ATE70828T1 - Quinonderivate, ihre herstellung und verwendung. - Google Patents

Quinonderivate, ihre herstellung und verwendung.

Info

Publication number: ATE70828T1
Authority: AT; Austria
Prior art keywords: sup; agents; sub; hydrogen atom; group
Prior art date: 1986-01-30

Application number

AT87300581T

Other languages

English (en)

Inventor

Shinji Terao

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-30

Filing date

1987-01-23

Publication date

1992-01-15

1987-01-23 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1992-01-15 Application granted granted Critical

1992-01-15 Publication of ATE70828T1 publication Critical patent/ATE70828T1/de

Links

150000004059 quinone derivatives Chemical class 0.000 title abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 3
230000005764 inhibitory process Effects 0.000 abstract 3
YZXBAPSDXZZRGB-DOFZRALJSA-M Arachidonate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC([O-])=O YZXBAPSDXZZRGB-DOFZRALJSA-M 0.000 abstract 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
JXASPPWQHFOWPL-UHFFFAOYSA-N Tamarixin Natural products C1=C(O)C(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 JXASPPWQHFOWPL-UHFFFAOYSA-N 0.000 abstract 1
108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
230000002137 anti-vascular effect Effects 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229960004676 antithrombotic agent Drugs 0.000 abstract 1
229940114078 arachidonate Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
210000000133 brain stem Anatomy 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
210000000748 cardiovascular system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
-1 fatty acid peroxides Chemical class 0.000 abstract 1
210000002216 heart Anatomy 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
201000008383 nephritis Diseases 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
230000002000 scavenging effect Effects 0.000 abstract 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03C—MODULATION
- H03C1/00—Amplitude modulation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Lubricants (AREA)

AT87300581T 1986-01-30 1987-01-23 Quinonderivate, ihre herstellung und verwendung. ATE70828T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP1954786		1986-01-30
JP9416886		1986-04-23
EP19870300581 EP0234729B1 (de)	1986-01-30	1987-01-23	Quinonderivate, ihre Herstellung und Verwendung

Publications (1)

Publication Number	Publication Date
ATE70828T1 true ATE70828T1 (de)	1992-01-15

Family

ID=26356389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87300581T ATE70828T1 (de)	1986-01-30	1987-01-23	Quinonderivate, ihre herstellung und verwendung.

Country Status (16)

Country	Link
US (3)	US4851413A (de)
EP (1)	EP0234729B1 (de)
JP (1)	JPH0830061B2 (de)
KR (1)	KR870007119A (de)
CN (1)	CN87100723A (de)
AT (1)	ATE70828T1 (de)
AU (1)	AU601657B2 (de)
CA (1)	CA1285562C (de)
DE (1)	DE3775427D1 (de)
DK (1)	DK28687A (de)
FI (1)	FI870394A7 (de)
HU (1)	HU198908B (de)
IL (1)	IL81264A (de)
NO (1)	NO870379L (de)
PT (1)	PT84217B (de)
SU (1)	SU1676442A3 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0301861B1 (de) *	1987-07-29	1992-04-01	Takeda Chemical Industries, Ltd.	Zellproliferationsinhibitor
JPH08768B2 (ja) *	1989-08-24	1996-01-10	武田薬品工業株式会社	神経成長因子分泌誘導剤
IE920595A1 (en) *	1991-03-11	1992-09-23	Eisai Co Ltd	Quinone derivatives
EP0560568A3 (en) *	1992-03-13	1994-06-29	Takeda Chemical Industries Ltd	Hydroquinone derivatives and intermediates for production thereof
WO1993024472A1 (fr) *	1992-05-29	1993-12-09	Otsuka Pharmaceutical Co., Ltd.	Derive de thiazole
US5639770A (en) *	1992-05-29	1997-06-17	Otsuka Pharmaceutical Co., Ltd.	Thiazole derivatives
EP0774967A1 (de) *	1994-08-12	1997-05-28	Takeda Chemical Industries, Ltd.	Verwendung von chinon- und hydrochinonderivaten zur behandlung von kachexie
CA2166017A1 (en) *	1994-12-26	1996-06-27	Yasuko Ashida	Pharmaceutical composition for the dermatitis
US6664255B1 (en)	1999-05-19	2003-12-16	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6908919B2 (en) *	1999-05-19	2005-06-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6750342B1 (en)	1999-05-19	2004-06-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en)	1999-05-19	2004-04-06	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6906068B1 (en)	1999-05-19	2005-06-14	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants
US6458952B1 (en) *	1999-05-19	2002-10-01	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) *	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en)	1999-05-19	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) *	1999-05-19	2003-11-25	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6660885B2 (en) *	2000-03-13	2003-12-09	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
US6693121B2 (en)	2000-04-05	2004-02-17	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
PT1268463E (pt) *	2000-04-05	2005-05-31	Pharmacia Corp	4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao
US6686484B2 (en)	2000-04-17	2004-02-03	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en)	2000-11-20	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
WO2002042272A2 (en) *	2000-11-20	2002-05-30	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7119094B1 (en)	2000-11-20	2006-10-10	Warner-Lambert Company	Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US20030236257A1 (en) *	2001-04-04	2003-12-25	South Michael S.	Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade
JP2005519866A (ja) *	2001-10-03	2005-07-07	ファルマシア・コーポレーション	凝固カスケードの選択阻害に有用な６員複素環式化合物
US20040106626A1 (en) *	2001-10-03	2004-06-03	Pharmacia Corporation	6-Membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
EP1432687A2 (de) *	2001-10-03	2004-06-30	Pharmacia Corporation	Substitutierte fünfgliedrige polyzyclischen vebindungen für die selektive hemmung der koagulationskaskade
US20040082585A1 (en) *	2001-10-03	2004-04-29	Pharmacia Corporation	Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
DE60222580T2 (de) *	2001-11-13	2008-06-12	Celator Pharmaceuticals, Inc.	Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
US20040068113A1 (en) *	2001-11-20	2004-04-08	South Michael S.	Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US6653311B1 (en)	2002-06-25	2003-11-25	Board Of Supervisors Of Louisiana State University	5-lipoxygenase inhibitors: (2-azinylamino) quinone derivatives
US8101371B2 (en)	2007-10-18	2012-01-24	Musc Foundation For Research Development	Methods for the diagnosis of genitourinary cancer
US8263094B2 (en) *	2008-09-23	2012-09-11	Eastman Chemical Company	Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
EP2505583A1 (de) *	2011-03-29	2012-10-03	Centre National de la Recherche Scientifique	Totalsynthese von redoxaktiven 1,4-Naphthochinone und deren Metaboliten und sowie deren therapeutische Verwendung als Antimalaria- und Schistomizidmittel
US10189830B2 (en)	2013-03-15	2019-01-29	Bioelectron Technology Corporation	Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders

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Publication number	Priority date	Publication date	Assignee	Title
US3929880A (en) *	1971-08-21	1975-12-30	Merck Patent Gmbh	Process for the preparation of oxocarboxylic acid amides and oxocarboxylic acids
US4201588A (en) *	1974-04-15	1980-05-06	Eastman Kodak Company	Radiation sensitive co(III)complex photoreduction element with image recording layer
US4271083A (en) *	1974-05-02	1981-06-02	Takeda Chemical Industries, Ltd.	6-Hydroxy-1,4-benzoquinone compounds
EP0003732B1 (de) *	1978-02-01	1983-10-19	The Wellcome Foundation Limited	Imidazolderivate und deren Salze, deren Herstellung sowie deren pharmazeutische Zusammensetzungen
EP0004727B1 (de) *	1978-04-12	1981-08-12	Imperial Chemical Industries Plc	Pyridinderivate, die die Aggregation von Blutplättchen hemmen, diese Derivate enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
US4393075A (en) *	1980-04-14	1983-07-12	Takeda Chemical Industries, Ltd.	Quinone compounds and their use in suppressing the production of SRS-A in mammals
JPS58177934A (ja) *	1982-04-13	1983-10-18	Takeda Chem Ind Ltd	ベンゾキノン誘導体
JPS5910541A (ja) *	1982-07-09	1984-01-20	Takeda Chem Ind Ltd	キノン化合物
MX9203040A (es) *	1984-08-01	1992-07-31	Takeda Chemical Industries Ltd	Derivados de quinona y composicion farmaceutica que los contiene.

