EA200401228A1 - Полипептиды и пути биосинтеза - Google Patents

Полипептиды и пути биосинтеза

Info

Publication number
EA200401228A1
EA200401228A1 EA200401228A EA200401228A EA200401228A1 EA 200401228 A1 EA200401228 A1 EA 200401228A1 EA 200401228 A EA200401228 A EA 200401228A EA 200401228 A EA200401228 A EA 200401228A EA 200401228 A1 EA200401228 A1 EA 200401228A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indole
methods
polypeptides
pyruvate
hydroxy
Prior art date
Application number
EA200401228A
Other languages
English (en)
Other versions
EA009284B1 (ru
Inventor
Тимоти В. Абрахам
Дуглас С. Камерон
Джозеф Даллуге
Паула М. Хикс
Рассел Дж. Ховсон
Сара С. Макфарлан
Джим Миллис
Джон Розацца
Лишэн Жао
Давид П. Вейнер
Original Assignee
Каргилл, Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29270554&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200401228(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Каргилл, Инкорпорейтед filed Critical Каргилл, Инкорпорейтед
Publication of EA200401228A1 publication Critical patent/EA200401228A1/ru
Publication of EA009284B1 publication Critical patent/EA009284B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Содержанием данного изобретения являются полипептиды, а также пути биосинтеза, которые могут найти применение при производстве индол-3-пирувата, 2-гидрокси 2-(индол-3-илметил)-4-кетоглутаровой кислоты (ПМ) и/или монатина. Приведены способы и соединения, которые могут быть использованы для получения монатина из глюкозы, триптофана, индол-3-лактата, индол-3-пирувата и 2-гидрокси 2-(иридол-3-илметил)-4-кетоглутаровой кислоты. Представлены также способы получения промежуточных продуктов индол-3-пирувата, 2-гидрокси 2-(индол-3-илметил)-4-кетоглутаровой кислоты. Представленные соединения содержат молекулы нуклеиновой кислоты, полипептиды, химические структуры и клетки. Способы включат процессы in vitro и in vivo, и способы in vitro включают химические реакции. Настоящее изобретение предназначено для использования в растениеводстве, а также в фармацевтике и медицине.
EA200401228A 2002-04-23 2003-04-23 Полипептиды и пути биосинтеза EA009284B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37483102P 2002-04-23 2002-04-23
PCT/US2003/012588 WO2003091396A2 (en) 2002-04-23 2003-04-23 Polypeptides and biosynthetic pathways

Publications (2)

Publication Number Publication Date
EA200401228A1 true EA200401228A1 (ru) 2006-04-28
EA009284B1 EA009284B1 (ru) 2007-12-28

Family

ID=29270554

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401228A EA009284B1 (ru) 2002-04-23 2003-04-23 Полипептиды и пути биосинтеза

Country Status (24)

Country Link
US (1) US20040063175A1 (ru)
EP (2) EP1503985B1 (ru)
JP (3) JP2005523696A (ru)
KR (1) KR100902813B1 (ru)
CN (1) CN100516043C (ru)
AT (1) ATE491803T1 (ru)
AU (2) AU2003263097A1 (ru)
BR (1) BRPI0309527B1 (ru)
CA (1) CA2483126C (ru)
CO (1) CO5631430A2 (ru)
DE (1) DE60335361D1 (ru)
EA (1) EA009284B1 (ru)
EC (1) ECSP045381A (ru)
ES (1) ES2356132T3 (ru)
GE (1) GEP20084387B (ru)
IL (1) IL164548A0 (ru)
MX (1) MXPA04010522A (ru)
NO (1) NO20045029L (ru)
NZ (2) NZ555884A (ru)
PL (2) PL208481B1 (ru)
RS (1) RS92604A (ru)
SG (1) SG146453A1 (ru)
WO (1) WO2003091396A2 (ru)
ZA (1) ZA200408379B (ru)

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Also Published As

Publication number Publication date
SG146453A1 (en) 2008-10-30
KR100902813B1 (ko) 2009-06-12
AU2010201699A1 (en) 2010-05-20
CN100516043C (zh) 2009-07-22
PL208998B1 (pl) 2011-07-29
ZA200408379B (en) 2006-05-31
JP5351230B2 (ja) 2013-11-27
JP2010004896A (ja) 2010-01-14
NZ535297A (en) 2008-05-30
EP1503985A2 (en) 2005-02-09
WO2003091396A2 (en) 2003-11-06
IL164548A0 (en) 2005-12-18
KR20080056274A (ko) 2008-06-20
BR0309527A (pt) 2005-06-28
JP2011250806A (ja) 2011-12-15
PL373423A1 (en) 2005-08-22
NZ555884A (en) 2008-10-31
EP1503985B1 (en) 2010-12-15
JP2005523696A (ja) 2005-08-11
EP2354240A1 (en) 2011-08-10
NO20045029L (no) 2005-01-04
ATE491803T1 (de) 2011-01-15
CA2483126C (en) 2014-05-20
AU2010201699B2 (en) 2013-02-07
PL208481B1 (pl) 2011-05-31
WO2003091396A3 (en) 2004-03-11
BRPI0309527B1 (pt) 2015-08-18
US20040063175A1 (en) 2004-04-01
CN1656068A (zh) 2005-08-17
ECSP045381A (es) 2005-01-03
GEP20084387B (en) 2008-06-10
RS92604A (sr) 2007-09-21
CA2483126A1 (en) 2003-11-06
EP2354240B1 (en) 2016-07-06
DE60335361D1 (de) 2011-01-27
AU2003263097A1 (en) 2003-11-10
MXPA04010522A (es) 2004-12-13
CO5631430A2 (es) 2006-04-28
JP4988803B2 (ja) 2012-08-01
ES2356132T3 (es) 2011-04-05
EA009284B1 (ru) 2007-12-28
EP1503985A4 (en) 2006-11-02

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