347601T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Country Status (10)

Country Link
US (4) US5593877A (de)
EP (2) EP0688362B1 (de)
JP (2) JP3816515B2 (de)
AT (2) ATE458817T1 (de)
AU (1) AU693785B2 (de)
CA (2) CA2157864C (de)
DE (2) DE69434890T2 (de)
DK (2) DK1650304T3 (de)
ES (1) ES2278379T3 (de)
WO (1) WO1994020623A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3637087B2 (ja) * 1994-11-28 2005-04-06 和男 鈴木 新規な白血球活性化因子
US5789194A (en) * 1995-05-23 1998-08-04 Heska Corporation Parasitic helminth venom allergen antigen 5-like genes and proteins
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
GB9724531D0 (en) * 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
JP2002506013A (ja) 1998-03-09 2002-02-26 イスタ ファーマシューティカルズ インコーポレイテッド 酵素角膜矯正術における角膜硬化剤の使用
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6372471B1 (en) 1998-10-01 2002-04-16 The Rockefeller University Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
US6773695B2 (en) 2000-10-05 2004-08-10 Mannkind Corporation Modulation of allergic response
JP2005508134A (ja) 2001-03-02 2005-03-31 ザ ロックフェラー ユニヴァーシティ 天然アレルゲンの免疫原性を保持する、アレルゲン性が低下した組み換えハイブリッドアレルゲン構築体
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
PT1786908E (pt) * 2004-08-18 2010-04-29 Bayer Cropscience Ag Plantas com um aumento da actividade da enzima de fosforilação do amido r3 nos plastídeos
WO2008149364A2 (en) * 2007-06-07 2008-12-11 Sarah Brenner Methods for diagnosing hypersensitivity reactions
DE102007031417A1 (de) * 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
EP2243791A1 (de) 2009-03-03 2010-10-27 PLS-Design GmbH Klonierung und rekombinante Produktion von Wespengiftprotease und zugehörige Verwendungsverfahren
RU2409671C1 (ru) * 2009-07-10 2011-01-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) Рекомбинантная плазмида для экспрессии в дрожжах pichia pastoris гена фосфолипазы, штамм дрожжей pichia pastoris - продуцент фосфолипазы
CN103079746A (zh) * 2010-09-01 2013-05-01 三菱电机株式会社 激光加工装置及基板位置检测方法
ES2994608T3 (en) 2012-08-10 2025-01-27 Osio Corp D/B/A Yolia Health Contact lens use in the treatment of an ophthalmologic condition
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
TWI826360B (zh) 2016-11-17 2023-12-21 美商艾歐凡斯生物治療公司 殘餘腫瘤浸潤性淋巴細胞及製備和使用彼之方法
CN108950015B (zh) * 2018-08-06 2021-11-23 中国计量大学 鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469677A (en) * 1980-02-19 1984-09-04 Michael J Gabriel Polypeptide active immunosuppressant fraction
US4822608A (en) * 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
DK0495064T3 (da) 1990-08-13 2001-10-15 Biomay Prod & Handel Birkepollenallergen P14 til diagnose og terapi af allergiske sygdomme
BR9206131A (pt) * 1991-06-10 1995-05-02 Lucky Ltd Hepatite C: diagnóstico e vacinas
GB9204583D0 (en) * 1992-03-03 1992-04-15 Unilever Plc Recombinant plant enzyme
CA2150378C (en) * 1992-11-30 2007-10-30 Joel Moss Mammalian muscle nad:arginine adp-ribosyltransferase
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides

Also Published As

Publication number Publication date
EP1650304A3 (de) 2006-07-12
ATE347601T1 (de) 2006-12-15
US5612209A (en) 1997-03-18
DE69434890T2 (de) 2007-10-18
DE69434890D1 (de) 2007-01-18
ES2278379T3 (es) 2007-08-01
CA2157864C (en) 2009-05-12
WO1994020623A1 (en) 1994-09-15
EP1650304B1 (de) 2010-02-24
JP2006000119A (ja) 2006-01-05
AU693785B2 (en) 1998-07-09
DK1650304T3 (da) 2010-06-14
US5593877A (en) 1997-01-14
DE69435277D1 (de) 2010-04-08
DK0688362T3 (da) 2007-04-10
CA2654420A1 (en) 1994-09-15
JP3816515B2 (ja) 2006-08-30
EP1650304A2 (de) 2006-04-26
CA2157864A1 (en) 1994-09-15
US6270763B1 (en) 2001-08-07
JPH08508399A (ja) 1996-09-10
US6287559B1 (en) 2001-09-11
EP0688362B1 (de) 2006-12-06
AU6404194A (en) 1994-09-26
EP0688362A1 (de) 1995-12-27

Similar Documents

Publication Publication Date Title
DE69435277D1 (de) Klonierung und rekombinante Herstellung von Phospholipase aus Vespidae und immunologische Therapien darauf basierend
NZ219485A (en) Production of human endothelial cell growth factor comprising transforming a host cell with an expression vector
LV5288A3 (lv) Nukleinskabes fragments kurs kode cilveka proapolipoproteinu A-1
DE69112611D1 (de) Proteinhydrolysate.
YU8997A (sh) Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži
DK0506825T3 (da) Rekombinante ekspressionsvektorer og oprensningsfremgangsmåder til Thermus thermophilus-DNA-polymerase
HUP9800765A2 (hu) Kevésbé adszorbeálódó és fokozottan hidrolizáló szubtilizin Carlsberg variánsok
DE69117123D1 (de) Menschliches MK Gen und Protein-Sequenz
PT851926E (pt) Variantes do interferao-gama (rhu-ifn-gama) recombinante humano com estabilidade termica melhorada
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
ATE86662T1 (de) Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase.
ES2056123T3 (es) Clonacion del gen que codifica la enzima isoamilasa y su empleo en la produccion de dicha enzima.
NO874704D0 (no) Minaktivin fremstilt ved rekombinant dna-teknikk.
DE69033553D1 (de) Rekombinante herstellung von laktoperoxidase
FR2602793B1 (fr) Sequence d'adn exercant une fonction se manifestant par une surproduction de proteines exocellulaires par diverses souches de bacillus, et vecteurs contenant cette sequence
HUP0104598A1 (hu) Hepatocita-eredetű növekedési faktorból (HGF) és makrofágstimuláló proteinből (MSP) származó rekombináns proteinek
ATE154074T1 (de) Verfahren zur herstellung und reinigung des carboxyterminalen fragments der dna-polymerase i von streptococcus pneumoniae

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties