ATE493513T1 - Verfahren zur sequenzierung einer polynukleotidmatrize - Google Patents
Verfahren zur sequenzierung einer polynukleotidmatrizeInfo
- Publication number
- ATE493513T1 ATE493513T1 AT06755782T AT06755782T ATE493513T1 AT E493513 T1 ATE493513 T1 AT E493513T1 AT 06755782 T AT06755782 T AT 06755782T AT 06755782 T AT06755782 T AT 06755782T AT E493513 T1 ATE493513 T1 AT E493513T1
- Authority
- AT
- Austria
- Prior art keywords
- sequencing
- matrice
- polynucleotide
- double
- stranded polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0514910.9A GB0514910D0 (en) | 2005-07-20 | 2005-07-20 | Method for sequencing a polynucleotide template |
| PCT/GB2006/002690 WO2007010252A1 (en) | 2005-07-20 | 2006-07-20 | Method for sequencing a polynucleotide template |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE493513T1 true ATE493513T1 (de) | 2011-01-15 |
Family
ID=34897536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06755782T ATE493513T1 (de) | 2005-07-20 | 2006-07-20 | Verfahren zur sequenzierung einer polynukleotidmatrize |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US8017335B2 (de) |
| EP (1) | EP1910560B1 (de) |
| AT (1) | ATE493513T1 (de) |
| DE (1) | DE602006019261D1 (de) |
| GB (1) | GB0514910D0 (de) |
| WO (1) | WO2007010252A1 (de) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514910D0 (en) * | 2005-07-20 | 2005-08-24 | Solexa Ltd | Method for sequencing a polynucleotide template |
| GB0514935D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Methods for sequencing a polynucleotide template |
| SG169356A1 (en) * | 2006-02-08 | 2011-03-30 | Illumina Cambridge Ltd | Method for sequencing a polynucleotide template |
| US8053191B2 (en) | 2006-08-31 | 2011-11-08 | Westend Asset Clearinghouse Company, Llc | Iterative nucleic acid assembly using activation of vector-encoded traits |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| JP2010537643A (ja) * | 2007-08-29 | 2010-12-09 | アプライド バイオシステムズ, エルエルシー | 代替的な核酸配列決定法 |
| US8263367B2 (en) | 2008-01-25 | 2012-09-11 | Agency For Science, Technology And Research | Nucleic acid interaction analysis |
| US8202691B2 (en) | 2008-01-25 | 2012-06-19 | Illumina, Inc. | Uniform fragmentation of DNA using binding proteins |
| US7767400B2 (en) * | 2008-02-03 | 2010-08-03 | Helicos Biosciences Corporation | Paired-end reads in sequencing by synthesis |
| US12060554B2 (en) | 2008-03-10 | 2024-08-13 | Illumina, Inc. | Method for selecting and amplifying polynucleotides |
| WO2010003132A1 (en) | 2008-07-02 | 2010-01-07 | Illumina Cambridge Ltd. | Using populations of beads for the fabrication of arrays on surfaces |
| US20100184045A1 (en) * | 2008-09-23 | 2010-07-22 | Helicos Biosciences Corporation | Methods for sequencing degraded or modified nucleic acids |
| WO2010038042A1 (en) | 2008-10-02 | 2010-04-08 | Illumina Cambridge Ltd. | Nucleic acid sample enrichment for sequencing applications |
| WO2010048337A2 (en) | 2008-10-22 | 2010-04-29 | Illumina, Inc. | Preservation of information related to genomic dna methylation |
| EP2607496B1 (de) | 2008-12-23 | 2014-07-16 | Illumina, Inc. | Für Nukleinsäuresequenzierungsprotokolle geeignete Verfahren |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| EP2456892B1 (de) | 2009-07-24 | 2014-10-01 | Illumina, Inc. | Verfahren zur sequenzierung einer polynukleotidmatrize |
| PT2669387T (pt) | 2009-08-25 | 2016-09-20 | Illumina Inc | Métodos para selecção e amplificação de polinucleótidos |
| WO2011053987A1 (en) * | 2009-11-02 | 2011-05-05 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence selection and amplification |
| CN102648295B (zh) | 2009-12-07 | 2017-08-08 | 伊鲁米那股份有限公司 | 用于多重基因分型的多样品索引 |
| US9029103B2 (en) | 2010-08-27 | 2015-05-12 | Illumina Cambridge Limited | Methods for sequencing polynucleotides |
| US8483969B2 (en) | 2010-09-17 | 2013-07-09 | Illuminia, Inc. | Variation analysis for multiple templates on a solid support |
| WO2012050920A1 (en) | 2010-09-29 | 2012-04-19 | Illumina, Inc. | Compositions and methods for sequencing nucleic acids |
| CN103502448B (zh) | 2010-11-12 | 2017-03-29 | Gen9股份有限公司 | 核酸合成的方法和设备 |
| WO2012064975A1 (en) | 2010-11-12 | 2012-05-18 | Gen9, Inc. | Protein arrays and methods of using and making the same |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| ES2986436T3 (es) | 2011-04-15 | 2024-11-11 | Univ Johns Hopkins | Sistema de secuenciación segura |
| LT2944693T (lt) | 2011-08-26 | 2019-08-26 | Gen9, Inc. | Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai |
| WO2013059746A1 (en) | 2011-10-19 | 2013-04-25 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| EP2807292B1 (de) | 2012-01-26 | 2019-05-22 | Tecan Genomics, Inc. | Zusammensetzungen und verfahren zur gezielten nukleinsäuresequenzanreicherung und erzeugung einer hocheffizienten bibliothek |
| US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
| CA2871505C (en) | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| CA2877094A1 (en) | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| IL236303B (en) | 2012-06-25 | 2022-07-01 | Gen9 Inc | Methods for high-throughput nucleic acid assembly and sequencing |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| CA2876505A1 (en) | 2012-07-17 | 2014-01-23 | Counsyl, Inc. | System and methods for detecting genetic variation |
| US9092401B2 (en) | 2012-10-31 | 2015-07-28 | Counsyl, Inc. | System and methods for detecting genetic variation |
| CN107760772B (zh) * | 2012-08-24 | 2022-02-01 | 生命技术公司 | 用于核酸配对末端测序的方法、组合物、系统、仪器和试剂盒 |
| US9181583B2 (en) | 2012-10-23 | 2015-11-10 | Illumina, Inc. | HLA typing using selective amplification and sequencing |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
| US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
| US9822408B2 (en) | 2013-03-15 | 2017-11-21 | Nugen Technologies, Inc. | Sequential sequencing |
| EP3597772A1 (de) | 2013-04-17 | 2020-01-22 | Agency For Science, Technology And Research | Verfahren zur erzeugung erweiterter sequenzauslesungen |
| CN105358715B (zh) | 2013-07-03 | 2018-09-18 | 伊鲁米那股份有限公司 | 正交合成测序 |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| US9745614B2 (en) | 2014-02-28 | 2017-08-29 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| WO2016044233A1 (en) | 2014-09-18 | 2016-03-24 | Illumina, Inc. | Methods and systems for analyzing nucleic acid sequencing data |
| US10233490B2 (en) | 2014-11-21 | 2019-03-19 | Metabiotech Corporation | Methods for assembling and reading nucleic acid sequences from mixed populations |
| WO2016090266A1 (en) | 2014-12-05 | 2016-06-09 | Amyris, Inc. | High-throughput sequencing of polynucleotides |
| AU2016269785B2 (en) | 2015-05-29 | 2019-02-28 | Illumina Cambridge Limited | Enhanced utilization of surface primers in clusters |
| WO2017019278A1 (en) | 2015-07-30 | 2017-02-02 | Illumina, Inc. | Orthogonal deblocking of nucleotides |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CN116218970A (zh) | 2015-11-19 | 2023-06-06 | 赛纳生物科技(北京)有限公司 | 用于获得和校正目标多核苷酸的序列信息的方法 |
| BR112019009949A2 (pt) | 2016-11-16 | 2019-08-20 | Illumina, Inc. | método implantado por computador para validar chamadas de variante e sistema para validar chamadas de variante |
