BRPI0417830A - métodos para a sìntese de bibliotecas codificadas - Google Patents

métodos para a sìntese de bibliotecas codificadas

Info

Publication number
BRPI0417830A
BRPI0417830A BRPI0417830-0A BRPI0417830A BRPI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A
Authority
BR
Brazil
Prior art keywords
methods
encoded libraries
synthesizing
libraries
synthesizing encoded
Prior art date
Application number
BRPI0417830-0A
Other languages
English (en)
Inventor
Barry Morgan
Stephen Hale
Christopher C Arico-Muendel
Mathew Clark
Richard Wagner
Davide I Israel
Malcolm L Gefter
Dennis Benjamin
Nils Jacob Vest Hansen
Malcolm J Kavarna
Steffan Phillip Creaser
George J Franklin
Paolo A Centrella
Raksha A Achrya
Original Assignee
Praecis Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc
Publication of BRPI0417830A publication Critical patent/BRPI0417830A/pt
Publication of BRPI0417830B1 publication Critical patent/BRPI0417830B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Structural Engineering (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MéTODOS PARA A SINTESE DE BIBLIOTECAS CODIFICADAS". A presente invenção proporciona um método de síntese de bibliotecas de moléculas as quais incluem um rótulo de oligonucleotídeo de codificação.
BRPI0417830-0A 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação BRPI0417830B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US53085403P 2003-12-17 2003-12-17
US60/530,854 2003-12-17
US54068104P 2004-01-30 2004-01-30
US60/540,681 2004-01-30
US55371504P 2004-03-15 2004-03-15
US60/553,715 2004-03-15
US58867204P 2004-07-16 2004-07-16
US60/588,672 2004-07-16
PCT/US2004/042964 WO2005058479A2 (en) 2003-12-17 2004-12-17 Methods for synthesis of encoded libraries

Publications (2)

Publication Number Publication Date
BRPI0417830A true BRPI0417830A (pt) 2007-04-17
BRPI0417830B1 BRPI0417830B1 (pt) 2021-02-17

Family

ID=34705305

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417830-0A BRPI0417830B1 (pt) 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação

Country Status (16)

