ATE533853T1 - Botulinumtoxin-screening-assays - Google Patents

Botulinumtoxin-screening-assays

Info

Publication number
ATE533853T1
ATE533853T1 AT05724048T AT05724048T ATE533853T1 AT E533853 T1 ATE533853 T1 AT E533853T1 AT 05724048 T AT05724048 T AT 05724048T AT 05724048 T AT05724048 T AT 05724048T AT E533853 T1 ATE533853 T1 AT E533853T1
Authority
AT
Austria
Prior art keywords
methods
botulinum toxin
screening assays
bont
toxin screening
Prior art date
Application number
AT05724048T
Other languages
English (en)
Inventor
Ester Fernandez-Salas
Patton Gary
Kei Aoki
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE533853T1 publication Critical patent/ATE533853T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • External Artificial Organs (AREA)
AT05724048T 2004-02-24 2005-02-23 Botulinumtoxin-screening-assays ATE533853T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54759104P 2004-02-24 2004-02-24
PCT/US2005/006421 WO2005082096A2 (en) 2004-02-24 2005-02-23 Botulinum toxin screening assays

Publications (1)

Publication Number Publication Date
ATE533853T1 true ATE533853T1 (de) 2011-12-15

Family

ID=34910920

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05724048T ATE533853T1 (de) 2004-02-24 2005-02-23 Botulinumtoxin-screening-assays

Country Status (9)

Country Link
US (3) US7598027B2 (de)
EP (1) EP1718756B1 (de)
JP (1) JP4970057B2 (de)
AT (1) ATE533853T1 (de)
AU (2) AU2005216547B2 (de)
CA (1) CA2558758C (de)
DK (1) DK1718756T3 (de)
ES (1) ES2374822T3 (de)
WO (1) WO2005082096A2 (de)

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US7374896B2 (en) * 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
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US8497081B2 (en) * 2004-02-24 2013-07-30 Allergan, Inc. Botulinum toxin screening assays
ES2374822T3 (es) * 2004-02-24 2012-02-22 Allergan, Inc. Ensayo de selección de toxinas botul�?nicas.
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AU2006227816B2 (en) 2005-03-15 2012-04-05 Allergan, Inc. Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems
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WO2008105901A2 (en) * 2006-07-11 2008-09-04 Allergan, Inc. Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity
US8445650B2 (en) * 2007-09-25 2013-05-21 Thomas Jefferson University Mutant botulinum neurotoxin serotype A polypeptide and uses thereof
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KR101604515B1 (ko) * 2008-03-14 2016-03-17 알러간, 인코포레이티드 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정
EP2313435A4 (de) * 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc An den fibroblastenwachstumsfaktorrezeptor 3 (fgfr3) bindende proteine
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WO2010085473A1 (en) 2009-01-20 2010-07-29 Trustees Of Tufts College Methods for the delivery of toxins or enzymatically active portions thereof
KR101923847B1 (ko) * 2009-03-13 2018-11-29 알러간, 인코포레이티드 면역 기반 재표적화된 엔도펩티다제 활성 검정
BRPI1008940A2 (pt) 2009-03-13 2020-10-27 Allergan, Inc. linhagem de célula clonal estabelecida suscetível à intoxicação por bont/a
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
ES2653249T3 (es) * 2011-09-29 2018-02-06 Cellsnap, Llc Composiciones y métodos para ensayos de toxigenicidad
EP2798077A2 (de) 2011-12-31 2014-11-05 Allergan, Inc. Hochempfindlicher zellbasierter test für den nachweis der anwesenheit von aktivem botulinum-neurotoxin-serotyp-a
US20150153325A1 (en) * 2012-05-11 2015-06-04 Patrick McNutt Toxin detection using stem cell derived neurons
UA116985C2 (uk) 2012-05-30 2018-06-11 Президент Енд Феллоуз Оф Гарвард Колледж Рекомбінантний ботулінічний нейротоксин
US8962340B2 (en) 2012-12-03 2015-02-24 Src, Inc. Real-time assay for the detection of botulinum toxin
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KR20170026624A (ko) 2014-07-07 2017-03-08 알러간, 인코포레이티드 조직 샘플에서 절단된 snap25를 검출하는 방법
PT3274364T (pt) 2015-03-26 2021-11-05 Harvard College Neurotoxina botulínica manipulada
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
MX2018016257A (es) 2016-07-07 2019-11-21 Therachon Sas Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos.
EP3504226A1 (de) 2016-08-24 2019-07-03 President and Fellows of Harvard College Manipuliertes botulinumneurotoxin
KR102480965B1 (ko) 2016-09-13 2022-12-26 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
AU2018389104A1 (en) 2017-12-20 2020-07-30 Allergan, Inc. Botulinum toxin cell binding domain polypeptides and methods of use for skin rejuvenation
KR101940500B1 (ko) * 2018-11-29 2019-01-21 주식회사 에이비바이오 보툴리눔 독소 활성을 결정하기 위한 세포주 및 이를 이용한 활성 결정 방법
EP3825689A3 (de) 2018-11-29 2021-09-15 Hugel Inc. Zellbasiertes verfahren zur bestimmung der aktivität von botulinumtoxin
TW202113072A (zh) * 2019-06-07 2021-04-01 美商辛那皮克研究有限責任公司 基因工程化細胞
JP2020015733A (ja) * 2019-08-19 2020-01-30 アンセルムＩｎｓｅｒｍ 骨格成長遅延障害の予防または処置における使用のための、可溶性線維芽細胞増殖因子受容体３（ｆｇｒ３）ポリペプチド
CA3189470A1 (en) 2020-08-21 2022-02-24 Yves SABBAGH Fgfr3 antibodies and methods of use
EP4349992A4 (de) * 2021-05-24 2025-09-24 Atgc Co Ltd Gegen botulinumtoxin empfindliche zellen mit durch lentivirus eingefügten spezifischen genen

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Also Published As

Publication number Publication date
DK1718756T3 (da) 2012-02-27
CA2558758A1 (en) 2005-09-09
AU2009202136B2 (en) 2011-12-22
ES2374822T3 (es) 2012-02-22
US7645570B2 (en) 2010-01-12
AU2005216547B2 (en) 2009-03-12
WO2005082096A2 (en) 2005-09-09
US7598027B2 (en) 2009-10-06
CA2558758C (en) 2015-06-23
JP4970057B2 (ja) 2012-07-04
EP1718756B1 (de) 2011-11-16
US20090317839A1 (en) 2009-12-24
AU2009202136A1 (en) 2009-06-18
US20080003240A1 (en) 2008-01-03
US8257914B2 (en) 2012-09-04
JP2007526770A (ja) 2007-09-20
AU2005216547A1 (en) 2005-09-09
EP1718756A4 (de) 2008-06-04
WO2005082096A3 (en) 2006-06-22
US20080182799A1 (en) 2008-07-31
EP1718756A2 (de) 2006-11-08

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