ZA200501137B - Pyrrolidone derivatives as MAOB inhibitors - Google Patents

Pyrrolidone derivatives as MAOB inhibitors

Info

Publication number: ZA200501137B
Authority: ZA; South Africa
Prior art keywords: pyrrolidone derivatives; maob inhibitors; maob; inhibitors; pyrrolidone
Prior art date: 2002-09-20

Application number

ZA200501137A

Other languages

English (en)

Inventor

Iding Hans

Krummenacher Daniela

Thomas Andrew William

Wostl Wolfgang

Jolidon Synese

Sarmiento Rosa Maria Rodriguez

Wirz Beat

Wyler Rene

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-20

Filing date

2005-02-08

Publication date

2006-12-27

2005-02-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-12-27 Publication of ZA200501137B publication Critical patent/ZA200501137B/xx

Links

102100028116 Amine oxidase [flavin-containing] B Human genes 0.000 title 1
101000768078 Homo sapiens Amine oxidase [flavin-containing] B Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000004040 pyrrolidinones Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA200501137A 2002-09-20 2005-02-08 Pyrrolidone derivatives as MAOB inhibitors ZA200501137B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02021319		2002-09-20

Publications (1)

Publication Number	Publication Date
ZA200501137B true ZA200501137B (en)	2006-12-27

Family

ID=32010924

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ZA200501137A ZA200501137B (en)	2002-09-20	2005-02-08	Pyrrolidone derivatives as MAOB inhibitors
ZA200501311A ZA200501311B (en)	2002-09-20	2005-02-14	Pyrrolidone derivatives as MAOB inhibitors
ZA200501557A ZA200501557B (en)	2002-09-20	2005-02-22	4-Pyrrolidino-phenyl-benzyl ether derivatives.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ZA200501311A ZA200501311B (en)	2002-09-20	2005-02-14	Pyrrolidone derivatives as MAOB inhibitors
ZA200501557A ZA200501557B (en)	2002-09-20	2005-02-22	4-Pyrrolidino-phenyl-benzyl ether derivatives.

Country Status (31)

Country	Link
US (4)	US7235581B2 (de)
EP (3)	EP1542971A1 (de)
JP (3)	JP4335142B2 (de)
KR (3)	KR100676015B1 (de)
CN (3)	CN100503562C (de)
AR (3)	AR041297A1 (de)
AT (2)	ATE472530T1 (de)
AU (3)	AU2003270213B8 (de)
BR (4)	BR0314314A (de)
CA (3)	CA2498785C (de)
CY (1)	CY1110745T1 (de)
DE (2)	DE60331559D1 (de)
DK (1)	DK1542970T3 (de)
ES (2)	ES2338646T3 (de)
GT (3)	GT200300206A (de)
HR (3)	HRP20050262A2 (de)
JO (2)	JO2604B1 (de)
MX (3)	MXPA05002881A (de)
MY (3)	MY134480A (de)
NO (3)	NO329754B1 (de)
NZ (3)	NZ538048A (de)
PA (3)	PA8583001A1 (de)
PE (3)	PE20050077A1 (de)
PL (3)	PL376018A1 (de)
PT (1)	PT1542970E (de)
RU (3)	RU2336268C2 (de)
SI (1)	SI1542970T1 (de)
TW (3)	TWI286132B (de)
UY (3)	UY27990A1 (de)
WO (3)	WO2004026827A1 (de)
ZA (3)	ZA200501137B (de)

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PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
GB0314373D0 (en)	2003-06-19	2003-07-23	Glaxo Group Ltd	Chemical compounds
CA2575018A1 (en)	2004-08-02	2006-02-09	F. Hoffman-La Roche Ag	Benzyloxy derivatives as maob inhibitors
KR100845366B1 (ko) *	2004-08-02	2008-07-09	에프. 호프만-라 로슈 아게	모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
KR20070094666A (ko)	2005-02-25	2007-09-20	에프. 호프만-라 로슈 아게	약제 물질 분산성이 향상된 정제
US7501528B2 (en) *	2005-03-15	2009-03-10	Hoffmann-La Roche Inc.	Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
DE602006003879D1 (de) *	2005-03-15	2009-01-08	Hoffmann La Roche	Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten
EP1943216B1 (de) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamidderivate als natriumkanalmodulatoren
TW200728258A (en) *	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
TW200730494A (en) *	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
EP2171478A4 (de) *	2007-03-30	2013-01-30	Univ California	In-vivo-bildgebungsverfahren für sulfotransferasen
KR101220182B1 (ko) *	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) *	2011-08-22	2013-09-04	Farmak, A. S.	Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) *	2013-02-28	2019-09-05	삼성디스플레이 주식회사	박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
WO2014158916A1 (en)	2013-03-14	2014-10-02	Dart Neuroscience, Llc	Substituted naphthyridine and quinoline compounds as mao inhibitors
CZ305213B6 (cs)	2013-04-29	2015-06-10	Farmak, A. S.	Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
HK1220203A1 (zh) *	2013-10-29	2017-04-28	豪夫迈．罗氏有限公司	可用於治疗阿尔茨海默病的吡咯烷酮衍生物的晶形及其制备
ES2912881T3 (es)	2014-12-23	2022-05-30	Convergence Pharmaceuticals	Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
CN107223052A (zh) *	2015-03-27	2017-09-29	豪夫迈·罗氏有限公司	包含sembragiline的药物制剂
US11365194B2 (en)	2017-09-27	2022-06-21	Kagoshima University	Analgesic drug using PAC1 receptor antagonistic drug
US11192856B2 (en)	2017-10-05	2021-12-07	Biogen Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
CN108299272B (zh) *	2018-01-31	2019-10-18	福州大学	一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
EP3762364B1 (de)	2018-03-08	2023-08-23	Sunshine Lake Pharma Co., Ltd.	Pyrrolidinamidderivate und verwendungen davon
WO2020175134A1 (ja)	2019-02-27	2020-09-03	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた鎮痒薬
EP4147701A4 (de)	2020-05-08	2024-06-12	Kagoshima University	Antidepressivum/anxiolytisches arzneimittel mit pac1-rezeptorantagonist
CN112851561A (zh) *	2021-01-29	2021-05-28	南京艾美斐生物医药科技有限公司	一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de)	2021-06-21	2022-12-29	Bayer Aktiengesellschaft	Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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FR2500831A1 (fr) *	1981-02-27	1982-09-03	Delalande Sa	Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
ES2087097T3 (es)	1989-04-19	1996-07-16	Otsuka Pharma Co Ltd	Derivados de acidos fenilcarboxilicos que contienen un heterociclo.
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US5679715A (en)	1995-06-07	1997-10-21	Harris; Richard Y.	Method for treating multiple sclerosis
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US5683404A (en) *	1996-06-05	1997-11-04	Metagen, Llc	Clamp and method for its use
DE19841895A1 (de)	1998-09-11	2000-03-23	Degussa	Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
EP1165546A2 (de) *	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Lactamverbindungen als metalloprotease, tnf-alpha und aggrecanase inhibitoren
AU1359801A (en)	1999-11-05	2001-06-06	Vela Pharmaceuticals Inc.	Methods and compositions for treating reward deficiency syndrome
CN1222254C (zh) *	2000-02-10	2005-10-12	波滕西亚医疗公司	用无线能量源进行尿失禁治疗
EP1255513B1 (de) *	2000-02-14	2005-05-25	Potencia Medical AG	Penisprothese
PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
US20040267291A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with non-mechanical attachment mechanism
US20040267292A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with transverse attachment mechanism

2003
- 2003-09-17 PE PE2003000952A patent/PE20050077A1/es not_active Application Discontinuation
- 2003-09-17 MY MYPI20033545A patent/MY134480A/en unknown
- 2003-09-17 PA PA20038583001A patent/PA8583001A1/es unknown
- 2003-09-17 TW TW092125618A patent/TWI286132B/zh not_active IP Right Cessation
- 2003-09-18 UY UY27990A patent/UY27990A1/es not_active Application Discontinuation
- 2003-09-18 KR KR1020057004683A patent/KR100676015B1/ko not_active Expired - Fee Related
- 2003-09-18 HR HR20050262A patent/HRP20050262A2/xx not_active Application Discontinuation
- 2003-09-18 PL PL03376018A patent/PL376018A1/xx not_active Application Discontinuation
- 2003-09-18 DE DE60331559T patent/DE60331559D1/de not_active Expired - Lifetime
- 2003-09-18 EP EP03757866A patent/EP1542971A1/de not_active Withdrawn
- 2003-09-18 RU RU2005111968/04A patent/RU2336268C2/ru not_active IP Right Cessation
- 2003-09-18 MY MYPI20033558A patent/MY133332A/en unknown
- 2003-09-18 BR BR0314314-7A patent/BR0314314A/pt not_active IP Right Cessation
- 2003-09-18 US US10/666,594 patent/US7235581B2/en not_active Expired - Fee Related
- 2003-09-18 AR ARP030103383A patent/AR041297A1/es unknown
- 2003-09-18 AU AU2003270213A patent/AU2003270213B8/en not_active Ceased
- 2003-09-18 GT GT200300206A patent/GT200300206A/es unknown
- 2003-09-18 PT PT03750564T patent/PT1542970E/pt unknown
- 2003-09-18 BR BR0314631-6A patent/BR0314631A/pt not_active IP Right Cessation
- 2003-09-18 NZ NZ538048A patent/NZ538048A/en not_active IP Right Cessation
- 2003-09-18 CA CA2498785A patent/CA2498785C/en not_active Expired - Fee Related
- 2003-09-18 EP EP03750564A patent/EP1542970B1/de not_active Expired - Lifetime
- 2003-09-18 HR HR20050261A patent/HRP20050261A2/hr not_active Application Discontinuation
- 2003-09-18 RU RU2005111974/04A patent/RU2336267C2/ru not_active IP Right Cessation
- 2003-09-18 GT GT200300204A patent/GT200300204A/es unknown
- 2003-09-18 US US10/667,087 patent/US7151111B2/en not_active Expired - Lifetime
- 2003-09-18 US US10/667,088 patent/US7037935B2/en not_active Expired - Fee Related
- 2003-09-18 AT AT03750564T patent/ATE472530T1/de active
- 2003-09-18 JP JP2004537121A patent/JP4335142B2/ja not_active Expired - Fee Related
- 2003-09-18 ES ES03748052T patent/ES2338646T3/es not_active Expired - Lifetime
- 2003-09-18 PL PL03376019A patent/PL376019A1/xx not_active Application Discontinuation
- 2003-09-18 PA PA20038583601A patent/PA8583601A1/es unknown
- 2003-09-18 BR BRPI0314631-6A patent/BRPI0314631B1/pt unknown
- 2003-09-18 ES ES03750564T patent/ES2344557T3/es not_active Expired - Lifetime
- 2003-09-18 CN CNB038212560A patent/CN100503562C/zh not_active Expired - Fee Related
- 2003-09-18 CA CA002498335A patent/CA2498335A1/en not_active Abandoned
- 2003-09-18 RU RU2005111969/04A patent/RU2323209C2/ru not_active IP Right Cessation
- 2003-09-18 BR BR0314299-0A patent/BR0314299A/pt active Search and Examination
- 2003-09-18 CN CNB038219522A patent/CN100383118C/zh not_active Expired - Fee Related
- 2003-09-18 CN CNB038217678A patent/CN100400509C/zh not_active Expired - Fee Related
- 2003-09-18 AU AU2003273901A patent/AU2003273901B2/en not_active Ceased
- 2003-09-18 AR ARP030103384A patent/AR041298A1/es unknown
- 2003-09-18 MX MXPA05002881A patent/MXPA05002881A/es active IP Right Grant
- 2003-09-18 AU AU2003267381A patent/AU2003267381B2/en not_active Ceased
- 2003-09-18 EP EP03748052A patent/EP1542969B1/de not_active Expired - Lifetime
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- 2003-09-18 GT GT200300205A patent/GT200300205A/es unknown
- 2003-09-18 PA PA20038583501A patent/PA8583501A1/es unknown
- 2003-09-18 SI SI200331830T patent/SI1542970T1/sl unknown
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- 2003-09-18 DE DE60333202T patent/DE60333202D1/de not_active Expired - Lifetime
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- 2003-09-18 DK DK03750564.1T patent/DK1542970T3/da active
- 2003-09-18 TW TW092125746A patent/TWI331994B/zh not_active IP Right Cessation
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- 2003-09-18 AT AT03748052T patent/ATE459601T1/de active
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2005
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- 2005-02-08 NO NO20050665A patent/NO330012B1/no not_active IP Right Cessation
- 2005-02-08 ZA ZA200501137A patent/ZA200501137B/xx unknown
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- 2005-02-14 ZA ZA200501311A patent/ZA200501311B/en unknown
- 2005-02-22 ZA ZA200501557A patent/ZA200501557B/xx unknown
2006
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Also Published As

