BR0207164A - ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo, molécula proteinácea, vetor, hospedeiro, planta ou material de propagação derivado da mesma, método para produzir um sabor, fragância e/ou agente de bio-controle, composto, usos de um composto, de um ácido nucleico ou de um fragmento do mesmo, e de uma molécula proteinácea, composição, e, método de tratamento de doença - Google Patents

ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo, molécula proteinácea, vetor, hospedeiro, planta ou material de propagação derivado da mesma, método para produzir um sabor, fragância e/ou agente de bio-controle, composto, usos de um composto, de um ácido nucleico ou de um fragmento do mesmo, e de uma molécula proteinácea, composição, e, método de tratamento de doença

Info

Publication number
BR0207164A
BR0207164A BR0207164-9A BR0207164A BR0207164A BR 0207164 A BR0207164 A BR 0207164A BR 0207164 A BR0207164 A BR 0207164A BR 0207164 A BR0207164 A BR 0207164A
Authority
BR
Brazil
Prior art keywords
nucleic acid
proteinaceous molecule
compound
bio
fragrance
Prior art date
Application number
BR0207164-9A
Other languages
English (en)
Inventor
Asaph Aharoni
Maarten Anthonie Jongsma
Henricus Adrianus Verhoeven
Hendrik Jan Bouwmeester
Original Assignee
Plant Res Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plant Res Int Bv filed Critical Plant Res Int Bv
Publication of BR0207164A publication Critical patent/BR0207164A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

"áCIDO NUCLEICO ISOLADO OU RECOMBINANTE OU FRAGMENTO FUNCIONAL DO MESMO, MOLéCULA PROTEINáCEA, VETOR, HOSPEDEIRO, PLANTA OU MATERIAL DE PROPAGAçãO DERIVADO DA MESMA, MéTODO PARA PRODUZIR UM SABOR, FRAGRâNCIA E/OU AGENTE DE BIO-CONTROLE, COMPOSTO, USOS DE UM COMPOSTO, DE UM áCIDO NUCLEICO OU DE UM FRAGMENTO DO MESMO, E DE UMA MOLéCULA PROTEINáCEA, COMPOSIçãO, E, MéTODO DE TRATAMENTO DE DOENçA". A invenção refere-se ao campo de engenharia genética de desenvolvimento de sabor, fragrância e agente de bio-controle. Mais especificamente, ela refere-se a um processo para a produção de sabores, fragrâncias e agentes de bio-controle naturais pelo controle de um ou mais genes implicados no processo. A invenção provê um ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo codificando uma molécula proteinácea essencialmente capaz de síntese de sabor, fragrância e/ou agente de bio-controle quando provido com um substrato apropriado sob condições de reação apropriadas. A invenção ainda provê um ácido nucleico ou fragrância funcional do mesmo codificando uma molécula proteinácea essencialmente capaz de sintetizar pelo menos um álcool monoterpeno linalool quando contatada com difosfatos de geranila (GPP) e/ou pelo menos um álcool sesquiterpeno nerolidol quando contatada com difosfato de farnesila (FPP) sob condições de reação apropriadas.
BR0207164-9A 2001-02-12 2002-02-12 ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo, molécula proteinácea, vetor, hospedeiro, planta ou material de propagação derivado da mesma, método para produzir um sabor, fragância e/ou agente de bio-controle, composto, usos de um composto, de um ácido nucleico ou de um fragmento do mesmo, e de uma molécula proteinácea, composição, e, método de tratamento de doença BR0207164A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200488A EP1231273A1 (en) 2001-02-12 2001-02-12 Terpene synthase/cyclase and olefin synthase and uses thereof
PCT/NL2002/000089 WO2002064764A2 (en) 2001-02-12 2002-02-12 Terpene synthase/cyclase and olefin synthase and uses thereof

Publications (1)

Publication Number Publication Date
BR0207164A true BR0207164A (pt) 2004-02-10

Family

ID=8179877

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207164-9A BR0207164A (pt) 2001-02-12 2002-02-12 ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo, molécula proteinácea, vetor, hospedeiro, planta ou material de propagação derivado da mesma, método para produzir um sabor, fragância e/ou agente de bio-controle, composto, usos de um composto, de um ácido nucleico ou de um fragmento do mesmo, e de uma molécula proteinácea, composição, e, método de tratamento de doença

Country Status (6)

