ATE488588T1 - Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker - Google Patents

Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker

Info

Publication number
ATE488588T1
ATE488588T1 AT07017847T AT07017847T ATE488588T1 AT E488588 T1 ATE488588 T1 AT E488588T1 AT 07017847 T AT07017847 T AT 07017847T AT 07017847 T AT07017847 T AT 07017847T AT E488588 T1 ATE488588 T1 AT E488588T1
Authority
AT
Austria
Prior art keywords
mesenchymal stem
marker
detecting
stem cell
gene
Prior art date
Application number
AT07017847T
Other languages
English (en)
Inventor
Chika Koike
Koichiro Tsuji
Yukio Kato
Original Assignee
Japan Science & Tech Agency
Yukio Kato
Two Cells Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science & Tech Agency, Yukio Kato, Two Cells Co Ltd filed Critical Japan Science & Tech Agency
Application granted granted Critical
Publication of ATE488588T1 publication Critical patent/ATE488588T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT07017847T 2003-03-10 2004-02-27 Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker ATE488588T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003063077 2003-03-10

Publications (1)

Publication Number Publication Date
ATE488588T1 true ATE488588T1 (de) 2010-12-15

Family

ID=32984419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07017847T ATE488588T1 (de) 2003-03-10 2004-02-27 Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker

Country Status (9)

Country Link
US (1) US20060166214A1 (de)
EP (2) EP1605044A4 (de)
JP (1) JP2004290189A (de)
KR (1) KR100818689B1 (de)
CN (2) CN101265503A (de)
AT (1) ATE488588T1 (de)
AU (1) AU2004219820B2 (de)
DE (1) DE602004030172D1 (de)
WO (1) WO2004081174A2 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2270226B1 (de) * 2005-03-31 2016-05-18 Two Cells Co., Ltd Verfahren zur Unterscheidung mesenchymaler Stammzellen mittels molekularem Marker und Nutzung dieses Marker
WO2006112390A1 (ja) * 2005-04-14 2006-10-26 Japan As Represented By General Director Of Agency Of National Cardiovascular Center 脂肪由来前駆細胞およびその利用
US20060246498A1 (en) * 2005-04-28 2006-11-02 Ramot At Tel Aviv University Ltd. HNRPLL polypeptides, polynucleotides encoding same and compositions and methods of using same
JP4958094B2 (ja) * 2005-09-22 2012-06-20 国立大学法人広島大学 間葉系幹細胞の均質性識別方法、その方法を利用して得られる均質間葉系幹細胞
AU2006321841C1 (en) 2005-12-08 2013-01-24 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use
WO2007085266A1 (en) * 2006-01-30 2007-08-02 Dako Denmark A/S High-speed quantification of antigen specific t-cells in whole blood by flow cytometry
JP2008092919A (ja) * 2006-10-16 2008-04-24 Hiroshima Univ 病変間葉系幹細胞の検出マーカーの利用
EA201201640A1 (ru) * 2007-01-30 2013-09-30 Фармасайкликс, Инк. Способы определения устойчивости рака к ингибиторам гистондеацетилазы
EP2155782A2 (de) 2007-03-26 2010-02-24 Dako Denmark A/S Mhc-peptid-komplexe und anwendungen davon bei infektionskrankheiten
KR100888924B1 (ko) 2007-06-04 2009-03-16 주식회사 제이비줄기세포연구소 인간 제대혈 유래 중간엽 줄기세포와 섬유아세포 분별방법
EP2167537A2 (de) 2007-07-03 2010-03-31 Dako Denmark A/S Zusammengestellte verfahren für die analyse und sortierung von proben
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
WO2009076638A2 (en) * 2007-12-13 2009-06-18 Robert Bradbury Compositions and methods relating to characterization and therapeutic application of pristine stem cells
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
JP2010189302A (ja) * 2009-02-17 2010-09-02 Hiroshima Univ 病変間葉系幹細胞が関連する疾患の治療剤および間葉系幹細胞の検出マーカーの利用
PT2453921E (pt) * 2009-07-14 2015-09-25 Novartis Ag Diferenciação de células estaminais mesenquimais
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
ES2384790B1 (es) * 2010-12-10 2013-05-20 Instituto De Salud Carlos Iii Células madre mesenquimales aisladas a partir de sangre periférica.
CN103562719B (zh) * 2011-03-16 2016-01-13 国立大学法人东北大学 生物体组织分析用探针及其使用方法
KR101374247B1 (ko) 2011-09-23 2014-03-13 가톨릭대학교기술지주 주식회사 고해상도 ｍｉｃａ 대립유전자 검출용 ｓｐｒｅｘ―ｄｎａ 칩 키트
BR112014019328A8 (pt) * 2012-02-17 2017-07-11 The Schepens Eye Res Institute Perfil de fenótipo de células progenitoras retinais humanas
US9868935B2 (en) * 2012-04-24 2018-01-16 Crioestaminal, Saúde E Tecnologia, Sa. Composition and method of stem cells for preservation of cardiac tissue
CN102732633B (zh) * 2012-07-06 2014-02-26 广州好芝生物科技有限公司 人idh基因突变的检测引物和试剂盒
CN102925579B (zh) * 2012-11-16 2014-12-17 上海赛安医学检验所有限公司 Idh2基因突变的快速检测方法
US20150368615A1 (en) 2013-02-01 2015-12-24 Tohoku University Method for separating cell from biological tissue
GB201310354D0 (en) * 2013-06-11 2013-07-24 Ge Healthcare Uk Ltd Method for cell differentiation
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
JP6339814B2 (ja) * 2014-02-05 2018-06-06 株式会社島津製作所 がん転移マーカー及びその分析方法
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2016086403A1 (en) * 2014-12-05 2016-06-09 Meridigen Biotech Co., Ltd. Method of distinguishing mesenchymal stem cells
CN104844705B (zh) * 2015-01-30 2018-08-03 暨南大学 Kctd12蛋白在细胞周期调控中的应用
CN104655857B (zh) * 2015-02-10 2017-05-31 南京大学 一种微生物细胞内多聚磷酸盐的定量检测方法
US10539553B2 (en) 2015-03-17 2020-01-21 National Institute Of Advanced Industrial Science And Technology Method and kit for detecting stem cell
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN105018524B (zh) * 2015-07-13 2020-03-27 广州赛琅生物技术有限公司 一种细胞寿命延长及成血管能力增强的人干细胞的制备方法及其试剂盒
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN106771256B (zh) * 2017-01-23 2019-02-01 福建医科大学 骨骼肌组织冰冻切片肌球蛋白三磷酸腺苷酶染色方法
US11253550B2 (en) 2017-03-03 2022-02-22 Rohto Pharmaceutical Co., Ltd. Method for treating fibrotic liver disease
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3609530A1 (de) * 2017-04-10 2020-02-19 Immatics Biotechnologies GmbH Peptide und kombination davon zur verwendung in der immuntherapie gegen krebs
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
PL241520B1 (pl) * 2020-03-27 2022-10-17 Polski Bank Komorek Macierzystych Spolka Akcyjna Zastosowanie panelu genów do określania potencjału teratogennego komórek mezenchymalnych i pochodzenia perinatalnego
CN116867909A (zh) * 2020-12-07 2023-10-10 社会福祉法人 三星生命公益财团 自我维持能力提高的间充质干细胞的筛选方法及由此筛选出的间充质干细胞
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
WO2023052820A1 (en) * 2021-09-30 2023-04-06 Polski Bank Komórek Macierzystych S.A. Expression analysis of a specific gene pool to determine whether the population of adipose tissue-derived mesenchymal cells (at-msc) selected for clinical application can undergo a transformation into neoplastic cells
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
CN114622019A (zh) * 2022-03-23 2022-06-14 新乡医学院 Birc5基因作为人骨髓间充质干细胞成骨分化抑制剂的应用
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340739A (en) * 1988-07-13 1994-08-23 Brigham & Women's Hospital Hematopoietic cell specific transcriptional regulatory elements of serglycin and uses thereof
CA2271758A1 (en) * 1996-11-15 1998-05-22 Osiris Therapeutics, Inc. Msc-megakaryocyte precursor composition and method of isolating mscs associated with isolated megakaryocytes by isolating megakaryocytes
AU2180799A (en) * 1998-02-13 1999-08-30 Peter Sonderegger Neuroserpin
DE60120151D1 (de) * 2000-04-28 2006-07-06 Childrens Medical Center Isolierung von mesenchymalen stammzellen und deren verwendung
EP1358349A2 (de) * 2000-06-05 2003-11-05 Avalon Pharmaceuticals Bestimmung von krebsgenen und therapeutisches screeningverfahren das signaturen von gensätzen verwendet
WO2002028999A2 (en) * 2000-10-03 2002-04-11 Gene Logic, Inc. Gene expression profiles in granulocytic cells
JP2003052365A (ja) * 2001-08-20 2003-02-25 Japan Science & Technology Corp 哺乳動物からの間葉系幹細胞の分離及びその利用方法
EP1288293A1 (de) * 2001-08-30 2003-03-05 Norio Sakuragawa Humane neuronale Stammzellen aus humanen mesenchymalen Amnionzellschichten

Also Published As

Publication number Publication date
EP1605044A4 (de) 2006-12-06
KR20050115278A (ko) 2005-12-07
EP1860186A2 (de) 2007-11-28
JP2004290189A (ja) 2004-10-21
CN1761749A (zh) 2006-04-19
KR100818689B1 (ko) 2008-04-02
AU2004219820B2 (en) 2008-06-12
CN101265503A (zh) 2008-09-17
EP1860186B1 (de) 2010-11-17
US20060166214A1 (en) 2006-07-27
AU2004219820A1 (en) 2004-09-23
WO2004081174A2 (ja) 2004-09-23
EP1605044A2 (de) 2005-12-14
DE602004030172D1 (de) 2010-12-30
WO2004081174A3 (ja) 2004-12-02
EP1860186A3 (de) 2008-03-12

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