ATE486077T1 - Verfahren zur herstellung von maytansinoidestern - Google Patents
Verfahren zur herstellung von maytansinoidesternInfo
- Publication number
- ATE486077T1 ATE486077T1 AT06718890T AT06718890T ATE486077T1 AT E486077 T1 ATE486077 T1 AT E486077T1 AT 06718890 T AT06718890 T AT 06718890T AT 06718890 T AT06718890 T AT 06718890T AT E486077 T1 ATE486077 T1 AT E486077T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- maytansinoid
- maytansinoide
- producing
- anion
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 abstract 1
- -1 activated carboxyl compound Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64498405P | 2005-01-21 | 2005-01-21 | |
| PCT/US2006/001885 WO2006078809A2 (en) | 2005-01-21 | 2006-01-20 | Method for the preparation of maytansinoid esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486077T1 true ATE486077T1 (de) | 2010-11-15 |
Family
ID=36692868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06718890T ATE486077T1 (de) | 2005-01-21 | 2006-01-20 | Verfahren zur herstellung von maytansinoidestern |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7301019B2 (de) |
| EP (1) | EP1838715B1 (de) |
| JP (2) | JP5425402B2 (de) |
| AT (1) | ATE486077T1 (de) |
| AU (1) | AU2006206421B2 (de) |
| CA (1) | CA2601670C (de) |
| CY (1) | CY1111157T1 (de) |
| DE (1) | DE602006017797D1 (de) |
| DK (1) | DK1838715T3 (de) |
| ES (1) | ES2355153T3 (de) |
| PL (1) | PL1838715T3 (de) |
| PT (1) | PT1838715E (de) |
| SI (1) | SI1838715T1 (de) |
| WO (1) | WO2006078809A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60234094D1 (de) | 2001-05-11 | 2009-12-03 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| EP1913002B9 (de) * | 2005-08-09 | 2012-04-25 | Millennium Pharmaceuticals, Inc. | Verfahren zur acylierung von maytansinol mit chiralen aminosäuren |
| CA2676244C (en) | 2007-01-25 | 2017-01-17 | Kwok-Kin Wong | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
| CL2008002083A1 (es) | 2007-07-16 | 2008-11-21 | Genentech Inc | Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico |
| NZ583367A (en) | 2007-07-16 | 2012-10-26 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| CA2696360C (en) | 2007-08-14 | 2018-11-20 | Ludwig Institute For Cancer Research | Monoclonal antibody targeting the egfr receptor and uses thereof |
| ES2643239T3 (es) | 2008-01-31 | 2017-11-21 | Genentech, Inc. | Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso |
| KR20120057565A (ko) | 2009-04-01 | 2012-06-05 | 제넨테크, 인크. | 항-ＦｃＲＨ５ 항체 및 면역접합체 및 사용 방법 |
| KR20120080611A (ko) | 2009-10-06 | 2012-07-17 | 이뮤노젠 아이엔씨 | 효능 있는 접합체 및 친수성 링커 |
| WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
| ES2544608T3 (es) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Conjugados de anticuerpo y de alaninil-maitansinol |
| KR20190089048A (ko) | 2011-02-15 | 2019-07-29 | 이뮤노젠 아이엔씨 | 컨쥬게이트의 제조방법 |
| SG10201605041VA (en) | 2011-06-21 | 2016-08-30 | Immunogen Inc | Novel maytansinoid derivatives with peptide linker and conjugates thereof |
| CN104136461B (zh) | 2011-09-22 | 2021-06-08 | 安姆根有限公司 | Cd27l抗原结合蛋白 |
| CN102731526B (zh) * | 2012-05-14 | 2014-09-10 | 福建省微生物研究所 | 安丝菌素类化合物及其制备方法 |
| JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
| HUE055443T2 (hu) * | 2012-09-26 | 2021-11-29 | Immunogen Inc | Javított eljárások maytansinol acilezéséhez |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| CN103333246B (zh) | 2012-12-21 | 2015-09-16 | 百奥泰生物科技(广州)有限公司 | 一种抗egfr受体的肿瘤生长抑制剂及其制备方法和用途 |
| CN103288957B (zh) | 2012-12-21 | 2015-01-28 | 百奥泰生物科技(广州)有限公司 | 一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途 |
| CN103254213B (zh) | 2012-12-21 | 2015-02-25 | 百奥泰生物科技(广州)有限公司 | 类美登素酯的制备方法及用于所述方法的组合物 |
| CN104688740A (zh) | 2012-12-21 | 2015-06-10 | 百奥泰生物科技(广州)有限公司 | 类美登素衍生物及其制备方法和用途 |
| ES2728936T3 (es) | 2013-01-25 | 2019-10-29 | Amgen Inc | Anticuerpos dirigidos contra CDH19 para melanoma |
| WO2014134483A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| CN110511279B (zh) | 2013-05-30 | 2024-03-29 | 基尼克萨制药有限公司 | 制瘤素m受体抗原结合蛋白 |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| CN106414465B (zh) | 2014-02-28 | 2021-11-16 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
| KR20170129769A (ko) * | 2015-03-17 | 2017-11-27 | 리제너론 파아마슈티컬스, 인크. | 아미노산 아실화 시약 및 이의 사용 방법 |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| WO2017148416A1 (zh) * | 2016-03-03 | 2017-09-08 | 凯惠科技发展(上海)有限公司 | 一种美登素酯的制备方法及其中间体 |
| CN116143678A (zh) | 2016-11-14 | 2023-05-23 | 杭州多禧生物科技有限公司 | 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
| PT3956332T (pt) | 2019-04-18 | 2023-04-24 | Indena Spa | Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários |
| MY209459A (en) | 2019-07-10 | 2025-07-09 | Cybrexa 3 Inc | Peptide conjugates of microtubule-targeting agents as therapeutics |
| CA3146560A1 (en) | 2019-07-10 | 2021-01-14 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| EP4178624A2 (de) | 2020-07-07 | 2023-05-17 | Bionecure Therapeutics, Inc. | Maytansinoide als adc-nutzlasten und deren verwendung zur behandlung von krebs |
| WO2022078524A2 (en) | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55164685A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) * | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US6020507A (en) * | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
-
2006
- 2006-01-19 US US11/334,478 patent/US7301019B2/en active Active
- 2006-01-20 PL PL06718890T patent/PL1838715T3/pl unknown
- 2006-01-20 WO PCT/US2006/001885 patent/WO2006078809A2/en not_active Ceased
- 2006-01-20 AT AT06718890T patent/ATE486077T1/de active
- 2006-01-20 SI SI200630900T patent/SI1838715T1/sl unknown
- 2006-01-20 DK DK06718890.4T patent/DK1838715T3/da active
- 2006-01-20 CA CA2601670A patent/CA2601670C/en not_active Expired - Lifetime
- 2006-01-20 AU AU2006206421A patent/AU2006206421B2/en not_active Expired
- 2006-01-20 JP JP2007552258A patent/JP5425402B2/ja not_active Expired - Lifetime
- 2006-01-20 EP EP06718890A patent/EP1838715B1/de not_active Expired - Lifetime
- 2006-01-20 DE DE602006017797T patent/DE602006017797D1/de not_active Expired - Lifetime
- 2006-01-20 ES ES06718890T patent/ES2355153T3/es not_active Expired - Lifetime
- 2006-01-20 PT PT06718890T patent/PT1838715E/pt unknown
-
2011
- 2011-01-27 CY CY20111100094T patent/CY1111157T1/el unknown
-
2013
- 2013-08-21 JP JP2013171071A patent/JP2014012693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006206421B2 (en) | 2010-12-16 |
| EP1838715A4 (de) | 2009-06-03 |
| AU2006206421A1 (en) | 2006-07-27 |
| JP2014012693A (ja) | 2014-01-23 |
| WO2006078809A2 (en) | 2006-07-27 |
| JP5425402B2 (ja) | 2014-02-26 |
| EP1838715B1 (de) | 2010-10-27 |
| PL1838715T3 (pl) | 2011-04-29 |
| CA2601670C (en) | 2013-04-02 |
| US7301019B2 (en) | 2007-11-27 |
| PT1838715E (pt) | 2011-01-27 |
| SI1838715T1 (sl) | 2011-02-28 |
| DE602006017797D1 (de) | 2010-12-09 |
| CY1111157T1 (el) | 2015-06-11 |
| WO2006078809A3 (en) | 2007-07-12 |
| CA2601670A1 (en) | 2006-07-27 |
| DK1838715T3 (da) | 2011-02-14 |
| EP1838715A2 (de) | 2007-10-03 |
| JP2008528493A (ja) | 2008-07-31 |
| US20060167245A1 (en) | 2006-07-27 |
| ES2355153T3 (es) | 2011-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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