Country Link
US (2) US7453024B2 (pt)
EP (2) EP1231273A1 (pt)
AT (1) ATE537260T1 (pt)
BR (1) BR0207164A (pt)
ES (1) ES2379461T3 (pt)
WO (1) WO2002064764A2 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939091B2 (en) * 1999-08-06 2011-05-10 Iowa State University Research Foundation, Inc. Biorational repellents obtained from terpenoids for use against arthropods
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
ES2607122T3 (es) * 2002-10-04 2017-03-29 Firmenich Sa Sesquiterpeno sintasas y procedimientos de uso
NZ523384A (en) * 2002-12-24 2005-12-23 Horticulture & Food Res Inst Enzymes and polynucleotides encoding the same
WO2004111254A1 (en) * 2003-06-19 2004-12-23 Poalis A/S A method of producing a low molecular weight organic compound in a cell
RU2006122534A (ru) 2003-11-26 2008-01-10 Фирмениш Са (Ch) Сесквитерпен синтезы из пачулей
WO2005056803A1 (en) * 2003-12-09 2005-06-23 Firmenich Sa Sesquiterpene synthases from patchouli
WO2006111924A2 (en) * 2005-04-19 2006-10-26 University Of Kentucky Research Foundation Transformed plants accumulating terpenes
JP5430929B2 (ja) * 2005-06-17 2014-03-05 フイルメニツヒ ソシエテ アノニム 新規セスキテルペン合成酵素ならびにその使用方法
EP2066778B1 (en) * 2006-09-26 2016-01-27 The Regents of The University of California Production of isoprenoids and isoprenoid precursors
US20080241329A1 (en) * 2007-03-28 2008-10-02 Kraft Foods Holdings, Inc. Antimicrobial composition and its use in ready-to-drink beverages
WO2008150461A2 (en) 2007-06-01 2008-12-11 Sapphire Energy High throughput screening of genetically modified photosynthetic organisms
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
WO2009015079A1 (en) * 2007-07-21 2009-01-29 The Samuel Roberts Noble Foundation, Inc. Modification of plant disease resistance
AU2008299020A1 (en) * 2007-09-11 2009-03-19 Sapphire Energy, Inc. Molecule production by photosynthetic organisms
NZ583620A (en) * 2007-09-11 2012-08-31 Sapphire Energy Inc Methods of producing organic fuel products with photosynthetic organisms
JP2011147432A (ja) * 2009-12-25 2011-08-04 Kirin Holdings Co Ltd 新規のテルペン類合成酵素活性を有するタンパク質とそれをコードする遺伝子
WO2012091165A1 (ja) * 2010-12-28 2012-07-05 サントリーホールディングス株式会社 モノテルペン配糖体化酵素の利用方法
US8741613B2 (en) 2012-05-16 2014-06-03 Glycos Biotechnologies, Inc. Microorganisms and processes for the production of isoprene
WO2016008885A1 (en) * 2014-07-14 2016-01-21 Photanol B.V. Biosynthesis of sesquiterpenes in cyanobacteria
WO2016064347A1 (en) 2014-10-22 2016-04-28 Temasek Life Sciences Laboratory Limited Terpene synthases from ylang ylang (cananga odorata var. fruticosa)
GB201500377D0 (en) 2015-01-09 2015-02-25 Micromass Ltd Lock mass using chromatographic peaks
EP3928776B1 (en) 2016-04-22 2025-11-12 Spoke Sciences, Inc. Fast-acting plant-based medicinal compounds and nutritional supplements
EA201892396A1 (ru) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. Быстродействующие растительные лекарственные соединения и биологически активные добавки
CN108893482B (zh) * 2018-06-22 2021-11-05 中国医学科学院药用植物研究所 丹参萜类合酶基因SmTPS8、其克隆引物、表达载体、催化产物及应用
AU2019385420A1 (en) 2018-11-19 2021-07-08 Spoke Sciences, Inc. N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions
EP3739055A1 (de) * 2019-05-15 2020-11-18 Symrise AG Biotechnologische herstellung von aromastoffen aus johannisbeertrester
CN113841707B (zh) * 2021-10-26 2022-07-05 中国热带农业科学院环境与植物保护研究所 反式法尼醇作为增效剂在防治荔枝霜疫病中的应用
EP4565691A1 (en) * 2022-11-14 2025-06-11 Agency for Science, Technology and Research Biosynthesis of isoprenoid

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4041185A (en) * 1975-08-25 1977-08-09 General Foods Corporation Blueberry flavor
US4775534A (en) 1986-02-05 1988-10-04 Fermone Chemicals, Inc. Miticidal composition and method for controlling spider mite populations
US5116602A (en) * 1989-09-27 1992-05-26 Colgate-Palmolive Company Antiplaque oral compositions
CA2071943C (en) 1989-12-22 2007-04-24 Joan Tellefsen Odell Site-specific recombination of dna in plant cells
US5196200A (en) * 1991-04-25 1993-03-23 International Flavors & Fragrances Inc. Bisabolene-containing composition, process for preparing same, organoleptic uses thereof and uses thereof as insect repellent
US6291745B1 (en) * 1993-04-02 2001-09-18 Pioneer Hi-Bred International, Inc. Limonene and other downstream metabolites of geranyl pyrophosphate for insect control in plants
CA2222023C (en) 1995-05-24 1999-11-23 Terry E. Meyer Corn rootworm control via formation of limonene in transgenic plants
EP0858507A2 (en) * 1995-10-12 1998-08-19 The Regents of The University of Michigan Use of linalool synthase in genetic engineering of scent production
US5849526A (en) * 1996-10-15 1998-12-15 The Regents Of The University Of Michigan Use of linalool synthase in genetic engineering of scent production
AU746684B2 (en) * 1997-09-02 2002-05-02 Washington State University Research Foundation Nucleic and amino acid sequences for a novel transketolase from $i (Mentha Piperita)
US6265639B1 (en) * 1998-01-22 2001-07-24 Washington State University Foundation Gymnosperm nucleic acid molecules encoding sesquiterpene synthases and methods of use
EP0982404A1 (en) 1998-08-27 2000-03-01 Wallaart, Thorvald Eelco DNA encoding amorpha-4,11-diene synthase

