ATE461289T1 - Polyketide-synthese - Google Patents

Polyketide-synthese

Info

Publication number
ATE461289T1
ATE461289T1 AT99928126T AT99928126T ATE461289T1 AT E461289 T1 ATE461289 T1 AT E461289T1 AT 99928126 T AT99928126 T AT 99928126T AT 99928126 T AT99928126 T AT 99928126T AT E461289 T1 ATE461289 T1 AT E461289T1
Authority
AT
Austria
Prior art keywords
pks
domain
loading
substituted
acyl
Prior art date
Application number
AT99928126T
Other languages
English (en)
Inventor
Peter LEADLAY
James Staunton
Jesus Cortes
Hamish Mcarthur
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE461289T1 publication Critical patent/ATE461289T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
AT99928126T 1998-06-29 1999-06-29 Polyketide-synthese ATE461289T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9814006.4A GB9814006D0 (en) 1998-06-29 1998-06-29 Polyketides and their synthesis
PCT/GB1999/002042 WO2000000500A2 (en) 1998-06-29 1999-06-29 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
ATE461289T1 true ATE461289T1 (de) 2010-04-15

Family

ID=10834580

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99928128T ATE321137T1 (de) 1998-06-29 1999-06-29 Polyketide und ihre herstellung
AT99928126T ATE461289T1 (de) 1998-06-29 1999-06-29 Polyketide-synthese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99928128T ATE321137T1 (de) 1998-06-29 1999-06-29 Polyketide und ihre herstellung

Country Status (22)

Country Link
US (3) US7148045B1 (de)
EP (2) EP1090123B1 (de)
JP (2) JP2002519014A (de)
KR (2) KR20010071683A (de)
CN (2) CN1315956A (de)
AT (2) ATE321137T1 (de)
AU (2) AU763230B2 (de)
BR (2) BR9911712A (de)
CA (2) CA2331764C (de)
CZ (2) CZ20004913A3 (de)
DE (2) DE69930510T2 (de)
ES (1) ES2341403T3 (de)
GB (1) GB9814006D0 (de)
HU (2) HUP0105179A2 (de)
ID (2) ID27419A (de)
IL (2) IL140438A0 (de)
MX (2) MXPA00012936A (de)
NZ (2) NZ509600A (de)
PL (2) PL345575A1 (de)
TR (2) TR200003771T2 (de)
WO (2) WO2000000500A2 (de)
YU (2) YU82700A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7630006B2 (en) * 1997-10-09 2009-12-08 Fotonation Ireland Limited Detecting red eye filter and apparatus using meta-data
US7738015B2 (en) * 1997-10-09 2010-06-15 Fotonation Vision Limited Red-eye filter method and apparatus
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) * 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
AU2001248588B2 (en) 2000-04-13 2006-02-02 Biotica Technology Limited Hybrid glycosylated products and their production and use
KR101016561B1 (ko) * 2002-02-19 2011-02-22 다우 아그로사이언시즈 엘엘씨 신규한 스피노신 생산 폴리케타이드 신타제
ES2544624T3 (es) 2002-07-16 2015-09-02 Buck Institute For Research On Aging Producción de policétidos
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
EP2254995A4 (de) * 2008-03-28 2011-05-25 Univ California Herstellung von dicarboxylsäuren mithilfe von polyketidsynthasen
CN102014623A (zh) * 2008-04-29 2011-04-13 加利福尼亚大学董事会 使用聚酮化物合酶制备生物燃料
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
WO2011011689A2 (en) * 2009-07-23 2011-01-27 The Regents Of The University Of Michigan Method for enzymatic production of decarboxylated polyketides and fatty acids
EP2456777A2 (de) 2009-07-24 2012-05-30 Université Henri Poincaré - Nancy 1 Stambomycin und derivate, ihre herstellung und verwendung als arzneimittel
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
EP4095146A1 (de) 2013-04-04 2022-11-30 President And Fellows Of Harvard College Makrolide sowie verfahren zu deren herstellung und verwendung
JP2017531663A (ja) * 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN106591388A (zh) * 2016-10-13 2017-04-26 中国农业科学院生物技术研究所 具有聚酮类化合物合成功能的基因Dr2091
AU2018225390B2 (en) 2017-02-22 2021-07-22 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolides
CA3053874A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
KR102741381B1 (ko) 2017-06-06 2024-12-11 지머젠 인코포레이티드 사카로폴리스포라 스피노사를 개량하기 위한 고 처리량(htp) 게놈 공학 플랫폼
CN112188893A (zh) 2018-03-23 2021-01-05 Isr免疫系统调节控股公共有限公司 大环内酯化合物和免疫检查点抑制剂的组合

