ATE542533T1 - Verfahren zur herstellung von isothiazol- derivaten - Google Patents

Verfahren zur herstellung von isothiazol- derivaten

Info

Publication number
ATE542533T1
ATE542533T1 AT05778840T AT05778840T ATE542533T1 AT E542533 T1 ATE542533 T1 AT E542533T1 AT 05778840 T AT05778840 T AT 05778840T AT 05778840 T AT05778840 T AT 05778840T AT E542533 T1 ATE542533 T1 AT E542533T1
Authority
AT
Austria
Prior art keywords
isothiazole derivatives
producing
producing isothiazole
derivatives
isothiazole
Prior art date
Application number
AT05778840T
Other languages
English (en)
Inventor
David DAMON
Brian Jones
Original Assignee
Pfizer
Osi Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Osi Pharmaceuticals Llc filed Critical Pfizer
Application granted granted Critical
Publication of ATE542533T1 publication Critical patent/ATE542533T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT05778840T 2004-08-26 2005-08-02 Verfahren zur herstellung von isothiazol- derivaten ATE542533T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60454204P 2004-08-26 2004-08-26
PCT/US2005/027398 WO2006026034A2 (en) 2004-08-26 2005-08-02 Processes for the preparation of isothiazole derivatives

Publications (1)

Publication Number Publication Date
ATE542533T1 true ATE542533T1 (de) 2012-02-15

Family

ID=36000502

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05778840T ATE542533T1 (de) 2004-08-26 2005-08-02 Verfahren zur herstellung von isothiazol- derivaten

Country Status (21)

Country Link
US (2) US8884025B2 (de)
EP (1) EP1784183B1 (de)
JP (2) JP5100390B2 (de)
KR (1) KR100893977B1 (de)
CN (1) CN101043888B (de)
AR (1) AR050613A1 (de)
AT (1) ATE542533T1 (de)
AU (1) AU2005280451B2 (de)
BR (1) BRPI0514667A (de)
CA (1) CA2578023C (de)
DK (1) DK1784183T3 (de)
ES (1) ES2378994T3 (de)
IL (1) IL181063A0 (de)
MX (1) MX2007002246A (de)
NO (1) NO20071319L (de)
PL (1) PL1784183T3 (de)
PT (1) PT1784183E (de)
RU (1) RU2349588C2 (de)
TW (1) TWI361688B (de)
WO (1) WO2006026034A2 (de)
ZA (1) ZA200701016B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole
ES2623652T3 (es) 2011-12-28 2017-07-11 Allergan, Inc. Derivados de 3-fenil-5-ureidoisotiazol-4-carboximida y 3-amino-5-fenilisotiazol como inhibidores de cinasa
CN103833665B (zh) * 2014-02-24 2015-09-23 杰达维（上海）医药科技发展有限公司 一种新的合成异噻唑的方法
US9353093B2 (en) 2014-10-07 2016-05-31 Allergan, Inc. Indole-1-carboxamides as kinase inhibitors
US9403803B2 (en) 2014-10-08 2016-08-02 Allergan, Inc. Indole-3-carboxamides as kinase inhibitors
US9359336B2 (en) 2014-10-09 2016-06-07 Allergan, Inc. Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
US9371314B2 (en) 2014-10-09 2016-06-21 Allergan, Inc. Pyridyl benzothiophenes as kinase inhibitors
AU2023416218A1 (en) * 2022-12-28 2025-07-10 Beyang Therapeutics Co., Ltd. Protein tyrosine kinase inhibitor and medical use thereof
WO2026002126A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其眼用制剂
WO2026002137A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂游离碱的晶型

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408234A1 (de) * 1974-02-21 1975-09-04 Celamerck Gmbh & Co Kg Isothiazolylharnstoffe
US4059433A (en) * 1976-06-18 1977-11-22 Fmc Corporation 3-Alkoxyisothiazole derivatives as herbicides
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
GB0010188D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
EP1527071A1 (de) * 2002-07-25 2005-05-04 Pfizer Products Inc. Isothiazolderivate und ihre verwendung zur krebsbekämpfung
US20060035954A1 (en) * 2004-08-11 2006-02-16 Sharma Padam N Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole

Also Published As

Publication number Publication date
ES2378994T3 (es) 2012-04-19
JP5100390B2 (ja) 2012-12-19
WO2006026034A3 (en) 2006-06-29
CN101043888A (zh) 2007-09-26
PL1784183T3 (pl) 2012-07-31
AR050613A1 (es) 2006-11-08
AU2005280451B2 (en) 2009-02-05
CA2578023C (en) 2012-05-15
WO2006026034A2 (en) 2006-03-09
JP5498524B2 (ja) 2014-05-21
US9371298B2 (en) 2016-06-21
NO20071319L (no) 2007-05-29
EP1784183B1 (de) 2012-01-25
DK1784183T3 (da) 2012-04-02
KR20070070158A (ko) 2007-07-03
IL181063A0 (en) 2007-07-04
BRPI0514667A (pt) 2008-06-17
US8884025B2 (en) 2014-11-11
EP1784183A2 (de) 2007-05-16
US20150065726A1 (en) 2015-03-05
US20090023924A1 (en) 2009-01-22
CA2578023A1 (en) 2006-03-09
RU2349588C2 (ru) 2009-03-20
JP2008510841A (ja) 2008-04-10
PT1784183E (pt) 2012-03-09
KR100893977B1 (ko) 2009-04-20
MX2007002246A (es) 2007-04-20
HK1111359A1 (en) 2008-08-08
ZA200701016B (en) 2008-05-28
AU2005280451A1 (en) 2006-03-09
EP1784183A4 (de) 2009-12-09
JP2012153705A (ja) 2012-08-16
TW200621241A (en) 2006-07-01
TWI361688B (en) 2012-04-11
CN101043888B (zh) 2010-08-11
RU2007106847A (ru) 2008-08-27

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