BRPI0411688A - antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados - Google Patents

antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados

Info

Publication number
BRPI0411688A
BRPI0411688A BRPI0411688-7A BRPI0411688A BRPI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A BR PI0411688 A BRPI0411688 A BR PI0411688A
Authority
BR
Brazil
Prior art keywords
derivatives
substituted oxazolidinone
group substituted
cyclopropyl group
antibiotics
Prior art date
Application number
BRPI0411688-7A
Other languages
English (en)
Inventor
Yasumichi Fukuda
Original Assignee
Merck & Co Inc
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Kyorin Seiyaku Kk filed Critical Merck & Co Inc
Publication of BRPI0411688A publication Critical patent/BRPI0411688A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"ANTIBIóTICOS DE OXAZOLIDINONA SUBSTITUìDA DE GRUPO DE CICLOPROPIL E SEUS DERIVADOS". Esta invenção está relacionada a novas oxazolidinonas, que possuem metade de ciclopropil, que são eficazes contra patogêneses aeróbicas e anaeróbicas, como estafilococos, estreptococos e enterococos multi-resistentes espécie de Bacterióides spp., de Clostridia spp., bem como organismos de ácido rápido como Mycobacterium tuberculosis e outras espécies de micobactérias. Os compostos são representados pela fórmula estrutural (I) : seu enantiónero, diastereómero ou sal ou éster aceitável farmaceuticamente.
BRPI0411688-7A 2003-07-02 2004-06-29 antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados BRPI0411688A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
BRPI0411688A true BRPI0411688A (pt) 2006-12-26

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411688-7A BRPI0411688A (pt) 2003-07-02 2004-06-29 antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados

Country Status (23)

Country Link
US (2) US7462633B2 (pt)
EP (1) EP1646629B1 (pt)
JP (1) JP4607107B2 (pt)
KR (1) KR20060113625A (pt)
AR (1) AR044990A1 (pt)
AT (1) ATE471937T1 (pt)
AU (1) AU2004256083B2 (pt)
BR (1) BRPI0411688A (pt)
CA (1) CA2530140C (pt)
CL (1) CL2004001678A1 (pt)
DE (1) DE602004027811D1 (pt)
EC (1) ECSP056257A (pt)
IL (1) IL172785A0 (pt)
IS (1) IS8178A (pt)
MA (1) MA27938A1 (pt)
MX (1) MXPA06000228A (pt)
MY (1) MY140137A (pt)
NO (1) NO20060558L (pt)
NZ (1) NZ544237A (pt)
PE (1) PE20050732A1 (pt)
RU (1) RU2348628C2 (pt)
TW (1) TW200510421A (pt)
WO (1) WO2005005398A2 (pt)

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DE602004027811D1 (de) 2003-07-02 2010-08-05 Kyorin Seiyaku Kk Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
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KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
DE602006019870D1 (de) 2005-06-08 2011-03-10 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
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US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
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BR112012000657A2 (pt) 2009-06-26 2016-11-16 Panacea Biotec Ltd novos azabicilohexanos
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
US12109203B2 (en) 2018-07-25 2024-10-08 Zydus Lifesciences Limited Substituted oxazolidinones for the treatment of mammalian infections
JP2022541954A (ja) * 2019-07-17 2022-09-28 小野薬品工業株式会社 Ｋｄｍ５阻害活性を有する化合物およびその医薬用途
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DE602004027811D1 (de) * 2003-07-02 2010-08-05 Kyorin Seiyaku Kk Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Also Published As

Publication number Publication date
ECSP056257A (es) 2006-04-19
US20050038092A1 (en) 2005-02-17
NZ544237A (en) 2008-09-26
KR20060113625A (ko) 2006-11-02
ATE471937T1 (de) 2010-07-15
CA2530140C (en) 2010-11-09
IS8178A (is) 2005-12-13
EP1646629B1 (en) 2010-06-23
EP1646629A2 (en) 2006-04-19
JP2007521281A (ja) 2007-08-02
PE20050732A1 (es) 2005-11-02
US7582659B2 (en) 2009-09-01
MA27938A1 (fr) 2006-06-01
WO2005005398A2 (en) 2005-01-20
US20070203187A1 (en) 2007-08-30
CL2004001678A1 (es) 2005-05-20
MY140137A (en) 2009-11-30
US7462633B2 (en) 2008-12-09
TW200510421A (en) 2005-03-16
CA2530140A1 (en) 2005-01-20
RU2005140379A (ru) 2007-08-10
DE602004027811D1 (de) 2010-08-05
JP4607107B2 (ja) 2011-01-05
RU2348628C2 (ru) 2009-03-10
WO2005005398A3 (en) 2005-04-28
AR044990A1 (es) 2005-10-12
AU2004256083B2 (en) 2007-10-11
AU2004256083A1 (en) 2005-01-20
MXPA06000228A (es) 2006-06-27
NO20060558L (no) 2006-02-02
IL172785A0 (en) 2006-06-11

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: KYORIN PHARMACEUTICAL CO., LTD. (JP) , MERCK SHARP

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.