ATE500842T1 - Zusammensetzungen und verfahren zur förderung des neuronalen wachstums - Google Patents

Zusammensetzungen und verfahren zur förderung des neuronalen wachstums

Info

Publication number
ATE500842T1
ATE500842T1 AT03741780T AT03741780T ATE500842T1 AT E500842 T1 ATE500842 T1 AT E500842T1 AT 03741780 T AT03741780 T AT 03741780T AT 03741780 T AT03741780 T AT 03741780T AT E500842 T1 ATE500842 T1 AT E500842T1
Authority
AT
Austria
Prior art keywords
compositions
methods
neuronal growth
promoting neuronal
chondroitinase
Prior art date
Application number
AT03741780T
Other languages
English (en)
Inventor
Elliott Gruskin
J Iaci
A Vecchione
S Hogan
G Roy
Original Assignee
Acorda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Application granted granted Critical
Publication of ATE500842T1 publication Critical patent/ATE500842T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02005—Chondroitin AC lyase (4.2.2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02019—Chondroitin B lyase (4.2.2.19)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03741780T 2002-05-04 2003-05-05 Zusammensetzungen und verfahren zur förderung des neuronalen wachstums ATE500842T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37766902P 2002-05-04 2002-05-04
PCT/US2003/014156 WO2004108069A2 (en) 2002-05-04 2003-05-05 Compositions and methods for promoting neuronal outgrowth

Publications (1)

Publication Number Publication Date
ATE500842T1 true ATE500842T1 (de) 2011-03-15

Family

ID=33510266

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03741780T ATE500842T1 (de) 2002-05-04 2003-05-05 Zusammensetzungen und verfahren zur förderung des neuronalen wachstums

Country Status (7)

Country Link
US (4) US8183350B2 (de)
EP (2) EP1575548B1 (de)
AT (1) ATE500842T1 (de)
AU (1) AU2003304173A1 (de)
DE (1) DE60336341D1 (de)
ES (1) ES2362648T3 (de)
WO (1) WO2004108069A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE500842T1 (de) 2002-05-04 2011-03-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
WO2004017044A2 (en) * 2002-08-15 2004-02-26 Acorda Therapeutics, Inc. Chimeric protein
EP3211084B1 (de) 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Proteoglycan-abbauende mutanten zur behandlung des zns
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
WO2004103299A2 (en) * 2003-05-16 2004-12-02 Acorda Therapeutics, Inc. Compositions and methods for the treatment of cns injuries
AU2005244933B2 (en) 2004-05-18 2011-08-04 Acorda Therapeutics, Inc. Methods of purifying chondroitinase and stable formulations thereof
JP5189985B2 (ja) 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
US7722864B2 (en) 2006-10-10 2010-05-25 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
US8198083B1 (en) 2007-10-31 2012-06-12 William Gunter Loudon Organotypic slices of the central nervous system
EP2153844A1 (de) 2008-08-14 2010-02-17 HAUBECK, Hans-Dieter Humane Hyaluronidasen zum erneuten axonalen Wachstum
WO2012136768A1 (en) 2011-04-08 2012-10-11 Hans-Dieter Haubeck Use of mutants of human hyaluronidase ph-20 with increased chondroitinase activity for axonal regrowth
CN111593040B (zh) * 2020-06-20 2022-08-30 山东大学 硫酸皮肤素裂解酶及其应用

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Also Published As

Publication number Publication date
ES2362648T3 (es) 2011-07-08
WO2004108069A2 (en) 2004-12-16
DE60336341D1 (de) 2011-04-21
WO2004108069A3 (en) 2006-12-14
US9956273B2 (en) 2018-05-01
EP2301564A1 (de) 2011-03-30
US8785606B2 (en) 2014-07-22
EP1575548A4 (de) 2007-07-04
US8183350B2 (en) 2012-05-22
EP1575548B1 (de) 2011-03-09
US20160279210A1 (en) 2016-09-29
EP1575548A2 (de) 2005-09-21
US9468671B2 (en) 2016-10-18
AU2003304173A1 (en) 2005-01-04
AU2003304173A8 (en) 2005-01-04
US20120207732A1 (en) 2012-08-16
US20070274979A1 (en) 2007-11-29
US20150023942A1 (en) 2015-01-22

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