Country Link
US (4) US7972992B2 (pt)
EP (2) EP1694693A2 (pt)
JP (2) JP5646127B2 (pt)
KR (1) KR101300315B1 (pt)
CN (2) CN101864412A (pt)
AU (2) AU2004299145B2 (pt)
BR (1) BRPI0417830B1 (pt)
CA (1) CA2549386C (pt)
DK (1) DK180167B1 (pt)
IL (1) IL176008A (pt)
MX (1) MXPA06006863A (pt)
NO (1) NO20062702L (pt)
NZ (1) NZ547723A (pt)
RU (2) RU2470077C2 (pt)
WO (1) WO2005058479A2 (pt)
ZA (1) ZA200807366B (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
AU2003214031A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
EP1539980B1 (en) * 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
US8791053B2 (en) * 2002-09-27 2014-07-29 Mpm-Holding Aps Spatially encoded polymer matrix
EP2348124B1 (en) 2002-10-30 2013-12-11 Nuevolution A/S Synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
ATE420170T1 (de) 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
DK1910538T3 (da) * 2005-06-09 2011-08-08 Praecis Pharm Inc Fremgangsmåder til syntese af kodede biblioteker
JP2009513135A (ja) * 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
JP4270220B2 (ja) * 2006-04-04 2009-05-27 コニカミノルタビジネステクノロジーズ株式会社 画像処理システム、情報処理装置および情報処理方法
ES2638324T3 (es) * 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
US20100316998A1 (en) * 2009-06-15 2010-12-16 Massachusetts Institute Of Technology Methods and compositions for empirical selection of drugs or other molecules
EP2446033B1 (en) 2009-06-22 2013-10-23 Université de Strasbourg Method of preparing an adduct
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
WO2012041633A1 (en) * 2010-09-27 2012-04-05 Vipergen A method for making an enriched library
IN2014CN02574A (pt) * 2011-09-07 2015-06-26 Chem Inc X
CN102533752B (zh) * 2012-02-28 2015-01-21 盛司潼 一种Oligo dT引物及构建cDNA文库的方法
SG10201907347YA (en) * 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
JP2015529206A (ja) 2012-08-25 2015-10-05 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｇａｐｄｈカスケードインヒビター化合物ならびに使用の方法および精神病を含むストレス誘導障害の処置
CN103882532B (zh) * 2012-12-20 2015-10-21 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
CN103882531B (zh) * 2012-12-20 2015-12-09 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201404552D0 (en) * 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
WO2016074683A1 (en) 2014-11-11 2016-05-19 Lundorf Pedersen Materials Aps Method for identification of molecules with desired characteristics
MA41298A (fr) * 2014-12-30 2017-11-07 X Chem Inc Procédés de marquage de banques codées par de l'adn
WO2016164313A1 (en) * 2015-04-06 2016-10-13 The Regents Of The University Of California Methods and compositions for long-range haplotype phasing
JP6554180B6 (ja) * 2015-04-14 2019-09-11 成都先導薬物開発股▲フン▼有限公司 Ｄｎａコード化化合物ライブラリーの固相合成方法
WO2017151680A2 (en) * 2016-02-29 2017-09-08 Dodo Omnidata, Inc. Methods, compositions, and devices for information storage
EP3452591B1 (en) 2016-05-02 2023-08-16 Encodia, Inc. Macromolecule analysis employing nucleic acid encoding
WO2017218293A1 (en) * 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
IL266197B2 (en) 2016-10-24 2024-03-01 Geneinfosec Inc Hiding information contained within nucleic acids
CN108149325A (zh) * 2016-12-02 2018-06-12 杭州阿诺生物医药科技股份有限公司 Dna编码动态分子库的合成与筛选方法
KR102222242B1 (ko) 2017-03-17 2021-03-04 히트젠 주식회사 코드 라이브러리 합성방법 및 조성물
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
WO2019060856A1 (en) * 2017-09-25 2019-03-28 Haystack Sciences Corporation MULTINOMIAL CODING FOR COMBINATION CHEMISTRY DIRECTED BY OLIGONUCLEOTIDES
WO2019073072A1 (en) * 2017-10-13 2019-04-18 Ribbon Biolabs Gmbh A NOVEL METHOD OF SYNTHESIZING POLYNUCLEOTIDES USING A DIVERSIFIED LIBRARY OF OLIGONUCLEOTIDES
JP7390027B2 (ja) 2017-10-31 2023-12-01 エンコディア， インコーポレイテッド 核酸エンコーディングおよび／または標識を使用する解析のためのキット
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
CN107958139B (zh) * 2017-12-01 2021-04-16 上海药明康德新药开发有限公司 一种用于dna编码化合物文库的核苷酸双链的计算机编码方法
CN109868268A (zh) * 2017-12-04 2019-06-11 上海药明康德新药开发有限公司 一种优化dna编码化合物文库起始片段的方法
CN108070009B (zh) * 2017-12-12 2021-04-13 上海药明康德新药开发有限公司 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物
WO2019149198A1 (zh) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 一种dna编码化合物库及化合物筛选方法
CA3120895C (en) 2018-12-20 2024-07-02 Sergey N. Krylov BINDER SELECTION USING CAPILLARY ELECTROPHORESIS
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
CN112143783B (zh) * 2019-06-27 2024-09-24 成都先导药物开发股份有限公司 一种可识别混合物对复杂生物体系的鉴别方法
CA3185063A1 (en) * 2020-05-25 2021-12-02 Nissan Chemical Corporation Cleavable dna-encoded library
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
JP7592164B2 (ja) * 2020-11-27 2024-11-29 成都先導薬物開発股▲フン▼有限公司 Ｄｎａコード化化合物ライブラリー及び化合物のスクリーニング方法
CN114790578A (zh) * 2021-01-26 2022-07-26 成都先导药物开发股份有限公司 一种dna编码化合物库的rna靶标筛选方法
CN115506036B (zh) * 2021-06-22 2024-07-02 中国科学院上海药物研究所 Dna编码化合物文库起始片段及其制备和应用
US20250215615A1 (en) * 2021-11-24 2025-07-03 Nissan Chemical Corporation Method for evaluating dna-encoded library
EP4514984A4 (en) * 2022-04-25 2026-04-22 Beijing Hanmoluojie Tech Co Ltd 3D MOLECULAR SURFACE FEATURES MAPPING OF AAV CAPSIDS
CN115537416A (zh) * 2022-09-29 2022-12-30 杭州联川生物技术股份有限公司 一种纯化寡核苷酸的方法和试剂盒

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4416988A (en) 1980-12-23 1983-11-22 Harvey Rubin Detection and isolation of enkephalin mRNA using a synthetic oligodeoxynucleotide
JPS60222842A (ja) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤およびその製造方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4979118A (en) * 1989-03-10 1990-12-18 Gte Laboratories Incorporated Predictive access-control and routing system for integrated services telecommunication networks
AU638762B2 (en) 1989-10-05 1993-07-08 Optein Inc Cell-free synthesis and isolation of novel genes and polypeptides
US5360928A (en) 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
RU2145233C1 (ru) * 1990-07-02 2000-02-10 Дзе Аризона Борд оф Риджентс Неупорядоченная библиотека пептидов, способ ее получения и способ идентификации пептида, синтезированного твердофазным синтезом
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
WO1994013623A1 (en) * 1992-12-11 1994-06-23 Chiron Corporation Synthesis of encoded polymers
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
BR9407947A (pt) * 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
US5920701A (en) * 1995-01-19 1999-07-06 Starburst Communications Corporation Scheduling data transmission
US6505160B1 (en) * 1995-07-27 2003-01-07 Digimarc Corporation Connected audio and other media objects
US6920637B2 (en) * 1995-11-17 2005-07-19 Symbol Technologies, Inc. Method and apparatus for implementing alerts on a browser running on a portable handheld device
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5862325A (en) * 1996-02-29 1999-01-19 Intermind Corporation Computer-based communication system and method using metadata defining a control structure
US5996022A (en) * 1996-06-03 1999-11-30 Webtv Networks, Inc. Transcoding data in a proxy computer prior to transmitting the audio data to a client
US5774660A (en) * 1996-08-05 1998-06-30 Resonate, Inc. World-wide-web server with delayed resource-binding for resource-based load balancing on a distributed resource multi-node network
US5893920A (en) * 1996-09-30 1999-04-13 International Business Machines Corporation System and method for cache management in mobile user file systems
US6122514A (en) * 1997-01-03 2000-09-19 Cellport Systems, Inc. Communications channel selection
US6006264A (en) * 1997-08-01 1999-12-21 Arrowpoint Communications, Inc. Method and system for directing a flow between a client and a server
US6067565A (en) * 1998-01-15 2000-05-23 Microsoft Corporation Technique for prefetching a web page of potential future interest in lieu of continuing a current information download
US6697333B1 (en) * 1998-03-04 2004-02-24 Alcatel Canada Inc. Bandwidth load consideration in network route selection
US7756892B2 (en) * 2000-05-02 2010-07-13 Digimarc Corporation Using embedded data with file sharing
US6493758B1 (en) * 1998-09-08 2002-12-10 Microsoft Corporation Offline viewing of internet content with a mobile device
CA2346989A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6308209B1 (en) * 1998-10-22 2001-10-23 Electronic Data Systems Corporation Method and system for measuring usage of a computer network by a network user
US6240453B1 (en) * 1998-11-12 2001-05-29 International Business Machines Corporation Managing unused resources in a service application
US6304909B1 (en) * 1998-12-18 2001-10-16 International Business Machines Corporation Client-controlled link processing in computer network
US20030214800A1 (en) * 1999-07-15 2003-11-20 Dibene Joseph Ted System and method for processor power delivery and thermal management
US6577601B1 (en) * 1999-08-05 2003-06-10 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Masked proportional routing
US6470189B1 (en) * 1999-09-29 2002-10-22 Motorola, Inc. Method and apparatus in a wireless transceiver for seeking and transferring information available from a network server
US7287214B1 (en) * 1999-12-10 2007-10-23 Books24X7.Com, Inc. System and method for providing a searchable library of electronic documents to a user
US6920607B1 (en) * 1999-12-15 2005-07-19 Microsoft Corp. Methods and systems for dynamically creating user interfaces
US6678244B1 (en) * 2000-01-06 2004-01-13 Cisco Technology, Inc. Congestion management system and method
US7506034B2 (en) * 2000-03-03 2009-03-17 Intel Corporation Methods and apparatus for off loading content servers through direct file transfer from a storage center to an end-user
US6850980B1 (en) * 2000-06-16 2005-02-01 Cisco Technology, Inc. Content routing service protocol
US6751664B1 (en) * 2000-07-05 2004-06-15 At&T Corp. Method for monitoring and meeting customer bandwidth demand in operational IP data networks
