ATE533853T1 - Botulinumtoxin-screening-assays - Google Patents

Botulinumtoxin-screening-assays

Info

Publication number
ATE533853T1
ATE533853T1 AT05724048T AT05724048T ATE533853T1 AT E533853 T1 ATE533853 T1 AT E533853T1 AT 05724048 T AT05724048 T AT 05724048T AT 05724048 T AT05724048 T AT 05724048T AT E533853 T1 ATE533853 T1 AT E533853T1
Authority
AT
Austria
Prior art keywords
methods
botulinum toxin
screening assays
bont
toxin screening
Prior art date
Application number
AT05724048T
Other languages
English (en)
Inventor
Ester Fernandez-Salas
Patton Gary
Kei Aoki
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE533853T1 publication Critical patent/ATE533853T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • External Artificial Organs (AREA)
AT05724048T 2004-02-24 2005-02-23 Botulinumtoxin-screening-assays ATE533853T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54759104P 2004-02-24 2004-02-24
PCT/US2005/006421 WO2005082096A2 (en) 2004-02-24 2005-02-23 Botulinum toxin screening assays

Publications (1)

Publication Number Publication Date
ATE533853T1 true ATE533853T1 (de) 2011-12-15

Family

ID=34910920

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05724048T ATE533853T1 (de) 2004-02-24 2005-02-23 Botulinumtoxin-screening-assays

Country Status (9)

Country Link
US (3) US7598027B2 (de)
EP (1) EP1718756B1 (de)
JP (1) JP4970057B2 (de)
AT (1) ATE533853T1 (de)
AU (2) AU2005216547B2 (de)
CA (1) CA2558758C (de)
DK (1) DK1718756T3 (de)
ES (1) ES2374822T3 (de)
WO (1) WO2005082096A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332567B2 (en) * 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
US20080064054A1 (en) * 2001-08-28 2008-03-13 Ester Fernandez-Salas Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity
US7208285B2 (en) 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7374896B2 (en) * 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US7183066B2 (en) * 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
US8497081B2 (en) * 2004-02-24 2013-07-30 Allergan, Inc. Botulinum toxin screening assays
ATE533853T1 (de) * 2004-02-24 2011-12-15 Allergan Inc Botulinumtoxin-screening-assays
US7514088B2 (en) * 2005-03-15 2009-04-07 Allergan, Inc. Multivalent Clostridial toxin derivatives and methods of their use
US20080274480A1 (en) * 2004-08-04 2008-11-06 Allergan, Inc. Botulinum Toxin Type a Immunoresistant Assay
EP1861419B1 (de) * 2005-03-15 2011-06-29 Allergan, Inc. Modifizierte clostridientoxine mit erhöhter targeting-kapazität für endogene clostridientoxin-rezeptorsysteme
JP2009521666A (ja) * 2005-10-12 2009-06-04 アラーガン、インコーポレイテッド 共鳴エネルギー移動後の偏光解消（ｄａｒｅｔ）を用いる分子または細胞より小さい部分の相互作用力のアッセイ
CA2657460A1 (en) * 2006-07-11 2008-09-04 Allergan, Inc. Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity
US8445650B2 (en) * 2007-09-25 2013-05-21 Thomas Jefferson University Mutant botulinum neurotoxin serotype A polypeptide and uses thereof
KR101604515B1 (ko) * 2008-03-14 2016-03-17 알러간, 인코포레이티드 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정
LT3031825T (lt) * 2008-03-14 2020-02-10 Allergan, Inc. Botulino toksino serotipo a aktyvumo imuninio tyrimo būdai
EP2313435A4 (de) * 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc An den fibroblastenwachstumsfaktorrezeptor 3 (fgfr3) bindende proteine
KR20160103551A (ko) 2008-12-10 2016-09-01 알러간, 인코포레이티드 클로스트리디움 독소 약제학적 조성물
US8492109B2 (en) 2009-01-20 2013-07-23 Trustees Of Tufts College Methods for the delivery of toxins or enzymatically active portions thereof
WO2010105234A1 (en) * 2009-03-13 2010-09-16 Allergan, Inc. Cells useful for immuno-based botulinum toxin serotype a activity assays
EP2406629B9 (de) 2009-03-13 2014-03-26 Allergan, Inc. Immunbasierte testverfahren für endopeptidase-aktivität mit neuem ziel
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
LT2761065T (lt) * 2011-09-29 2018-01-10 Cellsnap, Llc Kompozicijos ir būdai toksigeniškumo testavimui
US10451621B2 (en) 2011-12-31 2019-10-22 Allergan, Inc. Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-A
US20150153325A1 (en) * 2012-05-11 2015-06-04 Patrick McNutt Toxin detection using stem cell derived neurons
CA3248592A1 (en) 2012-05-30 2025-11-29 President And Fellows Of Harvard College Engineered botulinum neurotoxin
US8962340B2 (en) 2012-12-03 2015-02-24 Src, Inc. Real-time assay for the detection of botulinum toxin
AU2013373679A1 (en) 2013-01-16 2015-08-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
EP3742165B1 (de) 2013-08-09 2023-06-21 BioMadison, Inc. Botulinumtoxin-assay mit erhöhter empfindlichkeit
EP3567055A1 (de) 2014-07-07 2019-11-13 Allergan, Inc. Verfahren zum nachweis von gespaltenem snap25 in gewebeproben
HUE057258T2 (hu) 2015-03-26 2022-05-28 Harvard College Szerkesztett Botulinum neurotoxin
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
MX2018016257A (es) 2016-07-07 2019-11-21 Therachon Sas Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos.
WO2018039506A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Engineered botulinum neurotoxin
WO2018053004A2 (en) 2016-09-13 2018-03-22 Allergan, Inc. Non-protein clostridial toxin compositions
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
RU2020123346A (ru) 2017-12-20 2022-01-20 Аллерган, Инк. Полипептиды клеточносвязывающего домена ботулинического токсина и способы применения для лечения расстройств, связанных с фиброзом
KR101940500B1 (ko) * 2018-11-29 2019-01-21 주식회사 에이비바이오 보툴리눔 독소 활성을 결정하기 위한 세포주 및 이를 이용한 활성 결정 방법
LT3660509T (lt) 2018-11-29 2022-05-10 Hugel Inc. Ląstelių panaudojimu paremtas būdas botulino toksino aktyvumui nustatyti
TW202113072A (zh) * 2019-06-07 2021-04-01 美商辛那皮克研究有限責任公司 基因工程化細胞
JP2020015733A (ja) * 2019-08-19 2020-01-30 アンセルムＩｎｓｅｒｍ 骨格成長遅延障害の予防または処置における使用のための、可溶性線維芽細胞増殖因子受容体３（ｆｇｒ３）ポリペプチド
AR123306A1 (es) 2020-08-21 2022-11-16 Genzyme Corp Anticuerpos fgfr3 y métodos de uso
BR112023024599A2 (pt) * 2021-05-24 2024-02-20 Atgc Co Ltd Células sensíveis à toxina botulínica dentro das quais um gene específico foi inserido por um lentivírus

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750365A (en) 1993-05-28 1998-05-12 The Ohio State University Research Foundation Isolated nucleic acid encoding a newt acidic fibroblast growth factor (AFGF)
US5962637A (en) * 1994-06-03 1999-10-05 Microbiological Research Authority Toxin assay
US5731161A (en) * 1995-04-24 1998-03-24 Allergan, Inc. Botulinum toxin antibody detection assay
US5965699A (en) * 1996-11-06 1999-10-12 The United States Of America As Represented By The Secretary Of The Army Assay for the proteolytic activity of serotype a from clostridium botulinum
US7923015B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
US7923216B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
US6794128B2 (en) * 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
IL128380A0 (en) 1999-02-04 2000-01-31 Yeda Res & Dev A method of screening for agonists and antagonists of FGFR
WO2001019973A2 (en) * 1999-09-15 2001-03-22 Janssen Pharmaceutica N.V. Nicotinic acetylcholine receptor: alpha10 subunit
US20030219462A1 (en) * 2000-07-21 2003-11-27 Allergan Sales, Inc Clostridial neurotoxin compositions and modified clostridial neurotoxins
US6913877B1 (en) * 2000-09-11 2005-07-05 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Methods for detecting bioactive compounds
IL138529A0 (en) * 2000-09-18 2003-09-17 Yeda Res & Dev High level expression of heterologous proteins
US7415358B2 (en) * 2001-05-22 2008-08-19 Ocimum Biosolutions, Inc. Molecular toxicology modeling
IL159177A0 (en) 2001-06-20 2004-06-01 Prochon Biotech Ltd Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
US7208285B2 (en) * 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US20080064054A1 (en) * 2001-08-28 2008-03-13 Ester Fernandez-Salas Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity
US20070118934A1 (en) * 2001-10-26 2007-05-24 Planet Biotechnology, Inc. Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax
WO2003083046A2 (en) * 2002-03-08 2003-10-09 Curagen Corporation Novel proteins and nucleic acids encoding same
IL149562A0 (en) * 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
JP2005538954A (ja) * 2002-05-31 2005-12-22 トーマス・ジェファーソン・ユニバーシティ 分子の経上皮輸送用組成物及び方法
US7183066B2 (en) 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
WO2004051222A2 (en) * 2002-12-03 2004-06-17 Ucb, S.A. Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
US7090985B2 (en) * 2002-12-03 2006-08-15 Ucb, S.A. Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
WO2004076634A2 (en) * 2003-02-24 2004-09-10 Ira Sanders Cell membrane translocation of regulated snare inhibitors , compositions therefor, and methods for treatment of disease
IL156495A0 (en) 2003-06-17 2004-01-04 Prochon Biotech Ltd Use of fgfr3 antagonists for treating t cell mediated diseases
CA2546970C (en) * 2003-12-02 2011-04-26 Ucb, S.A. Imidazole derivatives, processes for preparing them and their uses
US8048423B2 (en) * 2003-12-09 2011-11-01 Allergan, Inc. Botulinum toxin therapy for skin disorders
US20050129677A1 (en) * 2003-12-10 2005-06-16 Shengwen Li Lipid rafts and clostridial toxins
JP4656836B2 (ja) * 2003-12-19 2011-03-23 パナソニック株式会社 同期クロック生成装置及び同期クロック生成方法
ATE533853T1 (de) * 2004-02-24 2011-12-15 Allergan Inc Botulinumtoxin-screening-assays
WO2006012309A1 (en) * 2004-06-25 2006-02-02 Cold Spring Harbor Laboratory Inducible inactivation of synaptic transmission
ATE470857T1 (de) * 2005-04-05 2010-06-15 Allergan Inc Lipophile, farbstoffbasierte fret-assays für die clostridientoxinaktivität
EP1985276A1 (de) * 2007-04-26 2008-10-29 Merz Pharma GmbH & Co. KGaA Behandlung von Bewegungsstörungen durch die Verwendung einer Kombination aus einem Muskel entspannenden Wirkstoff und einer Bewegungstherapie

Also Published As

Publication number Publication date
EP1718756A2 (de) 2006-11-08
US20090317839A1 (en) 2009-12-24
US20080182799A1 (en) 2008-07-31
WO2005082096A3 (en) 2006-06-22
EP1718756A4 (de) 2008-06-04
CA2558758A1 (en) 2005-09-09
CA2558758C (en) 2015-06-23
JP4970057B2 (ja) 2012-07-04
AU2005216547B2 (en) 2009-03-12
US7598027B2 (en) 2009-10-06
EP1718756B1 (de) 2011-11-16
AU2005216547A1 (en) 2005-09-09
US8257914B2 (en) 2012-09-04
JP2007526770A (ja) 2007-09-20
DK1718756T3 (da) 2012-02-27
US20080003240A1 (en) 2008-01-03
AU2009202136B2 (en) 2011-12-22
AU2009202136A1 (en) 2009-06-18
US7645570B2 (en) 2010-01-12
WO2005082096A2 (en) 2005-09-09
ES2374822T3 (es) 2012-02-22

Similar Documents

Publication Publication Date Title
ATE533853T1 (de) Botulinumtoxin-screening-assays
ATE476659T1 (de) Sensor für mehrere analyte
ATE547705T1 (de) Kohlenhydratnachweissensor
EP1907001A4 (de) Ilt3-bindungsmoleküle und ihre verwendungen
WO2005073408A3 (en) Small segments of dna determine animal identity and source
ATE504002T1 (de) Erkennung und vorhersage von frühgeburten
BRPI0717633A2 (pt) Anticorpo, composição farmacêutica, e, métodos para detectar uma célula expressando cxcr7 em uma amostra biológica, para tratar, prevenir ou melhorar uma doença e para identificar um modulador de cxcr7
WO2008033427A3 (en) Compositions and methods for detection of lysosomal storage disease
MX2020006728A (es) Metodos para medir analito y/o proteina en muestras biologicas.
PT1989544E (pt) Ensaios com células t
CY1112090T1 (el) Μεθοδος για ανιχνευση βιολογικων οργανισμων με χρηση σκεδασης raman
ATE446509T1 (de) Serumfreie expansion von zellen in kultur
FR2901806B1 (fr) Dispositif et ensemble de controle microbiologique
ATE553386T1 (de) Bluttypisierung
DE602005015559D1 (de) Pharmakodynamische tests mit durchflusszytometrie
WO2012166630A3 (en) In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
DE602006008053D1 (de) Informationsverarbeitungsgerät mit Anzeige für Tintenbuchstaben und Braille, Informationsverarbeitungsverfahren und -programm
WO2007067984A3 (en) Neutralizing antibodies against primate psgl-1 and uses therefor
ATE460487T1 (de) Screening-test für ribosomale antibiotika
ATE540966T1 (de) Von phenoxazinon abgeleitete neue enzymsubstrate und deren verwendung als entwickler bei der detektion von mikroorganismen mit peptidaseaktivität
WO2005005955A8 (en) Specific detection of chitin using chitin-binding domain
ATE533053T1 (de) Nicht-elispot-test
SE0602683L (sv) Diagnostisk metod
ATE459000T1 (de) Verfahren für den nachweis von gad65 selbstreaktiven t-zellen
WO2009066454A1 (ja) 異常型プリオン蛋白質結合剤および異常型プリオン蛋白質の検出方法