ATE522520T1 - Neues syntheseverfahren für fluorquinolone - Google Patents

Neues syntheseverfahren für fluorquinolone

Info

Publication number
ATE522520T1
ATE522520T1 AT08104076T AT08104076T ATE522520T1 AT E522520 T1 ATE522520 T1 AT E522520T1 AT 08104076 T AT08104076 T AT 08104076T AT 08104076 T AT08104076 T AT 08104076T AT E522520 T1 ATE522520 T1 AT E522520T1
Authority
AT
Austria
Prior art keywords
alkyl
compound
nrr1a
optionally substituted
formula
Prior art date
Application number
AT08104076T
Other languages
English (en)
Inventor
Laurence Berthon-Cedille
Marie-Emmanuelle Leguern
Gilles Renaud
Francis Tombret
Original Assignee
Biocodex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocodex filed Critical Biocodex
Application granted granted Critical
Publication of ATE522520T1 publication Critical patent/ATE522520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08104076T 2007-05-24 2008-05-23 Neues syntheseverfahren für fluorquinolone ATE522520T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0755240A FR2916446B1 (fr) 2007-05-24 2007-05-24 Nouveau procede de synthese de fluoroquinolones

Publications (1)

Publication Number Publication Date
ATE522520T1 true ATE522520T1 (de) 2011-09-15

Family

ID=38935887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08104076T ATE522520T1 (de) 2007-05-24 2008-05-23 Neues syntheseverfahren für fluorquinolone

Country Status (7)

Country Link
US (1) US8093381B2 (de)
EP (1) EP2138490B1 (de)
JP (1) JP5373320B2 (de)
CN (1) CN101337934A (de)
AT (1) ATE522520T1 (de)
ES (1) ES2372885T3 (de)
FR (1) FR2916446B1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101759629B (zh) * 2009-12-22 2012-01-11 北大方正集团有限公司 西他沙星中间体的制备方法
CN101768167B (zh) * 2010-01-15 2012-07-04 浙江东亚药业有限公司 左氧氟沙星的缩哌合成方法
CN101792443A (zh) * 2010-03-09 2010-08-04 北京欧凯纳斯科技有限公司 氟代喹诺酮衍生物及其制备方法和用途
CN102827143A (zh) * 2012-08-14 2012-12-19 安徽赛诺医药化工有限公司 一种合成氟喹诺酮及其盐的新方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141286A (en) 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
SE440354B (sv) 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
GB2095171A (en) * 1981-02-27 1982-09-29 Ushio Electric Inc Apparatus for heat-laminating a sheet
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4473568A (en) 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
AU553415B2 (en) 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
EP0230053A3 (de) 1986-01-17 1988-03-30 American Cyanamid Company 7-(Substituierte)Piperazinyl-1-äthyl-6-fluor-1,4-dihydro-4-oxo-3-chinolinkarbonsäure
EP0329719A1 (de) 1987-06-24 1989-08-30 CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. Verfahren zur herstellung von chinolincarbonsäure abkömmlingen
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
JPH0794452B2 (ja) * 1987-10-16 1995-10-11 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPH02231424A (ja) * 1988-10-17 1990-09-13 Dainippon Pharmaceut Co Ltd 抗菌剤
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
GB2291421A (en) * 1994-07-16 1996-01-24 Pfizer A process for preparing a quinoline carboxylic acid
WO2003010144A2 (en) * 2001-07-25 2003-02-06 Farmaceutsko-Hemijska Industrija 'zdravlje' A process for synthesis of fluoroquinolonic derivatives

Also Published As

Publication number Publication date
ES2372885T3 (es) 2012-01-27
EP2138490A1 (de) 2009-12-30
US20090054643A1 (en) 2009-02-26
JP5373320B2 (ja) 2013-12-18
US8093381B2 (en) 2012-01-10
FR2916446A1 (fr) 2008-11-28
FR2916446B1 (fr) 2009-08-21
EP2138490B1 (de) 2011-08-31
JP2009001560A (ja) 2009-01-08
CN101337934A (zh) 2009-01-07

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Legal Events

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