ATE65392T1 - In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel. - Google Patents

In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel.

Info

Publication number: ATE65392T1
Authority: AT; Austria
Prior art keywords: particles; micellular; phospholipidic; antineoplastic agents; anthracycline
Prior art date: 1985-10-15

Application number

AT86301513T

Other languages

English (en)

Inventor

Eric Forssen

Original Assignee

Vestar Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-15

Filing date

1986-03-04

Publication date

1991-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25141806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE65392(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-03-04 Application filed by Vestar Inc filed Critical Vestar Inc

1991-08-15 Application granted granted Critical

1991-08-15 Publication of ATE65392T1 publication Critical patent/ATE65392T1/de

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 3
239000002245 particle Substances 0.000 title abstract 3
229940034982 antineoplastic agent Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
HVVJCLFLKMGEIY-UHFFFAOYSA-N 2,3-dioctadecoxypropyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)OCCCCCCCCCCCCCCCCCC HVVJCLFLKMGEIY-UHFFFAOYSA-N 0.000 abstract 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 1
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
229960000975 daunorubicin Drugs 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
239000008121 dextrose Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT86301513T 1985-10-15 1986-03-04 In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel. ATE65392T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78753585A	1985-10-15	1985-10-15
EP86301513A EP0219922B2 (de)	1985-10-15	1986-03-04	In mizellulare phospholipidische Partikel eingekapselte antineoplastische Anthracyclinmittel

Publications (1)

Publication Number	Publication Date
ATE65392T1 true ATE65392T1 (de)	1991-08-15

Family

ID=25141806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86301513T ATE65392T1 (de)	1985-10-15	1986-03-04	In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel.

Country Status (10)

Country	Link
US (1)	US4769250A (de)
EP (1)	EP0219922B2 (de)
JP (1)	JPH0761947B2 (de)
KR (1)	KR890004689B1 (de)
AT (1)	ATE65392T1 (de)
AU (1)	AU587232B2 (de)
DE (1)	DE3680447D1 (de)
DK (1)	DK175201B1 (de)
IE (1)	IE58981B1 (de)
NO (1)	NO172729C (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5435989A (en)	1982-03-30	1995-07-25	Vestar, Inc.	Method of targeting a specific location in a body
US5077056A (en) *	1984-08-08	1991-12-31	The Liposome Company, Inc.	Encapsulation of antineoplastic agents in liposomes
US5736155A (en) *	1984-08-08	1998-04-07	The Liposome Company, Inc.	Encapsulation of antineoplastic agents in liposomes
US5723147A (en) *	1987-02-23	1998-03-03	Depotech Corporation	Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
MX9203808A (es) *	1987-03-05	1992-07-01	Liposome Co Inc	Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5811119A (en) *	1987-05-19	1998-09-22	Board Of Regents, The University Of Texas	Formulation and use of carotenoids in treatment of cancer
US4863739A (en) *	1987-05-19	1989-09-05	Board Of Regents, The University Of Texas System	Liposome compositions of anthracycline derivatives
JP2501336B2 (ja) *	1987-07-02	1996-05-29	第一製薬株式会社	安定なリポソ−ム製剤
FI874742A7 (fi) *	1987-10-28	1989-04-29	K & V Licencing Oy	Menetelmä liposomien valmistamiseksi.
IE63518B1 (en) *	1987-11-18	1995-05-03	Vestar Inc	Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) *	1987-11-18	1990-08-07	Vestar, Inc.	Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
EP0396626A1 (de) *	1988-01-19	1990-11-14	Board Of Regents, The University Of Texas System	Glycoside, sie enthaltende liposome und ihre verwendung
US5807572A (en) *	1988-02-18	1998-09-15	Depotech Corporation	Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5422120A (en) *	1988-05-30	1995-06-06	Depotech Corporation	Heterovesicular liposomes
DE68916439T2 (de) *	1988-10-05	1994-10-20	Vestar Inc	Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.
US5013556A (en) *	1989-10-20	1991-05-07	Liposome Technology, Inc.	Liposomes with enhanced circulation time
US20010051183A1 (en) *	1989-10-20	2001-12-13	Alza Corporation	Liposomes with enhanced circulation time and method of treatment
US6060080A (en) *	1990-07-16	2000-05-09	Daiichi Pharmaceutical Co., Ltd.	Liposomal products
CA2046997C (en) *	1990-07-16	2000-12-12	Hiroshi Kikuchi	Liposomal products
DE4023241A1 (de) *	1990-07-21	1992-01-23	Knoll Ag	Stabile wirkstoff-formulierung
DK0555229T3 (da) *	1990-07-31	1996-08-19	Liposome Co Inc	Akkumulation af aminosyrer og peptider i liposomer
JP2599492B2 (ja) *	1990-08-21	1997-04-09	第一製薬株式会社	リポソーム製剤の製造法
JPH06511470A (ja) *	1991-07-03	1994-12-22	ネクスター・フアーマシユーテイカルズ・インコーポレイテツド	薬剤を含むリポソームの調製における充填技術
US5665381A (en) *	1992-02-25	1997-09-09	Nexstar Pharmaceuticals, Inc.	Inhibition of aggregation of drug containing particles
BR9201168A (pt) *	1992-04-02	1994-04-12	Zerbini E J Fundacao	Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
EP0619730B1 (de) *	1992-10-08	2000-12-27	Supratek Pharma Inc.	Zusammensetzung von in mizellen eingeschlossenen antineoplastischen wirkstoffen
US6093391A (en) *	1992-10-08	2000-07-25	Supratek Pharma, Inc.	Peptide copolymer compositions
US5817321A (en) *	1992-10-08	1998-10-06	Supratek Pharma, Inc.	Biological agent compositions
US5455044A (en) *	1993-05-14	1995-10-03	Depotech Corporation	Method for treating neurological disorders
AU686277B2 (en) *	1993-11-16	1998-02-05	Pacira Pharmaceuticals, Inc.	Vesicles with controlled release of actives
EP0664117A1 (de) *	1994-01-25	1995-07-26	F. Hoffmann-La Roche Ag	Liposomenlösungen
US5714163A (en) *	1994-06-27	1998-02-03	Nexstar Pharmaceuticals, Inc.	Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5993850A (en) *	1994-09-13	1999-11-30	Skyepharma Inc.	Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US20040208922A1 (en) *	1995-06-07	2004-10-21	The Regents Of The University Of California	Method for loading lipid like vesicles with drugs or other chemicals
US5931809A (en) *	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
ATE310505T1 (de) *	1996-05-14	2005-12-15	Stanislaw R Burzynski	Liposomale antineoplaston therapie mit bemerkenswert verbesserter antineoplastischer aktivität
US6060518A (en) *	1996-08-16	2000-05-09	Supratek Pharma Inc.	Polymer compositions for chemotherapy and methods of treatment using the same
DE19639811A1 (de) *	1996-09-27	1998-04-02	Artur Herzog Dr Mesmer	Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
US5997899A (en) *	1996-10-01	1999-12-07	Skyepharma Inc.	Method for producing liposomes with increased percent of compound encapsulated
US6123956A (en) *	1997-07-10	2000-09-26	Keith Baker	Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en)	1997-09-08	2001-10-23	Chiron Corporation	High and low load formulations of IGF-I in multivesicular liposomes
CA2304096C (en) *	1997-09-18	2003-09-09	Pacira Pharmaceuticals, Inc.	Sustained-release liposomal anesthetic compositions
US6120800A (en) *	1997-09-25	2000-09-19	Nexstar Pharmaceuticals, Inc.	Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
AU752802C (en) *	1997-11-14	2006-04-13	Pacira Pharmaceuticals, Inc.	Production of multivesicular liposomes
AU5246900A (en) *	1999-06-14	2001-01-02	Japan Science And Technology Corporation	Anticancer emulsions containing anthracycline compounds
KR100915741B1 (ko) *	2001-06-15	2009-09-04	코너스톤 파마슈티칼스	표적 조직 및 세포를 치료하기에 유용한 나노입자를함유하는 약제학적 및 진단학적 조성물
JP2005518266A (ja) *	2001-09-28	2005-06-23	エスペリオンセラピューティクス，インコーポレイテッド	高圧でベシクルを押し出す方法および装置
ES2387886T3 (es) *	2001-11-13	2012-10-03	Celator Pharmaceuticals, Inc.	Composiciones que transportan lípidos con una mejor estabilidad sanguínea
US20030180348A1 (en) *	2002-03-22	2003-09-25	Levinson R. Saul	Transcellular drug delivery system
US8980310B2 (en) *	2002-12-31	2015-03-17	Bharat Serums and Vaccines, Ltd.	Non-pegylated long-circulating liposomes
GB2398495B (en) *	2003-01-23	2007-08-22	Kent G Lau	A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
WO2007070705A2 (en) *	2005-12-15	2007-06-21	The Trustees Of The University Of Pennsylvania	Cationic lipid-mediated vectors
WO2009073517A2 (en) *	2007-11-30	2009-06-11	Indevus Pharmaceuticals, Inc.	Intravesical compositions with valrubicin for the treatment of bladder cancer
US11980636B2 (en)	2020-11-18	2024-05-14	Jazz Pharmaceuticals Ireland Limited	Treatment of hematological disorders
US11278494B1 (en)	2021-01-22	2022-03-22	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en)	2021-01-22	2024-11-26	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en)	2021-01-22	2021-06-15	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en)	2021-01-22	2022-06-14	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
EP4415713A4 (de)	2021-10-14	2025-08-06	Pacira Pharmaceuticals Inc	Bupivacain-multivesikuläre liposomformulierungen und verwendungen davon
US12251472B1 (en)	2024-05-20	2025-03-18	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en)	2024-05-20	2025-04-22	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en)	2024-05-20	2024-12-03	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1523965A (en) *	1976-03-19	1978-09-06	Ici Ltd	Pharmaceutical compositions containing steroids
CH621479A5 (de) *	1977-08-05	1981-02-13	Battelle Memorial Institute
US4356167A (en) *	1978-01-27	1982-10-26	Sandoz, Inc.	Liposome drug delivery systems
CA1173360A (en) *	1979-06-22	1984-08-28	Jurg Schrank	Pharmaceutical preparations
US4310505A (en) *	1979-11-08	1982-01-12	California Institute Of Technology	Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4331654A (en) *	1980-06-13	1982-05-25	Eli Lilly And Company	Magnetically-localizable, biodegradable lipid microspheres
JPS5793909A (en) *	1980-12-03	1982-06-11	Sankyo Co Ltd	Carcinostatic pharmaceutical having directivity to specific internal organ and its preparation
US4419348A (en) *	1981-04-27	1983-12-06	Georgetown University	Anthracycline glycoside compositions, their use and preparation
US4427664A (en) *	1981-05-29	1984-01-24	The United States Of America As Represented By The Department Of Health And Human Services	2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin
CA1187434A (en) *	1981-08-11	1985-05-21	Akihiro Yoshimoto	Anthracycline antibiotics and their preparation method
DE3374837D1 (en) *	1982-02-17	1988-01-21	Ciba Geigy Ag	Lipids in the aqueous phase
US4438105A (en) *	1982-04-19	1984-03-20	Farmaitalia Carlo Erba S.P.A	4'-Iododerivatives of anthracycline glycosides
US4515736A (en) *	1983-05-12	1985-05-07	The Regents Of The University Of California	Method for encapsulating materials into liposomes
EP0153955A1 (de) *	1983-09-06	1985-09-11	Health Research, Inc.	Verfahren zum verabreichen von liposomen zum herabsetzen der toxizität eines antitumor-arzneimittels
IL69720A (en) *	1983-09-14	1987-08-31	Univ Ramot	Anti-tumor pharmaceutical compositions comprising liposome-bound porphyrins

1986
- 1986-02-27 IE IE53586A patent/IE58981B1/en not_active IP Right Cessation
- 1986-02-28 AU AU54184/86A patent/AU587232B2/en not_active Expired
- 1986-03-04 DK DK198600988A patent/DK175201B1/da not_active IP Right Cessation
- 1986-03-04 EP EP86301513A patent/EP0219922B2/de not_active Expired - Lifetime
- 1986-03-04 AT AT86301513T patent/ATE65392T1/de not_active IP Right Cessation
- 1986-03-04 DE DE8686301513T patent/DE3680447D1/de not_active Expired - Lifetime
- 1986-03-10 JP JP61052346A patent/JPH0761947B2/ja not_active Expired - Lifetime
- 1986-03-31 KR KR1019860002412A patent/KR890004689B1/ko not_active Expired
- 1986-06-03 NO NO862193A patent/NO172729C/no not_active IP Right Cessation
1987
- 1987-10-26 US US07/112,073 patent/US4769250A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR870003775A (ko)	1987-05-04
EP0219922A2 (de)	1987-04-29
IE860535L (en)	1987-04-15
DK98886A (da)	1987-04-16
NO862193D0 (no)	1986-06-03
JPH0761947B2 (ja)	1995-07-05
IE58981B1 (en)	1993-12-15
US4769250A (en)	1988-09-06
KR890004689B1 (ko)	1989-11-25
EP0219922A3 (en)	1987-10-28
DE3680447D1 (de)	1991-08-29
EP0219922B2 (de)	2002-08-28
AU5418486A (en)	1987-04-16
DK175201B1 (da)	2004-07-05
NO862193L (no)	1987-04-21
NO172729C (no)	1993-09-01
NO172729B (no)	1993-05-24
EP0219922B1 (de)	1991-07-24
AU587232B2 (en)	1989-08-10
DK98886D0 (da)	1986-03-04
JPS6287514A (ja)	1987-04-22

Legal Events

Date

Code

Title

Description

2003-04-15

EEIH

Change in the person of patent owner

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0219922

Country of ref document: EP

2006-06-15

EELA

Cancelled due to lapse of time

Publication	Publication Date	Title
ATE65392T1 (de)	1991-08-15	In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel.
NO873492D0 (no)	1987-08-19	Fremgangsmaate for fremstilling av antifungale preparater.
DK86988A (da)	1988-08-26	Liposompraeparat og anvendelse deraf
DE3855265D1 (de)	1996-06-13	Liposomen-Formulierungen mit hohem antineoplastischem Wirkstoff/Lipid-Verhältnis
DE3782492D1 (de)	1992-12-10	Liposom-anthrachinon-arzneimittel-zusammensetzung und herstellung.
AR241117A2 (es)	1991-11-15	Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos
EP0140085A3 (en)	1986-08-06	Drug-containing lipid vesicle preparation and method for preparing them
KR950700725A (ko)	1995-02-20	리포솜 조성물(liposome composition)
DK32388A (da)	1988-07-28	Phospholipid-baeremiddel for vand-uoploeselige aktive bestanddele
DE3878922D1 (de)	1993-04-08	Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.
ATE70456T1 (de)	1992-01-15	Verwendung von micellaren partikeln zur herstellung von zusammensetzungen zum beschiessen von tumoren in menschen und deren verwendung.
JPS57179114A (en)	1982-11-04	Acetylsalicylic acid liposome preparation
ATE98481T1 (de)	1994-01-15	Heilungsfoerdernde zusammensetzung.