ATE470444T1 - Alpha,beta-ungesättigte sulfone zur behandlung von zellenwucherungsstörungen - Google Patents

Alpha,beta-ungesättigte sulfone zur behandlung von zellenwucherungsstörungen

Info

Publication number: ATE470444T1
Authority: AT; Austria
Prior art keywords: group; formula; independently selected; naphthyl; nitro
Prior art date: 2000-04-14

Application number

AT01925013T

Other languages

English (en)

Inventor

E Reddy

M Reddy

Original Assignee

Univ Temple

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-14

Filing date

2001-04-13

Publication date

2010-06-15

2001-04-13 Application filed by Univ Temple filed Critical Univ Temple

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE470444T1 publication Critical patent/ATE470444T1/de

Links

150000003457 sulfones Chemical class 0.000 title abstract 3
230000010261 cell growth Effects 0.000 title 1
208000037824 growth disorder Diseases 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
-1 for example Substances 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
239000011593 sulfur Substances 0.000 abstract 3
MNCMBBIFTVWHIP-UHFFFAOYSA-N 1-anthracen-9-yl-2,2,2-trifluoroethanone Chemical group C1=CC=C2C(C(=O)C(F)(F)F)=C(C=CC=C3)C3=CC2=C1 MNCMBBIFTVWHIP-UHFFFAOYSA-N 0.000 abstract 2
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 2
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
230000001028 anti-proliverative effect Effects 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
- C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Pyrrole Compounds (AREA)

AT01925013T 2000-04-14 2001-04-13 Alpha,beta-ungesättigte sulfone zur behandlung von zellenwucherungsstörungen ATE470444T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19736800P	2000-04-14	2000-04-14
PCT/US2001/012133 WO2001078733A1 (en)	2000-04-14	2001-04-13	Alpha,beta-unsaturated sulfones for treating proliferative disorders

Publications (1)

Publication Number	Publication Date
ATE470444T1 true ATE470444T1 (de)	2010-06-15

Family

ID=22729111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01925013T ATE470444T1 (de)	2000-04-14	2001-04-13	Alpha,beta-ungesättigte sulfone zur behandlung von zellenwucherungsstörungen

Country Status (11)

Country	Link
US (2)	US6541475B2 (de)
EP (1)	EP1292308B1 (de)
JP (1)	JP4972266B2 (de)
KR (1)	KR100828449B1 (de)
AT (1)	ATE470444T1 (de)
AU (2)	AU2001251614B2 (de)
CA (1)	CA2405172C (de)
DE (1)	DE60142336D1 (de)
IL (2)	IL152211A0 (de)
NZ (1)	NZ522715A (de)
WO (1)	WO2001078733A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2424884C (en) *	2000-10-05	2009-12-15	E. Premkumar Reddy	Substituted (e)-styryl benzylsulfones for treating proliferative disorders
DE10136485C1 (de) *	2001-07-27	2003-03-06	Bayer Ag	Polyaminosäure-katalysiertes Verfahren zur enantioselektiven Epoxidierung von alpha,ß-ungesättigten Eonen und alpha,ß-ungesättigten Sulfonen
NZ535232A (en) *	2002-02-28	2007-05-31	Univ Temple	Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
IL163608A0 (en) *	2002-02-28	2005-12-18	Univ Temple	Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
AU2004289281C1 (en) *	2003-11-14	2011-12-08	Onconova Therapeutics, Inc.	Alpha, beta-Unsaturated sulfoxides for treating proliferative disorders
AU2005222947B2 (en)	2004-03-16	2010-12-23	Onconova Therapeutics Inc.	Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
AU2005253966B2 (en) *	2004-06-08	2012-01-19	Temple University Of The Commonwealth System Of Higher Education	Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
US8058313B2 (en)	2004-06-24	2011-11-15	Temple University—Of the Commonwealth System of Higher Education	Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
US20090306207A1 (en) *	2005-01-05	2009-12-10	Reddy M V Ramana	Treatment of Drug-Resistant Proliferative Disorders
US8143453B2 (en) *	2005-02-25	2012-03-27	Temple University—Of the Commonwealth System of Higher Education	Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
US8664272B2 (en)	2006-08-30	2014-03-04	Temple University—Of the Commonwealth System of Higher Education	Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
EP2065374A1 (de) *	2007-11-30	2009-06-03	Bayer CropScience AG	2-(Benzyl- und 1H-pyrazol-4-ylmethyl)sulfinyl-Thiazol-Derivate als Herbizide und Pflanzenwachstumsregulatoren
CA2885217C (en)	2012-09-20	2019-10-08	Temple University - Of The Commonwealth System Of Higher Education	Substituted alkyl diaryl derivatives, methods of preparation and uses
ES2864681T3 (es)	2012-12-07	2021-10-14	Onconova Therapeutics Inc	Tratamiento del cáncer hematológico refractario a un agente contra el cáncer
US10383831B2 (en)	2015-08-03	2019-08-20	Temple University—Of the Commonwealth System of Higher Education	2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

