BRPI0814958A2 - Compostos de indazol ou indol, composição, e, método para preparar uma composição. - Google Patents

Compostos de indazol ou indol, composição, e, método para preparar uma composição.

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Publication number
BRPI0814958A2
BRPI0814958A2 BRPI0814958-5A2A BRPI0814958A BRPI0814958A2 BR PI0814958 A2 BRPI0814958 A2 BR PI0814958A2 BR PI0814958 A BRPI0814958 A BR PI0814958A BR PI0814958 A2 BRPI0814958 A2 BR PI0814958A2
Authority
BR
Brazil
Prior art keywords
composition
indazol
preparing
indol compounds
indol
Prior art date
Application number
BRPI0814958-5A2A
Other languages
English (en)
Inventor
Soon Ha Kim
Hyoung Jin Kim
Sun Young Koo
Chul Woong Chung
Sung Bae Lee
Heui Sul Park
Seung Hyun Yoon
Hyo Shin Kwak
Dong Ook Seo
Eok Park
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of BRPI0814958A2 publication Critical patent/BRPI0814958A2/pt
Publication of BRPI0814958B1 publication Critical patent/BRPI0814958B1/pt
Publication of BRPI0814958B8 publication Critical patent/BRPI0814958B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5323834B2 (ja) * 2007-08-17 2013-10-23 エルジー・ライフ・サイエンシーズ・リミテッド 細胞壊死阻害剤としてのインドール化合物
US20090142832A1 (en) * 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
JP5364103B2 (ja) * 2007-12-20 2013-12-11 エルジー・ライフ・サイエンシーズ・リミテッド グルコキナーゼ活性化剤およびそれを活性成分として含有する医薬組成物
RU2460525C2 (ru) * 2008-01-04 2012-09-10 Эл Джи Лайф Сайенсиз Лтд. Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам
PT2276760E (pt) 2008-04-10 2014-05-28 Takeda Pharmaceutical Compostos de anéis fundidos e sua utilização
WO2010076884A1 (ja) * 2008-12-29 2010-07-08 武田薬品工業株式会社 新規縮合環化合物およびその用途
TW201119651A (en) * 2009-10-26 2011-06-16 Lg Life Sciences Ltd Pharmaceutical composition comprising indole compound
KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 ＮｅｃｒｏＸ―５를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
CN102766083B (zh) * 2011-05-03 2014-10-22 中国科学院上海有机化学研究所 2-氨基-3-全氟乙酰吲哚类化合物及其衍生物、制备方法和应用
WO2013077579A1 (ko) * 2011-11-25 2013-05-30 가톨릭대학교 산학협력단 안과 질환의 예방 및 치료용 약학 조성물
KR101941004B1 (ko) * 2013-03-25 2019-01-23 주식회사 엘지화학 조절 t 세포로의 분화 유도 및 증식 촉진을 통한 면역 반응 억제용 약학 조성물
KR101985886B1 (ko) * 2013-06-24 2019-06-04 주식회사 엘지생활건강 인돌 화합물 및 판테놀을 포함하는 자외선에 의한 피부손상 예방 및 개선용 조성물
KR102139339B1 (ko) * 2013-06-24 2020-07-29 주식회사 엘지생활건강 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물
KR102139338B1 (ko) * 2013-06-24 2020-07-29 주식회사 엘지생활건강 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물
KR101986580B1 (ko) * 2013-08-22 2019-06-10 주식회사 엘지화학 세포괴사 저해제로서의 인돌 화합물
WO2015026172A1 (ko) * 2013-08-22 2015-02-26 주식회사 엘지생명과학 세포괴사 저해제로서의 인돌아미드 화합물
CN103601662B (zh) * 2013-11-21 2016-04-06 深圳市药品检验所 一种褪黑素半抗原、褪黑素完全抗原及其制备方法和应用
KR101636563B1 (ko) * 2014-01-24 2016-07-06 주식회사 엘지생명과학 급성 폐 손상 및 급성 호흡곤란 증후군의 예방 또는 치료용 조성물
KR102006247B1 (ko) * 2014-04-18 2019-08-01 주식회사 엘지화학 지방간 질환의 예방 또는 치료용 조성물
TW201707707A (zh) * 2015-03-26 2017-03-01 Ｌｇ生命科學股份有限公司 包含吲哚化合物之製劑及其製備方法
CN107690429B (zh) * 2015-04-07 2022-02-25 Ela制药有限公司 用于治疗和/或预防细胞或组织坏死的组合物，其特异性靶向组织蛋白酶c和/或cela1和/或cela3a和/或与其结构相关的酶
CN116462666B (zh) * 2017-01-10 2025-07-15 瑞士苏黎世联邦理工学院 细胞保护性化合物及其用途
IL283592B2 (en) 2018-12-17 2025-08-01 Vertex Pharma Inhibitors of apol1 and methods of using same
CN109884212A (zh) * 2019-03-27 2019-06-14 清华大学深圳研究生院 基于化学衍生化与hplc-ms的不饱和脂肪酸定量方法
WO2020256432A1 (ko) 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
KR102389718B1 (ko) * 2019-06-19 2022-04-25 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
EP3971186B1 (en) * 2019-06-19 2023-08-02 LG Chem, Ltd. Preparation method for indole or indazole compound
EP4046688B1 (en) * 2019-10-18 2025-04-09 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN115151540A (zh) 2019-12-02 2022-10-04 风暴治疗有限公司 作为mettl3抑制剂的多杂环化合物
EP4097083A1 (en) 2020-01-29 2022-12-07 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
IL294527B1 (en) * 2020-01-30 2026-02-01 Anima Biotech Inc 3-Methylindole Derivatives as Collagen 1 Translation Inhibitors and Their Uses in the Treatment of Fibrosis and Other Disorders
CN115209894B (zh) 2020-03-06 2025-05-02 弗特克斯药品有限公司 治疗apol-1依赖性局灶节段性肾小球硬化的方法
JP7601425B2 (ja) 2020-03-31 2024-12-17 エルジー・ケム・リミテッド 膵島移植保護用組成物
EP4165036A1 (en) 2020-06-12 2023-04-19 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and using the same
CN116157393A (zh) 2020-06-12 2023-05-23 弗特克斯药品有限公司 Apol1的抑制剂及其用途
CA3185144A1 (en) * 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
EP4201407A4 (en) * 2020-08-19 2024-07-31 MitoImmune Therapeutics Inc. ANTIOXIDANT TARGETING MITOCHONDRIA AS AN AGENT FOR THE TREATMENT OF PATHOLOGICAL INFLAMMATION CAUSED BY MABC-R INFECTION
UY39395A (es) 2020-08-26 2022-03-31 Vertex Pharma Inhibidores de apol1 y métodos para usar los mismos
US20240374646A1 (en) * 2021-04-12 2024-11-14 Mitoimmune Therapeutics Inc. Composition for inhibiting inflammation or aging of stem cells, and method for inhibiting inflammation or aging by using same
KR20220141252A (ko) 2021-04-12 2022-10-19 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민 황산염 및 이의 신규 결정형
EP4324830A4 (en) * 2021-04-12 2025-04-16 MitoImmune Therapeutics Inc. NEW CRYSTAL FORM OF 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOLE-7-AMINE
DE102021207925A1 (de) * 2021-07-23 2023-01-26 Continental Reifen Deutschland Gmbh Verbindung, Verfahren zu deren Herstellung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Ozonschutzmittel und/oder Farbstoff
CN117794922A (zh) * 2021-08-02 2024-03-29 水疗免疫疗法有限公司 吲哚衍生物、其制备方法及其用途
EP4382523A4 (en) * 2021-08-02 2025-09-03 Mitoimmune Therapeutics Inc NEW INDOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING IT AND ITS USE
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
WO2023106973A1 (ru) * 2021-12-10 2023-06-15 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые гепатопротекторные средства
AU2023213494A1 (en) * 2022-01-27 2024-08-08 Mitoimmune Therapeutics Inc. Ovarian anti-aging pharmaceutical composition and use thereof
US20250213583A1 (en) 2022-03-25 2025-07-03 Mitoimmune Therapeutics Inc. Antiviral pharmaceutical composition and use thereof
EP4656629A1 (en) 2023-01-25 2025-12-03 MitoImmune Therapeutics Inc. Indole derivative with substituent and pharmaceutical use
KR20240118677A (ko) * 2023-01-27 2024-08-05 주식회사 미토이뮨테라퓨틱스 페롭토시스 억제제로서 인돌 화합물의 용도
WO2024191106A1 (ko) 2023-03-13 2024-09-19 주식회사 미토이뮨테라퓨틱스 뇌전증 예방 또는 치료용 약학적 조성물
WO2025188159A1 (ko) 2024-03-06 2025-09-12 주식회사 미토이뮨테라퓨틱스 신장 섬유증 예방 또는 치료용 약학적 조성물

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB599834A (en) * 1943-04-08 1948-03-22 Francolor Sa Improvements in or relating to the manufacture of azodyestuffs
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
BE792078A (fr) * 1971-12-01 1973-05-29 Wander Ag Dr A Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
DE2653005A1 (de) * 1975-12-03 1977-06-08 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
JPS6160648A (ja) * 1984-08-31 1986-03-28 Teikoku Hormone Mfg Co Ltd ２−（３，５−ジアルキル−４−ヒドロキシフエニル）インド−ル誘導体
FR2659552B2 (fr) * 1989-10-20 1994-11-04 Oreal Procede de teinture des fibres keratiniques avec des aminoindoles, composition et dispositif de mise en óoeuvre.
US5254135A (en) * 1989-10-20 1993-10-19 L'oreal Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use
WO1992002500A1 (fr) * 1990-07-31 1992-02-20 Teikoku Hormone Mfg. Co., Ltd. Derive de 2-phenylindole
PT633886E (pt) * 1992-04-03 2001-03-30 Upjohn Co Aminas biciclicas-heterociclicas farmaceuticamente activas
EP0676967A4 (en) 1992-12-30 1996-10-02 Fmc Corp RELEASED, EXTENDED, EASY TO PRODUCE EXCIPIENT, BASED ON KONJAC GLUCOMANNANE.
JP3545461B2 (ja) * 1993-09-10 2004-07-21 エーザイ株式会社 二環式ヘテロ環含有スルホンアミド誘導体
PT673937E (pt) * 1993-09-10 2004-04-30 Eisai Co Ltd Derivados biciclicos heterociclicos de sulfonamida e de ester sulfonico
DE69728688T2 (de) * 1996-11-19 2004-08-19 Amgen Inc., Thousand Oaks Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel
FR2767475A1 (fr) * 1997-08-25 1999-02-26 Oreal Compositions de teinture des fibres keratiniques contenant des derives d'indazoles et procede
US6858577B1 (en) * 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
KR20020088406A (ko) * 1999-09-17 2002-11-27 애보트 게엠베하 운트 콤파니 카게 치료제로서의 피라졸로피리미딘
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
KR100767000B1 (ko) * 2000-02-03 2007-10-15 에자이 알앤드디 매니지먼트 가부시키가이샤 인테그린 발현 저해제
AU2001280187A1 (en) * 2000-08-28 2002-03-13 Toray Industries, Inc. Cyclic amine derivatives
EP1847263A3 (en) * 2000-12-18 2009-08-26 Institute of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines
WO2002083648A1 (fr) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
TW200306819A (en) * 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
RU2354648C2 (ru) * 2002-07-19 2009-05-10 Мемори Фармасьютиклз Корпорейшн Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4
BR0313059B8 (pt) * 2002-07-29 2021-07-27 Rigel Pharmaceuticals composto, e, composição farmacêutica
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
AU2003276919B2 (en) * 2002-09-25 2013-05-16 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
CN1742007A (zh) * 2003-01-22 2006-03-01 伊莱利利公司 甾族激素核受体的吲哚衍生物调控剂
US7563748B2 (en) * 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
EP2468729B1 (en) * 2003-10-15 2013-12-25 Ube Industries, Ltd. Novel indazole derivative
ES2414604T3 (es) * 2004-03-03 2013-07-22 Eli Lilly And Company Moduladores del receptor nuclear de hormonas esteroides de derivados bicíclicos sustituidos con indol
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
CA2589271A1 (en) * 2004-12-07 2006-06-15 Locus Pharmaceuticals, Inc. Urea inhibitors of map kinases
JP5094394B2 (ja) 2005-04-20 2012-12-12 武田薬品工業株式会社 縮合複素環化合物
WO2007076161A2 (en) * 2005-12-27 2007-07-05 Myriad Genetics, Inc Compounds with therapeutic activity
TW200736232A (en) * 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
UA97257C2 (en) * 2006-10-19 2012-01-25 Такеда Фармасьютикал Компани Лимитед Indole derivatives
JP5323834B2 (ja) * 2007-08-17 2013-10-23 エルジー・ライフ・サイエンシーズ・リミテッド 細胞壊死阻害剤としてのインドール化合物
JP5364103B2 (ja) * 2007-12-20 2013-12-11 エルジー・ライフ・サイエンシーズ・リミテッド グルコキナーゼ活性化剤およびそれを活性成分として含有する医薬組成物
RU2460525C2 (ru) * 2008-01-04 2012-09-10 Эл Джи Лайф Сайенсиз Лтд. Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам

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US8569307B2 (en) 2013-10-29
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BRPI0814958B8 (pt) 2021-05-25
EP2178870A1 (en) 2010-04-28
KR20090018593A (ko) 2009-02-20
WO2009025478A1 (en) 2009-02-26
EP2178869B1 (en) 2013-06-12
KR101098584B1 (ko) 2011-12-26
JP5517935B2 (ja) 2014-06-11
ES2691068T3 (es) 2018-11-23
US20120252798A1 (en) 2012-10-04
EP2178869A1 (en) 2010-04-28
RU2437883C1 (ru) 2011-12-27
PT2178870T (pt) 2018-11-09
CN101784543B (zh) 2013-10-16
US8222414B2 (en) 2012-07-17
BRPI0814958B1 (pt) 2021-05-11
ES2426641T3 (es) 2013-10-24
WO2009025477A1 (en) 2009-02-26
CN101784543A (zh) 2010-07-21
BRPI0815154B1 (pt) 2024-01-30
BRPI0815154A2 (pt) 2015-03-31
US20100197673A1 (en) 2010-08-05
MX368368B (es) 2019-09-30
CN101801965B (zh) 2014-07-30
KR20090018594A (ko) 2009-02-20
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US8436038B2 (en) 2013-05-07
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EP2178870B1 (en) 2018-09-19
US9000028B2 (en) 2015-04-07
US20130237532A1 (en) 2013-09-12
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US8889691B2 (en) 2014-11-18
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