ATE548450T1 - Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung - Google Patents

Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Info

Publication number: ATE548450T1
Authority: AT; Austria
Prior art keywords: polypeptides; activity; production; monatin; methods
Prior art date: 2006-03-07

Application number

AT07758102T

Other languages

English (en)

Inventor

Ellen Burke

Paula Hicks

Peter Luginbuhl

Toby Richardson

David Weiner

Lishan Zhao

Original Assignee

Verenium Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-07

Filing date

2007-03-07

Publication date

2012-03-15

2007-03-07 Application filed by Verenium Corp filed Critical Verenium Corp

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE548450T1 publication Critical patent/ATE548450T1/de

Links

102000003677 Aldehyde-Lyases Human genes 0.000 title 1
108090000072 Aldehyde-Lyases Proteins 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
230000000694 effects Effects 0.000 abstract 7
229920001184 polypeptide Polymers 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 7
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 4
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 4
102000040430 polynucleotide Human genes 0.000 abstract 4
108091033319 polynucleotide Proteins 0.000 abstract 4
239000002157 polynucleotide Substances 0.000 abstract 4
RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 abstract 3
RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 abstract 2
LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
SLWQCDYJBNGHQV-CQSZACIVSA-N (2r)-2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(C[C@@](O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-CQSZACIVSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03016—4-Hydroxy-2-oxoglutarate aldolase (4.1.3.16)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03017—4-Hydroxy-4-methyl-2-oxoglutarate aldolase (4.1.3.17)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nutrition Science (AREA)
Cell Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

AT07758102T 2006-03-07 2007-03-07 Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung ATE548450T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78051506P	2006-03-07	2006-03-07
PCT/US2007/063515 WO2007103989A2 (en)	2006-03-07	2007-03-07	Aldolases, nucleic acids encoding them and methods for making and using them

Publications (1)

Publication Number	Publication Date
ATE548450T1 true ATE548450T1 (de)	2012-03-15

Family

ID=38475839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07758102T ATE548450T1 (de)	2006-03-07	2007-03-07	Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Country Status (13)

Country	Link
US (3)	US8546118B2 (de)
EP (4)	EP2385108B1 (de)
JP (3)	JP5733777B2 (de)
KR (4)	KR101508249B1 (de)
CN (3)	CN102690833B (de)
AT (1)	ATE548450T1 (de)
AU (1)	AU2007223086B2 (de)
BR (2)	BR122017003017B1 (de)
CA (1)	CA2645225A1 (de)
EA (2)	EA029538B1 (de)
ES (1)	ES2383767T3 (de)
MX (1)	MX2008011442A (de)
WO (1)	WO2007103989A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8158389B2 (en) *	2005-04-20	2012-04-17	Cargill, Incorporated	Products and methods for in vivo secretion of monatin
WO2006113897A2 (en) *	2005-04-20	2006-10-26	Cargill, Incorporated	Products and methods for in vivo secretion of monatin
US8076108B2 (en) *	2005-04-26	2011-12-13	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2112227B1 (de) *	2006-03-07	2013-05-15	Cargill, Incorporated	Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung
EP2479272A4 (de)	2010-10-14	2013-11-20	Ajinomoto Kk	Verfahren zur herstellung von monatin
CN102181471B (zh) *	2011-03-23	2014-07-02	深圳大学	莱茵衣藻分泌型表达载体及分泌型表达系统的构建方法
US10436790B2 (en)	2011-09-28	2019-10-08	Waters Technologies Corporation	Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
SG10201602521XA (en) *	2011-12-22	2016-04-28	Xyleco Inc	Biomass processing
CN102559722B (zh) *	2012-03-12	2017-05-17	杭州师范大学	一种高酶活、耐热醛缩酶基因、酶、载体、工程菌及应用
JP2015519878A (ja)	2012-03-26	2015-07-16	プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ，Ｉｎｃ．	栄養断片、タンパク質、および方法
JP2015518470A (ja)	2012-03-26	2015-07-02	プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ，Ｉｎｃ．	栄養タンパク質および方法
WO2013148329A1 (en)	2012-03-26	2013-10-03	Pronutria, Inc.	Charged nutritive proteins and methods
WO2013148330A1 (en)	2012-03-26	2013-10-03	Pronutria, Inc.	Nutritive fragments, proteins and methods
US9850512B2 (en)	2013-03-15	2017-12-26	The Research Foundation For The State University Of New York	Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
EP3048904A2 (de)	2013-09-25	2016-08-03	Pronutria Biosciences, Inc.	Zusammensetzungen und formulierungen zur behandlung von absorptionsstörungen und entzündungen des magen-darm-trakts sowie verfahren zur herstellung und verwendung davon
US9951363B2 (en)	2014-03-14	2018-04-24	The Research Foundation for the State University of New York College of Environmental Science and Forestry	Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
DK3748340T3 (da)	2014-10-30	2022-04-19	Waters Technologies Corp	Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme
CN115536714B (zh)	2014-11-13	2026-04-24	沃特世科技公司	快速标记的n-聚糖的液相色谱校准方法
EP3472621A4 (de)	2016-06-21	2020-03-04	Waters Technologies Corporation	Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen
CN114839302A (zh) *	2016-07-01	2022-08-02	沃特世科技公司	使用分子量截留过滤和过滤器上去糖基化从复杂基质快速制备标记的葡基胺的方法
CN108079315B (zh) *	2016-11-21	2021-09-24	厦门华绰生物医药科技有限公司	FBP aldolase在制备激活AMPK的药物中的用途
EP3330380A1 (de) *	2016-12-05	2018-06-06	Evonik Degussa GmbH	Verfahren zur herstellung von l-methionin aus methional
CN107541540B (zh) *	2017-10-18	2021-07-20	南京财经大学	一种活性炭串联大孔树脂纯化菜籽肽的方法
JP2021531749A (ja) *	2018-07-12	2021-11-25	コデクシス，インコーポレイテッド	操作されたフェニルアラニンアンモニアリアーゼポリペプチド
CN120795059A (zh)	2018-08-27	2025-10-17	瑞泽恩制药公司	拉曼光谱在下游纯化中的应用
CN111315888A (zh) *	2018-10-30	2020-06-19	绿色地球研究所株式会社	有机化合物的制造方法及棒状细菌
JP7558167B2 (ja)	2018-12-03	2024-09-30	ボードオブリージェンツ，ザユニバーシティオブテキサスシステム	オリゴベンズアミド類似体およびがん処置におけるそれらの使用
WO2021055696A1 (en) *	2019-09-19	2021-03-25	The Regents Of The University Of California	Methods for producing d-tryptophan and substituted d-tryptophans
CN114279952B (zh) *	2020-09-27	2024-03-12	瑞辰星生物技术（广州）有限公司	用于造纸系统控制有机污染物沉积的生物酶酶活力的测定方法
CN112280773B (zh) *	2020-11-06	2022-07-12	杭州濡湜生物科技有限公司	一种制备2-氨基-3-取代苯基-3-羟基丙酸的生物酶催化流式工艺
CN112301067B (zh) *	2020-11-06	2022-07-05	杭州濡湜生物科技有限公司	一种制备2-氨基-3-取代苯基-3-羟基丙酸的绿色环保工艺
CN113151551A (zh) *	2021-04-22	2021-07-23	山西农业大学	Caps分子标记在鉴定谷子株高性状的用途及引物和检测试剂盒
CN116987601B (zh) *	2023-09-27	2023-12-15	菏泽学院	一种微生物制剂及其在多环芳烃降解中的应用
CN119685439B (zh) *	2024-12-17	2025-10-03	西安建筑科技大学	一种基于选择性金属离子脱除的微生态菌群原位筛选和厌氧产酸富集方法及装置

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366558A (en)	1979-03-23	1994-11-22	Brink David L	Method of treating biomass material
US4458066A (en)	1980-02-29	1984-07-03	University Patents, Inc.	Process for preparing polynucleotides
US5087571A (en)	1984-06-22	1992-02-11	President And Fellows Of Harvard College	Method for providing a cell culture from a transgenic non-human mammal
US4683195A (en)	1986-01-30	1987-07-28	Cetus Corporation	Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
DE3546807C2 (de)	1985-03-30	1991-03-28	Marc Genf/Geneve Ch Ballivet
US5780292A (en)	1987-04-29	1998-07-14	Alko Group Ltd.	Production of phytate degrading enzymes in trichoderma
US4962028A (en)	1986-07-09	1990-10-09	Dna Plant Technology Corporation	Plant promotors
US4946778A (en)	1987-09-21	1990-08-07	Genex Corporation	Single polypeptide chain binding molecules
US4987071A (en)	1986-12-03	1991-01-22	University Patents, Inc.	RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5015580A (en)	1987-07-29	1991-05-14	Agracetus	Particle-mediated transformation of soybean plants and lines
US5573933A (en)	1987-04-14	1996-11-12	Luminis Pty, Ltd.	Transgenic pigs
US6054270A (en)	1988-05-03	2000-04-25	Oxford Gene Technology Limited	Analying polynucleotide sequences
US5700637A (en)	1988-05-03	1997-12-23	Isis Innovation Limited	Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5217879A (en)	1989-01-12	1993-06-08	Washington University	Infectious Sindbis virus vectors
US5744101A (en)	1989-06-07	1998-04-28	Affymax Technologies N.V.	Photolabile nucleoside protecting groups
US5800992A (en)	1989-06-07	1998-09-01	Fodor; Stephen P.A.	Method of detecting nucleic acids
US5143854A (en)	1989-06-07	1992-09-01	Affymax Technologies N.V.	Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5527681A (en)	1989-06-07	1996-06-18	Affymax Technologies N.V.	Immobilized molecular synthesis of systematically substituted compounds
US5589583A (en)	1990-01-11	1996-12-31	Monsanto Company	Plant promoter
DE69101791T2 (de)	1990-01-19	1994-08-11	Technology Finance Corp	Verfahren zur Herstellung von 3-(1-Amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indol.
AU7791991A (en)	1990-04-24	1991-11-11	Stratagene	Methods for phenotype creation from multiple gene populations
WO1991019810A1 (en)	1990-06-15	1991-12-26	California Biotechnology Inc.	Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
ATE318318T1 (de)	1990-11-23	2006-03-15	Bayer Bioscience Nv	Verfahren zur transformation monokotyler pflanzen
DE69131017T2 (de)	1990-12-20	1999-07-15	Ixsys, Inc., San Diego, Calif.	Optimierung von bindenden proteinen
US6110700A (en)	1991-03-11	2000-08-29	The General Hospital Corporation	PRAD1 cyclin and its cDNA
US5922854A (en)	1991-06-14	1999-07-13	Kumar; Ramesh	Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
JP2648897B2 (ja)	1991-07-01	1997-09-03	塩野義製薬株式会社	ピリミジン誘導体
CA2075135A1 (en)	1991-08-02	1993-02-03	David E. Ellis	Particle-mediated transformation of gymnosperms
US5632957A (en)	1993-11-01	1997-05-27	Nanogen	Molecular biological diagnostic systems including electrodes
JPH05236997A (ja)	1992-02-28	1993-09-17	Hitachi Ltd	ポリヌクレオチド捕捉用チップ
AU5676394A (en)	1992-11-20	1994-06-22	Agracetus, Inc.	Transgenic cotton plants producing heterologous bioplastic
AU7925094A (en)	1993-09-30	1995-04-18	Agracetus, Inc.	Transgenic cotton plants producing heterologous peroxidase
US6045996A (en)	1993-10-26	2000-04-04	Affymetrix, Inc.	Hybridization assays on oligonucleotide arrays
US5965452A (en)	1996-07-09	1999-10-12	Nanogen, Inc.	Multiplexed active biologic array
US6468742B2 (en)	1993-11-01	2002-10-22	Nanogen, Inc.	Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US6117679A (en)	1994-02-17	2000-09-12	Maxygen, Inc.	Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en)	1995-04-18	1998-11-10	Glaxo Group Limited	End-complementary polymerase reaction
US6335160B1 (en)	1995-02-17	2002-01-01	Maxygen, Inc.	Methods and compositions for polypeptide engineering
US5605793A (en)	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
US5837458A (en)	1994-02-17	1998-11-17	Maxygen, Inc.	Methods and compositions for cellular and metabolic engineering
