ATE539057T1 - Verfahren zur herstellung von disubstituiertem piperidin und zwischenprodukten davon - Google Patents
Verfahren zur herstellung von disubstituiertem piperidin und zwischenprodukten davonInfo
- Publication number
- ATE539057T1 ATE539057T1 AT08870986T AT08870986T ATE539057T1 AT E539057 T1 ATE539057 T1 AT E539057T1 AT 08870986 T AT08870986 T AT 08870986T AT 08870986 T AT08870986 T AT 08870986T AT E539057 T1 ATE539057 T1 AT E539057T1
- Authority
- AT
- Austria
- Prior art keywords
- derivative
- action
- acid derivative
- hydroxyimino
- formula
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- YNHDBHLHJZFURN-UHFFFAOYSA-N 2-hydroxyiminohexanoic acid Chemical class CCCCC(=NO)C(O)=O YNHDBHLHJZFURN-UHFFFAOYSA-N 0.000 abstract 12
- 239000002253 acid Substances 0.000 abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- DNUTZBZXLPWRJG-UHFFFAOYSA-N 1-Piperidine carboxylic acid Chemical class OC(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical class CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 2
- 150000002443 hydroxylamines Chemical class 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- PEUGKEHLRUVPAN-UHFFFAOYSA-N piperidin-3-amine Chemical class NC1CCCNC1 PEUGKEHLRUVPAN-UHFFFAOYSA-N 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- SYNHCENRCUAUNM-UHFFFAOYSA-N Nitrogen mustard N-oxide hydrochloride Chemical compound Cl.ClCC[N+]([O-])(C)CCCl SYNHCENRCUAUNM-UHFFFAOYSA-N 0.000 abstract 1
- 125000006242 amine protecting group Chemical group 0.000 abstract 1
- XJLSEXAGTJCILF-UHFFFAOYSA-N nipecotic acid Chemical class OC(=O)C1CCCNC1 XJLSEXAGTJCILF-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0706449A FR2921060B1 (fr) | 2007-09-14 | 2007-09-14 | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
| PCT/FR2008/001280 WO2009090320A1 (fr) | 2007-09-14 | 2008-09-12 | Procede de preparation d'une piperidine disubstituee et intermediaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539057T1 true ATE539057T1 (de) | 2012-01-15 |
Family
ID=39428023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08870986T ATE539057T1 (de) | 2007-09-14 | 2008-09-12 | Verfahren zur herstellung von disubstituiertem piperidin und zwischenprodukten davon |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8288553B2 (de) |
| EP (1) | EP2200983B1 (de) |
| JP (1) | JP5421265B2 (de) |
| CN (1) | CN102056901B (de) |
| AT (1) | ATE539057T1 (de) |
| CA (1) | CA2699438C (de) |
| ES (1) | ES2380098T3 (de) |
| FR (1) | FR2921060B1 (de) |
| WO (1) | WO2009090320A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| SG191320A1 (en) * | 2010-12-22 | 2013-07-31 | Meiji Seika Pharma Co Ltd | Optically-active diazabicyclooctane derivative and method for manufacturing same |
| SG191831A1 (en) * | 2011-03-31 | 2013-08-30 | Kaneka Corp | Process for preparing cyclic amine compounds |
| TWI565706B (zh) | 2011-06-17 | 2017-01-11 | 阿斯特捷利康公司 | 用於製備包括反－７－酮基－６－（磺酸氧基）－１，６－二氮雜雙環［３，２，１］辛烷－２－甲醯胺之雜環化合物及其鹽類之方法 |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| US8969570B2 (en) | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| SG11201406123TA (en) | 2012-03-30 | 2014-10-30 | Cubist Pharm Inc | 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE β-LACTAMASE INHIBITORS |
| TW201343646A (zh) | 2012-03-30 | 2013-11-01 | Cubist Pharm Inc | 異□唑β－內醯胺酶抑制劑 |
| US8916709B2 (en) | 2012-03-30 | 2014-12-23 | Cubist Pharmaceuticals, Inc. | 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors |
| WO2013180197A1 (ja) * | 2012-05-30 | 2013-12-05 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 新規β－ラクタマーゼ阻害剤とその製造法 |
| UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| US9862718B2 (en) | 2013-03-08 | 2018-01-09 | Wockhardt Limited | Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation |
| US9120795B2 (en) | 2013-03-14 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | Crystalline form of a β-lactamase inhibitor |
| NZ718009A (en) | 2013-09-24 | 2018-03-23 | Meiji Seika Pharma Co Ltd | Process for producing diazabicyclooctane derivative and intermediate thereof |
| US9120796B2 (en) | 2013-10-02 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | B-lactamase inhibitor picoline salt |
| CN105612159A (zh) | 2013-10-08 | 2016-05-25 | 明治制果药业株式会社 | 二氮杂二环辛烷衍生物的结晶及其制备方法 |
| TWI691499B (zh) | 2014-12-05 | 2020-04-21 | 日商明治製菓藥業股份有限公司 | 二氮雜雙環辛烷衍生物之結晶及安定的凍結乾燥製劑的製造法 |
| EP3411359B1 (de) * | 2016-02-04 | 2021-10-13 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung von hydroxylaminderivaten, die in der herstellung von infektionsschutzmitteln nützlich sind |
| CN107540601B (zh) * | 2016-06-28 | 2019-07-19 | 新发药业有限公司 | 5r-苄氧氨基哌啶-2s-甲酸酯及其草酸盐的便捷制备方法 |
| CN107540600B (zh) * | 2016-06-28 | 2019-07-09 | 新发药业有限公司 | 一种阿维巴坦中间体生产废液的回收利用方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| CN109400521B (zh) * | 2017-08-18 | 2020-05-08 | 新发药业有限公司 | 一种改进的5r-苄氧氨基哌啶-2s-甲酸酯、其草酸盐的制备方法 |
| CN109956941B (zh) | 2017-12-25 | 2020-08-04 | 新发药业有限公司 | 一种阿维巴坦的简便制备方法 |
| CN109970625B (zh) | 2017-12-28 | 2021-02-26 | 新发药业有限公司 | 一种5r-苄氧氨基哌啶-2s-甲酸或其衍生物的制备方法 |
| WO2020219405A1 (en) * | 2019-04-26 | 2020-10-29 | Merck Sharp & Dohme Corp. | Process for the preparation of intermediates useful for making (2s,5r)-7-oxo-n-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide |
| CN110498762B (zh) * | 2019-08-28 | 2020-10-27 | 山东安信制药有限公司 | 一种(2s,5r)-5-[(苄氧基)氨基]-哌啶-2-甲酸乙酯的合成方法 |
| EP4146650B1 (de) | 2020-09-01 | 2026-01-21 | Ningxia Academy of Agriculture and Forestry Sciences | Beta-lactamase-hemmer und ihre herstellung |
| EP4146651B1 (de) | 2021-05-07 | 2026-03-04 | Ningxia Academy of Agriculture and Forestry Sciences | Sulfonylamidinsubstituierte verbindungen und ihre verwendung als beta-lactamase-hemmer |
| CN114989169A (zh) * | 2022-07-04 | 2022-09-02 | 哈药集团技术中心 | 一种阿维巴坦钠的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5059377A (de) * | 1973-10-04 | 1975-05-22 | ||
| JPS63162666A (ja) * | 1986-12-26 | 1988-07-06 | Asahi Chem Ind Co Ltd | アミノオキシ酢酸誘導体およびその製造方法 |
| JPH0393762A (ja) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法 |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| US6399793B1 (en) * | 2000-08-16 | 2002-06-04 | Bristol-Myers Squibb Company | Process for the preparation of α' chloroketones |
| FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2833596B1 (fr) | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| JP3935126B2 (ja) * | 2003-09-24 | 2007-06-20 | 雅裕 亀田 | 装飾用灯具 |
| US7396934B2 (en) | 2003-11-17 | 2008-07-08 | Youssef El-Ahmad | Process for preparing 3-fluoroquinolines |
| JP2007126358A (ja) * | 2004-01-20 | 2007-05-24 | Fujiyakuhin Co Ltd | フェニルアラニン誘導体 |
-
2007
- 2007-09-14 FR FR0706449A patent/FR2921060B1/fr active Active
-
2008
- 2008-09-12 AT AT08870986T patent/ATE539057T1/de active
- 2008-09-12 ES ES08870986T patent/ES2380098T3/es active Active
- 2008-09-12 WO PCT/FR2008/001280 patent/WO2009090320A1/fr not_active Ceased
- 2008-09-12 EP EP08870986A patent/EP2200983B1/de active Active
- 2008-09-12 US US12/677,741 patent/US8288553B2/en active Active
- 2008-09-12 CA CA2699438A patent/CA2699438C/en active Active
- 2008-09-12 JP JP2010524543A patent/JP5421265B2/ja active Active
- 2008-09-12 CN CN200880106715.8A patent/CN102056901B/zh active Active
-
2012
- 2012-09-14 US US13/616,995 patent/US20130012712A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| FR2921060A1 (fr) | 2009-03-20 |
| CN102056901B (zh) | 2014-09-03 |
| CN102056901A (zh) | 2011-05-11 |
| EP2200983B1 (de) | 2011-12-28 |
| FR2921060B1 (fr) | 2012-06-15 |
| JP5421265B2 (ja) | 2014-02-19 |
| EP2200983A1 (de) | 2010-06-30 |
| JP2010539147A (ja) | 2010-12-16 |
| CA2699438A1 (en) | 2009-07-23 |
| ES2380098T3 (es) | 2012-05-08 |
| US8288553B2 (en) | 2012-10-16 |
| HK1145324A1 (en) | 2011-04-15 |
| US20100197928A1 (en) | 2010-08-05 |
| CA2699438C (en) | 2016-11-22 |
| US20130012712A1 (en) | 2013-01-10 |
| WO2009090320A1 (fr) | 2009-07-23 |
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