BRPI0417830A - métodos para a sìntese de bibliotecas codificadas - Google Patents

métodos para a sìntese de bibliotecas codificadas

Info

Publication number
BRPI0417830A
BRPI0417830A BRPI0417830-0A BRPI0417830A BRPI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A
Authority
BR
Brazil
Prior art keywords
methods
encoded libraries
synthesizing
libraries
synthesizing encoded
Prior art date
Application number
BRPI0417830-0A
Other languages
English (en)
Inventor
Barry Morgan
Stephen Hale
Christopher C Arico-Muendel
Mathew Clark
Richard Wagner
Davide I Israel
Malcolm L Gefter
Dennis Benjamin
Nils Jacob Vest Hansen
Malcolm J Kavarna
Steffan Phillip Creaser
George J Franklin
Paolo A Centrella
Raksha A Achrya
Original Assignee
Praecis Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc
Publication of BRPI0417830A publication Critical patent/BRPI0417830A/pt
Publication of BRPI0417830B1 publication Critical patent/BRPI0417830B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Structural Engineering (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MéTODOS PARA A SINTESE DE BIBLIOTECAS CODIFICADAS". A presente invenção proporciona um método de síntese de bibliotecas de moléculas as quais incluem um rótulo de oligonucleotídeo de codificação.
BRPI0417830-0A 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação BRPI0417830B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US53085403P 2003-12-17 2003-12-17
US60/530,854 2003-12-17
US54068104P 2004-01-30 2004-01-30
US60/540,681 2004-01-30
US55371504P 2004-03-15 2004-03-15
US60/553,715 2004-03-15
US58867204P 2004-07-16 2004-07-16
US60/588,672 2004-07-16
PCT/US2004/042964 WO2005058479A2 (en) 2003-12-17 2004-12-17 Methods for synthesis of encoded libraries

Publications (2)

Publication Number Publication Date
BRPI0417830A true BRPI0417830A (pt) 2007-04-17
BRPI0417830B1 BRPI0417830B1 (pt) 2021-02-17

Family

ID=34705305

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417830-0A BRPI0417830B1 (pt) 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação

Country Status (16)

Country Link
US (4) US7972992B2 (pt)
EP (2) EP1694693A2 (pt)
JP (2) JP5646127B2 (pt)
KR (1) KR101300315B1 (pt)
CN (2) CN1898257B (pt)
AU (2) AU2004299145B2 (pt)
BR (1) BRPI0417830B1 (pt)
CA (1) CA2549386C (pt)
DK (1) DK180167B1 (pt)
IL (1) IL176008A (pt)
MX (1) MXPA06006863A (pt)
NO (1) NO20062702L (pt)
NZ (1) NZ547723A (pt)
RU (2) RU2470077C2 (pt)
WO (1) WO2005058479A2 (pt)
ZA (1) ZA200807366B (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
AU2003266932B2 (en) * 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
EP1723255B1 (en) * 2004-02-17 2010-12-29 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
WO2006053571A2 (en) 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
PL1910538T3 (pl) * 2005-06-09 2011-12-30 Praecis Pharm Inc Sposób syntezy kodowanych bibliotek
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
JP4270220B2 (ja) * 2006-04-04 2009-05-27 コニカミノルタビジネステクノロジーズ株式会社 画像処理システム、情報処理装置および情報処理方法
EP3653763A1 (en) 2009-02-13 2020-05-20 X-Chem, Inc. Methods of creating and screening dna-encoded libraries
US20100316998A1 (en) * 2009-06-15 2010-12-16 Massachusetts Institute Of Technology Methods and compositions for empirical selection of drugs or other molecules
DK2446033T3 (da) * 2009-06-22 2014-01-27 Univ Strasbourg Fremgangsmåde til fremstilling af et addukt
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
CN103119165B (zh) * 2010-09-27 2017-04-12 威泊根私人有限公司 制备富集文库的方法
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
CN102533752B (zh) * 2012-02-28 2015-01-21 盛司潼 一种Oligo dT引物及构建cDNA文库的方法
CA2879018A1 (en) 2012-07-13 2014-01-16 X-Chem, Inc. Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US20150218103A1 (en) 2012-08-25 2015-08-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
CN103882532B (zh) * 2012-12-20 2015-10-21 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
CN103882531B (zh) * 2012-12-20 2015-12-09 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201404552D0 (en) * 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
EP3218479A1 (en) 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
MA41298A (fr) * 2014-12-30 2017-11-07 X Chem Inc Procédés de marquage de banques codées par de l'adn
WO2016164313A1 (en) 2015-04-06 2016-10-13 The Regents Of The University Of California Methods and compositions for long-range haplotype phasing
CN106048736B (zh) * 2015-04-14 2019-09-03 成都先导药物开发股份有限公司 一种固相合成dna编码化合物库的方法
EP3423597A4 (en) * 2016-02-29 2020-03-04 Iridia, Inc. METHODS, COMPOSITIONS AND DEVICES FOR STORING INFORMATION
CN119574873A (zh) 2016-05-02 2025-03-07 Encodia公司 采用核酸编码的大分子分析
JP7283727B2 (ja) * 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
ES2870639T3 (es) 2016-10-24 2021-10-27 Geneinfosec Inc Ocultación de información presente en los ácidos nucleicos
CN108149325A (zh) * 2016-12-02 2018-06-12 杭州阿诺生物医药科技股份有限公司 Dna编码动态分子库的合成与筛选方法
US20200149034A1 (en) 2017-03-17 2020-05-14 Hitgen Ltd. Methods and Compositions for Synthesis of Encoded Libraries
EP3619340A4 (en) 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
CN111295444B (zh) * 2017-09-25 2024-08-09 哈斯达克科学公司 用于寡核苷酸指导的组合化学的多项式编码
EP3694994B1 (en) * 2017-10-13 2024-06-12 Ribbon Biolabs GmbH A novel method for synthesis of polynucleotides using a diverse library of oligonucleotides
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
US11513126B2 (en) 2017-10-31 2022-11-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
CN107958139B (zh) * 2017-12-01 2021-04-16 上海药明康德新药开发有限公司 一种用于dna编码化合物文库的核苷酸双链的计算机编码方法
CN109868268A (zh) * 2017-12-04 2019-06-11 上海药明康德新药开发有限公司 一种优化dna编码化合物文库起始片段的方法
CN108070009B (zh) * 2017-12-12 2021-04-13 上海药明康德新药开发有限公司 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物
WO2019149198A1 (zh) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 一种dna编码化合物库及化合物筛选方法
US12203130B2 (en) 2018-12-20 2025-01-21 Krylov Sergey N Binder selection using capillary electrophoresis
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
CN112143783B (zh) * 2019-06-27 2024-09-24 成都先导药物开发股份有限公司 一种可识别混合物对复杂生物体系的鉴别方法
US20230212214A1 (en) * 2020-05-25 2023-07-06 Nissan Chemical Corporation Cleavable dna-encoded library
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
EP4253610A4 (en) * 2020-11-27 2025-05-14 Hitgen Inc. Dna-encoded compound library and compound screening method
CN114790578A (zh) * 2021-01-26 2022-07-26 成都先导药物开发股份有限公司 一种dna编码化合物库的rna靶标筛选方法
CN115506036B (zh) * 2021-06-22 2024-07-02 中国科学院上海药物研究所 Dna编码化合物文库起始片段及其制备和应用
WO2023095841A1 (ja) * 2021-11-24 2023-06-01 日産化学株式会社 Ｄｎａコード化ライブラリの評価方法
EP4514984A1 (en) * 2022-04-25 2025-03-05 Beijing Hanmoluojie Technology Co., Ltd. Aav capsid 3d molecular surface feature mapping
CN115537416A (zh) * 2022-09-29 2022-12-30 杭州联川生物技术股份有限公司 一种纯化寡核苷酸的方法和试剂盒

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4416988A (en) 1980-12-23 1983-11-22 Harvey Rubin Detection and isolation of enkephalin mRNA using a synthetic oligodeoxynucleotide
JPS60222842A (ja) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤およびその製造方法
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4979118A (en) * 1989-03-10 1990-12-18 Gte Laboratories Incorporated Predictive access-control and routing system for integrated services telecommunication networks
DK0494955T3 (da) 1989-10-05 1998-10-26 Optein Inc Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
US5360928A (en) 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
RU2145233C1 (ru) * 1990-07-02 2000-02-10 Дзе Аризона Борд оф Риджентс Неупорядоченная библиотека пептидов, способ ее получения и способ идентификации пептида, синтезированного твердофазным синтезом
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2151473A1 (en) * 1992-12-11 1994-06-23 Ronald N . Zuckermann Synthesis of encoded polymers
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
NZ276860A (en) * 1993-11-02 1997-09-22 Affymax Tech Nv Apparatus and its use for synthesising diverse molecular products on substrates
US5920701A (en) * 1995-01-19 1999-07-06 Starburst Communications Corporation Scheduling data transmission
US6505160B1 (en) * 1995-07-27 2003-01-07 Digimarc Corporation Connected audio and other media objects
US6920637B2 (en) * 1995-11-17 2005-07-19 Symbol Technologies, Inc. Method and apparatus for implementing alerts on a browser running on a portable handheld device
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5862325A (en) * 1996-02-29 1999-01-19 Intermind Corporation Computer-based communication system and method using metadata defining a control structure
US5996022A (en) * 1996-06-03 1999-11-30 Webtv Networks, Inc. Transcoding data in a proxy computer prior to transmitting the audio data to a client
US5774660A (en) * 1996-08-05 1998-06-30 Resonate, Inc. World-wide-web server with delayed resource-binding for resource-based load balancing on a distributed resource multi-node network
US5893920A (en) * 1996-09-30 1999-04-13 International Business Machines Corporation System and method for cache management in mobile user file systems
US6122514A (en) * 1997-01-03 2000-09-19 Cellport Systems, Inc. Communications channel selection
US6006264A (en) * 1997-08-01 1999-12-21 Arrowpoint Communications, Inc. Method and system for directing a flow between a client and a server
US6067565A (en) * 1998-01-15 2000-05-23 Microsoft Corporation Technique for prefetching a web page of potential future interest in lieu of continuing a current information download
US6697333B1 (en) * 1998-03-04 2004-02-24 Alcatel Canada Inc. Bandwidth load consideration in network route selection
US7756892B2 (en) * 2000-05-02 2010-07-13 Digimarc Corporation Using embedded data with file sharing
US6493758B1 (en) * 1998-09-08 2002-12-10 Microsoft Corporation Offline viewing of internet content with a mobile device
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6308209B1 (en) * 1998-10-22 2001-10-23 Electronic Data Systems Corporation Method and system for measuring usage of a computer network by a network user
US6240453B1 (en) * 1998-11-12 2001-05-29 International Business Machines Corporation Managing unused resources in a service application
US6304909B1 (en) * 1998-12-18 2001-10-16 International Business Machines Corporation Client-controlled link processing in computer network
US20030214800A1 (en) * 1999-07-15 2003-11-20 Dibene Joseph Ted System and method for processor power delivery and thermal management
US6577601B1 (en) * 1999-08-05 2003-06-10 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Masked proportional routing
US6470189B1 (en) * 1999-09-29 2002-10-22 Motorola, Inc. Method and apparatus in a wireless transceiver for seeking and transferring information available from a network server
US7287214B1 (en) * 1999-12-10 2007-10-23 Books24X7.Com, Inc. System and method for providing a searchable library of electronic documents to a user
US6920607B1 (en) * 1999-12-15 2005-07-19 Microsoft Corp. Methods and systems for dynamically creating user interfaces
US6678244B1 (en) * 2000-01-06 2004-01-13 Cisco Technology, Inc. Congestion management system and method
US7506034B2 (en) * 2000-03-03 2009-03-17 Intel Corporation Methods and apparatus for off loading content servers through direct file transfer from a storage center to an end-user
US6850980B1 (en) * 2000-06-16 2005-02-01 Cisco Technology, Inc. Content routing service protocol
US6751664B1 (en) * 2000-07-05 2004-06-15 At&T Corp. Method for monitoring and meeting customer bandwidth demand in operational IP data networks
US7139844B2 (en) * 2000-08-04 2006-11-21 Goldman Sachs & Co. Method and system for processing financial data objects carried on broadcast data streams and delivering information to subscribing clients
US6732180B1 (en) * 2000-08-08 2004-05-04 The University Of Tulsa Method to inhibit the identification and retrieval of proprietary media via automated search engines utilized in association with computer compatible communications network
US7075919B1 (en) * 2000-08-22 2006-07-11 Cisco Technology, Inc. System and method for providing integrated voice, video and data to customer premises over a single network
US20020174246A1 (en) * 2000-09-13 2002-11-21 Amos Tanay Centralized system for routing signals over an internet protocol network
WO2002033541A2 (en) * 2000-10-16 2002-04-25 Tangis Corporation Dynamically determining appropriate computer interfaces
US7035828B2 (en) * 2000-10-25 2006-04-25 Topmoxie, Inc. Method and system for modifying and transmitting data between a portable computer and a network
WO2002039356A1 (en) * 2000-11-01 2002-05-16 Mark Landesmann System and method for granting deposit-contingent e-mailing rights
US20020073057A1 (en) * 2000-12-11 2002-06-13 Darlene Benoit Software distribution system and method
US20020083342A1 (en) * 2000-12-21 2002-06-27 Webb Brian T. Systems, methods and computer program products for accessing devices on private networks via clients on a public network
US6407680B1 (en) * 2000-12-22 2002-06-18 Generic Media, Inc. Distributed on-demand media transcoding system and method
US6751673B2 (en) * 2001-01-03 2004-06-15 Akamai Technologies, Inc. Streaming media subscription mechanism for a content delivery network
US20030049616A1 (en) * 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US20030088686A1 (en) * 2001-01-19 2003-05-08 Jennings Charles A. System and method for streaming media
US7127677B2 (en) * 2001-01-23 2006-10-24 Xerox Corporation Customizable remote order entry system and method
US20040148503A1 (en) * 2002-01-25 2004-07-29 David Sidman Apparatus, method, and system for accessing digital rights management information
US6871236B2 (en) * 2001-01-26 2005-03-22 Microsoft Corporation Caching transformed content in a mobile gateway
US7293115B2 (en) * 2001-02-28 2007-11-06 Sony Corporation Internet-aware agent for automatically updating applications without executing the application
US20020120607A1 (en) * 2001-02-28 2002-08-29 Lumenati, Inc. File sharing system for serving content from a computer
US7120702B2 (en) * 2001-03-03 2006-10-10 International Business Machines Corporation System and method for transcoding web content for display by alternative client devices
US6915328B2 (en) * 2001-03-17 2005-07-05 Hewlett-Packard Development Company, L.P. Web content format for mobile devices
IL158000A0 (en) 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
US7483958B1 (en) * 2001-03-26 2009-01-27 Microsoft Corporation Methods and apparatuses for sharing media content, libraries and playlists
US7139834B1 (en) * 2001-04-26 2006-11-21 Avvenu, Inc. Data routing monitoring and management
US20020187192A1 (en) 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US7171415B2 (en) * 2001-05-04 2007-01-30 Sun Microsystems, Inc. Distributed information discovery through searching selected registered information providers
ES2187353B1 (es) * 2001-06-15 2004-08-16 Consultores Ub 57, S.L. Interfaz dinamico de navegacion.
EP2305808B1 (en) 2001-06-20 2016-03-02 Nuevolution A/S Templated molecules and methods for using such molecules
EP1401850A1 (en) * 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US20030046703A1 (en) * 2001-08-29 2003-03-06 Knowles Gregory T. Systems and methods for facilitating user access to content stored on private networks
US6970918B2 (en) * 2001-09-24 2005-11-29 International Business Machines Corporation System and method for transcoding support of web content over secure connections
US20030110234A1 (en) * 2001-11-08 2003-06-12 Lightsurf Technologies, Inc. System and methodology for delivering media to multiple disparate client devices based on their capabilities
US6801777B2 (en) * 2001-11-27 2004-10-05 Intel Corporation Device and method for intelligent wireless communication selection
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
DE60231436D1 (de) * 2002-03-08 2009-04-16 Eidgenoess Tech Hochschule Kodierte, selbst-assemblierende chemische bibliotheken (esachel)
US7266611B2 (en) * 2002-03-12 2007-09-04 Dilithium Networks Pty Limited Method and system for improved transcoding of information through a telecommunication network
US7219163B2 (en) * 2002-03-14 2007-05-15 Hewlett-Packard Development Company, L.P. Method and system that tailors format of transmission to suit client capabilities and link characteristics
WO2003078446A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
WO2003078627A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
EP1490384A2 (en) 2002-03-15 2004-12-29 Nuevolution A/S A building block forming a c-c bond upon reaction
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
US7321769B2 (en) * 2002-04-12 2008-01-22 Intel Corporation Method and apparatus for managing personal cache in a wireless network
EP1504111A4 (en) * 2002-04-19 2005-11-23 California Inst Of Techn LIBRARY OF MOLECULES OF NUCLEIC ACIDS AND PEPTIDES IN WHICH THE PEPTIDES CONTAIN NON-NATURAL AMINO ACID RESIDUES AND METHODS FOR THEIR PRODUCTION
ES2566761T3 (es) 2002-05-30 2016-04-15 The Scripps Research Institute Ligación de azidas y acetilenos catalizada por cobre
US6937168B2 (en) * 2002-06-14 2005-08-30 Intel Corporation Transcoding media content from a personal video recorder for a portable device
EP1520040A2 (en) 2002-06-20 2005-04-06 Nuevolution A/S Microarrays displaying encoded molecules
US7133925B2 (en) * 2002-07-15 2006-11-07 Hewlett-Packard Development Company, L.P. System, method, and format thereof for scalable encoded media delivery
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
PT1558744E (pt) * 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
US7296295B2 (en) * 2002-12-11 2007-11-13 Broadcom Corporation Media processing system supporting different media formats via server-based transcoding
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US7451217B2 (en) * 2002-12-19 2008-11-11 International Business Machines Corporation Method and system for peer-to-peer authorization
EP1586045A1 (en) * 2002-12-27 2005-10-19 Nielsen Media Research, Inc. Methods and apparatus for transcoding metadata
US7769881B2 (en) * 2003-01-24 2010-08-03 Hitachi, Ltd. Method and apparatus for peer-to peer access
GB0303192D0 (en) * 2003-02-12 2003-03-19 Saviso Group Ltd Methods and apparatus for traffic management in peer-to-peer networks
EP1597394A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DK1608748T3 (da) * 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
US20070174471A1 (en) * 2003-04-30 2007-07-26 Cedric Van Rossum Secure, continous, proxy-optimized, device-to-device data download reception system and method of use
WO2004099441A2 (en) 2003-05-09 2004-11-18 Hyscite Discovery As Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US9612965B2 (en) * 2003-06-24 2017-04-04 Hewlett-Packard Development Company, L.P. Method and system for servicing streaming media
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
US7395339B2 (en) * 2003-08-07 2008-07-01 International Business Machines Corporation Method and system for providing on-demand media streaming from a user's own library to a receiving device of the user
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7529723B2 (en) * 2003-12-15 2009-05-05 Xerox Corporation Multi-tiered structure for file sharing based on social roles
US20050132264A1 (en) * 2003-12-15 2005-06-16 Joshi Ajit P. System and method for intelligent transcoding
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
EP1551144A1 (en) * 2003-12-31 2005-07-06 France Telecom System, method and apparatus for providing multimedia communications services
JP4269162B2 (ja) * 2004-01-07 2009-05-27 日本電気株式会社 携帯通信端末の無線経路選択方法およびその携帯通信端末並びに無線通信システム
EP1723255B1 (en) 2004-02-17 2010-12-29 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
ATE447020T1 (de) 2004-03-22 2009-11-15 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
ITRM20040212A1 (it) 2004-04-30 2004-07-30 Lay Line Genomics Spa Animale transgenico non umano come modello per malattie neurodegenerative e per la loro diagnosi precoce.
US7546299B2 (en) * 2004-05-12 2009-06-09 Alcatel-Lucent Usa Inc. Network supported network file sharing among mobile subscribers
WO2006053571A2 (en) 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
US20060117018A1 (en) * 2004-11-30 2006-06-01 Microsoft Corporation Method and system for caching remote files locally
US20060120385A1 (en) * 2004-12-02 2006-06-08 Atchison Darrell T Method and system for creating and managing multiple subscribers of a content delivery network
US20060173974A1 (en) * 2005-02-02 2006-08-03 Victor Tang System and method for providing mobile access to personal media
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
US20070288247A1 (en) * 2006-06-11 2007-12-13 Michael Mackay Digital life server
US7961645B2 (en) * 2006-08-23 2011-06-14 Computer Associates Think, Inc. Method and system for classifying devices in a wireless network

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