ATE524444T1 - Verbessertes verfahren zur herstellung von montelukast-natrium - Google Patents

Verbessertes verfahren zur herstellung von montelukast-natrium

Info

Publication number: ATE524444T1
Authority: AT; Austria
Prior art keywords: phenyl; metal salt; sodium; montelukast sodium; iii
Prior art date: 2006-04-12

Application number

AT06808904T

Other languages

English (en)

Inventor

Harmander Chawla

Anil Chowdhary

Ajay Patel

Manish Patel

Original Assignee

Glade Organics Private Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-12

Filing date

2006-09-28

Publication date

2011-09-15

2006-09-28 Application filed by Glade Organics Private Ltd filed Critical Glade Organics Private Ltd

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524444T1 publication Critical patent/ATE524444T1/de

Links

229960001951 montelukast sodium Drugs 0.000 title abstract 3
LBFBRXGCXUHRJY-HKHDRNBDSA-M montelukast sodium Chemical compound [Na+].CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC([O-])=O)CC1 LBFBRXGCXUHRJY-HKHDRNBDSA-M 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
229910052751 metal Inorganic materials 0.000 abstract 4
239000002184 metal Substances 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
UOPMCTRPKWKMSA-REFCXTLYSA-N acetic acid;2-[2-[(3r)-3-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-(cyclopropylmethylsulfanyl)propyl]phenyl]propan-2-ol Chemical class CC(O)=O.CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1CC1 UOPMCTRPKWKMSA-REFCXTLYSA-N 0.000 abstract 2
238000011065 in-situ storage Methods 0.000 abstract 2
229910052708 sodium Inorganic materials 0.000 abstract 2
239000011734 sodium Chemical class 0.000 abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
-1 amine salt Chemical class 0.000 abstract 1
150000002009 diols Chemical class 0.000 abstract 1
229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
150000004692 metal hydroxides Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
JRHLVNAWLWIHDN-UHFFFAOYSA-N methyl 2-[1-(sulfanylmethyl)cyclopropyl]acetate Chemical compound COC(=O)CC1(CS)CC1 JRHLVNAWLWIHDN-UHFFFAOYSA-N 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06808904T 2006-04-12 2006-09-28 Verbessertes verfahren zur herstellung von montelukast-natrium ATE524444T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN574MU2006		2006-04-12
PCT/IB2006/002690 WO2007116240A1 (en)	2006-04-12	2006-09-28	An improved process for the manufacture of montelukast sodium

Publications (1)

Publication Number	Publication Date
ATE524444T1 true ATE524444T1 (de)	2011-09-15

Family

ID=38580734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06808904T ATE524444T1 (de)	2006-04-12	2006-09-28	Verbessertes verfahren zur herstellung von montelukast-natrium

Country Status (5)

Country	Link
US (1)	US20090281323A1 (de)
EP (1)	EP2004608B1 (de)
AT (1)	ATE524444T1 (de)
CA (1)	CA2649189A1 (de)
WO (1)	WO2007116240A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1904448B1 (de)	2005-07-05	2011-02-02	Teva Pharmaceutical Industries, Ltd.	Reinigung von montelukast
ES2403067T3 (es)	2005-12-13	2013-05-13	Msn Laboratories Limited	Un procedimiento mejorado para la preparación de montelukast y sus sales farmaceúticamente aceptables
EP1886998A1 (de)	2006-08-09	2008-02-13	Esteve Quimica, S.A.	Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
US8115004B2 (en)	2006-11-20	2012-02-14	Msn Laboratories Limited	Process for pure montelukast sodium through pure intermediates as well as amine salts
EP2287154A1 (de)	2009-07-14	2011-02-23	KRKA, D.D., Novo Mesto	Effiziente Synthese zur Herstellung von Montelukast
WO2011076237A1 (en) *	2009-12-23	2011-06-30	Pharmathen S.A.	Improved process for the preparation of montelukast and salts thereof
EP2552892A1 (de)	2010-03-31	2013-02-06	KRKA, D.D., Novo Mesto	Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin
KR100990046B1 (ko) *	2010-07-30	2010-10-26	동국제약 주식회사	신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법
EP2850064B1 (de) *	2012-05-18	2018-11-07	Laurus Labs Limited	Verfahren zur herstellung von montelukast-natrium

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0480717T3 (da)	1990-10-12	1999-02-08	Merck Frosst Canada Inc	Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
TW448160B (en) *	1993-12-28	2001-08-01	Merck & Co Inc	Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US20050107612A1 (en) *	2002-12-30	2005-05-19	Dr. Reddy's Laboratories Limited	Process for preparation of montelukast and its salts
EP1631550B1 (de) *	2003-06-06	2012-01-11	Morepen Laboratories Ltd.	Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form
WO2005074893A1 (en)	2004-02-03	2005-08-18	Chemagis Ltd.	Stable amorphous forms of montelukast sodium
US20090143590A1 (en) *	2004-07-19	2009-06-04	Matrix Laboratories Ltd.	Process for the Preparation of Montelukast and its Salts
US20080214822A1 (en) *	2004-11-30	2008-09-04	Medichem, S.A.	Process For the Preparation of a Leukotriene Antagonist
WO2006064269A2 (en) *	2004-12-17	2006-06-22	Cipla Limited	Salts of leukotriene antagonist montelukast

2006
- 2006-09-28 CA CA002649189A patent/CA2649189A1/en not_active Abandoned
- 2006-09-28 US US12/296,644 patent/US20090281323A1/en not_active Abandoned
- 2006-09-28 EP EP06808904A patent/EP2004608B1/de not_active Not-in-force
- 2006-09-28 WO PCT/IB2006/002690 patent/WO2007116240A1/en not_active Ceased
- 2006-09-28 AT AT06808904T patent/ATE524444T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP2004608A4 (de)	2010-03-24
EP2004608B1 (de)	2011-09-14
CA2649189A1 (en)	2007-10-18
EP2004608A1 (de)	2008-12-24
WO2007116240A1 (en)	2007-10-18
US20090281323A1 (en)	2009-11-12

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Legal Events

Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties