ATE347601T1 - Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend - Google Patents

Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Info

Publication number
ATE347601T1
ATE347601T1 AT94911550T AT94911550T ATE347601T1 AT E347601 T1 ATE347601 T1 AT E347601T1 AT 94911550 T AT94911550 T AT 94911550T AT 94911550 T AT94911550 T AT 94911550T AT E347601 T1 ATE347601 T1 AT E347601T1
Authority
AT
Austria
Prior art keywords
enzymes
recombinant
nucleic acids
phospholypase
vespidae
Prior art date
Application number
AT94911550T
Other languages
English (en)
Inventor
Te Piao King
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Application granted granted Critical
Publication of ATE347601T1 publication Critical patent/ATE347601T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT94911550T 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend ATE347601T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3140093A 1993-03-11 1993-03-11
US08/180,209 US5593877A (en) 1993-03-11 1994-01-11 Nucleic acid and recombinant production of vespid venom hyaluronidase

Publications (1)

Publication Number Publication Date
ATE347601T1 true ATE347601T1 (de) 2006-12-15

Family

ID=21859247

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05017821T ATE458817T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend
AT94911550T ATE347601T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von enzymen aus vespidae-giften, beispielsweise phospholypase und hyaluronidase und immunologische therapien darauf basierend

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05017821T ATE458817T1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von phospholipase aus vespidae und immunologische therapien darauf basierend

Country Status (10)

Country Link
US (4) US5593877A (de)
EP (2) EP1650304B1 (de)
JP (2) JP3816515B2 (de)
AT (2) ATE458817T1 (de)
AU (1) AU693785B2 (de)
CA (2) CA2654420A1 (de)
DE (2) DE69435277D1 (de)
DK (2) DK1650304T3 (de)
ES (1) ES2278379T3 (de)
WO (1) WO1994020623A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3637087B2 (ja) * 1994-11-28 2005-04-06 和男 鈴木 新規な白血球活性化因子
US5789194A (en) * 1995-05-23 1998-08-04 Heska Corporation Parasitic helminth venom allergen antigen 5-like genes and proteins
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
GB9724531D0 (en) * 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
WO1999045869A1 (en) 1998-03-09 1999-09-16 Ista Pharmaceuticals, Inc. Use of corneal hardening agents in enzyme orthokeratology
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6372471B1 (en) * 1998-10-01 2002-04-16 The Rockefeller University Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
US6773695B2 (en) 2000-10-05 2004-08-10 Mannkind Corporation Modulation of allergic response
EP1499349B1 (de) 2001-03-02 2009-11-18 The Rockefeller University Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
MXPA03011987A (es) * 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
ATE459720T1 (de) * 2004-08-18 2010-03-15 Bayer Cropscience Ag Pflanzen mit erhöhter plastidär aktivität der stärkephosphorylierenden r3-enzyme
WO2008149364A2 (en) * 2007-06-07 2008-12-11 Sarah Brenner Methods for diagnosing hypersensitivity reactions
DE102007031417A1 (de) * 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
EP2243791A1 (de) 2009-03-03 2010-10-27 PLS-Design GmbH Klonierung und rekombinante Produktion von Wespengiftprotease und zugehörige Verwendungsverfahren
RU2409671C1 (ru) * 2009-07-10 2011-01-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) Рекомбинантная плазмида для экспрессии в дрожжах pichia pastoris гена фосфолипазы, штамм дрожжей pichia pastoris - продуцент фосфолипазы
JP5383920B2 (ja) * 2010-09-01 2014-01-08 三菱電機株式会社 レーザ加工装置および基板位置検出方法
MX364260B (es) 2012-08-10 2019-04-17 Osio Corp D/B/A Yolia Health Uso de lentes de contacto en el tratamiento de una afección oftalmológica.
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
TWI826360B (zh) 2016-11-17 2023-12-21 美商艾歐凡斯生物治療公司 殘餘腫瘤浸潤性淋巴細胞及製備和使用彼之方法
CN108950015B (zh) * 2018-08-06 2021-11-23 中国计量大学 鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469677A (en) * 1980-02-19 1984-09-04 Michael J Gabriel Polypeptide active immunosuppressant fraction
US4822608A (en) * 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
JPH05502589A (ja) 1990-08-13 1993-05-13 バイオメイ　バイオテクニック　プロダクションズ　ウント　ヘンデルスゲゼルシャフト　エム．ベー．ハー． アレルギー疾患の診断および治療用のカバ花粉アレルゲンｐ１４
BR9206131A (pt) * 1991-06-10 1995-05-02 Lucky Ltd Hepatite C: diagnóstico e vacinas
GB9204583D0 (en) * 1992-03-03 1992-04-15 Unilever Plc Recombinant plant enzyme
EP0673440A4 (de) * 1992-11-30 1997-10-01 Us Health Nad: arginin adp-ribosyltransferase aus dem muskel von säugetieren.
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides

Also Published As

Publication number Publication date
DE69434890D1 (de) 2007-01-18
ATE458817T1 (de) 2010-03-15
ES2278379T3 (es) 2007-08-01
JP2006000119A (ja) 2006-01-05
JPH08508399A (ja) 1996-09-10
US6287559B1 (en) 2001-09-11
DE69435277D1 (de) 2010-04-08
CA2157864C (en) 2009-05-12
JP3816515B2 (ja) 2006-08-30
DK1650304T3 (da) 2010-06-14
US5612209A (en) 1997-03-18
EP0688362A1 (de) 1995-12-27
WO1994020623A1 (en) 1994-09-15
EP1650304A3 (de) 2006-07-12
EP1650304A2 (de) 2006-04-26
EP0688362B1 (de) 2006-12-06
CA2157864A1 (en) 1994-09-15
DK0688362T3 (da) 2007-04-10
AU693785B2 (en) 1998-07-09
US6270763B1 (en) 2001-08-07
AU6404194A (en) 1994-09-26
CA2654420A1 (en) 1994-09-15
US5593877A (en) 1997-01-14
DE69434890T2 (de) 2007-10-18
EP1650304B1 (de) 2010-02-24

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