Also Published As

Publication number Publication date
US20100144893A1 (en) 2010-06-10
WO2002064764A3 (en) 2003-12-31
US20040161819A1 (en) 2004-08-19
US7453024B2 (en) 2008-11-18
US8338663B2 (en) 2012-12-25
ES2379461T3 (es) 2012-04-26
EP1231273A1 (en) 2002-08-14
WO2002064764A8 (en) 2003-11-06
ATE537260T1 (de) 2011-12-15
WO2002064764A2 (en) 2002-08-22
EP1379663A2 (en) 2004-01-14
EP1379663B1 (en) 2011-12-14

Similar Documents

Publication Publication Date Title
BR0207164A (pt) ácido nucleico isolado ou recombinante ou fragmento funcional do mesmo, molécula proteinácea, vetor, hospedeiro, planta ou material de propagação derivado da mesma, método para produzir um sabor, fragância e/ou agente de bio-controle, composto, usos de um composto, de um ácido nucleico ou de um fragmento do mesmo, e de uma molécula proteinácea, composição, e, método de tratamento de doença
Wang et al. Transcriptomics integrated with free and bound terpenoid aroma profiling during “shine muscat”(Vitis labrusca× V. vinifera) grape berry development reveals coordinate regulation of MEP pathway and terpene synthase gene expression
Oberhauser et al. Exploiting the synthetic potential of sesquiterpene cyclases for generating unnatural terpenoids
Agudelo-Romero et al. Search for transcriptional and metabolic markers of grape pre-ripening and ripening and insights into specific aroma development in three Portuguese cultivars
Wang et al. Heteromeric geranylgeranyl diphosphate synthase contributes to carotenoid biosynthesis in ripening fruits of red pepper (Capsicum annuum var. conoides)
WO2002072758A3 (en) Cytochrome p450s and uses thereof
BRPI0418019A (pt) molécula de ácido nucléico isolada, cassette de expressão, vetor e métodos de expressão de sequências de nucleotìdeos em plantas e células de planta
Ibdah et al. Identification and cloning of an NADPH-dependent hydroxycinnamoyl-CoA double bond reductase involved in dihydrochalcone formation in Malus× domestica Borkh.
BR0112979A (pt) Método de produzir domìnios de proteìna funcional
ATE409512T1 (de) Verbindungen zur kontrollierten freigabe aktiver molekülen
ATE297460T1 (de) Hopfenextrakte, verfahren zu ihrer herstellung und verwendung
BR0208453A (pt) composições e métodos de desintoxicação de zearalenona
Jirovetz et al. Purity, antimicrobial activities and olfactoric evaluations of geraniol/nerol and various of their derivatives
AR036962A1 (es) Metiltransferasas aromaticas y usos de las mismas
RU2010101024A (ru) Способ синтеза белка с модифицированным профилем n-гликозилирования в растениях
AR036272A1 (es) Genes de metiltransferasas y usos de los mismos
JP2000508902A (ja) タキソール生合成のための組成物および製造方法
BR0211661A (pt) Molécula de ácido nucléico isolada, polipeptìdeo, gene quimérico, célula hospedeira transformada, método de obtenção, produto, método de produção, método de regulação e gene mutado
BRPI0415362A (pt) molécula de ácido nucleico isolada a partir de nicotina, proteìna isolada de nicotina, planta transgênica, métodos de produção de uma planta transgênica, de seleção de uma planta contendo uma molécula de ácido nucleico, e de aumento ou diminuição dos nìveis de nornicotina em uma planta, produto e folha de tabaco tendo quantidades reduzidas de nìveis de nornicotina, e, método de isolamento de um gene de uma planta
ATE397067T1 (de) Saatpflanzen mit charakteristisch verzögerter samenstreuung
Tan et al. Transcriptomic and metabolomics of flavonoid compounds in Actinidia arguta var. arguta
Cao et al. Identification and functional analysis of floral terpene synthase genes in Curcuma alismatifolia
AU778014B2 (en) Method for the production of vitamin A
JP4488453B2 (ja) エーテル化合物、香料組成物、香料賦与製品、風味組成物、風味付けされた製品および芳香または風味特性を賦与、改良、増加または改質する方法
WO2005021705A3 (en) Citrus sesquiterpene synthase, methods of production and uses thereof

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: PLANT RESEARCH INTERNATIONAL B.V. (NL)

Free format text: ALTERADA A SEDE DO TITULAR CONFORME SOLICITADO NA PETICAO NO 017783/RJ DE 31/03/2004.

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]