ATE486878T1 - Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin - Google Patents
Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesinInfo
- Publication number
- ATE486878T1 ATE486878T1 AT05777861T AT05777861T ATE486878T1 AT E486878 T1 ATE486878 T1 AT E486878T1 AT 05777861 T AT05777861 T AT 05777861T AT 05777861 T AT05777861 T AT 05777861T AT E486878 T1 ATE486878 T1 AT E486878T1
- Authority
- AT
- Austria
- Prior art keywords
- benzothienopyridines
- kinesin inhibitors
- compounds
- kinesin
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006909 anti-apoptosis Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103958 | 2004-08-18 | ||
| EP04104175 | 2004-08-31 | ||
| PCT/EP2005/054054 WO2006018435A1 (en) | 2004-08-18 | 2005-08-17 | Benzothienopyridines for use as inhibitors of eg5 kinesin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE486878T1 true ATE486878T1 (de) | 2010-11-15 |
Family
ID=35285513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05777861T ATE486878T1 (de) | 2004-08-18 | 2005-08-17 | Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7718665B2 (de) |
| EP (1) | EP1781667B1 (de) |
| JP (1) | JP2008509971A (de) |
| AT (1) | ATE486878T1 (de) |
| AU (1) | AU2005273867B2 (de) |
| CA (1) | CA2576619A1 (de) |
| DE (1) | DE602005024572D1 (de) |
| WO (1) | WO2006018435A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718665B2 (en) | 2004-08-18 | 2010-05-18 | 4Sc Ag | Benzothienopyridines for use as inhibitors of Eg5 kinesin |
| AU2006208709A1 (en) * | 2005-01-27 | 2006-08-03 | 4Sc Ag | Novel indolopyridines , benzofuranopyridines and benzothienopyridines |
| JP2008528551A (ja) * | 2005-01-28 | 2008-07-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | インドロピリジン、ベンゾフラノピリジン及びベンゾチエノピリジン |
| JP5349056B2 (ja) * | 2006-02-22 | 2013-11-20 | ４エスツェー アクチェンゲゼルシャフト | Ｅｇ５キネシンモジュレーターとしてのインドロピリジン類 |
| EA015151B1 (ru) * | 2006-02-22 | 2011-06-30 | 4ЭсЦэ АГ | Индолопиридины в качестве модуляторов кинезина eg5 |
| JP2009542777A (ja) * | 2006-07-13 | 2009-12-03 | ４エスツェー アクチェンゲゼルシャフト | ベンゾピラノピラゾール |
| AU2007358076A1 (en) * | 2007-08-22 | 2009-02-26 | 4Sc Ag | Indolopyridines as inhibitors of the kinesin spindle protein (Eg5 ) |
| EP2033962A1 (de) * | 2007-08-22 | 2009-03-11 | 4Sc Ag | Tetrazyclische Indolopyridinderivate als EG5-Hemmer |
| US20130210733A1 (en) | 2010-06-17 | 2013-08-15 | Cytokinetics, Inc. | Methods of treating lung disease |
| KR101390616B1 (ko) | 2012-03-28 | 2014-04-29 | 주식회사 두산 | 신규 화합물 및 이를 포함하는 유기 전계 발광 소자 |
| EA202191730A1 (ru) | 2018-12-20 | 2021-08-24 | Эмджен Инк. | Ингибиторы kif18a |
| CN110464722B (zh) * | 2019-06-06 | 2023-05-23 | 暨南大学 | 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用 |
| EP4392407A1 (de) | 2021-08-26 | 2024-07-03 | Volastra Therapeutics, Inc. | Spiroindolinhemmer von kif18a |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
| GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| US6217104B1 (en) * | 1999-06-16 | 2001-04-17 | Cts Fahrzeug Dachsysteme Gmbh | Retractable hard top module |
| US6890933B1 (en) * | 2000-02-24 | 2005-05-10 | President And Fellows Of Harvard College | Kinesin inhibitors |
| EP1335923B1 (de) | 2000-10-03 | 2006-07-12 | Lilly Icos LLC | Kondensierte pyridoindolderivate |
| AU2002310099A1 (en) * | 2001-05-22 | 2002-12-03 | President And Fellows Of Harvard College | Identification of anti-protozoal agents |
| ES2286275T3 (es) | 2001-09-19 | 2007-12-01 | Pharmacia Corporation | Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion. |
| WO2004004652A2 (en) | 2002-07-08 | 2004-01-15 | Merck & Co., Inc. | Mitotic kinesin binding site |
| US7022850B2 (en) | 2003-05-22 | 2006-04-04 | Bristol-Myers Squibb Co. | Bicyclicpyrimidones and their use to treat diseases |
| AU2004248160B2 (en) | 2003-06-12 | 2010-05-27 | Merck Sharp & Dohme Corp. | Prodrugs of mitotic kinesin inhibitors |