US5639940A (en)	1994-03-03	1997-06-17	Pharmaceutical Proteins Ltd.	Production of fibrinogen in transgenic animals
WO1995024488A1 (en)	1994-03-09	1995-09-14	Abbott Laboratories	Transgenic animals producing oligosaccharides and glycoconjugates
AU694181B2 (en)	1994-03-09	1998-07-16	Abbott Laboratories	Humanized milk
US5750870A (en)	1994-06-17	1998-05-12	Agritope, Inc.	Plant genetic transformation methods and transgenic plants
US5807522A (en)	1994-06-17	1998-09-15	The Board Of Trustees Of The Leland Stanford Junior University	Methods for fabricating microarrays of biological samples
US5959171A (en)	1994-08-17	1999-09-28	Pharming B.V.	Method for the production of biologically active polypeptides in a mammal's
JPH10504964A (ja)	1994-09-01	1998-05-19	メルクエンドカンパニーインコーポレーテッド	家族性型ヒトアミロイド前駆タンパク質を発現するトランスジェニック動物
US6111166A (en)	1994-09-19	2000-08-29	Medarex, Incorporated	Transgenic mice expressing human Fcα and β receptors
US5795737A (en)	1994-09-19	1998-08-18	The General Hospital Corporation	High level expression of proteins
US5880327A (en)	1994-09-21	1999-03-09	American National Red Cross	Transgenic mammals expressing human coagulation factor VIII
US5556752A (en)	1994-10-24	1996-09-17	Affymetrix, Inc.	Surface-bound, unimolecular, double-stranded DNA
US6187992B1 (en)	1994-12-05	2001-02-13	Merck & Co., Inc.	Transgenic mouse having a disrupted amyloid precursor protein gene
US5830645A (en)	1994-12-09	1998-11-03	The Regents Of The University Of California	Comparative fluorescence hybridization to nucleic acid arrays
US5633440A (en)	1994-12-20	1997-05-27	Dna Plant Technology Corporation	P119 promoters and their uses
US5705369A (en)	1994-12-27	1998-01-06	Midwest Research Institute	Prehydrolysis of lignocellulose
EP0805856B2 (de)	1995-01-26	2009-04-01	Novozymes A/S	Xylanase beinhaltende futterzusätze für tiere
US5959098A (en)	1996-04-17	1999-09-28	Affymetrix, Inc.	Substrate preparation process
US5795749A (en)	1995-04-05	1998-08-18	The Scripps Research Institution	Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
JPH10510433A (ja)	1995-06-06	1998-10-13	アイシス・ファーマシューティカルス・インコーポレーテッド	高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド
US5856174A (en)	1995-06-29	1999-01-05	Affymetrix, Inc.	Integrated nucleic acid diagnostic device
US5985662A (en)	1995-07-13	1999-11-16	Isis Pharmaceuticals Inc.	Antisense inhibition of hepatitis B virus replication
US5958672A (en)	1995-07-18	1999-09-28	Diversa Corporation	Protein activity screening of clones having DNA from uncultivated microorganisms
US6057103A (en)	1995-07-18	2000-05-02	Diversa Corporation	Screening for novel bioactivities
US5962258A (en)	1995-08-23	1999-10-05	Diversa Corporation	Carboxymethyl cellulase fromthermotoga maritima
WO1997016533A1 (en)	1995-10-31	1997-05-09	The Regents Of The University Of California	Mammalian artificial chromosomes and methods of using same
US6537776B1 (en)	1999-06-14	2003-03-25	Diversa Corporation	Synthetic ligation reassembly in directed evolution
US5939250A (en)	1995-12-07	1999-08-17	Diversa Corporation	Production of enzymes having desired activities by mutagenesis
US5965408A (en)	1996-07-09	1999-10-12	Diversa Corporation	Method of DNA reassembly by interrupting synthesis
US5830696A (en)	1996-12-05	1998-11-03	Diversa Corporation	Directed evolution of thermophilic enzymes
US20030215798A1 (en)	1997-06-16	2003-11-20	Diversa Corporation	High throughput fluorescence-based screening for novel enzymes
US6361974B1 (en)	1995-12-07	2002-03-26	Diversa Corporation	Exonuclease-mediated nucleic acid reassembly in directed evolution
US6358709B1 (en)	1995-12-07	2002-03-19	Diversa Corporation	End selection in directed evolution
US6740506B2 (en)	1995-12-07	2004-05-25	Diversa Corporation	End selection in directed evolution
US6171820B1 (en)	1995-12-07	2001-01-09	Diversa Corporation	Saturation mutagenesis in directed evolution
US6022963A (en)	1995-12-15	2000-02-08	Affymetrix, Inc.	Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6013440A (en)	1996-03-11	2000-01-11	Affymetrix, Inc.	Nucleic acid affinity columns
US6096548A (en)	1996-03-25	2000-08-01	Maxygen, Inc.	Method for directing evolution of a virus