Publication number	Publication date
HK1083498A1 (zh)	2006-07-07
GT200300205A (es)	2004-04-29
ZA200501557B (en)	2005-09-08
NZ538046A (en)	2007-08-31
NO20050652L (no)	2005-03-08
RU2005111969A (ru)	2006-01-20
RU2323209C2 (ru)	2008-04-27
KR20050057456A (ko)	2005-06-16
TW200408624A (en)	2004-06-01
TW200413350A (en)	2004-08-01
DE60333202D1 (de)	2010-08-12
DK1542970T3 (da)	2010-08-02
EP1542971A1 (de)	2005-06-22
NO20050701L (no)	2005-03-02
PL376021A1 (en)	2005-12-12
EP1542969A1 (de)	2005-06-22
HRP20050261A2 (en)	2006-05-31
PA8583501A1 (es)	2004-04-23
PA8583001A1 (es)	2004-04-23
AR041297A1 (es)	2005-05-11
UY27990A1 (es)	2004-03-31
CA2498785C (en)	2011-07-26
AU2003267381B2 (en)	2009-08-27
GT200300204A (es)	2004-04-29
PE20050077A1 (es)	2005-03-01
MXPA05002881A (es)	2005-05-27
PL216030B1 (pl)	2014-02-28
MY135696A (en)	2008-06-30
JP2006503834A (ja)	2006-02-02
CN100400509C (zh)	2008-07-09
PA8583601A1 (es)	2004-09-16
NZ538049A (en)	2007-05-31
US20040097578A1 (en)	2004-05-20
JP2006503833A (ja)	2006-02-02
UY27993A1 (es)	2004-03-31
ATE472530T1 (de)	2010-07-15
MY133332A (en)	2007-11-30
JP2006510596A (ja)	2006-03-30
HK1084383A1 (en)	2006-07-28
CN1681777A (zh)	2005-10-12
HRP20050263B1 (hr)	2013-09-30
PT1542970E (pt)	2010-07-19
CA2496756C (en)	2012-01-10
KR100676015B1 (ko)	2007-01-30
AU2003270213A1 (en)	2004-04-08
ATE459601T1 (de)	2010-03-15
BR0314314A (pt)	2005-07-26
NO330012B1 (no)	2011-02-07
CA2496756A1 (en)	2004-04-01
US7122562B2 (en)	2006-10-17
AU2003273901B2 (en)	2008-07-10
JO2605B1 (en)	2011-11-01
EP1542969B1 (de)	2010-03-03
EP1542970A1 (de)	2005-06-22
DE60331559D1 (de)	2010-04-15
MXPA05002880A (es)	2005-05-27
AR041299A1 (es)	2005-05-11
TWI331994B (en)	2010-10-21
MXPA05002878A (es)	2005-05-27
PE20050078A1 (es)	2005-02-28
RU2005111974A (ru)	2006-01-20
CA2498335A1 (en)	2004-04-01
ZA200501311B (en)	2006-10-25
KR20050057466A (ko)	2005-06-16
JO2604B1 (en)	2011-11-01
HK1083499A1 (zh)	2006-07-07
TW200410935A (en)	2004-07-01
HRP20050263A2 (en)	2006-12-31
AU2003270213B8 (en)	2009-03-05
PL376018A1 (en)	2005-12-12
AU2003270213B2 (en)	2009-02-12
US7151111B2 (en)	2006-12-19
WO2004026825A1 (en)	2004-04-01
CY1110745T1 (el)	2015-06-10
TWI286132B (en)	2007-09-01
RU2336267C2 (ru)	2008-10-20
KR100676014B1 (ko)	2007-01-30
RU2005111968A (ru)	2006-11-10
WO2004026826A1 (en)	2004-04-01
NZ538048A (en)	2007-05-31
AU2003267381A1 (en)	2004-04-08
MY134480A (en)	2007-12-31
GT200300206A (es)	2004-04-29
NO20050665L (no)	2005-04-18
BR0314299A (pt)	2005-12-13
JP4335142B2 (ja)	2009-09-30
RU2336268C2 (ru)	2008-10-20
US20040106650A1 (en)	2004-06-03
AR041298A1 (es)	2005-05-11
CN100383118C (zh)	2008-04-23
UY27991A1 (es)	2004-03-31
BR0314631A (pt)	2005-08-02
WO2004026827A1 (en)	2004-04-01
PL376019A1 (en)	2005-12-12
CA2498785A1 (en)	2004-04-01
US20060122235A1 (en)	2006-06-08
HRP20050262A2 (en)	2006-06-30
PE20050079A1 (es)	2005-03-01
CN100503562C (zh)	2009-06-24
ES2344557T3 (es)	2010-08-31
SI1542970T1 (sl)	2010-08-31
ES2338646T3 (es)	2010-05-11
AU2003273901A1 (en)	2004-04-08
EP1542970B1 (de)	2010-06-30
CN1681779A (zh)	2005-10-12
JP4335141B2 (ja)	2009-09-30
CN1681778A (zh)	2005-10-12
US7037935B2 (en)	2006-05-02
NO329754B1 (no)	2010-12-13
KR100681586B1 (ko)	2007-02-09
TWI337604B (en)	2011-02-21
US7235581B2 (en)	2007-06-26
US20040116707A1 (en)	2004-06-17
BRPI0314631B1 (pt)	2018-04-17
JP4335140B2 (ja)	2009-09-30
KR20050057450A (ko)	2005-06-16

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