ATE492644T1 - Transfer von mrna unter verwendung von polykationischen verbindungen - Google Patents

Transfer von mrna unter verwendung von polykationischen verbindungen

Info

Publication number
ATE492644T1
ATE492644T1 AT05022610T AT05022610T ATE492644T1 AT E492644 T1 ATE492644 T1 AT E492644T1 AT 05022610 T AT05022610 T AT 05022610T AT 05022610 T AT05022610 T AT 05022610T AT E492644 T1 ATE492644 T1 AT E492644T1
Authority
AT
Austria
Prior art keywords
transfer
mrna
rna
polycationic compounds
protein
Prior art date
Application number
AT05022610T
Other languages
English (en)
Inventor
Ingmar Hoerr
Hans-Georg Rammensee
Guenther Jung
Reinhard Obst
Original Assignee
Curevac Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Gmbh filed Critical Curevac Gmbh
Application granted granted Critical
Publication of ATE492644T1 publication Critical patent/ATE492644T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05022610T 1999-09-09 1999-09-09 Transfer von mrna unter verwendung von polykationischen verbindungen ATE492644T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99117771A EP1083232B1 (de) 1999-09-09 1999-09-09 Transfer von mRNAs unter Verwendung von polykationischen Verbindungen
EP05002916A EP1541690A3 (de) 1999-09-09 1999-09-09 Transfer von mRNA unter Verwendung von polykationischen Verbindungen
EP05022610A EP1619254B1 (de) 1999-09-09 1999-09-09 Transfer von mRNA unter Verwendung von polykationischen Verbindungen

Publications (1)

Publication Number Publication Date
ATE492644T1 true ATE492644T1 (de) 2011-01-15

Family

ID=8238953

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05022610T ATE492644T1 (de) 1999-09-09 1999-09-09 Transfer von mrna unter verwendung von polykationischen verbindungen
AT99117771T ATE289630T1 (de) 1999-09-09 1999-09-09 Transfer von mrnas unter verwendung von polykationischen verbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99117771T ATE289630T1 (de) 1999-09-09 1999-09-09 Transfer von mrnas unter verwendung von polykationischen verbindungen

Country Status (4)

Country Link
EP (4) EP1619254B1 (de)
AT (2) ATE492644T1 (de)
DE (2) DE69943068D1 (de)
ES (1) ES2238799T3 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
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ATE289630T1 (de) 2005-03-15
DE69943068D1 (de) 2011-02-03
EP1541690A3 (de) 2005-07-27
ES2238799T3 (es) 2005-09-01
EP1619254A1 (de) 2006-01-25
EP1541690A2 (de) 2005-06-15
EP1083232A1 (de) 2001-03-14
EP1619254B1 (de) 2010-12-22
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EP1083232B1 (de) 2005-02-23
EP1818409A1 (de) 2007-08-15

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