| US20210072255A1 (en) | 2016-12-16 | 2021-03-11 | The Brigham And Women's Hospital, Inc. | System and method for protein corona sensor array for early detection of diseases |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| AU2018260627B2 (en) | 2017-04-23 | 2024-08-22 | Illumina Cambridge Limited | Compositions and methods for improving sample identification in indexed nucleic acid libraries |
| AU2018259206B2 (en) | 2017-04-23 | 2024-07-11 | Illumina Cambridge Limited | Compositions and methods for improving sample identification in indexed nucleic acid libraries |
| CN110770353B (zh) | 2017-04-23 | 2024-11-26 | 伊鲁米那股份有限公司 | 用于改进编索引的核酸文库中的样品鉴定的组合物和方法 |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| WO2019079202A1 (en) | 2017-10-16 | 2019-04-25 | Illumina, Inc. | ABERRANT CONNECTION DETECTION USING CONVOLUTION NEURAL NETWORKS (CNN) |
| CN110832596B (zh) | 2017-10-16 | 2021-03-26 | 因美纳有限公司 | 基于深度学习的深度卷积神经网络训练方法 |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| CN110870016B (zh) | 2017-11-30 | 2024-09-06 | 伊鲁米那股份有限公司 | 用于序列变体呼出的验证方法和系统 |
| CA3065939A1 (en) | 2018-01-15 | 2019-07-18 | Illumina, Inc. | Deep learning-based variant classifier |
| NL2020861B1 (en) | 2018-04-12 | 2019-10-22 | Illumina Inc | Variant classifier based on deep neural networks |
| US20190318806A1 (en) | 2018-04-12 | 2019-10-17 | Illumina, Inc. | Variant Classifier Based on Deep Neural Networks |
| US12073922B2 (en) | 2018-07-11 | 2024-08-27 | Illumina, Inc. | Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs) |
| JP6888123B2 (ja) | 2018-10-15 | 2021-06-16 | イルミナ インコーポレイテッド | 深層畳み込みニューラルネットワークを事前訓練するための深層学習ベースの技術 |
| KR20260016611A (ko) | 2018-11-07 | 2026-02-03 | 시어 인코퍼레이티드 | 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도 |
| SG11202012762WA (en) | 2018-12-05 | 2021-01-28 | Illumina Cambridge Ltd | Methods and compositions for cluster generation by bridge amplification |
| JP7587425B2 (ja) | 2018-12-18 | 2024-11-20 | イルミナ ケンブリッジ リミテッド | 単一表面プライマーを使用したペアエンドシーケンシングのための方法および組成物 |
| NL2023310B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Training data generation for artificial intelligence-based sequencing |
| NL2023311B9 (en) | 2019-03-21 | 2021-03-12 | Illumina Inc | Artificial intelligence-based generation of sequencing metadata |
| US11210554B2 (en) | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| WO2020191389A1 (en) | 2019-03-21 | 2020-09-24 | Illumina, Inc. | Training data generation for artificial intelligence-based sequencing |
| NL2023316B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based sequencing |
| NL2023312B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based base calling |
| NL2023314B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based quality scoring |
| CN117169534A (zh) | 2019-08-05 | 2023-12-05 | 禧尔公司 | 用于样品制备、数据生成和蛋白质冠分析的系统和方法 |
| EP3851542A1 (de) | 2020-01-20 | 2021-07-21 | Tecan Genomics, Inc. | Verarmung von reichlich uninformativen sequenzen |
| US12059674B2 (en) | 2020-02-03 | 2024-08-13 | Tecan Genomics, Inc. | Reagent storage system |
| EP4103748A4 (de) | 2020-02-14 | 2024-03-13 | The Johns Hopkins University | Verfahren und materialien zur beurteilung von nukleinsäuren |
| US12354008B2 (en) | 2020-02-20 | 2025-07-08 | Illumina, Inc. | Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller |
| CA3173798A1 (en) | 2020-03-03 | 2021-09-10 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
| PL3969618T3 (pl) | 2020-03-09 | 2024-01-03 | Illumina, Inc. | Sposoby sekwencjonowania polinukleotydów |
| US11188778B1 (en) | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
| IL300826A (en) | 2020-08-25 | 2023-04-01 | Seer Inc | Compositions and methods for testing proteins and nucleic acids |
| US11427855B1 (en) | 2021-06-17 | 2022-08-30 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11455487B1 (en) | 2021-10-26 | 2022-09-27 | Illumina Software, Inc. | Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling |
| EP4374343B1 (de) | 2021-07-19 | 2025-12-03 | Illumina, Inc. | Intensitätsextraktion mit interpolation und anpassung für basisanrufe |
| WO2023049212A2 (en) | 2021-09-22 | 2023-03-30 | Illumina, Inc. | State-based base calling |
| EP4448792A1 (de) | 2021-12-16 | 2024-10-23 | Illumina, Inc. | Hybrides clustering |
| AU2022413263A1 (en) | 2021-12-17 | 2024-01-18 | Illumina, Inc. | Orthogonal hybridization |
| CN119082279A (zh) * | 2022-01-28 | 2024-12-06 | 赛纳生物科技(北京)有限公司 | 一种固相介质表面双端扩增测序的方法 |
| AU2023236924A1 (en) | 2022-03-15 | 2024-10-24 | Illumina, Inc. | Paired-end sequencing |
| US20230295719A1 (en) * | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Paired-end sequencing |
| AU2023234670A1 (en) | 2022-03-15 | 2024-01-18 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection |
| WO2023183937A1 (en) | 2022-03-25 | 2023-09-28 | Illumina, Inc. | Sequence-to-sequence base calling |
| CA3223037A1 (en) * | 2022-03-30 | 2023-10-05 | Oliver MILLER | Methods for chemical cleavage of surface-bound polynucleotides |
| US20230392201A1 (en) | 2022-06-06 | 2023-12-07 | Element Biosciences, Inc. | Methods for assembling and reading nucleic acid sequences from mixed populations |
| WO2023239917A1 (en) | 2022-06-09 | 2023-12-14 | Illumina, Inc. | Dependence of base calling on flow cell tilt |
| EP4569102A1 (de) | 2022-08-12 | 2025-06-18 | Miltenyi Biotec B.V. & Co. KG | Barcodierung von nukleinsäuren aus einzelzellen |
| EP4573213A1 (de) | 2022-08-15 | 2025-06-25 | Element Biosciences, Inc. | Ortsaufgelöste oberflächenerfassung von nukleinsäuren |
| US20240124916A1 (en) | 2022-09-16 | 2024-04-18 | Illumina Cambridge Limited | Nanoparticle with polynucleotide binding site and method of making thereof |
| KR20250075532A (ko) | 2022-09-19 | 2025-05-28 | 일루미나, 인코포레이티드 | 고정된 프라이머를 포함하는 변형가능한 중합체 |
| US20240102067A1 (en) | 2022-09-26 | 2024-03-28 | Illumina, Inc. | Resynthesis Kits and Methods |
| US20240110221A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Methods of modulating clustering kinetics |
| US20240124929A1 (en) | 2022-09-30 | 2024-04-18 | Illumina, Inc. | Mesophilic compositions for nucleic acid amplification |
| US20240124914A1 (en) | 2022-09-30 | 2024-04-18 | Illumina, Inc. | Thermophilic compositions for nucleic acid amplification |
| US20240110234A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Amplification Compositions and Methods |
| WO2024137316A1 (en) | 2022-12-23 | 2024-06-27 | Foundation Medicine, Inc. | Oligonucleotides and methods for capturing single-stranded templates and/or templates with 3' overhangs |
| EP4720334A1 (de) | 2023-05-26 | 2026-04-08 | Illumina, Inc. | Verfahren zur bewahrung des methylierungsstatus während des clusterns |
| WO2024249061A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Detecting a methylated nucleotide using a quencher |
| WO2024256580A1 (en) | 2023-06-14 | 2024-12-19 | Illumina, Inc. | Concurrent sequencing with spatially separated rings |
| EP4728092A1 (de) | 2023-06-14 | 2026-04-22 | Illumina, Inc. | Bestimmung von modifizierten cytosinen |
| WO2025062002A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Concurrent sequencing using nick translation |
| WO2025062001A1 (en) | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Optimised nucleic acid sequencing |
| WO2025072683A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Solid supports and methods for strand invasion-based amplification |
| US20250207193A1 (en) | 2023-12-22 | 2025-06-26 | Illumina, Inc. | Reusable flow cells and methods of using them for nucleic acid sequencing |
| WO2025264831A1 (en) | 2024-06-18 | 2025-12-26 | Illumina, Inc. | Methods for increasing sequencing quality of gc-rich regions |
| WO2025264836A1 (en) | 2024-06-18 | 2025-12-26 | Illumina, Inc. | Methods for increasing sequencing quality of gc-rich regions |
| WO2026006314A1 (en) | 2024-06-28 | 2026-01-02 | Illumina, Inc. | Tagging target regions prior to nucleotide sequencing |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB205153A (en) | 1922-07-04 | 1923-10-04 | Charles Ashton Henry Bullock | Improvements in type setting apparatus |
| GB522310A (en) | 1938-12-02 | 1940-06-14 | Corning Glass Works | Improvements in wall structures and in glass construction blocks therefor |
| US4292503A (en) | 1979-05-14 | 1981-09-29 | Emerson Electric Co. | Split-band electric heater |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EP0224126A3 (de) | 1985-11-25 | 1989-02-01 | The University of Calgary | Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| SE8801070D0 (sv) | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
| US6107023A (en) * | 1988-06-17 | 2000-08-22 | Genelabs Technologies, Inc. | DNA amplification and subtraction techniques |
| GB8818020D0 (en) | 1988-07-28 | 1988-09-01 | Ici Plc | Method for amplification of nucleotide sequences |
| CA2004326A1 (en) | 1988-12-23 | 1990-06-23 | Nanibushan Dattagupta | Assay of sequences using amplified genes |
| US5629158A (en) * | 1989-03-22 | 1997-05-13 | Cemu Bitecknik Ab | Solid phase diagnosis of medical conditions |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5302509A (en) * | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| JP3096722B2 (ja) | 1990-01-17 | 2000-10-10 | 日本ケミカルリサーチ株式会社 | ポリメラーゼ・チェーン・リアクション用プライマーの作製法およびそれを用いるdnaの増幅法 |
| US5118604A (en) * | 1990-06-15 | 1992-06-02 | Yale University | Restriction-fragment DNA probes and probe clusters |
| WO1993004199A2 (en) | 1991-08-20 | 1993-03-04 | Scientific Generics Limited | Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids |
| AU672760B2 (en) | 1991-09-24 | 1996-10-17 | Keygene N.V. | Selective restriction fragment amplification: a general method for DNA fingerprinting |
| EP0675966B1 (de) * | 1992-02-19 | 2004-10-06 | The Public Health Research Institute Of The City Of New York, Inc. | Neue anordnungen von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzierung und manipulieren von nukleinsäuren |
| US5849544A (en) | 1992-07-24 | 1998-12-15 | University Of Australia | Amplification and detection process |
| RU2048522C1 (ru) * | 1992-10-14 | 1995-11-20 | Институт белка РАН | Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления |
| JPH07203998A (ja) | 1994-01-26 | 1995-08-08 | Hamamatsu Photonics Kk | 核酸塩基配列決定方法 |
| ATE220424T1 (de) | 1994-05-28 | 2002-07-15 | Tepnel Medical Ltd | Herstellung von nukleinsaeurekopien |
| US6090592A (en) * | 1994-08-03 | 2000-07-18 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid on supports |
| US6060288A (en) * | 1994-08-03 | 2000-05-09 | Mosaic Technologies | Method for performing amplification of nucleic acid on supports |
| US5641658A (en) * | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
| AU5544696A (en) | 1995-04-11 | 1996-10-30 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| DE19515552A1 (de) * | 1995-04-27 | 1996-10-31 | Europ Lab Molekularbiolog | Simultane Sequenzierung von Nukleinsäuren |
| SE9504099D0 (sv) * | 1995-11-16 | 1995-11-16 | Pharmacia Biotech Ab | A method of sequencing |
| US5935788A (en) * | 1996-06-25 | 1999-08-10 | Lifespan Biosciences, Inc. | Subtractive hybridization techniques for identifying differentially expressed and commonly expressed nucleic acid |
| US5837466A (en) * | 1996-12-16 | 1998-11-17 | Vysis, Inc. | Devices and methods for detecting nucleic acid analytes in samples |
| US20020061532A1 (en) * | 1997-02-14 | 2002-05-23 | Mosaic Technologies, Inc. | Method and apparatus for performing amplification of nucleic acids on supports |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| JP2001517948A (ja) * | 1997-04-01 | 2001-10-09 | グラクソ、グループ、リミテッド | 核酸配列決定法 |
| US6326489B1 (en) * | 1997-08-05 | 2001-12-04 | Howard Hughes Medical Institute | Surface-bound, bimolecular, double-stranded DNA arrays |
| US6087099A (en) * | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
| US6511803B1 (en) * | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US20030022207A1 (en) * | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| AR021833A1 (es) * | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| CA2345441A1 (en) * | 1998-10-27 | 2000-05-04 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
| US20030108867A1 (en) * | 1999-04-20 | 2003-06-12 | Chee Mark S | Nucleic acid sequencing using microsphere arrays |
| US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| US6339147B1 (en) | 1999-07-29 | 2002-01-15 | Epoch Biosciences, Inc. | Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids |
| DE10051564A1 (de) | 2000-10-18 | 2002-08-01 | Axaron Bioscience Ag | Neue Verfahren zur parallelen Sequenzierung eines Nukleinsäuregemisches an einer Oberfläche |
| WO2001049882A2 (en) | 1999-12-29 | 2001-07-12 | Keygene N.V. | METHOD FOR GENERATING OLIGONUCLEOTIDES, IN PARTICULAR FOR THE DETECTION OF AMPLIFIED RESTRICTION FRAGMENTS OBTAINED USING AFLP$m(3) |
| WO2001079553A1 (en) | 2000-04-14 | 2001-10-25 | Lynx Therapeutics, Inc. | Method and compositions for ordering restriction fragments |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| EP1256632A3 (de) | 2001-05-07 | 2004-01-02 | Smithkline Beecham Corporation | Hochdurchsatz-Screening von Polymorphismen |
| WO2003056030A2 (en) | 2001-11-08 | 2003-07-10 | The Johns Hopkins University | Methods and systems of nucleic acid sequencing |
| GB0205153D0 (en) | 2002-03-05 | 2002-04-17 | Manteia S A | Methods for detecting genome-wide sequence variations associated with a phenotype |
| US20040002090A1 (en) * | 2002-03-05 | 2004-01-01 | Pascal Mayer | Methods for detecting genome-wide sequence variations associated with a phenotype |
| JP2005518811A (ja) | 2002-03-05 | 2005-06-30 | ソレックサ リミテッド | 表現型に関連するゲノム全域での配列変化を決定するための方法 |
| US20040126765A1 (en) * | 2002-12-27 | 2004-07-01 | Adams Craig W. | Method and compositions for sequencing nucleic acid molecules |
| CA2513899C (en) * | 2003-01-29 | 2013-03-26 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| EP1592810A2 (de) | 2003-02-12 | 2005-11-09 | Genizon Svenska AB | Verfahren und vorrichtungen zur nukleinsäuresequenzierung |
| GB0324456D0 (en) | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
| US20060024681A1 (en) * | 2003-10-31 | 2006-02-02 | Agencourt Bioscience Corporation | Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof |
| GB0400584D0 (en) | 2004-01-12 | 2004-02-11 | Solexa Ltd | Nucleic acid chacterisation |
| GB2412170A (en) | 2004-03-16 | 2005-09-21 | Plant Bioscience Ltd | A method for enriching for target nucleic acids in a sample |
| GB2413796B (en) | 2004-03-25 | 2006-03-29 | Global Genomics Ab | Methods and means for nucleic acid sequencing |
| US20060078899A1 (en) | 2004-10-12 | 2006-04-13 | Scheffer Alicia F | Methods and compositions for reducing label variation in array-based comparative genome hybridization assays |
| DE102004061843A1 (de) | 2004-12-22 | 2006-07-20 | Car Trim Biermann, Marktfort und Dr. Rau GbR (vertretungsberechtigter Gesellschafter: Herr Dr. Friedrich Rau, 08261 Schöneck) | Verfahren und Einrichtung zum Einbringen von Nähten in Textilien, insbesondere in technische Textilien |
| ES2404311T3 (es) | 2005-04-12 | 2013-05-27 | 454 Life Sciences Corporation | Métodos para determinar variantes de secuencias usando secuenciación ultraprofunda |
| CA2615323A1 (en) * | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
| US8428882B2 (en) | 2005-06-14 | 2013-04-23 | Agency For Science, Technology And Research | Method of processing and/or genome mapping of diTag sequences |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| GB0514935D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Methods for sequencing a polynucleotide template |
| GB0514910D0 (en) * | 2005-07-20 | 2005-08-24 | Solexa Ltd | Method for sequencing a polynucleotide template |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| ATE483804T1 (de) | 2006-01-04 | 2010-10-15 | Si Lok | Verfahren zur zuordnung von nukleinsäuren und zur identifikation fein strukturierter variationen in nukleinsäuren sowie hilfsmittel dafür |
| SG169356A1 (en) | 2006-02-08 | 2011-03-30 | Illumina Cambridge Ltd | Method for sequencing a polynucleotide template |
| WO2007107710A1 (en) | 2006-03-17 | 2007-09-27 | Solexa Limited | Isothermal methods for creating clonal single molecule arrays |
| WO2007111937A1 (en) | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
| EP2032686B1 (de) | 2006-06-23 | 2022-01-12 | Illumina, Inc. | Vorrichtung und verfahren zur erzeugung von dna-cluster-anordnungen |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| US20090093378A1 (en) | 2007-08-29 | 2009-04-09 | Helen Bignell | Method for sequencing a polynucleotide template |
-
2005
- 2005-07-20 GB GBGB0514910.9A patent/GB0514910D0/en not_active Ceased
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2006
- 2006-07-20 WO PCT/GB2006/002690 patent/WO2007010252A1/en not_active Ceased
- 2006-07-20 DE DE602006019261T patent/DE602006019261D1/de active Active
- 2006-07-20 US US11/989,172 patent/US8017335B2/en active Active
- 2006-07-20 EP EP06755782A patent/EP1910560B1/de not_active Not-in-force
- 2006-07-20 AT AT06755782T patent/ATE493513T1/de not_active IP Right Cessation
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2011
- 2011-08-04 US US13/198,527 patent/US8247177B2/en not_active Expired - Fee Related
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- 2012-07-23 US US13/556,053 patent/US9017945B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20160160277A1 (en) | 2016-06-09 |
| US20120053074A1 (en) | 2012-03-01 |
| US20130171648A1 (en) | 2013-07-04 |
| DE602006019261D1 (de) | 2011-02-10 |
| US8247177B2 (en) | 2012-08-21 |
| US20150203911A1 (en) | 2015-07-23 |
| US8017335B2 (en) | 2011-09-13 |
| WO2007010252A1 (en) | 2007-01-25 |
| US11781184B2 (en) | 2023-10-10 |
| US20090181370A1 (en) | 2009-07-16 |
| GB0514910D0 (en) | 2005-08-24 |
| US9297043B2 (en) | 2016-03-29 |
| US20170327885A1 (en) | 2017-11-16 |
| US20200216896A1 (en) | 2020-07-09 |
| US10563256B2 (en) | 2020-02-18 |
| EP1910560A1 (de) | 2008-04-16 |
| US20230193384A1 (en) | 2023-06-22 |
| EP1910560B1 (de) | 2010-12-29 |
| US9017945B2 (en) | 2015-04-28 |
| US9637786B2 (en) | 2017-05-02 |
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