| US7718665B2 (en) | 2004-08-18 | 2010-05-18 | 4Sc Ag | Benzothienopyridines for use as inhibitors of Eg5 kinesin |
| US7595337B2 (en) | 2005-02-10 | 2009-09-29 | Merck & Co. Inc. | Mitotic kinesin inhibitors |
| EA015151B1 (ru) | 2006-02-22 | 2011-06-30 | 4ЭсЦэ АГ | Индолопиридины в качестве модуляторов кинезина eg5 |
| JP5349056B2 (ja) | 2006-02-22 | 2013-11-20 | ４エスツェー アクチェンゲゼルシャフト | Ｅｇ５キネシンモジュレーターとしてのインドロピリジン類 |
| WO2007144384A1 (en) | 2006-06-14 | 2007-12-21 | 4Sc Ag | Pyrazolopyrimidones |
| JP2009542777A (ja) | 2006-07-13 | 2009-12-03 | ４エスツェー アクチェンゲゼルシャフト | ベンゾピラノピラゾール |
-
2005
- 2005-08-17 US US11/659,738 patent/US7718665B2/en not_active Expired - Fee Related
- 2005-08-17 JP JP2007526460A patent/JP2008509971A/ja active Pending
- 2005-08-17 AT AT05777861T patent/ATE486878T1/de not_active IP Right Cessation
- 2005-08-17 EP EP05777861A patent/EP1781667B1/de not_active Expired - Lifetime
- 2005-08-17 AU AU2005273867A patent/AU2005273867B2/en not_active Ceased
- 2005-08-17 WO PCT/EP2005/054054 patent/WO2006018435A1/en not_active Ceased
- 2005-08-17 DE DE602005024572T patent/DE602005024572D1/de not_active Expired - Lifetime
- 2005-08-17 CA CA002576619A patent/CA2576619A1/en not_active Abandoned
-
2010
- 2010-03-30 US US12/749,623 patent/US8044065B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005024572D1 (de) | 2010-12-16 |
| JP2008509971A (ja) | 2008-04-03 |
| US8044065B2 (en) | 2011-10-25 |
| US7718665B2 (en) | 2010-05-18 |
| EP1781667A1 (de) | 2007-05-09 |
| US20100183550A1 (en) | 2010-07-22 |
| CA2576619A1 (en) | 2006-02-23 |
| AU2005273867B2 (en) | 2010-12-23 |
| EP1781667B1 (de) | 2010-11-03 |
| AU2005273867A1 (en) | 2006-02-23 |
| US20070232596A1 (en) | 2007-10-04 |
| WO2006018435A1 (en) | 2006-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2008010801A (es) | Indolopiridinas como moduladores de quinesina eg5. | |
| ATE517896T1 (de) | P38-kinase-inhibitoren | |
| CY1108399T1 (el) | Τετραϋδροπυριδοθειοφαινια | |
| NO20071127L (no) | Triazoloftalaziner | |
| NO20073921L (no) | Triazoloftalaziner | |
| ATE360627T1 (de) | Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren | |
| ATE477249T1 (de) | Heteroarylbenzamidderivate zur verwendung als glk-aktivatoren bei der behandlung von diabetes | |
| ATE348616T1 (de) | 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer | |
| ATE353217T1 (de) | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren | |
| ATE395336T1 (de) | Chinolinderivate zur verwendung als inhibitoren von mycobakterien | |
| ATE486878T1 (de) | Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin | |
| EA200601568A1 (ru) | Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4 | |
| DE602005010821D1 (de) | Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren | |
| ATE445402T1 (de) | Neue verwendung von pde5-hemmern | |
| ATE397000T1 (de) | Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs | |
| ATE448234T1 (de) | Olanzapin-analoga und verfahren zu ihrer verwendung | |
| BRPI0615141A2 (pt) | inibidores pentacìclicos de quinase | |
| NO20064491L (no) | Nye difluomtoksysubstituee hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer | |
| DE602006007549D1 (de) | Verwendung von morpholino-verbindungen zur verhinderung bakteriellen befalls | |
| EA200701626A1 (ru) | Новые 6-пиридилфенантридины | |
| ATE508130T1 (de) | 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren | |
| DE602006018725D1 (de) | Amidin-derivate zur verwendung in der vorbeugung oder behandlung von glaukom | |
| ATE423772T1 (de) | Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin | |
| DE60321248D1 (de) | Verwendung von pollen-isolierten proteinen zur inhibierung der aktivität des anthrax-toxins | |
| ATE490767T1 (de) | Amidin-derivate zur verwendung in der vorbeugung oder behandlung von glaukom |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |