ATE482950T1 - Verfahren zur entfernung der triphenylmethanschutzgruppe - Google Patents

Verfahren zur entfernung der triphenylmethanschutzgruppe

Info

Publication number: ATE482950T1
Authority: AT; Austria
Prior art keywords: sup; protecting group; removal; triphenylmethane protecting; triphenylmethane
Prior art date: 2003-08-27

Application number

AT04762303T

Other languages

English (en)

Inventor

Stanislav Radl

Jan Stach

Ondrej Klecan

Original Assignee

Zentiva Ks

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-27

Filing date

2004-08-26

Publication date

2010-10-15

2003-08-27 Priority claimed from CZ20032319A external-priority patent/CZ297016B6/cs

2004-06-16 Priority claimed from CZ20040733A external-priority patent/CZ298329B6/cs

2004-08-26 Application filed by Zentiva Ks filed Critical Zentiva Ks

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE482950T1 publication Critical patent/ATE482950T1/de

Links

238000000034 method Methods 0.000 title abstract 3
AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical group C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 title abstract 2
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
239000004072 C09CA03 - Valsartan Chemical class 0.000 abstract 1
239000002947 C09CA04 - Irbesartan Chemical class 0.000 abstract 1
GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical class C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 abstract 1
AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229960004349 candesartan cilexetil Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
229960002198 irbesartan Drugs 0.000 abstract 1
YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical class O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 abstract 1
229960004773 losartan Drugs 0.000 abstract 1
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical class CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
159000000001 potassium salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
238000003797 solvolysis reaction Methods 0.000 abstract 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical class C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 abstract 1
229960004699 valsartan Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
Dicing (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Manufacture Of Electron Tubes, Discharge Lamp Vessels, Lead-In Wires, And The Like (AREA)

AT04762303T 2003-08-27 2004-08-26 Verfahren zur entfernung der triphenylmethanschutzgruppe ATE482950T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CZ20032319A CZ297016B6 (cs)	2003-08-27	2003-08-27	Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím
CZ20040733A CZ298329B6 (cs)	2004-06-16	2004-06-16	Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2´-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu)
PCT/CZ2004/000051 WO2005021535A2 (en)	2003-08-27	2004-08-26	A method of removing the triphenylmethane protecting group

Publications (1)

Publication Number	Publication Date
ATE482950T1 true ATE482950T1 (de)	2010-10-15

Family

ID=34276338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04762303T ATE482950T1 (de)	2003-08-27	2004-08-26	Verfahren zur entfernung der triphenylmethanschutzgruppe

Country Status (13)

