ATE59962T1 - Thrombin bindender stoff und verfahren zu seiner herstellung. - Google Patents
Thrombin bindender stoff und verfahren zu seiner herstellung.Info
- Publication number
- ATE59962T1 ATE59962T1 AT87100603T AT87100603T ATE59962T1 AT E59962 T1 ATE59962 T1 AT E59962T1 AT 87100603 T AT87100603 T AT 87100603T AT 87100603 T AT87100603 T AT 87100603T AT E59962 T1 ATE59962 T1 AT E59962T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- affinity
- binding substance
- production
- substance
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 4
- 229960004072 thrombin Drugs 0.000 title abstract 4
- 239000000126 substance Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 abstract 1
- 229940043264 dodecyl sulfate Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001962 electrophoresis Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 210000002826 placenta Anatomy 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- AWLUSOLTCFEHNE-UHFFFAOYSA-N sodium;urea Chemical compound [Na].NC(N)=O AWLUSOLTCFEHNE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Pregnancy & Childbirth (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61010620A JPH0689014B2 (ja) | 1986-01-21 | 1986-01-21 | トロンビン結合性物質およびその製法 |
| EP87100603A EP0230945B1 (de) | 1986-01-21 | 1987-01-19 | Thrombin bindender Stoff und Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE59962T1 true ATE59962T1 (de) | 1991-02-15 |
Family
ID=11755265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87100603T ATE59962T1 (de) | 1986-01-21 | 1987-01-19 | Thrombin bindender stoff und verfahren zu seiner herstellung. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4748156A (de) |
| EP (1) | EP0230945B1 (de) |
| JP (1) | JPH0689014B2 (de) |
| AT (1) | ATE59962T1 (de) |
| DE (1) | DE3767311D1 (de) |
| ES (1) | ES2037669T3 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066788A (en) * | 1984-09-21 | 1991-11-19 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
| DK166587B1 (da) * | 1984-09-21 | 1993-06-14 | Boehringer Ingelheim Int | Blodkoagulationshaemmende proteiner, fremgangsmaade til deres fremstilling samt deres anvendelse |
| ATE113062T1 (de) * | 1986-07-15 | 1994-11-15 | Kowa Co | Throminbindende substanz und verfahren zu ihrer herstellung. |
| JPS63146898A (ja) * | 1986-07-15 | 1988-06-18 | Kowa Co | トロンビン結合性物質およびその製法 |
| JPS6330423A (ja) * | 1986-07-22 | 1988-02-09 | Kowa Co | トロンビン結合性物質およびその製法 |
| DE3639561A1 (de) * | 1986-11-20 | 1988-06-01 | Baumann Hanno | Verfahren zur herstellung von nicht-thrombogenen substraten |
| DE3856335T2 (de) * | 1987-01-08 | 2000-01-27 | Asahi Kasei Kogyo K.K., Osaka | Peptid zur beschleunigung der wirkung des proteins-c mit thrombin |
| JP2766473B2 (ja) * | 1987-01-08 | 1998-06-18 | 旭化成工業株式会社 | トロンビンによるプロテインcの活性化を促進するペプチド |
| JPH0720997B2 (ja) * | 1988-08-29 | 1995-03-08 | 興和株式会社 | 新規なトロンビン結合性物質及びその製法 |
| US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
| AU646633B2 (en) * | 1989-02-17 | 1994-03-03 | Codon | Soluble analogs of thrombomodulin |
| US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| US5574134A (en) * | 1989-07-11 | 1996-11-12 | University Of Delaware | Polypeptide monomers, linearly extended and/or crosslinked forms thereof, and applications thereof |
| US5320945A (en) * | 1989-07-14 | 1994-06-14 | Boehringer Mannheim Gmbh | Method and reagent for the determination of antithrombin III |
| ATE89169T1 (de) * | 1989-07-15 | 1993-05-15 | Boehringer Ingelheim Int | Antikoagulanz enthaltendes mittel. |
| AU643306B2 (en) * | 1990-06-27 | 1993-11-11 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant polypeptides |
| AU1456092A (en) * | 1991-02-21 | 1992-09-15 | Gilead Sciences, Inc. | Aptamers specific for thrombin and methods of use |
| US5840867A (en) * | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| EP0572529A4 (de) * | 1991-02-21 | 1994-11-02 | Gilead Sciences Inc | Spezifisches aptamer für biomolekülen und verfahren zu dessen produktion. |
| US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| WO1993007491A1 (en) * | 1991-10-04 | 1993-04-15 | Board Of Regents Of The University Of Nebraska | A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins |
| US5716795A (en) * | 1991-10-04 | 1998-02-10 | Matschiner; John T. | Thrombomodulin-based coagulometric assay of the protein C system |
| US5756291A (en) * | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| US20070215548A1 (en) * | 2006-01-05 | 2007-09-20 | Zhou Joe Xin H | Systems and methods for packing chromatography columns |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE636817A (de) * | 1962-08-31 | |||
| BE787961A (fr) * | 1971-08-24 | 1973-02-26 | Behringwerke Ag | Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere |
| DE2640387C3 (de) * | 1976-09-08 | 1981-01-22 | Behringwerke Ag, 3550 Marburg | Gewebespezifisches Protein und Verfahren zu dessen Herstellung |
| DE2720704C2 (de) * | 1977-05-07 | 1986-09-25 | Behringwerke Ag, 3550 Marburg | Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung |
| DE2842467A1 (de) * | 1978-09-29 | 1980-04-10 | Behringwerke Ag | Neues ubiquitaeres gewebsprotein pp tief 8 |
| DE2854759A1 (de) * | 1978-12-19 | 1980-07-10 | Behringwerke Ag | Neues plazentaspezifisches gewebsprotein pp tief 10 |
| DE3013724A1 (de) * | 1980-04-10 | 1981-10-15 | Behringwerke Ag, 3550 Marburg | Neues protein pp (pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner anreicherung und gewinnung sowieseine verwendung |
| DE3109629A1 (de) * | 1981-03-13 | 1982-09-23 | Behringwerke Ag, 3550 Marburg | "neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung" |
| DE3228503A1 (de) * | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)7(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung |
| DE3230996A1 (de) * | 1982-08-20 | 1984-02-23 | Behringwerke Ag, 3550 Marburg | Neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)3(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung |
| DE3315000A1 (de) * | 1983-04-26 | 1984-10-31 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
| DE3404563A1 (de) * | 1984-02-09 | 1985-08-14 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
| JPS60199819A (ja) * | 1984-03-23 | 1985-10-09 | Kowa Co | トロンビン結合性物質およびその製法 |
| DE3410694A1 (de) * | 1984-03-23 | 1985-10-03 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)2(pfeil abwaerts)(pfeil abwaerts)1(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
-
1986
- 1986-01-21 JP JP61010620A patent/JPH0689014B2/ja not_active Expired - Lifetime
-
1987
- 1987-01-15 US US07/003,465 patent/US4748156A/en not_active Expired - Fee Related
- 1987-01-19 EP EP87100603A patent/EP0230945B1/de not_active Expired - Lifetime
- 1987-01-19 AT AT87100603T patent/ATE59962T1/de not_active IP Right Cessation
- 1987-01-19 ES ES198787100603T patent/ES2037669T3/es not_active Expired - Lifetime
- 1987-01-19 DE DE8787100603T patent/DE3767311D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0689014B2 (ja) | 1994-11-09 |
| ES2037669T3 (es) | 1993-07-01 |
| JPS62169728A (ja) | 1987-07-25 |
| EP0230945B1 (de) | 1991-01-16 |
| US4748156A (en) | 1988-05-31 |
| EP0230945A2 (de) | 1987-08-05 |
| EP0230945A3 (en) | 1988-03-23 |
| DE3767311D1 (de) | 1991-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |