ATE486077T1 - Verfahren zur herstellung von maytansinoidestern - Google Patents
Verfahren zur herstellung von maytansinoidesternInfo
- Publication number
- ATE486077T1 ATE486077T1 AT06718890T AT06718890T ATE486077T1 AT E486077 T1 ATE486077 T1 AT E486077T1 AT 06718890 T AT06718890 T AT 06718890T AT 06718890 T AT06718890 T AT 06718890T AT E486077 T1 ATE486077 T1 AT E486077T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- maytansinoid
- maytansinoide
- producing
- anion
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 abstract 1
- -1 activated carboxyl compound Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64498405P | 2005-01-21 | 2005-01-21 | |
| PCT/US2006/001885 WO2006078809A2 (en) | 2005-01-21 | 2006-01-20 | Method for the preparation of maytansinoid esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486077T1 true ATE486077T1 (de) | 2010-11-15 |
Family
ID=36692868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06718890T ATE486077T1 (de) | 2005-01-21 | 2006-01-20 | Verfahren zur herstellung von maytansinoidestern |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7301019B2 (de) |
| EP (1) | EP1838715B1 (de) |
| JP (2) | JP5425402B2 (de) |
| AT (1) | ATE486077T1 (de) |
| AU (1) | AU2006206421B2 (de) |
| CA (1) | CA2601670C (de) |
| CY (1) | CY1111157T1 (de) |
| DE (1) | DE602006017797D1 (de) |
| DK (1) | DK1838715T3 (de) |
| ES (1) | ES2355153T3 (de) |
| PL (1) | PL1838715T3 (de) |
| PT (1) | PT1838715E (de) |
| SI (1) | SI1838715T1 (de) |
| WO (1) | WO2006078809A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AU2002311919B8 (en) | 2001-05-11 | 2007-03-22 | Ludwig Institute For Cancer Research Ltd | Specific binding proteins and uses thereof |
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| ATE535529T1 (de) * | 2005-08-09 | 2011-12-15 | Millennium Pharm Inc | Verfahren zur acylierung von maytansinol mit chiralen aminosäuren |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| PE20090943A1 (es) | 2007-07-16 | 2009-08-05 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados |
| EP2176295B1 (de) | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanisierte anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| KR101607346B1 (ko) | 2008-01-31 | 2016-03-29 | 제넨테크, 인크. | 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법 |
| RU2587621C2 (ru) | 2009-04-01 | 2016-06-20 | Дженентек, Инк. | АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| CN102596922A (zh) | 2009-10-06 | 2012-07-18 | 免疫基因公司 | 有效的缀合物和亲水性连接体 |
| KR20130009760A (ko) | 2010-02-10 | 2013-01-23 | 이뮤노젠 아이엔씨 | Ｃｄ２０ 항체 및 이의 용도 |
| US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| JP6209159B2 (ja) | 2011-06-21 | 2017-10-04 | イミュノジェン・インコーポレーテッド | ペプチドリンカーを有する新規メイタンシノイド誘導体およびその結合体 |
| MX353958B (es) | 2011-09-22 | 2018-02-07 | Amgen Inc | Proteinas de union al antigeno cd27l. |
| CN102731526B (zh) * | 2012-05-14 | 2014-09-10 | 福建省微生物研究所 | 安丝菌素类化合物及其制备方法 |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| LT3486248T (lt) * | 2012-09-26 | 2021-08-25 | Immunogen, Inc. | Patobulinti maitansinolio acilinimo būdai |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| CN104530235A (zh) | 2012-12-21 | 2015-04-22 | 百奥泰生物科技(广州)有限公司 | 一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途 |
| CN103254213B (zh) | 2012-12-21 | 2015-02-25 | 百奥泰生物科技(广州)有限公司 | 类美登素酯的制备方法及用于所述方法的组合物 |
| CN103333246B (zh) | 2012-12-21 | 2015-09-16 | 百奥泰生物科技(广州)有限公司 | 一种抗egfr受体的肿瘤生长抑制剂及其制备方法和用途 |
| CN104688740A (zh) | 2012-12-21 | 2015-06-10 | 百奥泰生物科技(广州)有限公司 | 类美登素衍生物及其制备方法和用途 |
| EP2948478B1 (de) | 2013-01-25 | 2019-04-03 | Amgen Inc. | Antikörper gegen cdh19 für melanome |
| EP3566750A3 (de) | 2013-02-28 | 2020-04-08 | ImmunoGen, Inc. | Konjugate aus zellbindenden und zytotoxischen verbindungen |
| HUE056580T2 (hu) | 2013-05-30 | 2022-02-28 | Kiniksa Pharmaceuticals Ltd | Onkosztatin-M-receptor antigénjét kötõ fehérjék |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
| MX376146B (es) * | 2015-03-17 | 2025-03-07 | Regeneron Pharma | Reactivos de acilacion de aminoacidos y metodos para usar los mismos. |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| WO2017148416A1 (zh) * | 2016-03-03 | 2017-09-08 | 凯惠科技发展(上海)有限公司 | 一种美登素酯的制备方法及其中间体 |
| KR20220150408A (ko) | 2016-11-14 | 2022-11-10 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| EP3554544A4 (de) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | Anti-cub-haltige protein 1-(cdcp1)-antikörper, antikörper-wirkstoff-konjugate und verfahren zur verwendung davon |
| US11420981B2 (en) | 2019-04-18 | 2022-08-23 | Indena S.P.A. | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| US11555019B2 (en) | 2019-07-10 | 2023-01-17 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
| WO2022010797A2 (en) | 2020-07-07 | 2022-01-13 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
| EP4426727A2 (de) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Spezifische konjugation eines antikörpers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55164685A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) * | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US6020507A (en) * | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
-
2006
- 2006-01-19 US US11/334,478 patent/US7301019B2/en not_active Expired - Lifetime
- 2006-01-20 ES ES06718890T patent/ES2355153T3/es not_active Expired - Lifetime
- 2006-01-20 DE DE602006017797T patent/DE602006017797D1/de not_active Expired - Lifetime
- 2006-01-20 PL PL06718890T patent/PL1838715T3/pl unknown
- 2006-01-20 AT AT06718890T patent/ATE486077T1/de active
- 2006-01-20 JP JP2007552258A patent/JP5425402B2/ja not_active Expired - Lifetime
- 2006-01-20 PT PT06718890T patent/PT1838715E/pt unknown
- 2006-01-20 AU AU2006206421A patent/AU2006206421B2/en not_active Expired
- 2006-01-20 CA CA2601670A patent/CA2601670C/en not_active Expired - Lifetime
- 2006-01-20 DK DK06718890.4T patent/DK1838715T3/da active
- 2006-01-20 EP EP06718890A patent/EP1838715B1/de not_active Expired - Lifetime
- 2006-01-20 SI SI200630900T patent/SI1838715T1/sl unknown
- 2006-01-20 WO PCT/US2006/001885 patent/WO2006078809A2/en not_active Ceased
-
2011
- 2011-01-27 CY CY20111100094T patent/CY1111157T1/el unknown
-
2013
- 2013-08-21 JP JP2013171071A patent/JP2014012693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014012693A (ja) | 2014-01-23 |
| WO2006078809A3 (en) | 2007-07-12 |
| JP2008528493A (ja) | 2008-07-31 |
| EP1838715A2 (de) | 2007-10-03 |
| CY1111157T1 (el) | 2015-06-11 |
| ES2355153T3 (es) | 2011-03-23 |
| PT1838715E (pt) | 2011-01-27 |
| US7301019B2 (en) | 2007-11-27 |
| DE602006017797D1 (de) | 2010-12-09 |
| EP1838715A4 (de) | 2009-06-03 |
| SI1838715T1 (sl) | 2011-02-28 |
| DK1838715T3 (da) | 2011-02-14 |
| US20060167245A1 (en) | 2006-07-27 |
| CA2601670C (en) | 2013-04-02 |
| WO2006078809A2 (en) | 2006-07-27 |
| JP5425402B2 (ja) | 2014-02-26 |
| EP1838715B1 (de) | 2010-10-27 |
| AU2006206421B2 (en) | 2010-12-16 |
| AU2006206421A1 (en) | 2006-07-27 |
| PL1838715T3 (pl) | 2011-04-29 |
| CA2601670A1 (en) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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