Country	Link
US (1)	US20060287537A1 (de)
EP (1)	EP1658281B1 (de)
AT (1)	ATE482950T1 (de)
CA (1)	CA2536781A1 (de)
DE (1)	DE602004029373D1 (de)
EA (1)	EA011507B1 (de)
ES (1)	ES2348300T3 (de)
HR (1)	HRP20060119A2 (de)
PL (2)	PL1658281T3 (de)
PT (1)	PT1658281E (de)
RS (1)	RS20060125A (de)
SK (1)	SK50142006A3 (de)
WO (1)	WO2005021535A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005077941A2 (en)	2004-02-11	2005-08-25	Teva Pharmaceutical Industries Ltd.	Candesartan cilexetil polymorphs
EP1812423A1 (de) *	2004-11-11	2007-08-01	LEK Pharmaceuticals D.D.	Verfahren zur synthese von tetrazolen
EP1661891A1 (de) *	2004-11-30	2006-05-31	KRKA, D.D., Novo Mesto	Verfahren zur Herstellung von Valsartan
SI22127A (sl)	2005-10-07	2007-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Postopek za pripravo kandesartan cileksetila
CZ299902B6 (cs) *	2005-10-27	2008-12-29	Zentiva, A. S	Zpusob odstranování trifenylmethanové chránicí skupiny u prekurzoru antihypertenzních léciv
WO2008018843A1 (en) *	2006-08-08	2008-02-14	Ulkar Kimya Sanayi Ve Ticaret As	Process for producing useful salts form of biphenyl-tetrazole compounds
US8492577B2 (en)	2008-04-07	2013-07-23	Hetero Research Foundation	Process for preparation of valsartan intermediate
WO2010046804A2 (en) *	2008-10-21	2010-04-29	Alembic Limited	A process for preparation of losartan potassium form i
KR20120046115A (ko)	2009-05-20	2012-05-09	랜박시 래보러터리스 리미티드	올메사르탄 메독소밀의 제조 방법
WO2011080684A1 (en)	2009-12-31	2011-07-07	Ranbaxy Laboratories Limited	Process for the preparation of candesartan cilexetil
WO2011092666A1 (en)	2010-01-29	2011-08-04	Ranbaxy Laboratories Limited	An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
CN103012382B (zh) *	2012-12-05	2016-10-05	迪沙药业集团有限公司	一种奥美沙坦酯的制备方法
WO2016053855A1 (en)	2014-09-29	2016-04-07	The Scripps Research Institute	Sphingosine-1-phospate receptor modulators for treatment of cardiopulmonary disorders
US11327065B1 (en) *	2021-08-27	2022-05-10	Jubilant Generics Limited	Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof
CN116606282A (zh) *	2023-05-17	2023-08-18	杭州新曦科技有限公司	用于制备氯沙坦钾及其相关中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122010000024I1 (de) *	1990-02-19	2010-07-08	Novartis Ag	Acylverbindungen
US5270317A (en) *	1990-03-20	1993-12-14	Elf Sanofi	N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
AT395853B (de) *	1991-01-31	1993-03-25	Chem Pharm Forsch Gmbh	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
US5281604A (en) *	1993-04-23	1994-01-25	American Cyanamid Company	Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
SK722003A3 (en) *	2001-05-18	2003-12-02	Aurobindo Pharma Ltd	Process for the crystallization of losartan potassium

2004
- 2004-08-26 EA EA200600079A patent/EA011507B1/ru not_active IP Right Cessation
- 2004-08-26 PL PL04762303T patent/PL1658281T3/pl unknown
- 2004-08-26 SK SK5014-2006A patent/SK50142006A3/sk unknown
- 2004-08-26 AT AT04762303T patent/ATE482950T1/de not_active IP Right Cessation
- 2004-08-26 PL PL379886A patent/PL379886A1/pl not_active Application Discontinuation
- 2004-08-26 DE DE602004029373T patent/DE602004029373D1/de not_active Expired - Lifetime
- 2004-08-26 HR HR20060119A patent/HRP20060119A2/hr not_active Application Discontinuation
- 2004-08-26 CA CA002536781A patent/CA2536781A1/en not_active Abandoned
- 2004-08-26 PT PT04762303T patent/PT1658281E/pt unknown
- 2004-08-26 ES ES04762303T patent/ES2348300T3/es not_active Expired - Lifetime
- 2004-08-26 EP EP04762303A patent/EP1658281B1/de not_active Expired - Lifetime
- 2004-08-26 WO PCT/CZ2004/000051 patent/WO2005021535A2/en not_active Ceased
- 2004-08-26 US US10/569,428 patent/US20060287537A1/en not_active Abandoned
- 2004-08-26 RS YUP-2006/0125A patent/RS20060125A/sr unknown

Also Published As

Publication number	Publication date
RS20060125A (sr)	2008-06-05
WO2005021535A3 (en)	2005-06-09
SK50142006A3 (sk)	2006-05-04
DE602004029373D1 (de)	2010-11-11
ES2348300T3 (es)	2010-12-02
EP1658281A2 (de)	2006-05-24
EP1658281B1 (de)	2010-09-29
PT1658281E (pt)	2010-10-12
PL1658281T3 (pl)	2010-12-31
CA2536781A1 (en)	2005-03-10
US20060287537A1 (en)	2006-12-21
EA200600079A1 (ru)	2006-08-25
PL379886A1 (pl)	2006-11-27
HRP20060119A2 (en)	2006-05-31
EA011507B1 (ru)	2009-04-28
WO2005021535A2 (en)	2005-03-10

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Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties