ATE537260T1 - Terpen synthase/cyclase und olefin synthase sowie deren verwendung - Google Patents

Terpen synthase/cyclase und olefin synthase sowie deren verwendung

Info

Publication number: ATE537260T1
Authority: AT; Austria
Prior art keywords: bio; synthase; fragrance; flavor; encoding
Prior art date: 2001-02-12

Application number

AT02700889T

Other languages

English (en)

Inventor

Asaph Aharoni

Maarten Jongsma

Henricus Verhoeven

Hendrik Bouwmeester

Original Assignee

Monsanto Invest Nv

Enza Zaden Beheer Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-12

Filing date

2002-02-12

Publication date

2011-12-15

2002-02-12 Application filed by Monsanto Invest Nv, Enza Zaden Beheer Bv filed Critical Monsanto Invest Nv

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537260T1 publication Critical patent/ATE537260T1/de

Links

101710135150 (+)-T-muurolol synthase ((2E,6E)-farnesyl diphosphate cyclizing) Proteins 0.000 title 1
101710119400 Geranylfarnesyl diphosphate synthase Proteins 0.000 title 1
101710107752 Geranylgeranyl diphosphate synthase Proteins 0.000 title 1
150000001336 alkenes Chemical class 0.000 title 1
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 title 1
108010087432 terpene synthase Proteins 0.000 title 1
239000012681 biocontrol agent Substances 0.000 abstract 3
239000000796 flavoring agent Substances 0.000 abstract 3
235000019634 flavors Nutrition 0.000 abstract 3
239000003205 fragrance Substances 0.000 abstract 3
VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
VWFJDQUYCIWHTN-FBXUGWQNSA-N Farnesyl diphosphate Natural products CC(C)=CCC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-FBXUGWQNSA-N 0.000 abstract 2
GVVPGTZRZFNKDS-YFHOEESVSA-N Geranyl diphosphate Natural products CC(C)=CCC\C(C)=C/COP(O)(=O)OP(O)(O)=O GVVPGTZRZFNKDS-YFHOEESVSA-N 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
GVVPGTZRZFNKDS-JXMROGBWSA-N geranyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O GVVPGTZRZFNKDS-JXMROGBWSA-N 0.000 abstract 2
CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108020004707 nucleic acids Proteins 0.000 abstract 2
150000007523 nucleic acids Chemical class 0.000 abstract 2
102000039446 nucleic acids Human genes 0.000 abstract 2
FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 abstract 1
239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 abstract 1
CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 abstract 1
FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000010353 genetic engineering Methods 0.000 abstract 1
229930007744 linalool Natural products 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229930003658 monoterpene Natural products 0.000 abstract 1
150000002773 monoterpene derivatives Chemical class 0.000 abstract 1
235000002577 monoterpenes Nutrition 0.000 abstract 1
WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
229930004725 sesquiterpene Natural products 0.000 abstract 1
150000004354 sesquiterpene derivatives Chemical class 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Insects & Arthropods (AREA)
Pest Control & Pesticides (AREA)
Nutrition Science (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fats And Perfumes (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
General Preparation And Processing Of Foods (AREA)

AT02700889T 2001-02-12 2002-02-12 Terpen synthase/cyclase und olefin synthase sowie deren verwendung ATE537260T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01200488A EP1231273A1 (de)	2001-02-12	2001-02-12	Terpen Synthase/Cyclase und Olefin Synthase sowie deren Verwendung
PCT/NL2002/000089 WO2002064764A2 (en)	2001-02-12	2002-02-12	Terpene synthase/cyclase and olefin synthase and uses thereof

Publications (1)

Publication Number	Publication Date
ATE537260T1 true ATE537260T1 (de)	2011-12-15

Family

ID=8179877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02700889T ATE537260T1 (de)	2001-02-12	2002-02-12	Terpen synthase/cyclase und olefin synthase sowie deren verwendung

Country Status (6)

Country	Link
US (2)	US7453024B2 (de)
EP (2)	EP1231273A1 (de)
AT (1)	ATE537260T1 (de)
BR (1)	BR0207164A (de)
ES (1)	ES2379461T3 (de)
WO (1)	WO2002064764A2 (de)

