ATE463245T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents

Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Info

Publication number
ATE463245T1
ATE463245T1 AT05796847T AT05796847T ATE463245T1 AT E463245 T1 ATE463245 T1 AT E463245T1 AT 05796847 T AT05796847 T AT 05796847T AT 05796847 T AT05796847 T AT 05796847T AT E463245 T1 ATE463245 T1 AT E463245T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
anilide
tricyclic
spirohydantoin
Prior art date
Application number
AT05796847T
Other languages
English (en)
Inventor
Ian Bell
Steven Gallicchio
Craig Stump
Cory Theberge
Joseph VACCA
Blair C Zartman
Xufang Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE463245T1 publication Critical patent/ATE463245T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05796847T 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten ATE463245T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60829404P 2004-09-09 2004-09-09
PCT/US2005/031617 WO2006031491A2 (en) 2004-09-09 2005-09-06 Tricyclic anilide spirolactam cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE463245T1 true ATE463245T1 (de) 2010-04-15

Family

ID=36060520

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796847T ATE463245T1 (de) 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Country Status (9)

Country Link
US (2) US7696192B2 (de)
EP (1) EP1793827B1 (de)
JP (1) JP2008512456A (de)
CN (1) CN101014345A (de)
AT (1) ATE463245T1 (de)
AU (1) AU2005285270B2 (de)
CA (1) CA2579717A1 (de)
DE (1) DE602005020472D1 (de)
WO (1) WO2006031491A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014345A (zh) * 2004-09-09 2007-08-08 默克公司 三环酰苯胺螺环内酰胺cgrp受体拮抗剂
EP1794133B1 (de) * 2004-09-09 2011-12-14 Merck Sharp & Dohme Corp. Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors
US7750010B2 (en) 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
CA2579847A1 (en) * 2004-09-13 2006-03-23 Merck & Co., Inc. Bicyclic anilide spirolactam cgrp receptor antagonists
AU2006316642A1 (en) * 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam tricyclic CGRP receptor antagonists
AU2006316644B2 (en) 2005-11-18 2011-11-10 Merck Sharp & Dohme Corp. Spirohydantoin tricyclic CGRP receptor antagonists
JP2009515971A (ja) * 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド スピロヒダントインアリールｃｇｒｐ受容体アンタゴニスト
WO2007061677A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
TW200732302A (en) * 2005-12-13 2007-09-01 Daicel Chem Indoline derivative
AU2007284994B2 (en) 2006-05-09 2010-04-22 Merck Sharp & Dohme Corp. Substituted spirocyclic CGRP receptor antagonists
US7951795B2 (en) * 2006-12-08 2011-05-31 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
US8372859B2 (en) * 2007-04-11 2013-02-12 Merck, Sharp & Dohme Corp. CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups
WO2008130524A1 (en) * 2007-04-16 2008-10-30 Merck & Co., Inc. Aryl heterocyclic cgrp receptor antagonists
AU2008241488A1 (en) * 2007-04-16 2008-10-30 Merck Sharp & Dohme Corp. Bicyclic anilide heterocyclic CGRP receptor antagonists
CA2689217C (en) * 2007-06-05 2016-02-16 Merck & Co., Inc. Carboxamide heterocyclic cgrp receptor antagonists
WO2008153852A1 (en) * 2007-06-07 2008-12-18 Merck & Co., Inc. Tricyclic anilide heterocyclic cgrp receptor antagonists
JP2011523958A (ja) 2008-06-12 2011-08-25 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体アンタゴニストとしての分岐状３−及び６−置換キノリン
CA2735821A1 (en) * 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Monocyclic amide cgrp receptor antagonists
EP2378877A4 (de) * 2008-12-17 2012-05-23 Merck Sharp & Dohme Imidazolinonderivate als cgrp-rezeptorantagonisten
EP2471776A1 (de) 2010-12-28 2012-07-04 Bayer CropScience AG Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide
US9174989B2 (en) * 2012-05-09 2015-11-03 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
WO2018005865A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
CN106008528A (zh) * 2016-07-28 2016-10-12 安徽赛迪生物科技有限公司 一种合成4-氯-5,7-二氢-6h-吡咯并[2,3-d]嘧啶-6-酮的方法
WO2019006393A1 (en) 2017-06-29 2019-01-03 G1 Therapeutics, Inc. Morphic forms of git38 and methods of manufacture thereof
US20210130445A1 (en) * 2019-07-05 2021-05-06 Allergan Pharmaceuticals International Limited CGRP Antagonists and Botulinum Toxins for the Treatment of Inflammatory and Neurologic Disorders
US20210121541A1 (en) * 2019-07-05 2021-04-29 Allergan Pharmaceuticals International Limited CGRP Antagonists and Clostridial Derivatives for the Treatment of Neuropsychiatric and Neurological Disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
WO1989008654A1 (en) * 1988-03-11 1989-09-21 Pfizer Inc. Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
AUPN449295A0 (en) * 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
JPH11512396A (ja) * 1995-09-05 1999-10-26 スミスクライン・ビーチャム・コーポレイション 化合物および方法
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU5227001A (en) * 2000-05-03 2001-11-12 Hoffmann La Roche Hydantoin-containing glucokinase activators
JP2004537526A (ja) * 2001-06-12 2004-12-16 メルク　エンド　カムパニー　インコーポレーテッド 片頭痛の治療又は予防用ｎｒ２ｂ受容体拮抗薬
RS52552B (sr) * 2002-06-05 2013-04-30 Bristol-Myers Squibb Company Antagonisti, peptidnog receptora koji je u vezi sa kalcitoninskim genom
EP1606264B1 (de) 2003-03-14 2012-05-02 Merck Sharp & Dohme Corp. Monocyclische anilidspirohydantoine als cgrp-rezeptorantagonisten
US7659300B2 (en) * 2004-09-08 2010-02-09 Merck Sharp & Dohme Corp. Monocyclic anilide spirolactam CGRP receptor antagonists
CN101014345A (zh) * 2004-09-09 2007-08-08 默克公司 三环酰苯胺螺环内酰胺cgrp受体拮抗剂

