ATE548450T1 - Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung - Google Patents

Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Info

Publication number: ATE548450T1
Authority: AT; Austria
Prior art keywords: polypeptides; activity; production; monatin; methods
Prior art date: 2006-03-07

Application number

AT07758102T

Other languages

English (en)

Inventor

Ellen Burke

Paula Hicks

Peter Luginbuhl

Toby Richardson

David Weiner

Lishan Zhao

Original Assignee

Verenium Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-07

Filing date

2007-03-07

Publication date

2012-03-15

2007-03-07 Application filed by Verenium Corp filed Critical Verenium Corp

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE548450T1 publication Critical patent/ATE548450T1/de

Links

102000003677 Aldehyde-Lyases Human genes 0.000 title 1
108090000072 Aldehyde-Lyases Proteins 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
230000000694 effects Effects 0.000 abstract 7
229920001184 polypeptide Polymers 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 7
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 4
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 4
102000040430 polynucleotide Human genes 0.000 abstract 4
108091033319 polynucleotide Proteins 0.000 abstract 4
239000002157 polynucleotide Substances 0.000 abstract 4
RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 3
RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 2
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
SLWQCDYJBNGHQV-CQSZACIVSA-N (2r)-2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(C[C@@](O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-CQSZACIVSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03016—4-Hydroxy-2-oxoglutarate aldolase (4.1.3.16)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03017—4-Hydroxy-4-methyl-2-oxoglutarate aldolase (4.1.3.17)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nutrition Science (AREA)
Cell Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

AT07758102T 2006-03-07 2007-03-07 Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung ATE548450T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78051506P	2006-03-07	2006-03-07
PCT/US2007/063515 WO2007103989A2 (en)	2006-03-07	2007-03-07	Aldolases, nucleic acids encoding them and methods for making and using them

Publications (1)

Publication Number	Publication Date
ATE548450T1 true ATE548450T1 (de)	2012-03-15

Family

ID=38475839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07758102T ATE548450T1 (de)	2006-03-07	2007-03-07	Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Country Status (13)

Country	Link
US (3)	US8546118B2 (de)
EP (4)	EP1999256B1 (de)
JP (3)	JP5733777B2 (de)
KR (4)	KR101508249B1 (de)
CN (3)	CN102690833B (de)
AT (1)	ATE548450T1 (de)
AU (1)	AU2007223086B2 (de)
BR (2)	BRPI0708614A2 (de)
CA (1)	CA2645225A1 (de)
EA (2)	EA019971B1 (de)
ES (1)	ES2383767T3 (de)
MX (1)	MX2008011442A (de)
WO (1)	WO2007103989A2 (de)

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CA2643416C (en)	2006-03-07	2016-07-26	Cargill, Incorporated	Aldolases, nucleic acids encoding them and methods for making and using them
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JP5793486B2 (ja)	2015-10-14
EP1999256A2 (de)	2008-12-10
CN102690833B (zh)	2015-09-09
US20100095390A1 (en)	2010-04-15
EP1999256B1 (de)	2012-03-07
KR101588539B1 (ko)	2016-01-25
EA201301267A1 (ru)	2014-11-28
JP2013063068A (ja)	2013-04-11
JP2009531025A (ja)	2009-09-03
KR20150020722A (ko)	2015-02-26
JP2013066469A (ja)	2013-04-18
US20160251643A1 (en)	2016-09-01
KR20090004918A (ko)	2009-01-12
KR101744157B1 (ko)	2017-06-08
US9719079B2 (en)	2017-08-01
CN102690833A (zh)	2012-09-26
JP5733777B2 (ja)	2015-06-10
KR20160058194A (ko)	2016-05-24
EP2388316A3 (de)	2012-03-14
KR101622894B1 (ko)	2016-05-19
CN101443446A (zh)	2009-05-27
JP5793487B2 (ja)	2015-10-14
EP3153580A2 (de)	2017-04-12
CN105063072A (zh)	2015-11-18
US8546118B2 (en)	2013-10-01
EP3153580A3 (de)	2017-04-19
MX2008011442A (es)	2008-11-18
WO2007103989A2 (en)	2007-09-13
WO2007103989A9 (en)	2007-11-29
EA019971B1 (ru)	2014-07-30
EP2385108A1 (de)	2011-11-09
EA200870329A1 (ru)	2009-06-30
US9290755B2 (en)	2016-03-22
CN101443446B (zh)	2013-08-21
CA2645225A1 (en)	2007-09-13
BRPI0708614A2 (pt)	2011-06-07
KR101508249B1 (ko)	2015-04-10
EP2385108B1 (de)	2016-11-23
EP1999256A4 (de)	2009-06-03
KR20140023424A (ko)	2014-02-26
AU2007223086B2 (en)	2013-09-26
WO2007103989A8 (en)	2009-07-23
ES2383767T3 (es)	2012-06-26
US20140053287A1 (en)	2014-02-20
EA029538B1 (ru)	2018-04-30
BR122017003017B1 (pt)	2018-10-23
EP2388316A2 (de)	2011-11-23
AU2007223086A1 (en)	2007-09-13

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