ATE458817T1 - Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend - Google Patents

Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend

Info

Publication number: ATE458817T1
Authority: AT; Austria
Prior art keywords: phospholipase; nucleic acids; recombinant; vespidae; cloning
Prior art date: 1993-03-11

Application number

AT05017821T

Other languages

English (en)

Inventor

Te Piao King

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-11

Filing date

1994-03-10

Publication date

2010-03-15

1994-03-10 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458817T1 publication Critical patent/ATE458817T1/de

Links

ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 title abstract 4
102000015439 Phospholipases Human genes 0.000 title abstract 4
108010064785 Phospholipases Proteins 0.000 title abstract 4
241000256856 Vespidae Species 0.000 title 1
238000010367 cloning Methods 0.000 title 1
230000001900 immune effect Effects 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 abstract 4
102000039446 nucleic acids Human genes 0.000 abstract 4
108020004707 nucleic acids Proteins 0.000 abstract 4
239000002578 wasp venom Substances 0.000 abstract 3
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
206010020751 Hypersensitivity Diseases 0.000 abstract 2
208000026935 allergic disease Diseases 0.000 abstract 2
230000007815 allergy Effects 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
239000013598 vector Substances 0.000 abstract 2
241000256868 Dolichovespula maculata Species 0.000 abstract 1
241000256834 Vespula vulgaris Species 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Pulmonology (AREA)
Toxicology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

AT05017821T 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend ATE458817T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3140093A	1993-03-11	1993-03-11
US08/180,209 US5593877A (en)	1993-03-11	1994-01-11	Nucleic acid and recombinant production of vespid venom hyaluronidase

Publications (1)

Publication Number	Publication Date
ATE458817T1 true ATE458817T1 (de)	2010-03-15

Family

ID=21859247

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05017821T ATE458817T1 (de)	1993-03-11	1994-03-10	Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend
AT94911550T ATE347601T1 (de)	1993-03-11	1994-03-10	Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT94911550T ATE347601T1 (de)	1993-03-11	1994-03-10	Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Country Status (10)

Country	Link
US (4)	US5593877A (de)
EP (2)	EP1650304B1 (de)
JP (2)	JP3816515B2 (de)
AT (2)	ATE458817T1 (de)
AU (1)	AU693785B2 (de)
CA (2)	CA2157864C (de)
DE (2)	DE69435277D1 (de)
DK (2)	DK1650304T3 (de)
ES (1)	ES2278379T3 (de)
WO (1)	WO1994020623A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3637087B2 (ja) *	1994-11-28	2005-04-06	和男鈴木	新規な白血球活性化因子
US5789194A (en) *	1995-05-23	1998-08-04	Heska Corporation	Parasitic helminth venom allergen antigen 5-like genes and proteins
US6610292B2 (en)	1995-11-22	2003-08-26	Ista Pharmaceuticals, Inc.	Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en)	1995-11-22	1999-02-02	Advanced Corneal Systems, Inc.	Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5804201A (en) *	1996-03-11	1998-09-08	The Rockefeller University	Immunomodulatory peptides of vespid antigen 5
GB9724531D0 (en) *	1997-11-19	1998-01-21	Smithkline Biolog	Novel compounds
BR9908692A (pt) *	1998-03-09	2001-12-04	Ista Pharmaceuticals Inc	Uso de agentes de enrijecimento corneal emortocerotologia enzimática
US6838269B1 (en) *	1998-04-15	2005-01-04	Genencor International, Inc.	Proteins producing an altered immunogenic response and methods of making and using the same
US6835550B1 (en) *	1998-04-15	2004-12-28	Genencor International, Inc.	Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6936249B1 (en) *	1998-04-15	2005-08-30	Genencor International, Inc.	Proteins producing an altered immunogenic response and methods of making and using the same
US6372471B1 (en)	1998-10-01	2002-04-16	The Rockefeller University	Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
US6773695B2 (en)	2000-10-05	2004-08-10	Mannkind Corporation	Modulation of allergic response
ATE448793T1 (de)	2001-03-02	2009-12-15	Univ Rockefeller	Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
MXPA03011987A (es)	2003-12-19	2005-06-23	Osio Sancho Alberto	Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
ATE459720T1 (de) *	2004-08-18	2010-03-15	Bayer Cropscience Ag	Pflanzen mit erhöhter plastidär aktivität der stärkephosphorylierenden r3-enzyme
WO2008149364A2 (en) *	2007-06-07	2008-12-11	Sarah Brenner	Methods for diagnosing hypersensitivity reactions
DE102007031417A1 (de) *	2007-07-04	2009-01-08	Friedrich-Schiller-Universität Jena	Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
EP2243791A1 (de)	2009-03-03	2010-10-27	PLS-Design GmbH	Klonierung und rekombinante Produktion von Wespengiftprotease und zugehörige Verwendungsverfahren
RU2409671C1 (ru) *	2009-07-10	2011-01-20	Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика)	Рекомбинантная плазмида для экспрессии в дрожжах pichia pastoris гена фосфолипазы, штамм дрожжей pichia pastoris - продуцент фосфолипазы
WO2012029142A1 (ja) *	2010-09-01	2012-03-08	三菱電機株式会社	レーザ加工装置および基板位置検出方法
MX364260B (es)	2012-08-10	2019-04-17	Osio Corp D/B/A Yolia Health	Uso de lentes de contacto en el tratamiento de una afección oftalmológica.
TWI788307B (zh)	2016-10-31	2023-01-01	美商艾歐凡斯生物治療公司	用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
US11401507B2 (en)	2016-11-17	2022-08-02	Iovance Biotherapeutics, Inc.	Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
CN108950015B (zh) *	2018-08-06	2021-11-23	中国计量大学	鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4469677A (en) *	1980-02-19	1984-09-04	Michael J Gabriel	Polypeptide active immunosuppressant fraction
US4822608A (en) *	1987-09-14	1989-04-18	Vespa Laboratories, Inc.	Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
CA2067182A1 (en)	1990-08-13	1992-02-14	Rudolf Valenta	Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
JPH06508024A (ja) *	1991-06-10	1994-09-14	ラッキー・リミテッド	Ｃ型肝炎診断試薬およびワクチン
GB9204583D0 (en) *	1992-03-03	1992-04-15	Unilever Plc	Recombinant plant enzyme
CA2150378C (en) *	1992-11-30	2007-10-30	Joel Moss	Mammalian muscle nad:arginine adp-ribosyltransferase
US5532142A (en) *	1993-02-12	1996-07-02	Board Of Regents, The University Of Texas System	Method of isolation and purification of fusion polypeptides

1994
- 1994-01-11 US US08/180,209 patent/US5593877A/en not_active Expired - Lifetime
- 1994-03-10 DK DK05017821.9T patent/DK1650304T3/da active
- 1994-03-10 AT AT05017821T patent/ATE458817T1/de not_active IP Right Cessation
- 1994-03-10 EP EP05017821A patent/EP1650304B1/de not_active Expired - Lifetime
- 1994-03-10 CA CA002157864A patent/CA2157864C/en not_active Expired - Fee Related
- 1994-03-10 AT AT94911550T patent/ATE347601T1/de not_active IP Right Cessation
- 1994-03-10 EP EP94911550A patent/EP0688362B1/de not_active Expired - Lifetime
- 1994-03-10 DE DE69435277T patent/DE69435277D1/de not_active Expired - Lifetime
- 1994-03-10 ES ES94911550T patent/ES2278379T3/es not_active Expired - Lifetime
- 1994-03-10 DK DK94911550T patent/DK0688362T3/da active
- 1994-03-10 AU AU64041/94A patent/AU693785B2/en not_active Ceased
- 1994-03-10 WO PCT/US1994/002629 patent/WO1994020623A1/en not_active Ceased
- 1994-03-10 JP JP52032094A patent/JP3816515B2/ja not_active Expired - Fee Related
- 1994-03-10 DE DE69434890T patent/DE69434890T2/de not_active Expired - Lifetime
- 1994-03-10 CA CA002654420A patent/CA2654420A1/en not_active Abandoned
1995
- 1995-02-08 US US08/385,745 patent/US5612209A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,853 patent/US6287559B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/485,388 patent/US6270763B1/en not_active Expired - Fee Related
2005
- 2005-08-18 JP JP2005238009A patent/JP2006000119A/ja active Pending

Also Published As

Publication number	Publication date
US5593877A (en)	1997-01-14
JP3816515B2 (ja)	2006-08-30
AU693785B2 (en)	1998-07-09
WO1994020623A1 (en)	1994-09-15
DK1650304T3 (da)	2010-06-14
US6287559B1 (en)	2001-09-11
EP1650304A2 (de)	2006-04-26
DE69435277D1 (de)	2010-04-08
CA2157864A1 (en)	1994-09-15
CA2157864C (en)	2009-05-12
DK0688362T3 (da)	2007-04-10
EP1650304A3 (de)	2006-07-12
EP0688362A1 (de)	1995-12-27
JP2006000119A (ja)	2006-01-05
JPH08508399A (ja)	1996-09-10
US6270763B1 (en)	2001-08-07
DE69434890T2 (de)	2007-10-18
US5612209A (en)	1997-03-18
ATE347601T1 (de)	2006-12-15
ES2278379T3 (es)	2007-08-01
AU6404194A (en)	1994-09-26
EP1650304B1 (de)	2010-02-24
DE69434890D1 (de)	2007-01-18
EP0688362B1 (de)	2006-12-06
CA2654420A1 (en)	1994-09-15

Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE458817T1 (de)	2010-03-15	Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend
EP0259475A4 (de)	1989-10-12	Rekombinanter menschlicher endothelzellenwachstumsfaktor.
LV5288A3 (lv)	1993-10-10	Nukleinskabes fragments kurs kode cilveka proapolipoproteinu A-1
DE69112611D1 (de)	1995-10-05	Proteinhydrolysate.
ATE169337T1 (de)	1998-08-15	Rekombinante expressionsvektoren und reinigungsverfahren für dns-polymerase aus thermus thermophilus
YU8997A (sh)	1999-09-27	Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži
ATE71632T1 (de)	1992-02-15	Cdns und gen fuer menschliches angiogenin (angiogenesis-faktor) und expression.
ATE380867T1 (de)	2007-12-15	Lactoferrinrezeptorgen von moraxella
ATE134219T1 (de)	1996-02-15	Menschliches mk gen und protein-sequenz
PT851926E (pt)	2003-12-31	Variantes do interferao-gama (rhu-ifn-gama) recombinante humano com estabilidade termica melhorada
ATE264913T1 (de)	2004-05-15	Protease-resistente analoge des thrombomodulin
ATE86662T1 (de)	1993-03-15	Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase.
NO955258L (no)	1996-02-22	Medisinsk anvendelse av enzymer
ES2056123T3 (es)	1994-10-01	Clonacion del gen que codifica la enzima isoamilasa y su empleo en la produccion de dicha enzima.
NO874704L (no)	1987-11-11	Minaktivin fremstilt ved rekombinant dna-teknikk.
FR2602793B1 (fr)	1989-04-07	Sequence d'adn exercant une fonction se manifestant par une surproduction de proteines exocellulaires par diverses souches de bacillus, et vecteurs contenant cette sequence
ATE154074T1 (de)	1997-06-15	Verfahren zur herstellung und reinigung des carboxyterminalen fragments der dna-polymerase i von streptococcus pneumoniae