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
WO1995008548A1 (en) * 1993-09-20 1995-03-30 The Leland Stanford Junior University Recombinant production of novel polyketides
EP1493814A1 (de) * 1995-07-06 2005-01-05 The Leland Stanford Junior University Zellfreie Synthese von Polyketiden
CA2259420C (en) * 1996-07-05 2007-09-18 Biotica Technology Limited Erythromycins and process for their preparation
JPH10303641A (ja) * 1997-04-23 1998-11-13 Mitsubishi Electric Corp 発振器及び無線機
CA2288030A1 (en) * 1997-04-30 1998-11-05 Kosan Biosciences, Inc. Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.

Also Published As

Publication number Publication date
US20060240528A1 (en) 2006-10-26
HUP0105179A2 (hu) 2002-05-29
KR20010071684A (ko) 2001-07-31
CZ20004912A3 (cs) 2001-08-15
CA2331764C (en) 2008-03-11
WO2000000618A3 (en) 2000-04-27
AU4524599A (en) 2000-01-17
DE69942149D1 (en) 2010-04-29
WO2000000500A2 (en) 2000-01-06
EP1091971A2 (de) 2001-04-18
BR9911710A (pt) 2001-03-20
TR200003771T2 (tr) 2001-10-22
CA2331764A1 (en) 2000-01-06
EP1090123A2 (de) 2001-04-11
JP4489947B2 (ja) 2010-06-23
GB9814006D0 (en) 1998-08-26
EP1091971B1 (de) 2010-03-17
US20050090461A1 (en) 2005-04-28
WO2000000500A3 (en) 2000-03-16
ID28285A (id) 2001-05-10
ID27419A (id) 2001-04-05
CN1315956A (zh) 2001-10-03
MXPA00012936A (es) 2002-06-21
TR200003770T2 (tr) 2001-04-20
ATE321137T1 (de) 2006-04-15
CZ20004913A3 (cs) 2001-11-14
AU4524799A (en) 2000-01-17
YU82700A (sh) 2003-10-31
IL140440A0 (en) 2002-02-10
ES2341403T3 (es) 2010-06-18
DE69930510D1 (de) 2006-05-11
AU763230B2 (en) 2003-07-17
YU82500A (sh) 2004-03-12
HUP0102945A2 (hu) 2001-12-28
US7198922B2 (en) 2007-04-03
CA2335523A1 (en) 2000-01-06
AU765257B2 (en) 2003-09-11
PL345575A1 (en) 2001-12-17
IL140438A0 (en) 2002-02-10
EP1090123B1 (de) 2006-03-22
JP2002519014A (ja) 2002-07-02
PL345578A1 (en) 2001-12-17
NZ509600A (en) 2004-03-26
WO2000000618A2 (en) 2000-01-06
HK1034536A1 (en) 2001-10-26
CN1316001A (zh) 2001-10-03
US7148045B1 (en) 2006-12-12
BR9911712A (pt) 2001-03-20
DE69930510T2 (de) 2006-12-07
JP2002519032A (ja) 2002-07-02
MXPA00012885A (es) 2002-07-02
KR20010071683A (ko) 2001-07-31
NZ509601A (en) 2004-04-30

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