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US2532612A (en)	1945-08-29	1950-12-05	Union Oil Co	Preparation of unsaturated thio-ethers
US3185743A (en)	1960-08-24	1965-05-25	Union Carbide Corp	Production of olefinic compounds from allyl sulfones
US3418101A (en)	1965-12-15	1968-12-24	Pennsalt Chemicals Corp	Process for plant desiccation
US3514386A (en)	1967-12-11	1970-05-26	Exxon Research Engineering Co	Stereoselective addition of thiols to acetylenic compounds
US3917714A (en)	1972-09-06	1975-11-04	American Cyanamid Co	Bis(alkylsulfonyl)vinylbenzenes
US4161407A (en)	1977-10-06	1979-07-17	Eastman Kodak Company	Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin
US4386221A (en)	1981-10-28	1983-05-31	Eastman Kodak Company	Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones
US4937388A (en)	1985-08-09	1990-06-26	Imperial Chemical Industries Plc	Insecticidal ethers
US5659087A (en)	1995-06-07	1997-08-19	Eli Lilly And Company	Diarylvinyl sulfoxides
US5710173A (en) *	1995-06-07	1998-01-20	Sugen, Inc.	Thienyl compounds for inhibition of cell proliferative disorders
JP3660395B2 (ja) *	1995-06-22	2005-06-15	大鵬薬品工業株式会社	フェニルスルホン誘導体及びその製造方法
ATE284386T1 (de)	1997-10-03	2004-12-15	Univ Temple	Styrolsulfone als antikrebsmittel
US6201154B1 (en) *	1999-03-31	2001-03-13	Temple University-Of The Commonwealth Of Higher Education	Z-styryl sulfone anticancer agents
WO2000059494A1 (en) *	1999-04-02	2000-10-12	Temple University- Of The Commonwealth System Of Higher Education	Styryl sulfone anticancer agents
WO2000059495A1 (en) *	1999-04-02	2000-10-12	Temple University - Of The Commonwealth System Of Higher Education	(e)-styryl sulfone anticancer agents
IL149064A0 (en) *	1999-10-12	2002-11-10	Univ Temple	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents

2001
- 2001-04-12 US US09/833,834 patent/US6541475B2/en not_active Expired - Lifetime
- 2001-04-13 IL IL15221101A patent/IL152211A0/xx active IP Right Grant
- 2001-04-13 DE DE60142336T patent/DE60142336D1/de not_active Expired - Lifetime
- 2001-04-13 CA CA002405172A patent/CA2405172C/en not_active Expired - Fee Related
- 2001-04-13 AU AU2001251614A patent/AU2001251614B2/en not_active Ceased
- 2001-04-13 AT AT01925013T patent/ATE470444T1/de not_active IP Right Cessation
- 2001-04-13 EP EP01925013A patent/EP1292308B1/de not_active Expired - Lifetime
- 2001-04-13 JP JP2001576033A patent/JP4972266B2/ja not_active Expired - Fee Related
- 2001-04-13 AU AU5161401A patent/AU5161401A/xx active Pending
- 2001-04-13 KR KR1020027013800A patent/KR100828449B1/ko not_active Expired - Fee Related
- 2001-04-13 WO PCT/US2001/012133 patent/WO2001078733A1/en not_active Ceased
- 2001-04-13 NZ NZ522715A patent/NZ522715A/en not_active IP Right Cessation
2002
- 2002-10-09 IL IL152211A patent/IL152211A/en not_active IP Right Cessation
- 2002-11-21 US US10/301,332 patent/US6599932B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60142336D1 (de)	2010-07-22
EP1292308A1 (de)	2003-03-19
JP2003530439A (ja)	2003-10-14
KR100828449B1 (ko)	2008-05-13
CA2405172C (en)	2009-08-25
US20030130339A1 (en)	2003-07-10
IL152211A0 (en)	2003-05-29
US6541475B2 (en)	2003-04-01
AU2001251614B2 (en)	2005-05-05
WO2001078733A1 (en)	2001-10-25
NZ522715A (en)	2003-09-26
US6599932B1 (en)	2003-07-29
IL152211A (en)	2008-08-07
AU2001251614C1 (en)	2001-10-30
EP1292308B1 (de)	2010-06-09
CA2405172A1 (en)	2001-10-25
KR20030011304A (ko)	2003-02-07
EP1292308A4 (de)	2005-09-14
AU5161401A (en)	2001-10-30
JP4972266B2 (ja)	2012-07-11
US20020028818A1 (en)	2002-03-07

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60142336D1 (de)	2010-07-22	Alpha,beta-ungesättigte sulfone zur behandlung von zellenwucherungsstörungen
AP2003002841A0 (en)	2003-09-30	Quinazolines as MMP-13 inhibitors
ATE277889T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
MY147780A (en)	2013-01-31	Carboxamide compounds and their use as calpain inhibitors
NO20035327D0 (no)	2003-11-28	Biologisk aktive metylen-blått derivater
DE60132309D1 (de)	2008-02-21	Amin-derivate zur behandlung von apoptosis
MXPA02005604A (es)	2004-09-10	Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa.
DK1204654T3 (da)	2003-11-17	Benzofurylpiperaziner og benzofurylhomopiperaziner: Serotonin agonister
YU69902A (sh)	2005-07-19	Novi derivati piperazina
UY27431A1 (es)	2003-03-31	Compuestos químicos
UY27435A1 (es)	2003-04-30	Compuestos químicos
EA200400466A1 (ru)	2004-08-26	Производные пиперазина с антагонистической активностью к рецептору ccr1
EA200400223A1 (ru)	2004-12-30	Новые производные 2h-пиридазин-3-она, фармацевтические композиции, содержащие эти производные, и способ получения активного ингредиента
PL376324A1 (en)	2005-12-27	Piperazinyl and diazapanyl benzamides and benzthioamides
GB9925955D0 (en)	1999-12-29	Hcv n33 protease inhibitors
ATE277897T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
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