Also Published As

Publication number Publication date
US7696192B2 (en) 2010-04-13
US8133891B2 (en) 2012-03-13
JP2008512456A (ja) 2008-04-24
EP1793827A2 (de) 2007-06-13
WO2006031491A3 (en) 2006-11-09
AU2005285270B2 (en) 2011-04-21
EP1793827A4 (de) 2009-07-29
CN101014345A (zh) 2007-08-08
DE602005020472D1 (de) 2010-05-20
US20080214511A1 (en) 2008-09-04
EP1793827B1 (de) 2010-04-07
US20100160334A1 (en) 2010-06-24
AU2005285270A1 (en) 2006-03-23
WO2006031491A2 (en) 2006-03-23
CA2579717A1 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
ATE463245T1 (de) Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
ATE464305T1 (de) Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors
ATE518852T1 (de) Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
ATE537153T1 (de) Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors
WO2006029153A3 (en) Monocyclic anilide spirolactam cgrp receptor antagonists
NO20072435L (no) CGRP-reseptorantagonister
WO2006031606A3 (en) Carboxamide spirolactam cgrp receptor antagonists
ATE394400T1 (de) Bicyclische anilidspirohydantoine als cgrp- rezeptorantagonisten
ATE509019T1 (de) Benzodiazepinspirohydantoine als cgrp- rezeptorantagonisten
ATE535514T1 (de) Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten
JO2355B1 (en) Hereditary calcitonin polypeptide receptor antagonists
ATE516803T1 (de) Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
ATE466860T1 (de) Cgrp-rezeptorantagonisten
ATE556060T1 (de) Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten
WO2008112159A3 (en) Monocyclic anilide spirolactam cgrp receptor antagonists
ATE537170T1 (de) Cgrp-rezeptorantagonisten
WO2005000807A3 (en) Benzodiazepine cgrp receptor antagonists
ATE503755T1 (de) Cgrp-rezeptorantagonisten
WO2007016087A3 (en) Heterocyclic benzodiazepine cgrp receptor antagonists
WO2006041830A3 (en) Cgrp receptor antagonists
DE602005027870D1 (de) Cgrp-rezeptorantagonisten
ATE466853T1 (de) Cgrp-rezeptorantagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties