ATE511538T1 - Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase - Google Patents
Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenaseInfo
- Publication number
- ATE511538T1 ATE511538T1 AT05792997T AT05792997T ATE511538T1 AT E511538 T1 ATE511538 T1 AT E511538T1 AT 05792997 T AT05792997 T AT 05792997T AT 05792997 T AT05792997 T AT 05792997T AT E511538 T1 ATE511538 T1 AT E511538T1
- Authority
- AT
- Austria
- Prior art keywords
- gdh
- pyrrolocinoline
- quinone
- glucose dehydrogenase
- dependent glucose
- Prior art date
Links
- 230000001419 dependent effect Effects 0.000 title abstract 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 title 1
- 101000806049 Acinetobacter calcoaceticus Quinoprotein glucose dehydrogenase B Proteins 0.000 abstract 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04024593 | 2004-10-15 | ||
| PCT/EP2005/011077 WO2006040172A1 (en) | 2004-10-15 | 2005-10-14 | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE511538T1 true ATE511538T1 (de) | 2011-06-15 |
Family
ID=34926995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05792997T ATE511538T1 (de) | 2004-10-15 | 2005-10-14 | Thermostabile mutanten pyrrolochinolin-chinon- abhängiger glucose-dehydrogenase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7781196B2 (de) |
| EP (2) | EP2251420B1 (de) |
| JP (1) | JP4782138B2 (de) |
| CN (1) | CN101040044B (de) |
| AT (1) | ATE511538T1 (de) |
| CA (1) | CA2581226C (de) |
| ES (2) | ES2537106T3 (de) |
| PL (2) | PL2251420T3 (de) |
| WO (1) | WO2006040172A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2581226C (en) | 2004-10-15 | 2011-06-14 | Mara Boenitz-Dulat | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
| FR2948680B1 (fr) * | 2009-07-28 | 2013-10-04 | Centre Nat Rech Scient | Nouveaux mutants de la pqq s-gdh |
| JP6194251B2 (ja) | 2010-12-20 | 2017-09-06 | レツク・フアーマシユーテイカルズ・デー・デー | 医薬品有効成分およびこれの中間体の酵素的合成 |
| EP2465936A1 (de) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Enzymatische Synthese von Statinen und deren Zwischenprodukte |
| CN102559624B (zh) * | 2012-03-05 | 2013-10-16 | 浙江德清汇宁生物科技有限公司 | 一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法 |
| WO2015063025A1 (en) | 2013-10-29 | 2015-05-07 | F. Hoffmann-La Roche Ag | Nano-enzyme containers for test elements |
| CN105331591B (zh) | 2015-10-29 | 2020-02-28 | 英科隆生物技术（杭州）有限公司 | PQQ-sGDH突变体、聚核苷酸及葡萄糖检测装置 |
| WO2017109003A1 (en) | 2015-12-21 | 2017-06-29 | F. Hoffmann-La Roche Ag | Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same |
| WO2017137491A1 (en) | 2016-02-09 | 2017-08-17 | Roche Diabetes Care Gmbh | Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same |
| CN110494568B (zh) * | 2017-03-31 | 2024-03-19 | 龟甲万株式会社 | 使用fad依赖性葡糖脱氢酶的连续葡萄糖监测 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3716957A1 (de) | 1987-05-20 | 1988-12-01 | Boehringer Mannheim Gmbh | Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten |
| DE4311464A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase |
| DE19639169A1 (de) | 1996-09-24 | 1998-04-02 | Boehringer Mannheim Gmbh | Redoxaktive Verbindungen und deren Anwendung |
| JPH10243786A (ja) | 1997-03-03 | 1998-09-14 | Koji Hayade | 改変型グルコース脱水素酵素 |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| JPH11243949A (ja) | 1998-03-03 | 1999-09-14 | Toyobo Co Ltd | Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法 |
| JP2000350588A (ja) | 1999-04-08 | 2000-12-19 | Koji Hayade | グルコース脱水素酵素 |
| TWI224136B (en) | 1999-04-30 | 2004-11-21 | Koji Sode | Glucose dehydrogenase |
| AU1596602A (en) | 2000-10-27 | 2002-05-06 | Peter Kratzsch | Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase |
| US7476525B2 (en) | 2002-05-27 | 2009-01-13 | Toyo Boseki Kabushiki Kaisha | Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase with superior substrate specificity and stability |
| JP2004173538A (ja) | 2002-11-25 | 2004-06-24 | Amano Enzyme Inc | ピロロキノリンキノン依存性グルコース脱水素酵素 |
| CA2581226C (en) | 2004-10-15 | 2011-06-14 | Mara Boenitz-Dulat | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase |
-
2005
- 2005-10-14 CA CA2581226A patent/CA2581226C/en not_active Expired - Lifetime
- 2005-10-14 EP EP10168981.8A patent/EP2251420B1/de not_active Expired - Lifetime
- 2005-10-14 AT AT05792997T patent/ATE511538T1/de not_active IP Right Cessation
- 2005-10-14 ES ES10168981.8T patent/ES2537106T3/es not_active Expired - Lifetime
- 2005-10-14 ES ES05792997T patent/ES2366479T3/es not_active Expired - Lifetime
- 2005-10-14 CN CN200580034780.0A patent/CN101040044B/zh not_active Expired - Lifetime
- 2005-10-14 PL PL10168981T patent/PL2251420T3/pl unknown
- 2005-10-14 JP JP2007533967A patent/JP4782138B2/ja not_active Expired - Lifetime
- 2005-10-14 EP EP05792997A patent/EP1802748B1/de not_active Expired - Lifetime
- 2005-10-14 WO PCT/EP2005/011077 patent/WO2006040172A1/en not_active Ceased
- 2005-10-14 PL PL05792997T patent/PL1802748T3/pl unknown
- 2005-10-14 US US11/665,437 patent/US7781196B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101040044A (zh) | 2007-09-19 |
| US7781196B2 (en) | 2010-08-24 |
| CA2581226A1 (en) | 2006-04-20 |
| JP4782138B2 (ja) | 2011-09-28 |
| HK1111723A1 (en) | 2008-08-15 |
| CN101040044B (zh) | 2014-06-11 |
| ES2366479T3 (es) | 2011-10-20 |
| EP2251420B1 (de) | 2015-03-04 |
| PL2251420T3 (pl) | 2015-08-31 |
| JP2008515400A (ja) | 2008-05-15 |
| EP1802748A1 (de) | 2007-07-04 |
| ES2537106T3 (es) | 2015-06-02 |
| PL1802748T3 (pl) | 2011-11-30 |
| WO2006040172A1 (en) | 2006-04-20 |
| CA2581226C (en) | 2011-06-14 |
| US20090305316A1 (en) | 2009-12-10 |
| EP1802748B1 (de) | 2011-06-01 |
| EP2251420A1 (de) | 2010-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |