ATE550344T1 - Verfahren zur spaltung von polypeptiden - Google Patents

Verfahren zur spaltung von polypeptiden

Info

Publication number: ATE550344T1
Authority: AT; Austria
Prior art keywords: polypeptide; palladate; palladium; cleaving polypeptides; cys
Prior art date: 2002-05-24

Application number

AT03736710T

Other languages

English (en)

Inventor

Jin Seog Seo

Daniel Strydom

Barton Holmquist

Original Assignee

Medtronic Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-24

Filing date

2003-05-23

Publication date

2012-04-15

2003-05-23 Application filed by Medtronic Inc filed Critical Medtronic Inc

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE550344T1 publication Critical patent/ATE550344T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 2
230000007017 scission Effects 0.000 abstract 2
LVNMAAGSAUGNIC-BQBZGAKWSA-N Cys-His Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CNC=N1 LVNMAAGSAUGNIC-BQBZGAKWSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT03736710T 2002-05-24 2003-05-23 Verfahren zur spaltung von polypeptiden ATE550344T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38348802P	2002-05-24	2002-05-24
PCT/US2003/016468 WO2003100015A2 (en)	2002-05-24	2003-05-23	Polypeptide cleavage process

Publications (1)

Publication Number	Publication Date
ATE550344T1 true ATE550344T1 (de)	2012-04-15

Family

ID=29584571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03736710T ATE550344T1 (de)	2002-05-24	2003-05-23	Verfahren zur spaltung von polypeptiden

Country Status (7)

Country	Link
US (2)	US7771966B2 (de)
EP (1)	EP1532142B1 (de)
JP (1)	JP4638223B2 (de)
AT (1)	ATE550344T1 (de)
AU (1)	AU2003237244B2 (de)
CA (1)	CA2485737A1 (de)
WO (1)	WO2003100015A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE487486T1 (de) *	2002-05-24	2010-11-15	Medtronic Inc	Polypeptid-spaltungsprozess
WO2003099854A2 (en) *	2002-05-24	2003-12-04	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
AU2003243315B8 (en) *	2002-05-24	2009-05-21	Medtronic, Inc.	Peptide amidation process
US7318925B2 (en)	2003-08-08	2008-01-15	Amgen Fremont, Inc.	Methods of use for antibodies against parathyroid hormone
US7288253B2 (en)	2003-08-08	2007-10-30	Amgen Fremont, Inc.	Antibodies directed to parathyroid hormone (PTH) and uses thereof
HRP20120315T1 (hr) *	2003-11-21	2012-05-31	Nps Pharmaceuticals	Proizvodnja peptida 2 nalik glukagonu i analoga
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
BRPI0606992A2 (pt)	2005-02-11	2009-07-28	Amylin Pharmaceuticals Inc	análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
CN111349153A (zh) *	2020-04-10	2020-06-30	四川吉晟生物医药有限公司	一种心钠肽的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5352771A (en) *	1992-08-31	1994-10-04	Iowa State University Research Foundation Inc.	Hydrolysis of peptide bonds using Pt (II) and Pd (II) complexes
US6376529B1 (en) *	1995-06-07	2002-04-23	Peng Cho Tang	Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US6660758B1 (en) *	1996-12-13	2003-12-09	The Scripps Research Institute	Epothilone analogs
ATE487486T1 (de)	2002-05-24	2010-11-15	Medtronic Inc	Polypeptid-spaltungsprozess
AU2003243315B8 (en)	2002-05-24	2009-05-21	Medtronic, Inc.	Peptide amidation process

2003
- 2003-05-23 JP JP2004508257A patent/JP4638223B2/ja not_active Expired - Fee Related
- 2003-05-23 EP EP03736710A patent/EP1532142B1/de not_active Expired - Lifetime
- 2003-05-23 AU AU2003237244A patent/AU2003237244B2/en not_active Ceased
- 2003-05-23 AT AT03736710T patent/ATE550344T1/de active
- 2003-05-23 WO PCT/US2003/016468 patent/WO2003100015A2/en not_active Ceased
- 2003-05-23 CA CA002485737A patent/CA2485737A1/en not_active Abandoned
2004
- 2004-11-24 US US10/997,762 patent/US7771966B2/en not_active Expired - Lifetime
2010
- 2010-06-07 US US12/795,073 patent/US8288130B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20100311947A1 (en)	2010-12-09
US20050227313A1 (en)	2005-10-13
WO2003100015A2 (en)	2003-12-04
AU2003237244A1 (en)	2003-12-12
EP1532142A2 (de)	2005-05-25
EP1532142A4 (de)	2007-08-08
EP1532142B1 (de)	2012-03-21
JP4638223B2 (ja)	2011-02-23
US7771966B2 (en)	2010-08-10
US8288130B2 (en)	2012-10-16
AU2003237244B2 (en)	2009-11-12
CA2485737A1 (en)	2003-12-04
JP2005527632A (ja)	2005-09-15
WO2003100015A3 (en)	2004-04-08

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