ATE445642T1 - Trennung von polypeptiden mit einer racemisierten aminosäure - Google Patents

Trennung von polypeptiden mit einer racemisierten aminosäure

Info

Publication number
ATE445642T1
ATE445642T1 AT04739039T AT04739039T ATE445642T1 AT E445642 T1 ATE445642 T1 AT E445642T1 AT 04739039 T AT04739039 T AT 04739039T AT 04739039 T AT04739039 T AT 04739039T AT E445642 T1 ATE445642 T1 AT E445642T1
Authority
AT
Austria
Prior art keywords
polypeptides
separation
amino acid
racemized
racemized amino
Prior art date
Application number
AT04739039T
Other languages
English (en)
Inventor
Thomas Budde Hansen
Steffen Kidal
Camilla Kornbeck
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE445642T1 publication Critical patent/ATE445642T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
AT04739039T 2003-08-21 2004-08-18 Trennung von polypeptiden mit einer racemisierten aminosäure ATE445642T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301196 2003-08-21
US49825003P 2003-08-27 2003-08-27
PCT/DK2004/000542 WO2005019261A1 (en) 2003-08-21 2004-08-18 Separation of polypeptides comprising a racemized amino acid

Publications (1)

Publication Number Publication Date
ATE445642T1 true ATE445642T1 (de) 2009-10-15

Family

ID=34219529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04739039T ATE445642T1 (de) 2003-08-21 2004-08-18 Trennung von polypeptiden mit einer racemisierten aminosäure

Country Status (14)

Country Link
US (1) US7749955B2 (de)
EP (1) EP1664108B1 (de)
JP (2) JP5622998B2 (de)
KR (1) KR20060106812A (de)
AT (1) ATE445642T1 (de)
AU (1) AU2004266757A1 (de)
BR (1) BRPI0413644A (de)
CA (1) CA2532340A1 (de)
DE (1) DE602004023626D1 (de)
ES (1) ES2335211T3 (de)
MX (1) MXPA06001814A (de)
PL (1) PL1664108T3 (de)
RU (1) RU2006103860A (de)
WO (1) WO2005019261A1 (de)

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US20090318353A1 (en) * 2006-08-25 2009-12-24 Novo Nordisk A/S Acylated Exendin-4 Compounds
CN102027005A (zh) * 2008-05-15 2011-04-20 诺沃-诺迪斯克有限公司 通过固相合成制备的肽的纯化
JP5756407B2 (ja) * 2008-12-08 2015-07-29 ノヴォ ノルディスク アー／エス ポリペプチドの向流精製
BRPI1013626B8 (pt) * 2009-03-20 2021-05-25 Hanmi Holdings Co Ltd método para preparar conjugado de polipeptídeo fisiologicamente ativo em sítio específico
WO2012121302A1 (ja) * 2011-03-08 2012-09-13 株式会社 三和化学研究所 分析方法
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
EP2931301B2 (de) * 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Verfahren zum reinigen von insulin und analoga davon
HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
JP6558699B2 (ja) 2013-10-01 2019-08-14 国立大学法人三重大学 抗原提示を促進するエピトープ間配列を含むｔ細胞誘導ワクチン
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080152A1 (de) 2013-12-13 2016-10-19 Sanofi Nicht-acylierte exendin-4-peptidanaloga
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
KR102770425B1 (ko) 2016-02-08 2025-02-18 고쿠리츠다이가쿠호진 미에다이가쿠 면역체크포인트 저해제 저항성 종양에 대한 t세포 수주요법의 전처치약
JP7011643B2 (ja) 2016-03-23 2022-02-10 バッヘン・ホールディング・アクチエンゲゼルシャフト グルカゴン様ペプチド１類似体の精製
EP3897570A1 (de) 2018-12-19 2021-10-27 KRKA, d.d., Novo mesto Pharmazeutische zusammensetzung mit glp-1-analog
WO2021123228A1 (en) 2019-12-18 2021-06-24 Krka, D.D., Novo Mesto Pharmaceutical composition comprising glp-1 analogue
JP7547824B2 (ja) 2020-07-15 2024-09-10 株式会社リコー 装置、及び液体吐出装置
US20250134933A1 (en) * 2021-08-12 2025-05-01 Youth Bio Global Co., Ltd. Composition for treatment of cartilage-related disease and preparation method therefor
CN113702561B (zh) * 2021-08-23 2024-03-22 成都诺和晟泰生物科技有限公司 一种手性多肽类药物非对映异构体杂质的检测方法

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DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
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RU2122549C1 (ru) * 1997-12-29 1998-11-27 Закрытое акционерное общество "Фосфосорб" Способ хроматографического выделения и очистки белков, пептидов и их комплексов
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WO2000055203A1 (en) * 1999-03-15 2000-09-21 Novo Nordisk A/S Ion exchange chromatographic separation of glp-1 and related peptides

Also Published As

Publication number Publication date
DE602004023626D1 (de) 2009-11-26
EP1664108B1 (de) 2009-10-14
CA2532340A1 (en) 2005-03-03
US7749955B2 (en) 2010-07-06
JP5622998B2 (ja) 2014-11-12
MXPA06001814A (es) 2006-05-04
BRPI0413644A (pt) 2006-10-17
ES2335211T3 (es) 2010-03-23
JP2012102104A (ja) 2012-05-31
PL1664108T3 (pl) 2010-03-31
WO2005019261A1 (en) 2005-03-03
KR20060106812A (ko) 2006-10-12
US20060183669A1 (en) 2006-08-17
RU2006103860A (ru) 2006-07-27
AU2004266757A1 (en) 2005-03-03
EP1664108A1 (de) 2006-06-07
JP2007526234A (ja) 2007-09-13

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