US6025155A (en)	1996-04-10	2000-02-15	Chromos Molecular Systems, Inc.	Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US5697987A (en)	1996-05-10	1997-12-16	The Trustees Of Princeton University	Alternative fuel
AU3568897A (en)	1996-06-07	1998-01-05	Eos Biotechnology, Inc.	Immobilised linear oligonucleotide arrays
US6326204B1 (en)	1997-01-17	2001-12-04	Maxygen, Inc.	Evolution of whole cells and organisms by recursive sequence recombination
AU743305C (en)	1997-01-17	2006-03-30	Maxygen, Inc.	Evolution of whole cells and organisms by recursive sequence recombination
DK0996718T3 (da)	1997-03-18	2009-04-06	Novozymes As	Fremgangsmåde til konstruktion af et bibliotek ved anvendelse af DNA-shuffling
BR9808368A (pt)	1997-03-18	2000-05-23	Novo Nordisk As	Processos para a construção de uma biblioteca de polinucleotideos homólogos recombinados, para a identificação um polipeptìdeo de interesse, e, para a produção de um polipeptìdeo de interesse.
US5948653A (en)	1997-03-21	1999-09-07	Pati; Sushma	Sequence alterations using homologous recombination
US6153410A (en)	1997-03-25	2000-11-28	California Institute Of Technology	Recombination of polynucleotide sequences using random or defined primers
US6333181B1 (en)	1997-04-07	2001-12-25	University Of Florida Research Foundation, Inc.	Ethanol production from lignocellulose
US5916780A (en)	1997-06-09	1999-06-29	Iogen Corporation	Pretreatment process for conversion of cellulose to fuel ethanol
US7019827B2 (en)	1997-06-16	2006-03-28	Diversa Corporation	GigaMatrix holding tray having through-hole wells
AUPO758297A0 (en)	1997-06-27	1997-07-24	Rowe, James Baber	Control of acidic gut syndrome
US6826296B2 (en)	1997-07-25	2004-11-30	Affymetrix, Inc.	Method and system for providing a probe array chip design database
AU8908198A (en)	1997-08-15	1999-03-08	Hyseq, Inc.	Methods and compositions for detection or quantification of nucleic acid species
IL134702A (en)	1997-09-11	2004-03-28	Bioventures Inc	High density arrays and methods of making the same
US6465178B2 (en)	1997-09-30	2002-10-15	Surmodics, Inc.	Target molecule attachment to surfaces
AU1124499A (en)	1997-10-28	1999-05-17	Maxygen, Inc.	Human papillomavirus vectors
EP1030861A4 (de)	1997-10-31	2001-09-05	Maxygen Inc	Modifizierung des virustropismius und des wirtspektrums durch virale genomdurchmischung
DE69828574T2 (de)	1997-11-14	2005-10-06	Sankyo Co., Ltd.	Transgenes Tier als Modell für Allergie und seine Verwendung
AU746786B2 (en)	1997-12-08	2002-05-02	California Institute Of Technology	Method for creating polynucleotide and polypeptide sequences
WO1999041383A1 (en)	1998-02-11	1999-08-19	Maxygen, Inc.	Antigen library immunization
CA2320960A1 (en)	1998-02-11	1999-08-19	Maxygen, Inc.	Optimization of immunomodulatory properties of genetic vaccines
EP1068356B8 (de)	1998-04-03	2007-01-03	Adnexus Therapeutics, Inc.	Adressierbare protein arrays
US6156952A (en)	1998-04-09	2000-12-05	Constituent Institution Of The University Of Maryland System	HIV transgenic animals and uses therefor
US6048695A (en)	1998-05-04	2000-04-11	Baylor College Of Medicine	Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
ES2381824T3 (es)	1998-06-29	2012-05-31	Bristol-Myers Squibb Company	Procedimientos para generar genotecas muy diversas
FR2782323B1 (fr)	1998-08-12	2002-01-11	Proteus	Procede de production in vitro de sequences polynucleotidiques recombinees, banques de sequences et sequences ainsi obtenues
GB2340755B (en)	1998-08-24	2002-09-25	Cannon Rubber Ltd	Breast pump insert
US6277628B1 (en)	1998-10-02	2001-08-21	Incyte Genomics, Inc.	Linear microarrays
US6277489B1 (en)	1998-12-04	2001-08-21	The Regents Of The University Of California	Support for high performance affinity chromatography and other uses
US6436675B1 (en)	1999-09-28	2002-08-20	Maxygen, Inc.	Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6376246B1 (en)	1999-02-05	2002-04-23	Maxygen, Inc.	Oligonucleotide mediated nucleic acid recombination
US6368861B1 (en)	1999-01-19	2002-04-09	Maxygen, Inc.	Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en)	1999-01-19	2006-04-04	Maxygen, Inc.	Methods for making character strings, polynucleotides and polypeptides having desired characteristics
DE19910464A1 (de)	1999-03-10	2000-09-14	Bayer Ag	Verfahren zur Herstellung von Cyclobutanon
