ATE521633T1 - Fgf18 produktion in prokaryotischen zellen - Google Patents

Fgf18 produktion in prokaryotischen zellen

Info

Publication number
ATE521633T1
ATE521633T1 AT05853969T AT05853969T ATE521633T1 AT E521633 T1 ATE521633 T1 AT E521633T1 AT 05853969 T AT05853969 T AT 05853969T AT 05853969 T AT05853969 T AT 05853969T AT E521633 T1 ATE521633 T1 AT E521633T1
Authority
AT
Austria
Prior art keywords
fgf18
coli
production
expression
prokaryotic cells
Prior art date
Application number
AT05853969T
Other languages
English (en)
Inventor
Brian J Reardon
Susan D Julien
Chung-Leung Chan
Hong Liu
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE521633T1 publication Critical patent/ATE521633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT05853969T 2004-12-10 2005-12-12 Fgf18 produktion in prokaryotischen zellen ATE521633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63502304P 2004-12-10 2004-12-10
PCT/US2005/045166 WO2006063362A1 (en) 2004-12-10 2005-12-12 Fgf18 production in prokaryotic hosts

Publications (1)

Publication Number Publication Date
ATE521633T1 true ATE521633T1 (de) 2011-09-15

Family

ID=36061577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05853969T ATE521633T1 (de) 2004-12-10 2005-12-12 Fgf18 produktion in prokaryotischen zellen

Country Status (12)

Country Link
US (1) US7858341B2 (de)
EP (1) EP1828239B1 (de)
AT (1) ATE521633T1 (de)
AU (1) AU2005314438B2 (de)
CA (1) CA2592261C (de)
CY (1) CY1112394T1 (de)
DK (1) DK1828239T3 (de)
ES (1) ES2371219T3 (de)
PL (1) PL1828239T3 (de)
PT (1) PT1828239E (de)
SI (1) SI1828239T1 (de)
WO (1) WO2006063362A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1931704T3 (da) * 2005-10-04 2011-03-14 Zymogenetics L L C Frembringelse og rensning af IL-29
KR101419961B1 (ko) * 2006-08-25 2014-07-30 아레스 트레이딩 에스.에이. Ｆｇｆ-18 로 연골 질환의 치료
MY148277A (en) * 2006-08-25 2013-03-29 Ares Trading Sa Treatment of cartilage disorders with fgf-18
KR101741859B1 (ko) 2009-06-22 2017-06-15 암젠 인크 화학적으로 조절된 산화환원 상태를 사용한 단백질의 재폴딩
SI3660032T1 (sl) 2009-06-25 2026-02-27 Amgen Inc. Postopki zajemanja in čiščenja beljakovin, izraženih v nesesalskem sistemu
WO2012038953A2 (en) 2010-09-21 2012-03-29 Hepacore Ltd. Fgf-18 truncated variants having increased receptor specificity and uses thereof
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
TW201307563A (zh) * 2011-05-19 2013-02-16 Shire Human Genetic Therapies 純化乙醯肝素－ｎ－硫酸酯酶之方法
TWI527590B (zh) 2011-06-17 2016-04-01 艾瑞斯貿易公司 Ｆｇｆ－１８之凍乾調配物
WO2013130001A1 (en) * 2012-02-29 2013-09-06 Ge Healthcare Bio-Sciences Ab Method for endotoxin removal
US10041050B2 (en) 2012-02-29 2018-08-07 Ge Healthcare Bioprocess R&D Ab Method for endotoxin removal
CA2881024C (en) 2012-08-06 2021-06-15 Christoph Hubertus LADEL Genetic markers for predicting responsiveness to fgf-18 compound
HRP20181573T1 (hr) * 2014-02-20 2018-11-30 Merck Patent Gmbh Implantat koji sadrži fgf-18
KR101608734B1 (ko) 2014-03-21 2016-04-04 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법
CA2971315C (en) 2015-01-29 2023-02-14 Ares Trading S.A. Immunoassays for high positively charged proteins
CN107849151B (zh) * 2015-07-15 2022-05-24 德益阳光生物技术（北京）有限责任公司 融合多肽及使用方法
DK3688468T3 (da) 2017-09-29 2022-06-20 Merck Patent Gmbh Inflammatoriske biomarkører til forudsigelse af modtageligheden for fgf-18 forbindelse
DK3687558T3 (da) 2017-09-29 2022-06-20 Merck Patent Gmbh Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse
IL281333B2 (en) 2018-09-10 2025-11-01 Merck Patent Gmbh A method for reducing risk in a clinical trial
CN110759986B (zh) * 2019-10-18 2023-01-31 大连工业大学 一种可逆自组装蛋白的高效制备方法
CN114181321B (zh) * 2021-12-10 2023-04-11 中国海洋大学 花鲈fgf6a、fgf6b以及fgf18重组蛋白及其制备方法和应用
JPWO2024084807A1 (de) * 2022-10-19 2024-04-25

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604293A (en) 1985-09-12 1997-02-18 Scios Inc. Recombinant human basic fibroblast growth factor
US5439818A (en) 1985-09-12 1995-08-08 Scios Nova Inc. DNA encoding human recombinant basic fibroblast growth factor
US5773252A (en) 1995-06-05 1998-06-30 Human Genome Sciences, Inc. Fibroblast growth factor 15
US7135459B2 (en) 1996-10-16 2006-11-14 Zymogenetics, Inc. Methods of use of FGF homologs
US20050043234A1 (en) 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
ATE491029T1 (de) * 1996-10-16 2010-12-15 Zymogenetics Inc Fibroblasten-wachstumsfaktoren-homologe
US6518236B1 (en) 1996-10-16 2003-02-11 Zymogenetics, Inc. FGF homologs
EP1234033B1 (de) * 1999-12-02 2011-12-28 ZymoGenetics, Inc. Methoden welche auf Zellen zielen, die die Fibroblasten Wachtumsfaktor-Rezeptoren-3 oder -2 exprimieren
US20040136970A1 (en) 2002-10-07 2004-07-15 Ellsworth Jeff L. Methods for administering FGF18
US20040229292A1 (en) 2002-11-26 2004-11-18 Sebastiano Cavallaro Use of FGF-18 in the diagnosis and treatment of memory disorders

Also Published As

Publication number Publication date
ES2371219T3 (es) 2011-12-28
WO2006063362A1 (en) 2006-06-15
CA2592261A1 (en) 2006-06-15
US20060172384A1 (en) 2006-08-03
PL1828239T3 (pl) 2012-01-31
SI1828239T1 (sl) 2011-11-30
AU2005314438B2 (en) 2012-03-29
AU2005314438A1 (en) 2006-06-15
US7858341B2 (en) 2010-12-28
EP1828239A1 (de) 2007-09-05
CA2592261C (en) 2015-11-24
HK1113161A1 (en) 2008-09-26
DK1828239T3 (da) 2011-12-19
CY1112394T1 (el) 2015-12-09
EP1828239B1 (de) 2011-08-24
PT1828239E (pt) 2011-10-27

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