US7139844B2 (en) * 2000-08-04 2006-11-21 Goldman Sachs & Co. Method and system for processing financial data objects carried on broadcast data streams and delivering information to subscribing clients
US6732180B1 (en) * 2000-08-08 2004-05-04 The University Of Tulsa Method to inhibit the identification and retrieval of proprietary media via automated search engines utilized in association with computer compatible communications network
US7075919B1 (en) * 2000-08-22 2006-07-11 Cisco Technology, Inc. System and method for providing integrated voice, video and data to customer premises over a single network
US20020174246A1 (en) * 2000-09-13 2002-11-21 Amos Tanay Centralized system for routing signals over an internet protocol network
WO2002033541A2 (en) * 2000-10-16 2002-04-25 Tangis Corporation Dynamically determining appropriate computer interfaces
US7035828B2 (en) * 2000-10-25 2006-04-25 Topmoxie, Inc. Method and system for modifying and transmitting data between a portable computer and a network
US7072943B2 (en) * 2000-11-01 2006-07-04 Buyerleverage Email Solutions Llc System and method for granting deposit-contingent E-mailing rights
US20020073057A1 (en) * 2000-12-11 2002-06-13 Darlene Benoit Software distribution system and method
US20020083342A1 (en) * 2000-12-21 2002-06-27 Webb Brian T. Systems, methods and computer program products for accessing devices on private networks via clients on a public network
US6407680B1 (en) * 2000-12-22 2002-06-18 Generic Media, Inc. Distributed on-demand media transcoding system and method
US6751673B2 (en) * 2001-01-03 2004-06-15 Akamai Technologies, Inc. Streaming media subscription mechanism for a content delivery network
US20030049616A1 (en) * 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
US20030088686A1 (en) * 2001-01-19 2003-05-08 Jennings Charles A. System and method for streaming media
US7127677B2 (en) * 2001-01-23 2006-10-24 Xerox Corporation Customizable remote order entry system and method
US20040148503A1 (en) * 2002-01-25 2004-07-29 David Sidman Apparatus, method, and system for accessing digital rights management information
US6871236B2 (en) * 2001-01-26 2005-03-22 Microsoft Corporation Caching transformed content in a mobile gateway
US20020120607A1 (en) * 2001-02-28 2002-08-29 Lumenati, Inc. File sharing system for serving content from a computer
US7293115B2 (en) * 2001-02-28 2007-11-06 Sony Corporation Internet-aware agent for automatically updating applications without executing the application
US7120702B2 (en) * 2001-03-03 2006-10-10 International Business Machines Corporation System and method for transcoding web content for display by alternative client devices
US6915328B2 (en) * 2001-03-17 2005-07-05 Hewlett-Packard Development Company, L.P. Web content format for mobile devices
EP1423400B2 (en) 2001-03-19 2013-05-22 President and Fellows of Harvard College Evolving new molecular function
US7483958B1 (en) * 2001-03-26 2009-01-27 Microsoft Corporation Methods and apparatuses for sharing media content, libraries and playlists
US7139834B1 (en) * 2001-04-26 2006-11-21 Avvenu, Inc. Data routing monitoring and management
US20020187192A1 (en) 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US7171415B2 (en) * 2001-05-04 2007-01-30 Sun Microsystems, Inc. Distributed information discovery through searching selected registered information providers
ES2187353B1 (es) * 2001-06-15 2004-08-16 Consultores Ub 57, S.L. Interfaz dinamico de navegacion.
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
IL159268A0 (en) * 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules
US20030046703A1 (en) * 2001-08-29 2003-03-06 Knowles Gregory T. Systems and methods for facilitating user access to content stored on private networks
US6970918B2 (en) * 2001-09-24 2005-11-29 International Business Machines Corporation System and method for transcoding support of web content over secure connections
US20030110234A1 (en) * 2001-11-08 2003-06-12 Lightsurf Technologies, Inc. System and methodology for delivering media to multiple disparate client devices based on their capabilities
US6801777B2 (en) * 2001-11-27 2004-10-05 Intel Corporation Device and method for intelligent wireless communication selection
AU2002310846B2 (en) * 2002-03-08 2008-03-20 Eidgenossische Technische Hochschule Zurich Encoded self-assembling chemical libraries (ESACHEL)
US7266611B2 (en) * 2002-03-12 2007-09-04 Dilithium Networks Pty Limited Method and system for improved transcoding of information through a telecommunication network
US7219163B2 (en) * 2002-03-14 2007-05-15 Hewlett-Packard Development Company, L.P. Method and system that tailors format of transmission to suit client capabilities and link characteristics