US6221653B1 (en)	1999-04-27	2001-04-24	Agilent Technologies, Inc.	Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
ATE311199T1 (de)	1999-05-07	2005-12-15	Genentech Inc	Behandlung von autoimmunkrankheiten mit antagonisten die oberflächenmarker von b zellen binden
US6653151B2 (en)	1999-07-30	2003-11-25	Large Scale Proteomics Corporation	Dry deposition of materials for microarrays using matrix displacement
US6409841B1 (en)	1999-11-02	2002-06-25	Waste Energy Integrated Systems, Llc.	Process for the production of organic products from diverse biomass sources
US20010008765A1 (en)	1999-12-06	2001-07-19	Fuji Photo Film Co., Ltd.	DNA chip and reactive solid carrier
ES2166316B1 (es)	2000-02-24	2003-02-16	Ct Investig Energeticas Ciemat	Procedimiento de produccion de etanol a partir de biomasa lignocelulosica utilizando una nueva levadura termotolerante.
JP2001328984A (ja)	2000-05-19	2001-11-27	Kuraray Co Ltd	メバロラクトンの製造方法
CA2413022A1 (en)	2000-06-14	2001-12-20	Diversa Corporation	Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US6423145B1 (en)	2000-08-09	2002-07-23	Midwest Research Institute	Dilute acid/metal salt hydrolysis of lignocellulosics
WO2002014261A2 (en)	2000-08-10	2002-02-21	Eli Lilly And Company	4-substituted d-glutamic acid derivatives for use as antibiotic
WO2002029032A2 (en)	2000-09-30	2002-04-11	Diversa Corporation	Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
IL150020A0 (en)	2000-10-10	2002-12-01	Diversa Corp	High throughput or capillary-based screening for a bioactivity or biomolecule
US6309872B1 (en)	2000-11-01	2001-10-30	Novozymes Biotech, Inc	Polypeptides having glucoamylase activity and nucleic acids encoding same
JP2004523219A (ja)	2000-11-30	2004-08-05	ディヴァーサコーポレイション	タンパク質ポリマーの製造方法および前記ポリマーの使用
US20060019913A1 (en)	2001-05-18	2006-01-26	Sirna Therapeutics, Inc.	RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
CA2462641A1 (en)	2001-10-01	2003-04-10	Diversa Corporation	Whole cell engineering using real-time metabolic flux analysis
US7572607B2 (en)	2002-04-23	2009-08-11	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CA2483126C (en)	2002-04-23	2014-05-20	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of monatin
DK1533376T3 (da) *	2002-08-26	2010-07-19	Ajinomoto Kk	Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre
JP2006512086A (ja) *	2002-09-20	2006-04-13	ダイヴァーサコーポレイション	スタチンおよびスタチン中間体の合成のための酵素化学的方法
US6776979B2 (en)	2002-12-30	2004-08-17	Marvin B. Frager	Periodontal treatment compound and method of use
CN1890377B (zh)	2003-10-21	2013-06-05	嘉吉有限公司	生产莫纳甜和莫纳甜前体
JP4500977B2 (ja)	2003-11-05	2010-07-14	味の素株式会社	新規アミノ酸誘導体及び甘味剤
JP4604524B2 (ja) *	2004-03-16	2011-01-05	味の素株式会社	変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法
US20060014260A1 (en)	2004-05-07	2006-01-19	Zhiliang Fan	Lower cellulase requirements for biomass cellulose hydrolysis and fermentation
US20060030003A1 (en)	2004-05-12	2006-02-09	Simon Michael R	Composition and method for introduction of RNA interference sequences into targeted cells and tissues
US7338763B2 (en)	2004-06-02	2008-03-04	Eppendorf Array Technologies S.A.	Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
ATE536418T1 (de)	2004-06-07	2011-12-15	Protiva Biotherapeutics Inc	Lipidverkapselte interferenz-rna
CA2506247C (en) *	2004-06-07	2012-02-21	Ajinomoto Co., Inc.	Novel aldolase, and method for producing optically active ihog and monatin
CN100519756C (zh) *	2004-06-07	2009-07-29	味之素株式会社	新的醛缩酶及光学活性ihog及莫那亭的制备方法
US7635563B2 (en)	2004-06-30	2009-12-22	Massachusetts Institute Of Technology	High throughput methods relating to microRNA expression analysis
US20060019258A1 (en)	2004-07-20	2006-01-26	Illumina, Inc.	Methods and compositions for detection of small interfering RNA and micro-RNA
US7923231B2 (en)	2004-12-17	2011-04-12	Cargill, Incorporated	Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
US7582455B2 (en) *	2005-04-26	2009-09-01	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076108B2 (en) *	2005-04-26	2011-12-13	Cargill, Incorporated	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP3011302B1 (de)	2013-06-21	2019-11-27	Bio-Rad Laboratories, Inc.	Mikrofluidisches system mit flüssigkeitsaufnehmern

2007
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ES2383767T3 (es)	2012-06-26
CN102690833B (zh)	2015-09-09
US9719079B2 (en)	2017-08-01
EP3153580A3 (de)	2017-04-19
CN101443446A (zh)	2009-05-27
EP2385108B1 (de)	2016-11-23
AU2007223086A1 (en)	2007-09-13
US8546118B2 (en)	2013-10-01
KR101588539B1 (ko)	2016-01-25
KR20090004918A (ko)	2009-01-12
EA201301267A1 (ru)	2014-11-28
US20140053287A1 (en)	2014-02-20
WO2007103989A8 (en)	2009-07-23
KR101508249B1 (ko)	2015-04-10
JP5733777B2 (ja)	2015-06-10
JP5793486B2 (ja)	2015-10-14
EP2385108A1 (de)	2011-11-09
KR101744157B1 (ko)	2017-06-08
EA029538B1 (ru)	2018-04-30
EP1999256A2 (de)	2008-12-10
KR101622894B1 (ko)	2016-05-19
WO2007103989A2 (en)	2007-09-13
EA019971B1 (ru)	2014-07-30
JP5793487B2 (ja)	2015-10-14
KR20150020722A (ko)	2015-02-26
MX2008011442A (es)	2008-11-18
CN101443446B (zh)	2013-08-21
BR122017003017B1 (pt)	2018-10-23
US20100095390A1 (en)	2010-04-15
EP2388316A2 (de)	2011-11-23
EP2388316A3 (de)	2012-03-14
CA2645225A1 (en)	2007-09-13
EP3153580A2 (de)	2017-04-12
EP1999256A4 (de)	2009-06-03
KR20160058194A (ko)	2016-05-24
BRPI0708614A2 (pt)	2011-06-07
JP2009531025A (ja)	2009-09-03
JP2013063068A (ja)	2013-04-11
CN105063072A (zh)	2015-11-18
JP2013066469A (ja)	2013-04-18
EP1999256B1 (de)	2012-03-07
WO2007103989A9 (en)	2007-11-29
KR20140023424A (ko)	2014-02-26
US9290755B2 (en)	2016-03-22
EA200870329A1 (ru)	2009-06-30
AU2007223086B2 (en)	2013-09-26
US20160251643A1 (en)	2016-09-01
CN102690833A (zh)	2012-09-26

