ATE471937T1 - Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon - Google Patents

Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Info

Publication number
ATE471937T1
ATE471937T1 AT04777196T AT04777196T ATE471937T1 AT E471937 T1 ATE471937 T1 AT E471937T1 AT 04777196 T AT04777196 T AT 04777196T AT 04777196 T AT04777196 T AT 04777196T AT E471937 T1 ATE471937 T1 AT E471937T1
Authority
AT
Austria
Prior art keywords
derivatives
group substituted
cyclopropyl group
substituted oxazolidinone
oxazolidinone antibiotics
Prior art date
Application number
AT04777196T
Other languages
English (en)
Inventor
Yasumichi Fukuda
Original Assignee
Merck Sharp & Dohme
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Kyorin Seiyaku Kk filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE471937T1 publication Critical patent/ATE471937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04777196T 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon ATE471937T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE471937T1 true ATE471937T1 (de) 2010-07-15

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04777196T ATE471937T1 (de) 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Country Status (23)

Country Link
US (2) US7462633B2 (de)
EP (1) EP1646629B1 (de)
JP (1) JP4607107B2 (de)
KR (1) KR20060113625A (de)
AR (1) AR044990A1 (de)
AT (1) ATE471937T1 (de)
AU (1) AU2004256083B2 (de)
BR (1) BRPI0411688A (de)
CA (1) CA2530140C (de)
CL (1) CL2004001678A1 (de)
DE (1) DE602004027811D1 (de)
EC (1) ECSP056257A (de)
IL (1) IL172785A0 (de)
IS (1) IS8178A (de)
MA (1) MA27938A1 (de)
MX (1) MXPA06000228A (de)
MY (1) MY140137A (de)
NO (1) NO20060558L (de)
NZ (1) NZ544237A (de)
PE (1) PE20050732A1 (de)
RU (1) RU2348628C2 (de)
TW (1) TW200510421A (de)
WO (1) WO2005005398A2 (de)

Families Citing this family (22)

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ATE304536T1 (de) * 2001-04-17 2005-09-15 Merck & Co Inc Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1656370B1 (de) * 2003-06-03 2012-08-15 Rib-X Pharmaceuticals, Inc. Heterocyclische biarylverbindungen und verfahren zu deren herstellung und anwendung
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
AU2004256086B2 (en) * 2003-07-02 2007-12-06 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
AR046782A1 (es) * 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP5534497B2 (ja) * 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド トリアゾール類の合成方法
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
AU2008260647A1 (en) * 2007-05-23 2008-12-11 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
RU2659792C1 (ru) 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Оксазолидиноны и способ их очистки
MY156354A (en) 2009-02-03 2016-02-15 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR20120106697A (ko) 2009-06-26 2012-09-26 파나세아 바이오테크 리미티드 신규 아자비시클로헥산
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2020021468A1 (en) 2018-07-25 2020-01-30 Cadila Healthcare Limited Substituted oxazolidinones for the treatment of mammalian infections
EP3999183A4 (de) * 2019-07-17 2023-11-15 Ono Pharmaceutical Co., Ltd. Verbindungen mit kdm5-hemmender wirkung und deren pharmazeutische verwendungen
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

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US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
EP0610265B1 (de) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituierte aryl- und heteroaryl-phenyloxazolidinone
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HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE69614847T2 (de) 1995-05-11 2002-04-04 Pharmacia & Upjohn Co., Kalamazoo Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
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KR20020072311A (ko) 2000-02-10 2002-09-14 파마시아 앤드 업존 캄파니 피페라진 아미드 치환기를 갖는 옥사졸리디논 티오아미드
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AU5889701A (en) * 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
HUP0302918A2 (hu) * 2000-07-17 2003-12-29 Ranbaxy Laboratories Limited Mikrobaellenes oxazolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására
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ATE471937T1 (de) * 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
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US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo

Also Published As

Publication number Publication date
RU2005140379A (ru) 2007-08-10
EP1646629B1 (de) 2010-06-23
JP4607107B2 (ja) 2011-01-05
AU2004256083A1 (en) 2005-01-20
US7462633B2 (en) 2008-12-09
PE20050732A1 (es) 2005-11-02
US7582659B2 (en) 2009-09-01
KR20060113625A (ko) 2006-11-02
WO2005005398A2 (en) 2005-01-20
TW200510421A (en) 2005-03-16
EP1646629A2 (de) 2006-04-19
IL172785A0 (en) 2006-06-11
AU2004256083B2 (en) 2007-10-11
ECSP056257A (es) 2006-04-19
WO2005005398A3 (en) 2005-04-28
CA2530140A1 (en) 2005-01-20
DE602004027811D1 (de) 2010-08-05
AR044990A1 (es) 2005-10-12
BRPI0411688A (pt) 2006-12-26
NZ544237A (en) 2008-09-26
US20050038092A1 (en) 2005-02-17
CL2004001678A1 (es) 2005-05-20
MY140137A (en) 2009-11-30
IS8178A (is) 2005-12-13
RU2348628C2 (ru) 2009-03-10
MXPA06000228A (es) 2006-06-27
US20070203187A1 (en) 2007-08-30
JP2007521281A (ja) 2007-08-02
MA27938A1 (fr) 2006-06-01
NO20060558L (no) 2006-02-02
CA2530140C (en) 2010-11-09

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