ATE486878T1 - Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin - Google Patents

Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin

Info

Publication number
ATE486878T1
ATE486878T1 AT05777861T AT05777861T ATE486878T1 AT E486878 T1 ATE486878 T1 AT E486878T1 AT 05777861 T AT05777861 T AT 05777861T AT 05777861 T AT05777861 T AT 05777861T AT E486878 T1 ATE486878 T1 AT E486878T1
Authority
AT
Austria
Prior art keywords
benzothienopyridines
kinesin inhibitors
compounds
kinesin
inhibitors
Prior art date
Application number
AT05777861T
Other languages
English (en)
Inventor
Matthias Vennemann
Thomas Baer
Gudrun Groegor
Juergen Braunger
Petra Gimmnich
Thomas Maier
Heike Rothfels
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Application granted granted Critical
Publication of ATE486878T1 publication Critical patent/ATE486878T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT05777861T 2004-08-18 2005-08-17 Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin ATE486878T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04103958 2004-08-18
EP04104175 2004-08-31
PCT/EP2005/054054 WO2006018435A1 (en) 2004-08-18 2005-08-17 Benzothienopyridines for use as inhibitors of eg5 kinesin

Publications (1)

Publication Number Publication Date
ATE486878T1 true ATE486878T1 (de) 2010-11-15

Family

ID=35285513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05777861T ATE486878T1 (de) 2004-08-18 2005-08-17 Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin

Country Status (8)

Country Link
US (2) US7718665B2 (de)
EP (1) EP1781667B1 (de)
JP (1) JP2008509971A (de)
AT (1) ATE486878T1 (de)
AU (1) AU2005273867B2 (de)
CA (1) CA2576619A1 (de)
DE (1) DE602005024572D1 (de)
WO (1) WO2006018435A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE486878T1 (de) 2004-08-18 2010-11-15 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
WO2006079645A1 (en) * 2005-01-27 2006-08-03 Nycomed Gmbh Novel indolopyridines , benzofuranopyridines and benzothienopyridines
JP2008528551A (ja) * 2005-01-28 2008-07-31 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング インドロピリジン、ベンゾフラノピリジン及びベンゾチエノピリジン
EA015151B1 (ru) * 2006-02-22 2011-06-30 4ЭсЦэ АГ Индолопиридины в качестве модуляторов кинезина eg5
KR101415354B1 (ko) * 2006-02-22 2014-07-04 4에스체 악티엔게젤샤프트 Ｅｇ5 키네신 조절제로서의 인돌로피리딘
JP2009542777A (ja) * 2006-07-13 2009-12-03 ４エスツェー アクチェンゲゼルシャフト ベンゾピラノピラゾール
EP2033962A1 (de) * 2007-08-22 2009-03-11 4Sc Ag Tetrazyclische Indolopyridinderivate als EG5-Hemmer
WO2009024190A1 (en) * 2007-08-22 2009-02-26 4Sc Ag Indolopyridines as inhibitors of the kinesin spindle protein (eg5 )
EP2582682B1 (de) 2010-06-17 2015-01-14 Cytokinetics, Inc. Mitotische kinesin-hemmer zur behandlung der pulmonalen arteriellen hypertonie
KR101390616B1 (ko) 2012-03-28 2014-04-29 주식회사 두산 신규 화합물 및 이를 포함하는 유기 전계 발광 소자
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
CN110464722B (zh) * 2019-06-06 2023-05-23 暨南大学 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用
IL310863A (en) 2021-08-26 2024-04-01 Volastra Therapeutics Inc Spiro indoline inhibitors of kif18a

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357122A3 (de) * 1988-08-29 1991-10-23 Duphar International Research B.V Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
US6217104B1 (en) * 1999-06-16 2001-04-17 Cts Fahrzeug Dachsysteme Gmbh Retractable hard top module
US6890933B1 (en) * 2000-02-24 2005-05-10 President And Fellows Of Harvard College Kinesin inhibitors
DE60121461T2 (de) 2000-10-03 2007-02-08 Lilly Icos Llc, Wilmington Kondensierte pyridoindolderivate
AU2002310099A1 (en) * 2001-05-22 2002-12-03 President And Fellows Of Harvard College Identification of anti-protozoal agents
ATE363473T1 (de) * 2001-09-19 2007-06-15 Pharmacia Corp Substituierte pyrazoloverbindungen zur behandlung von entzündungen
AU2003247891A1 (en) * 2002-07-08 2004-01-23 Merck & Co., Inc. Mitotic kinesin binding site
US7022850B2 (en) * 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
WO2004111193A2 (en) 2003-06-12 2004-12-23 Merck & Co., Inc. Prodrugs of mitotic kinesin inhibitors
ATE486878T1 (de) 2004-08-18 2010-11-15 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
JP2008530094A (ja) 2005-02-10 2008-08-07 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
EA015151B1 (ru) 2006-02-22 2011-06-30 4ЭсЦэ АГ Индолопиридины в качестве модуляторов кинезина eg5
KR101415354B1 (ko) 2006-02-22 2014-07-04 4에스체 악티엔게젤샤프트 Ｅｇ5 키네신 조절제로서의 인돌로피리딘
WO2007144384A1 (en) 2006-06-14 2007-12-21 4Sc Ag Pyrazolopyrimidones
JP2009542777A (ja) 2006-07-13 2009-12-03 ４エスツェー アクチェンゲゼルシャフト ベンゾピラノピラゾール

Also Published As

Publication number Publication date
US20070232596A1 (en) 2007-10-04
AU2005273867A1 (en) 2006-02-23
EP1781667B1 (de) 2010-11-03
EP1781667A1 (de) 2007-05-09
JP2008509971A (ja) 2008-04-03
CA2576619A1 (en) 2006-02-23
WO2006018435A1 (en) 2006-02-23
AU2005273867B2 (en) 2010-12-23
US20100183550A1 (en) 2010-07-22
US7718665B2 (en) 2010-05-18
US8044065B2 (en) 2011-10-25
DE602005024572D1 (de) 2010-12-16

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