Publication	Publication Date	Title
EP1999256A4 (de)	2009-06-03	Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung
MX2008011477A (es)	2008-09-23	Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
DK1863851T3 (da)	2009-05-11	Fremgangsmåde til fremstilling af cellulosesulfat med forbedrede egenskaber
EA201001445A1 (ru)	2011-06-30	ПОЛУЧЕНИЕ 6-АМИНОКАПРОНОВОЙ КИСЛОТЫ ИЗ α-КЕТОПИМЕЛИНОВОЙ КИСЛОТЫ
WO2007136762A3 (en)	2008-04-17	Production of fatty acids and derivatives thereof
EP2182063A3 (de)	2012-07-18	Modulierung von EIF4E-Expression
MA29858B1 (fr)	2008-10-03	Derives de carbamoylbenzotriazole en tant qu'inhibiteurs de lipases et phospholipases
WO2009018065A3 (en)	2009-05-07	Novel glucokinase activators and methods of using same
ATE453622T1 (de)	2010-01-15	Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren
WO2008102720A1 (ja)	2008-08-28	光学活性３－アミノピペリジン又はその塩の製造方法
WO2008019069A3 (en)	2008-06-05	Enzymatic aqueous acylation
MY151183A (en)	2014-04-30	Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof
WO2004055162A3 (en)	2004-10-07	Modulation of endothelial lipase expression
WO2007133184A3 (en)	2008-08-28	Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
ATE402265T1 (de)	2008-08-15	Verfahren zur herstellung von biologisch abbaubaren milchsäurepolymeren
WO2007096654A3 (en)	2007-10-18	Methods for production of dioic acids
DE502006006865D1 (de)	2010-06-10	Neue dehydrogenasen, deren derivate und ein verfahren zur herstellung von optisch aktiven alkanolen
BRPI0413329A (pt)	2006-10-10	plantas tendo caracterìsticas de crescimento modificado e método para produzir as mesmas
EP1621529A4 (de)	2007-10-17	3-amino-3-arylpropionsäure-n-alkylester, verfahren zu deren herstellung und verfahren zur herstellung von optisch aktiven 3-amino-3-arylpropionsäuren und estern der enantiomere davon
WO2008053206A3 (en)	2008-07-03	Process for preparation of aldonic acids and derivatives thereof
ATE489355T1 (de)	2010-12-15	Mandelsäurederivate und deren herstellung
ATE444069T1 (de)	2009-10-15	Chinolin-derivate zur behandlung von mglur5- rezeptor-vermittelten erkrankungen
EP2067857A4 (de)	2010-05-26	Verfahren zur dipeptidherstellung
EP1367132A4 (de)	2006-05-31	Verfahren zur herstellung optisch aktiver propoxyanilinderivate
EP1493819A4 (de)	2010-12-22	Verfahren zur herstellung entweder einer optisch aktiven n-substituierten beta-aminosäure und eines optisch aktiven n-substituierten beta-aminosäureesters oder einer optisch aktiven n-substituierten 2-homopipecolinsäure und eines optisch aktiven n-substituierten 2-homopipecolinsäureesters