ATE64590T1 - 2-hydroxy-3-aryloxypropyl oder 2-hydroxy-2benzofuranylethyl tertiaeres amin mit antihyperglycemischer und/oder antiobesitaetswirkung. - Google Patents
2-hydroxy-3-aryloxypropyl oder 2-hydroxy-2benzofuranylethyl tertiaeres amin mit antihyperglycemischer und/oder antiobesitaetswirkung.Info
- Publication number
- ATE64590T1 ATE64590T1 AT85108609T AT85108609T ATE64590T1 AT E64590 T1 ATE64590 T1 AT E64590T1 AT 85108609 T AT85108609 T AT 85108609T AT 85108609 T AT85108609 T AT 85108609T AT E64590 T1 ATE64590 T1 AT E64590T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- aryloxypropyl
- substituted
- compound
- formula
- Prior art date
Links
- -1 2-HYDROXY-2BENZOFURANYLETHYL TERTIARY AMINE Chemical class 0.000 title abstract 4
- 230000002058 anti-hyperglycaemic effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848418472A GB8418472D0 (en) | 1984-07-19 | 1984-07-19 | Compounds |
| EP85108609A EP0170121B1 (de) | 1984-07-19 | 1985-07-10 | 2-Hydroxy-3-aryloxypropyl oder 2-Hydroxy-2-benzofuranylethyl tertiäres Amin mit antihyperglycemischer und/oder Antiobesitäts-Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE64590T1 true ATE64590T1 (de) | 1991-07-15 |
Family
ID=10564149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85108609T ATE64590T1 (de) | 1984-07-19 | 1985-07-10 | 2-hydroxy-3-aryloxypropyl oder 2-hydroxy-2benzofuranylethyl tertiaeres amin mit antihyperglycemischer und/oder antiobesitaetswirkung. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0170121B1 (de) |
| JP (1) | JPS6176446A (de) |
| AT (1) | ATE64590T1 (de) |
| AU (1) | AU4517385A (de) |
| DE (1) | DE3583261D1 (de) |
| DK (1) | DK325385A (de) |
| ES (2) | ES8701143A1 (de) |
| GB (1) | GB8418472D0 (de) |
| GR (1) | GR851779B (de) |
| PT (1) | PT80835B (de) |
| ZA (1) | ZA855400B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166218A (en) * | 1983-10-19 | 1992-11-24 | Hoffmann-La Roche Inc. | Phenoxypropanolamines and pharmaceutical compositions thereof |
| CA1262729A (en) * | 1983-10-19 | 1989-11-07 | Leo Alig | Phenoxypropanolamines |
| CA1337429C (en) * | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| GB8620951D0 (en) * | 1986-08-29 | 1986-10-08 | Beecham Group Plc | Compounds |
| EP0300290B1 (de) * | 1987-07-21 | 1991-12-18 | F. Hoffmann-La Roche Ag | Phenoxypropanolamine |
| US5321036A (en) * | 1993-02-10 | 1994-06-14 | Bristol-Myers Squibb Company | Thiazole and oxazole-based β3 adrenergic receptor agonists |
| US5578638A (en) * | 1993-11-05 | 1996-11-26 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists |
| US5563171A (en) * | 1993-11-05 | 1996-10-08 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists |
| WO1998013333A1 (en) * | 1996-09-26 | 1998-04-02 | Kissei Pharmaceutical Co., Ltd. | 2-amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives |
| MY126489A (en) * | 1998-07-08 | 2006-10-31 | Kissei Pharmaceutical | Phenoxyacetic acid derivatives and medicinal compositions containing the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146638A (en) * | 1976-02-17 | 1979-03-27 | Boehringer Ingelheim Gmbh | N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines |
| EP0099707B1 (de) * | 1982-07-16 | 1986-12-10 | Beecham Group Plc | 2-Aminoethyläther-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| CA1258454A (en) * | 1982-08-10 | 1989-08-15 | Leo Alig | Phenethanolamines |
| CA1262729A (en) * | 1983-10-19 | 1989-11-07 | Leo Alig | Phenoxypropanolamines |
-
1984
- 1984-07-19 GB GB848418472A patent/GB8418472D0/en active Pending
-
1985
- 1985-07-10 DE DE8585108609T patent/DE3583261D1/de not_active Expired - Fee Related
- 1985-07-10 AT AT85108609T patent/ATE64590T1/de active
- 1985-07-10 EP EP85108609A patent/EP0170121B1/de not_active Expired - Lifetime
- 1985-07-17 ZA ZA855400A patent/ZA855400B/xx unknown
- 1985-07-17 DK DK325385A patent/DK325385A/da not_active Application Discontinuation
- 1985-07-17 GR GR851779A patent/GR851779B/el unknown
- 1985-07-18 ES ES545365A patent/ES8701143A1/es not_active Expired
- 1985-07-18 JP JP60157137A patent/JPS6176446A/ja active Pending
- 1985-07-18 PT PT80835A patent/PT80835B/pt unknown
- 1985-07-19 AU AU45173/85A patent/AU4517385A/en not_active Abandoned
-
1986
- 1986-03-10 ES ES552860A patent/ES8705362A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB8418472D0 (en) | 1984-08-22 |
| PT80835B (en) | 1987-03-23 |
| ES8701143A1 (es) | 1986-11-16 |
| DE3583261D1 (de) | 1991-07-25 |
| DK325385D0 (da) | 1985-07-17 |
| PT80835A (en) | 1985-08-01 |
| ZA855400B (en) | 1986-05-28 |
| EP0170121B1 (de) | 1991-06-19 |
| ES545365A0 (es) | 1986-11-16 |
| GR851779B (de) | 1985-11-26 |
| EP0170121A1 (de) | 1986-02-05 |
| DK325385A (da) | 1986-01-20 |
| JPS6176446A (ja) | 1986-04-18 |
| AU4517385A (en) | 1986-01-23 |
| ES552860A0 (es) | 1987-05-01 |
| ES8705362A1 (es) | 1987-05-01 |
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