ATE544452T1 - Pharmazeutisch aktive isoindolin-derivate - Google Patents

Pharmazeutisch aktive isoindolin-derivate

Info

Publication number: ATE544452T1
Authority: AT; Austria
Prior art keywords: pharmaceutically active; isoindoline derivatives; active isoindoline; derivatives; oxoisoindoline
Prior art date: 1999-11-12

Application number

AT10176420T

Other languages

English (en)

Inventor

Hon-Wah Man

George W Muller

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-12

Filing date

2000-11-09

Publication date

2012-02-15

2000-11-09 Application filed by Celgene Corp filed Critical Celgene Corp

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE544452T1 publication Critical patent/ATE544452T1/de

Links

GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
QDZOBXFRIVOQBR-LJQANCHMSA-N n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-3-oxo-1h-isoindol-4-yl]cyclopropanecarboxamide Chemical compound C1=C(OC)C(OCC)=CC([C@@H](CS(C)(=O)=O)N2C(C3=C(NC(=O)C4CC4)C=CC=C3C2)=O)=C1 QDZOBXFRIVOQBR-LJQANCHMSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Virology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT10176420T 1999-11-12 2000-11-09 Pharmazeutisch aktive isoindolin-derivate ATE544452T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16516899P	1999-11-12	1999-11-12
US59034400A	2000-06-08	2000-06-08
US09/708,199 US6667316B1 (en)	1999-11-12	2000-11-08	Pharmaceutically active isoindoline derivatives

Publications (1)

Publication Number	Publication Date
ATE544452T1 true ATE544452T1 (de)	2012-02-15

Family

ID=27389110

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
AT06009632T ATE506058T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch aktive isoindolin-derivate
AT10176390T ATE544451T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch aktive isoindolin-derivate
AT00977095T ATE357913T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch-aktive isoindolin-derivate
AT10176420T ATE544452T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch aktive isoindolin-derivate

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
AT06009632T ATE506058T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch aktive isoindolin-derivate
AT10176390T ATE544451T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch aktive isoindolin-derivate
AT00977095T ATE357913T1 (de)	1999-11-12	2000-11-09	Pharmazeutisch-aktive isoindolin-derivate

Country Status (19)

Country	Link
US (1)	US6667316B1 (de)
EP (4)	EP1228071B8 (de)
JP (1)	JP5116201B2 (de)
CN (1)	CN1325497C (de)
AT (4)	ATE506058T1 (de)
AU (2)	AU782409B2 (de)
CA (1)	CA2392081C (de)
CY (2)	CY1107610T1 (de)
DE (1)	DE60034139T2 (de)
DK (2)	DK1228071T3 (de)
ES (4)	ES2282147T3 (de)
FI (1)	FI119931B (de)
HK (1)	HK1049158A1 (de)
MX (1)	MXPA02004793A (de)
NO (2)	NO323633B1 (de)
NZ (1)	NZ519459A (de)
PT (2)	PT1228071E (de)
SI (1)	SI1228071T1 (de)
WO (1)	WO2001034606A1 (de)

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2000
- 2000-11-08 US US09/708,199 patent/US6667316B1/en not_active Expired - Lifetime
- 2000-11-09 CN CNB00818254XA patent/CN1325497C/zh not_active Expired - Fee Related
- 2000-11-09 ES ES00977095T patent/ES2282147T3/es not_active Expired - Lifetime
- 2000-11-09 AT AT06009632T patent/ATE506058T1/de not_active IP Right Cessation
- 2000-11-09 EP EP00977095A patent/EP1228071B8/de not_active Expired - Lifetime
- 2000-11-09 MX MXPA02004793A patent/MXPA02004793A/es active IP Right Grant
- 2000-11-09 ES ES06009632T patent/ES2363933T3/es not_active Expired - Lifetime
- 2000-11-09 ES ES10176420T patent/ES2380574T3/es not_active Expired - Lifetime
- 2000-11-09 EP EP10176420A patent/EP2263669B1/de not_active Expired - Lifetime
- 2000-11-09 DK DK00977095T patent/DK1228071T3/da active
- 2000-11-09 CA CA002392081A patent/CA2392081C/en not_active Expired - Fee Related
- 2000-11-09 NZ NZ519459A patent/NZ519459A/en not_active IP Right Cessation
- 2000-11-09 JP JP2001536553A patent/JP5116201B2/ja not_active Expired - Fee Related
- 2000-11-09 DE DE60034139T patent/DE60034139T2/de not_active Expired - Lifetime
- 2000-11-09 AU AU14780/01A patent/AU782409B2/en not_active Ceased
- 2000-11-09 DK DK10176420.7T patent/DK2263669T3/da active
- 2000-11-09 AT AT10176390T patent/ATE544451T1/de active
- 2000-11-09 AT AT00977095T patent/ATE357913T1/de active
- 2000-11-09 EP EP10176390A patent/EP2255801B1/de not_active Expired - Lifetime
- 2000-11-09 SI SI200030951T patent/SI1228071T1/sl unknown
- 2000-11-09 PT PT00977095T patent/PT1228071E/pt unknown
- 2000-11-09 ES ES10176390T patent/ES2381174T3/es not_active Expired - Lifetime
- 2000-11-09 PT PT10176420T patent/PT2263669E/pt unknown
- 2000-11-09 HK HK03100819.6A patent/HK1049158A1/zh unknown
- 2000-11-09 AT AT10176420T patent/ATE544452T1/de active
- 2000-11-09 WO PCT/US2000/030770 patent/WO2001034606A1/en not_active Ceased
- 2000-11-09 EP EP06009632A patent/EP1698334B1/de not_active Expired - Lifetime
2002
- 2002-05-08 NO NO20022223A patent/NO323633B1/no not_active IP Right Cessation
- 2002-05-10 FI FI20020892A patent/FI119931B/fi not_active IP Right Cessation
2005
- 2005-07-07 AU AU2005202964A patent/AU2005202964B2/en not_active Ceased
2007
- 2007-03-21 NO NO20071490A patent/NO336210B1/no not_active IP Right Cessation
- 2007-04-05 CY CY20071100487T patent/CY1107610T1/el unknown
2012
- 2012-04-26 CY CY20121100399T patent/CY1112707T1/el unknown

Also Published As

Publication number	Publication date
CN1420889A (zh)	2003-05-28
JP5116201B2 (ja)	2013-01-09
ATE544451T1 (de)	2012-02-15
CY1107610T1 (el)	2013-03-13
CY1112707T1 (el)	2016-02-10
ES2282147T3 (es)	2007-10-16
DE60034139D1 (de)	2007-05-10
NO20022223L (no)	2002-07-08
AU782409B2 (en)	2005-07-28
NO20022223D0 (no)	2002-05-08
EP1228071A4 (de)	2002-12-04
NO20071490L (no)	2002-07-08
ES2381174T3 (es)	2012-05-23
DE60034139T2 (de)	2007-12-06
FI20020892L (fi)	2002-06-20
CN1325497C (zh)	2007-07-11
HK1053467A1 (en)	2003-10-24
AU2005202964A1 (en)	2005-08-11
AU2005202964B2 (en)	2007-11-22
EP2255801A1 (de)	2010-12-01
EP1228071A1 (de)	2002-08-07
JP2004500346A (ja)	2004-01-08
NZ519459A (en)	2003-11-28
DK2263669T3 (da)	2012-04-23
CA2392081C (en)	2010-01-05
FI119931B (fi)	2009-05-15
EP1698334B1 (de)	2011-04-20
PT1228071E (pt)	2007-05-31
ES2380574T3 (es)	2012-05-16
EP1228071B8 (de)	2012-02-29
PT2263669E (pt)	2012-04-23
WO2001034606A1 (en)	2001-05-17
EP2255801B1 (de)	2012-02-08
MXPA02004793A (es)	2003-10-14
SI1228071T1 (sl)	2007-08-31
EP1228071B1 (de)	2007-03-28
DK1228071T3 (da)	2007-08-06
CA2392081A1 (en)	2001-05-17
ES2363933T3 (es)	2011-08-19
HK1049158A1 (zh)	2003-05-02
ATE506058T1 (de)	2011-05-15
US6667316B1 (en)	2003-12-23
FI20020892A0 (fi)	2002-05-10
EP2263669B1 (de)	2012-02-08
NO323633B1 (no)	2007-06-18
AU1478001A (en)	2001-06-06
ATE357913T1 (de)	2007-04-15
EP1698334A1 (de)	2006-09-06
NO336210B1 (no)	2015-06-15
EP2263669A1 (de)	2010-12-22

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