1987
- 1987-01-14 IL IL81264A patent/IL81264A/xx not_active IP Right Cessation
- 1987-01-15 CA CA000527381A patent/CA1285562C/en not_active Expired - Lifetime
- 1987-01-16 US US07/004,138 patent/US4851413A/en not_active Expired - Lifetime
- 1987-01-20 DK DK028687A patent/DK28687A/da not_active Application Discontinuation
- 1987-01-22 AU AU67933/87A patent/AU601657B2/en not_active Ceased
- 1987-01-23 EP EP19870300581 patent/EP0234729B1/de not_active Expired - Lifetime
- 1987-01-23 AT AT87300581T patent/ATE70828T1/de not_active IP Right Cessation
- 1987-01-23 DE DE8787300581T patent/DE3775427D1/de not_active Expired - Fee Related
- 1987-01-27 KR KR870000637A patent/KR870007119A/ko not_active Abandoned
- 1987-01-29 SU SU874028912A patent/SU1676442A3/ru active
- 1987-01-29 PT PT84217A patent/PT84217B/pt not_active IP Right Cessation
- 1987-01-29 FI FI870394A patent/FI870394A7/fi not_active Application Discontinuation
- 1987-01-29 NO NO870379A patent/NO870379L/no unknown
- 1987-01-30 JP JP62021516A patent/JPH0830061B2/ja not_active Expired - Lifetime
- 1987-01-30 CN CN198787100723A patent/CN87100723A/zh active Pending
- 1987-01-30 HU HU87310A patent/HU198908B/hu not_active IP Right Cessation
1989
- 1989-04-25 US US07/343,142 patent/US4985447A/en not_active Expired - Fee Related
1990
- 1990-10-19 US US07/600,149 patent/US5106858A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA1285562C (en)	1991-07-02
JPS6345257A (ja)	1988-02-26
US4851413A (en)	1989-07-25
EP0234729A3 (en)	1988-01-27
PT84217A (en)	1987-02-01
DK28687A (da)	1987-07-31
DK28687D0 (da)	1987-01-20
HUT44504A (en)	1988-03-28
IL81264A0 (en)	1987-08-31
NO870379L (no)	1987-07-31
HU198908B (en)	1989-12-28
NO870379D0 (no)	1987-01-29
DE3775427D1 (de)	1992-02-06
KR870007119A (ko)	1987-08-14
US4985447A (en)	1991-01-15
IL81264A (en)	1990-11-05
FI870394A7 (fi)	1987-07-31
PT84217B (pt)	1989-09-14
EP0234729B1 (de)	1991-12-27
AU601657B2 (en)	1990-09-13
EP0234729A2 (de)	1987-09-02
AU6793387A (en)	1987-08-06
CN87100723A (zh)	1987-09-16
JPH0830061B2 (ja)	1996-03-27
SU1676442A3 (ru)	1991-09-07
FI870394A0 (fi)	1987-01-29
US5106858A (en)	1992-04-21

Legal Events

Date	Code	Title	Description
1992-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE70828T1 (de)	1992-01-15	Quinonderivate, ihre herstellung und verwendung.
ES8704870A1 (es)	1987-04-16	Un procedimiento para preparar derivados de quiniona.
IL107185A0 (en)	1994-01-25	25-Carboxylic acid derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
FR2360587A1 (fr)	1978-03-03	Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
JPS6483010A (en)	1989-03-28	Melanization inhibitory drug for external use
DE69705902T2 (de)	2001-11-15	Verbindungen zur Modulierung von Hormonrezeptoren, diese enthaltende Zusammensetzungen und ihre Verwendung in Therapie
ES448397A1 (es)	1977-08-01	Procedimiento para la obtencion de esteres de alcoxialquil- hidropiridinas.
ES8603184A1 (es)	1986-01-01	Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
GB1453828A (en)	1976-10-27	Fluoro-substituted thiaxanthene derivatives
ES8102563A1 (es)	1981-01-16	Procedimiento para la preparacion de nuevas sustancias analogas de prostaciclina
YU45900B (sh)	1992-09-07	Postupak za dobijanje n-oksid estara piridilkarbonske kiseline
IT1130997B (it)	1986-06-18	Esteri e derivati chinucleidinici di acidi fenossicarbossilici,procedimento per la loro preparazione e relative composizioni farmaceutiche
JPS5695188A (en)	1981-08-01	Theophyllin derivative and its production
ES482469A1 (es)	1980-04-01	Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas.
DE3469734D1 (en)	1988-04-14	Biphenylylalkanoic acid derivatives, methods of preparation and pharmaceutical compositions therefrom
GB1510092A (en)	1978-05-10	Derivatives of vincaminic acid hydrazide
JPS5598200A (en)	1980-07-25	Preparation of 24xi, 25-dihydroxycholesta-1,4,6-trien-3-one
JPS51115481A (en)	1976-10-12	Process for preparation of (3,4-dihydro-6-carbostyril)carboxylic and e ster derivatives
ES8307782A1 (es)	1983-08-01	Procedimiento para la preparacion de un nuevo derivado perteneciente a la familia de los 3-amino-1-heteroariloxi-2-propanoles.