AU2003214032A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c=c double bond upon reaction
AU2003214031A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
WO2003078627A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US20050247001A1 (en) 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
WO2003078050A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
US7321769B2 (en) * 2002-04-12 2008-01-22 Intel Corporation Method and apparatus for managing personal cache in a wireless network
WO2003089454A2 (en) * 2002-04-19 2003-10-30 California Institute Of Technology Unnatural amino acid containing display libraries
JP4638225B2 (ja) 2002-05-30 2011-02-23 ザ スクリプス リサーチ インスティテュート 銅を触媒とするアジドとアセチレンのライゲーション
US6937168B2 (en) * 2002-06-14 2005-08-30 Intel Corporation Transcoding media content from a personal video recorder for a portable device
EP1520040A2 (en) 2002-06-20 2005-04-06 Nuevolution A/S Microarrays displaying encoded molecules
US7133925B2 (en) * 2002-07-15 2006-11-07 Hewlett-Packard Development Company, L.P. System, method, and format thereof for scalable encoded media delivery
WO2004009814A1 (en) 2002-07-23 2004-01-29 Nuevolution A/S Gene shuffling by template switching
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
EP2348124B1 (en) * 2002-10-30 2013-12-11 Nuevolution A/S Synthesis of a bifunctional complex
US7296295B2 (en) * 2002-12-11 2007-11-13 Broadcom Corporation Media processing system supporting different media formats via server-based transcoding
US7451217B2 (en) * 2002-12-19 2008-11-11 International Business Machines Corporation Method and system for peer-to-peer authorization
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
MXPA05007001A (es) * 2002-12-27 2005-11-23 Nielsen Media Res Inc Metodos y aparatos para transcodificar metadatos.
US7769881B2 (en) * 2003-01-24 2010-08-03 Hitachi, Ltd. Method and apparatus for peer-to peer access
GB0303192D0 (en) * 2003-02-12 2003-03-19 Saviso Group Ltd Methods and apparatus for traffic management in peer-to-peer networks
WO2004074501A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US7915201B2 (en) * 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
WO2004100010A1 (en) * 2003-04-30 2004-11-18 Iptv Systems, Llc Secure, continuous, proxy-optimized, device-to-device data download reception system and method of use
EP1625230A2 (en) 2003-05-09 2006-02-15 Thorleif Möller Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US9612965B2 (en) * 2003-06-24 2017-04-04 Hewlett-Packard Development Company, L.P. Method and system for servicing streaming media
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
US7395339B2 (en) * 2003-08-07 2008-07-01 International Business Machines Corporation Method and system for providing on-demand media streaming from a user's own library to a receiving device of the user
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US20050132264A1 (en) * 2003-12-15 2005-06-16 Joshi Ajit P. System and method for intelligent transcoding
US7529723B2 (en) * 2003-12-15 2009-05-05 Xerox Corporation Multi-tiered structure for file sharing based on social roles
EP1694693A2 (en) 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1551144A1 (en) * 2003-12-31 2005-07-06 France Telecom System, method and apparatus for providing multimedia communications services
JP4269162B2 (ja) * 2004-01-07 2009-05-27 日本電気株式会社 携帯通信端末の無線経路選択方法およびその携帯通信端末並びに無線通信システム
WO2005078122A2 (en) 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DE602005017370D1 (de) 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
ITRM20040212A1 (it) 2004-04-30 2004-07-30 Lay Line Genomics Spa Animale transgenico non umano come modello per malattie neurodegenerative e per la loro diagnosi precoce.
US7546299B2 (en) * 2004-05-12 2009-06-09 Alcatel-Lucent Usa Inc. Network supported network file sharing among mobile subscribers
ATE420170T1 (de) 2004-11-22 2009-01-15 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
US20060117018A1 (en) * 2004-11-30 2006-06-01 Microsoft Corporation Method and system for caching remote files locally
US20060120385A1 (en) * 2004-12-02 2006-06-08 Atchison Darrell T Method and system for creating and managing multiple subscribers of a content delivery network
US20060173974A1 (en) * 2005-02-02 2006-08-03 Victor Tang System and method for providing mobile access to personal media
JP2009513135A (ja) 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
US20070288247A1 (en) * 2006-06-11 2007-12-13 Michael Mackay Digital life server
US7961645B2 (en) * 2006-08-23 2011-06-14 Computer Associates Think, Inc. Method and system for classifying devices in a wireless network

Also Published As

Publication number Publication date
RU2006125522A (ru) 2008-01-27
CN1898257A (zh) 2007-01-17
AU2009200121A1 (en) 2009-02-12
KR20060134951A (ko) 2006-12-28
US20120245040A1 (en) 2012-09-27
US20110136697A1 (en) 2011-06-09
WO2005058479A2 (en) 2005-06-30
AU2009200121B2 (en) 2012-11-15
AU2004299145A1 (en) 2005-06-30
AU2004299145B2 (en) 2011-08-25
ZA200807366B (en) 2012-09-26
CN101864412A (zh) 2010-10-20
CN1898257B (zh) 2010-06-23
US8598089B2 (en) 2013-12-03
DK180167B1 (da) 2020-07-09
CA2549386A1 (en) 2005-06-30
US20090062147A1 (en) 2009-03-05
CA2549386C (en) 2014-07-29
NZ547723A (en) 2009-09-25
WO2005058479A3 (en) 2005-10-13
DK200600841A (da) 2006-07-17
KR101300315B1 (ko) 2013-08-28
US7972992B2 (en) 2011-07-05
IL176008A (en) 2012-10-31
JP2011188858A (ja) 2011-09-29
BRPI0417830B1 (pt) 2021-02-17
IL176008A0 (en) 2006-10-05
EP2366705A1 (en) 2011-09-21
US20050158765A1 (en) 2005-07-21
NO20062702L (no) 2006-09-12
MXPA06006863A (es) 2006-09-04
RU2470077C2 (ru) 2012-12-20
RU2011135010A (ru) 2013-02-27
US7935658B2 (en) 2011-05-03
JP5646127B2 (ja) 2014-12-24
RU2592673C2 (ru) 2016-07-27
EP1694693A2 (en) 2006-08-30
JP2007524662A (ja) 2007-08-30

Similar Documents

Publication Publication Date Title
BRPI0417830A (pt) métodos para a sìntese de bibliotecas codificadas
ZA201004791B (en) Methods for synthesis of encoded libraries
WO2007053358A3 (en) Methods for identifying compounds of interest using encoded libraries
BRPI0412667A (pt) sìntese regiosseletiva de cci - 779
DK1483585T3 (da) Kodede, selvsamlende kemiske biblioteker (ESACHEL)
PT1509517E (pt) Nova síntese de irbesartan
ITMI20030330A1 (it) Apparato per la lettura di codice di informazione.
MXPA05010882A (es) Preparacion y purificacion de capsaicina sintetica.
BR0314663A (pt) Processo para a conversão de polissulfanos
DE602004004677D1 (de) Verfahren zur herstellung substituierter 5-amino-pyrazolo-ä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine
IL176321A (en) Process for eco-friendly synthesis of bromobenzene
DE60231630D1 (de) Verfahren zur synthese metallorganischer verbindungen
GT200400248A (es) Proceso para la preparacion de inhibidores de tubulina
GB0409165D0 (en) Text-to-speech system for generating information annoucements
EP1485498A4 (en) SYNTHESIS OF SYNTHESES FOR THE MANUFACTURE OF BIOACTIVE COMPOUNDS
ITMI20032185A1 (it) Processo per la sintesi di lipidi cationici.
ZA200600529B (en) Methods for synthesis of encoded libraries
ITMI20031354A1 (it) Sintesis enantioselettiva di composti enantiomericamente arricchiti.
ITMI20031558A1 (it) Procedimento per la sintesi di cetirizina-2hcl.
HK1097849A (en) Methods for synthesis of encoded libraries
ITMI20031905A1 (it) Procedimento per la produzione di pellame.
ITRE20020101A1 (it) Sistema per la produzione di idrogeno da idrocarburi.
AU2003905817A0 (en) Method & apparatus for synthesizing metrics of stock or share indices
ITTO20030781A1 (it) Procedimento per la sintesi di acilati di aminoacidi o

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2859 DE 21-10-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.