PL1802748T3 - Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu - Google Patents

Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu

Info

Publication number: PL1802748T3
Authority: PL; Poland
Prior art keywords: gdh; glucose dehydrogenase; pyrroloquinoline quinone; dependent glucose; thermostable mutants
Prior art date: 2004-10-15

Application number

PL05792997T

Other languages

English (en)

Inventor

Mara Boenitz-Dulat

Peter Kratzsch

Rainer Schmuck

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-15

Filing date

2005-10-14

Publication date

2011-11-30

2005-10-14 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-11-30 Publication of PL1802748T3 publication Critical patent/PL1802748T3/pl

Links

230000001419 dependent effect Effects 0.000 title abstract 2
MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 title 2
108010050375 Glucose 1-Dehydrogenase Proteins 0.000 title 1
101000806049 Acinetobacter calcoaceticus Quinoprotein glucose dehydrogenase B Proteins 0.000 abstract 4
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
241000588624 Acinetobacter calcoaceticus Species 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
102000008300 Mutant Proteins Human genes 0.000 abstract 1
108010021466 Mutant Proteins Proteins 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL05792997T 2004-10-15 2005-10-14 Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu PL1802748T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP04024593		2004-10-15
EP05792997A EP1802748B1 (en)	2004-10-15	2005-10-14	Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase
PCT/EP2005/011077 WO2006040172A1 (en)	2004-10-15	2005-10-14	Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase

Publications (1)

Publication Number	Publication Date
PL1802748T3 true PL1802748T3 (pl)	2011-11-30

Family

ID=34926995

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL10168981T PL2251420T3 (pl)	2004-10-15	2005-10-14	Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu
PL05792997T PL1802748T3 (pl)	2004-10-15	2005-10-14	Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL10168981T PL2251420T3 (pl)	2004-10-15	2005-10-14	Termostabilne mutanty dehydrogenazy glukozowej zależnej od pirolochinolinochinonu

Country Status (9)

Country	Link
US (1)	US7781196B2 (pl)
EP (2)	EP2251420B1 (pl)
JP (1)	JP4782138B2 (pl)
CN (1)	CN101040044B (pl)
AT (1)	ATE511538T1 (pl)
CA (1)	CA2581226C (pl)
ES (2)	ES2537106T3 (pl)
PL (2)	PL2251420T3 (pl)
WO (1)	WO2006040172A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2581226C (en)	2004-10-15	2011-06-14	Mara Boenitz-Dulat	Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase
FR2948680B1 (fr) *	2009-07-28	2013-10-04	Centre Nat Rech Scient	Nouveaux mutants de la pqq s-gdh
JP6194251B2 (ja)	2010-12-20	2017-09-06	レツク・フアーマシユーテイカルズ・デー・デー	医薬品有効成分およびこれの中間体の酵素的合成
EP2465936A1 (en)	2010-12-20	2012-06-20	LEK Pharmaceuticals d.d.	Enzymatic synthesis of statins and intermediates thereof
CN102559624B (zh) *	2012-03-05	2013-10-16	浙江德清汇宁生物科技有限公司	一种吡咯喹啉醌依赖型葡萄糖脱氢酶的热稳定性突变体及其高通量筛选方法
WO2015063025A1 (en)	2013-10-29	2015-05-07	F. Hoffmann-La Roche Ag	Nano-enzyme containers for test elements
CN105331591B (zh)	2015-10-29	2020-02-28	英科隆生物技术（杭州）有限公司	PQQ-sGDH突变体、聚核苷酸及葡萄糖检测装置
WO2017109003A1 (en)	2015-12-21	2017-06-29	F. Hoffmann-La Roche Ag	Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same
WO2017137491A1 (en)	2016-02-09	2017-08-17	Roche Diabetes Care Gmbh	Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same
CN110494568B (zh) *	2017-03-31	2024-03-19	龟甲万株式会社	使用fad依赖性葡糖脱氢酶的连续葡萄糖监测

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3716957A1 (de)	1987-05-20	1988-12-01	Boehringer Mannheim Gmbh	Expressionsvektor zur regulierbaren expression von fremdgenen in prokaryonten
DE4311464A1 (de)	1993-04-08	1994-10-13	Boehringer Mannheim Gmbh	Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase
DE19639169A1 (de)	1996-09-24	1998-04-02	Boehringer Mannheim Gmbh	Redoxaktive Verbindungen und deren Anwendung
JPH10243786A (ja)	1997-03-03	1998-09-14	Koji Hayade	改変型グルコース脱水素酵素
US5997817A (en)	1997-12-05	1999-12-07	Roche Diagnostics Corporation	Electrochemical biosensor test strip
JPH11243949A (ja)	1998-03-03	1999-09-14	Toyobo Co Ltd	Ｐｑｑを補欠分子族とするグルコースデヒドロゲナーゼおよびその製造方法
JP2000350588A (ja)	1999-04-08	2000-12-19	Koji Hayade	グルコース脱水素酵素
TWI224136B (en)	1999-04-30	2004-11-21	Koji Sode	Glucose dehydrogenase
AU1596602A (en)	2000-10-27	2002-05-06	Peter Kratzsch	Variants of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase
US7476525B2 (en)	2002-05-27	2009-01-13	Toyo Boseki Kabushiki Kaisha	Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase with superior substrate specificity and stability
JP2004173538A (ja)	2002-11-25	2004-06-24	Amano Enzyme Inc	ピロロキノリンキノン依存性グルコース脱水素酵素
CA2581226C (en)	2004-10-15	2011-06-14	Mara Boenitz-Dulat	Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase

2005
- 2005-10-14 CA CA2581226A patent/CA2581226C/en not_active Expired - Lifetime
- 2005-10-14 EP EP10168981.8A patent/EP2251420B1/en not_active Expired - Lifetime
- 2005-10-14 AT AT05792997T patent/ATE511538T1/de not_active IP Right Cessation
- 2005-10-14 ES ES10168981.8T patent/ES2537106T3/es not_active Expired - Lifetime
- 2005-10-14 ES ES05792997T patent/ES2366479T3/es not_active Expired - Lifetime
- 2005-10-14 CN CN200580034780.0A patent/CN101040044B/zh not_active Expired - Lifetime
- 2005-10-14 PL PL10168981T patent/PL2251420T3/pl unknown
- 2005-10-14 JP JP2007533967A patent/JP4782138B2/ja not_active Expired - Lifetime
- 2005-10-14 EP EP05792997A patent/EP1802748B1/en not_active Expired - Lifetime
- 2005-10-14 WO PCT/EP2005/011077 patent/WO2006040172A1/en not_active Ceased
- 2005-10-14 PL PL05792997T patent/PL1802748T3/pl unknown
- 2005-10-14 US US11/665,437 patent/US7781196B2/en active Active

Also Published As

Publication number	Publication date
CN101040044A (zh)	2007-09-19
US7781196B2 (en)	2010-08-24
ATE511538T1 (de)	2011-06-15
CA2581226A1 (en)	2006-04-20
JP4782138B2 (ja)	2011-09-28
HK1111723A1 (en)	2008-08-15
CN101040044B (zh)	2014-06-11
ES2366479T3 (es)	2011-10-20
EP2251420B1 (en)	2015-03-04
PL2251420T3 (pl)	2015-08-31
JP2008515400A (ja)	2008-05-15
EP1802748A1 (en)	2007-07-04
ES2537106T3 (es)	2015-06-02
WO2006040172A1 (en)	2006-04-20
CA2581226C (en)	2011-06-14
US20090305316A1 (en)	2009-12-10
EP1802748B1 (en)	2011-06-01
EP2251420A1 (en)	2010-11-17

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