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DE10201458A1 (de) *	2001-04-11	2002-10-17	Adelbert Bacher	Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
ES2607122T3 (es) *	2002-10-04	2017-03-29	Firmenich Sa	Sesquiterpeno sintasas y procedimientos de uso
NZ523384A (en) *	2002-12-24	2005-12-23	Horticulture & Food Res Inst	Enzymes and polynucleotides encoding the same
EP2388333A3 (de) *	2003-06-19	2012-04-04	Evolva SA	Verfahren zur Herstellung einer organischen Verbindung mit geringem Molekulargewicht in einer Zelle
BRPI0416912B1 (pt) *	2003-11-26	2020-01-28	Firmenich & Cie	método para a produção de patchoulol, método para preparar uma patchoulol sintase funcional variante, construção de ácido nucleico, vetor, método de obtenção de uma célula hospedeira recombinante, célula de microrganismo hospedeira, método de fabricação de uma patchoulol sintase
AU2003304604A1 (en) *	2003-12-09	2005-06-29	Firmenich Sa	Sesquiterpene synthases from patchouli
EP1874934B1 (de)	2005-04-19	2013-11-27	University of Kentucky Research Foundation	Transformierte pflanzen mit terpenanreicherung
JP5430929B2 (ja)	2005-06-17	2014-03-05	フイルメニツヒソシエテアノニム	新規セスキテルペン合成酵素ならびにその使用方法
EP2066778B1 (de) *	2006-09-26	2016-01-27	The Regents of The University of California	Herstellung von isoprenoiden und isoprenoidvorläufern
US20080241329A1 (en) *	2007-03-28	2008-10-02	Kraft Foods Holdings, Inc.	Antimicrobial composition and its use in ready-to-drink beverages
CN101896603A (zh) *	2007-06-01	2010-11-24	蓝宝石能源公司	使用遗传修饰的生物产生生物质降解酶
WO2009005704A1 (en) *	2007-07-03	2009-01-08	The Regents Of The University Of California	Methods of increasing isoprenoid or isoprenoid precursor production
WO2009015079A1 (en) *	2007-07-21	2009-01-29	The Samuel Roberts Noble Foundation, Inc.	Modification of plant disease resistance
NZ583620A (en) *	2007-09-11	2012-08-31	Sapphire Energy Inc	Methods of producing organic fuel products with photosynthetic organisms
EP2188376A4 (de) *	2007-09-11	2013-07-10	Sapphire Energy Inc	Molekülproduktion mittels photosynthetischer organismen
JP2011147432A (ja) *	2009-12-25	2011-08-04	Kirin Holdings Co Ltd	新規のテルペン類合成酵素活性を有するタンパク質とそれをコードする遺伝子
WO2012091165A1 (ja) *	2010-12-28	2012-07-05	サントリーホールディングス株式会社	モノテルペン配糖体化酵素の利用方法
US8741613B2 (en)	2012-05-16	2014-06-03	Glycos Biotechnologies, Inc.	Microorganisms and processes for the production of isoprene
WO2016008885A1 (en) *	2014-07-14	2016-01-21	Photanol B.V.	Biosynthesis of sesquiterpenes in cyanobacteria
US10266837B2 (en)	2014-10-22	2019-04-23	Temasek Life Sciences Laboratory Limited	Terpene synthases from ylang ylang (Cananga odorata var. fruticosa)
GB201500377D0 (en)	2015-01-09	2015-02-25	Micromass Ltd	Lock mass using chromatographic peaks
BR112018071518A2 (pt)	2016-04-22	2019-02-19	Receptor Life Sciences, Inc.	compostos medicinais à base de planta de ação rápida e suplementos nutricionais
EA201892396A1 (ru)	2016-12-02	2019-04-30	Ресептор Лайф Сайенсиз, Инк.	Быстродействующие растительные лекарственные соединения и биологически активные добавки
CN108893482B (zh) *	2018-06-22	2021-11-05	中国医学科学院药用植物研究所	丹参萜类合酶基因SmTPS8、其克隆引物、表达载体、催化产物及应用
AU2019385420A1 (en)	2018-11-19	2021-07-08	Spoke Sciences, Inc.	N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions
EP3739055A1 (de) *	2019-05-15	2020-11-18	Symrise AG	Biotechnologische herstellung von aromastoffen aus johannisbeertrester
CN113841707B (zh) *	2021-10-26	2022-07-05	中国热带农业科学院环境与植物保护研究所	反式法尼醇作为增效剂在防治荔枝霜疫病中的应用
EP4565691A1 (de) *	2022-11-14	2025-06-11	Agency for Science, Technology and Research	Biosynthese von isoprenoid

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2001
- 2001-02-12 EP EP01200488A patent/EP1231273A1/de not_active Withdrawn
2002
- 2002-02-12 WO PCT/NL2002/000089 patent/WO2002064764A2/en not_active Ceased
- 2002-02-12 ES ES02700889T patent/ES2379461T3/es not_active Expired - Lifetime
- 2002-02-12 BR BR0207164-9A patent/BR0207164A/pt not_active Application Discontinuation
- 2002-02-12 EP EP02700889A patent/EP1379663B1/de not_active Expired - Lifetime
- 2002-02-12 AT AT02700889T patent/ATE537260T1/de active
2003
- 2003-08-05 US US10/635,223 patent/US7453024B2/en not_active Expired - Fee Related
2008
- 2008-11-17 US US12/272,329 patent/US8338663B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20040161819A1 (en)	2004-08-19
WO2002064764A2 (en)	2002-08-22
US7453024B2 (en)	2008-11-18
US8338663B2 (en)	2012-12-25
ES2379461T3 (es)	2012-04-26
US20100144893A1 (en)	2010-06-10
EP1379663B1 (de)	2011-12-14
EP1379663A2 (de)	2004-01-14
EP1231273A1 (de)	2002-08-14
WO2002064764A3 (en)	2003-12-31
WO2002064764A8 (en)	2003-11-06
BR0207164A (pt)	2004-02-10

Publication	Publication Date	Title
ATE537260T1 (de)	2011-12-15	Terpen synthase/cyclase und olefin synthase sowie deren verwendung
NO20101157L (no)	2003-05-15	FAD4, FAD5, FAD5-2 og FAD6, nye fettsyredesaturase familiemedlemmer og anvendelser derav
GB2392672A (en)	2004-03-10	Mouse lambda light chain locus
Gräwert et al.	2004	IspH protein of Escherichia c oli: studies on Iron− Sulfur cluster implementation and catalysis
AU9635901A (en)	2002-04-08	Isoprenoid production
WO2002072758A3 (en)	2003-10-30	Cytochrome p450s and uses thereof
AU2003296151A1 (en)	2004-07-22	Process for producing dipeptide
PL371541A1 (en)	2005-06-27	Compounds for a controlled release of active molecules
AU8131294A (en)	1995-05-23	Human kunitz-type protease inhibitors
BR0102718A (pt)	2002-02-26	Processo em mais do que uma etapa para a preparação de oxo-aldeìdos e/ou de alcoóis
WO2005030984A3 (en)	2005-12-22	Method for small volume nucleic acid synthesis
DE60112200D1 (de)	2005-09-01	Verfahren zur Herstellung von Carbonyl- oder Hydroxy-Verbindungen
WO2005051984A3 (en)	2005-10-20	Methods for producing olfactory gpcrs
ATE458046T1 (de)	2010-03-15	Verfahren zur herstellung zytotoxischer lymphozyten
EP1406489A4 (de)	2005-08-24	Eukaryontische gene, die an der regulation des lebensalters als erwachsener beteiligt sind
WO2002101071A3 (en)	2006-02-02	Cd43:modulators of mast cell degranulation
ATE429439T1 (de)	2009-05-15	Ligierungsverfahren
WO2005021705A3 (en)	2005-04-21	Citrus sesquiterpene synthase, methods of production and uses thereof
WO2004021978A3 (en)	2005-04-21	Antisense modulation of endothelial specific molecule 1 expression
SE9502259L (sv)	1995-12-30	Oligonukleotider för att inhibera expression av isoprenylproteintransferas
MXPA03011134A (es)	2004-03-19	Produccion de 1,3-propanodiol, en un paso, a partir de oxido de etileno y gas de sintesis con catalizador que contiene ligando fosfolanoalcano.
BR0316224A (pt)	2005-10-04	Sequência de dna da região genÈmica tcd de photorhabdus luminescens
EP1318131A3 (de)	2003-10-29	Verfahren zur Herstellung von Tetrahydrogeraniol
WO2004102488A3 (de)	2005-03-03	Verfahren zur doppelbindungsisomerisierung bei olefinen
WO2023012111A3 (en)	2023-07-06	Novel production of aroma compounds with ionylideneethane synthases