ATE76296T1 - Pharmazeutische zusammensetzung zur behandlung von akuter myocardischer ischaemie. - Google Patents
Pharmazeutische zusammensetzung zur behandlung von akuter myocardischer ischaemie.Info
- Publication number
- ATE76296T1 ATE76296T1 AT85200159T AT85200159T ATE76296T1 AT E76296 T1 ATE76296 T1 AT E76296T1 AT 85200159 T AT85200159 T AT 85200159T AT 85200159 T AT85200159 T AT 85200159T AT E76296 T1 ATE76296 T1 AT E76296T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- pharmaceutical composition
- acute myocardial
- myocardial ischaemia
- ischaemia
- Prior art date
Links
- 208000031225 myocardial ischemia Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 210000001557 animal structure Anatomy 0.000 abstract 1
- 229960004120 defibrotide Drugs 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8419645A IT1206341B (it) | 1984-02-16 | 1984-02-16 | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| EP85200159A EP0152148B1 (de) | 1984-02-16 | 1985-02-11 | Pharmazeutische Zusammensetzung zur Behandlung von akuter myocardischer Ischämie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE76296T1 true ATE76296T1 (de) | 1992-06-15 |
Family
ID=11160049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85200159T ATE76296T1 (de) | 1984-02-16 | 1985-02-11 | Pharmazeutische zusammensetzung zur behandlung von akuter myocardischer ischaemie. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4693995A (de) |
| EP (1) | EP0152148B1 (de) |
| JP (1) | JPH0649651B2 (de) |
| AT (1) | ATE76296T1 (de) |
| AU (1) | AU585495B2 (de) |
| BE (1) | BE901737A (de) |
| CH (1) | CH662509A5 (de) |
| DE (1) | DE3505359C2 (de) |
| IT (1) | IT1206341B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1170214B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per la cura delle arteriopatie periferiche |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| EP0290496B2 (de) * | 1986-10-06 | 1995-12-20 | The University Of Virginia Alumni Patents Foundation | Verwendung einer adenosin, hypoxanthin und ribose enthaltender lösung zur schonung des herzens während chirurgischer eingriffe |
| IT1223322B (it) * | 1987-10-23 | 1990-09-19 | Crinos Industria Farmaco | Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso |
| IT1231509B (it) * | 1989-09-07 | 1991-12-07 | Crinos Industria Farmaco | Composizione farmceutica ad uso topico per la terapia della fragilita' capillare. |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| US5977083A (en) * | 1991-08-21 | 1999-11-02 | Burcoglu; Arsinur | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
| US6699985B2 (en) | 1991-08-21 | 2004-03-02 | Arsinur Burcoglu | Method of treating HIV infection and related secondary infections thereof |
| IT1252174B (it) * | 1991-12-09 | 1995-06-05 | Crinos Industria Farmaco | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
| EP0678029A1 (de) * | 1993-01-13 | 1995-10-25 | BURCOGLU, Arsinur | Verfahren zum gebrauch von poly-, oligonukleotiden und deren derivate für die behandelung von verschiedenen krankheitsstadien |
| US5852000A (en) * | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
| JP3057295B2 (ja) * | 1993-08-25 | 2000-06-26 | 株式会社大塚製薬工場 | 心機能回復剤 |
| CA2259041A1 (en) * | 1997-04-28 | 1998-11-05 | Arsinur Burcoglu | Method of treating hiv infection and related secondary infections thereof |
| US7252818B2 (en) * | 1998-07-24 | 2007-08-07 | Cardiovascular Biotherapeutics, Inc. | Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis |
| EP1147777A1 (de) | 2000-04-18 | 2001-10-24 | Crinos Industria Farmacobiologica S.p.A. | Kombination von Defibrotid und G-CSF und ihre Verwendung zur Aktivierung der hämatopoiestischen Vorläuferzellen |
| EP1325962A1 (de) * | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | Methode zur Bestimmung der biologischen Aktivität von Defibrotide |
| EP1495702A1 (de) | 2003-07-10 | 2005-01-12 | Nestec S.A. | Vorrichtung zur Extraktion einer Kartusche |
| ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
| EP1855697A2 (de) * | 2005-03-03 | 2007-11-21 | Gentium Spa | Oligodesoxyribonukleotide von 4000-10000 dalton zur behandlung von tumoren |
| EP1872787A1 (de) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Verwendung von Defibrotide als Heparanasehemmer |
| EP1982722A1 (de) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Verwendung von Oligotid zur Behandlung von Nierenerkrankungen |
| EP2103689A1 (de) | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetische Phosphodiester-Oligonukleotide und deren therapeutische Verwendungen |
| IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
| DE102010039631A1 (de) | 2010-08-22 | 2012-02-23 | Ulrich Schubert | Pharmazeutische Zusammensetzungen mit immunmodulatorischen Eigenschaften |
| EP2637672B1 (de) | 2010-11-12 | 2018-08-22 | Gentium S.r.l. | Defibrotid zur prophylaxe und/oder behandlung von graft-versus-host-reaktion (gvhr) |
| KR102038357B1 (ko) | 2012-06-22 | 2019-10-31 | 젠티엄 에스알엘 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (de) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Zellenbasiertes Verfahren zur Bestimmung der Wirksamkeit von Defibrotid |
| EP3661484A1 (de) | 2017-08-03 | 2020-06-10 | Jazz Pharmaceuticals Ireland Limited | Formulierungen mit einer nukleinsäure in hoher konzentration |
| WO2019200251A1 (en) | 2018-04-12 | 2019-10-17 | Jazz Pharmaceuticals, Inc. | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
| WO2020118165A1 (en) | 2018-12-07 | 2020-06-11 | Jazz Pharmaceuticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| US20230190783A1 (en) | 2020-02-28 | 2023-06-22 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| US20230086833A1 (en) | 2020-04-17 | 2023-03-23 | Jazz Pharmaceuticals Ireland Limited | Defibrotide treatment for the prevention of organ rejection and injury |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
-
1984
- 1984-02-16 IT IT8419645A patent/IT1206341B/it active
-
1985
- 1985-02-11 AT AT85200159T patent/ATE76296T1/de active
- 1985-02-11 EP EP85200159A patent/EP0152148B1/de not_active Expired - Lifetime
- 1985-02-14 US US06/701,695 patent/US4693995A/en not_active Expired - Fee Related
- 1985-02-14 BE BE0/214518A patent/BE901737A/fr not_active IP Right Cessation
- 1985-02-15 JP JP60029218A patent/JPH0649651B2/ja not_active Expired - Lifetime
- 1985-02-15 DE DE3505359A patent/DE3505359C2/de not_active Expired - Fee Related
- 1985-02-15 CH CH722/85A patent/CH662509A5/it not_active IP Right Cessation
- 1985-02-15 AU AU38787/85A patent/AU585495B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE3505359A1 (de) | 1985-08-22 |
| AU585495B2 (en) | 1989-06-22 |
| AU3878785A (en) | 1985-08-22 |
| JPH0649651B2 (ja) | 1994-06-29 |
| US4693995A (en) | 1987-09-15 |
| EP0152148B1 (de) | 1992-05-20 |
| IT8419645A0 (it) | 1984-02-16 |
| JPS60188323A (ja) | 1985-09-25 |
| BE901737A (fr) | 1985-05-29 |
| DE3505359C2 (de) | 1994-01-20 |
| IT1206341B (it) | 1989-04-14 |
| EP0152148A2 (de) | 1985-08-21 |
| CH662509A5 (it) | 1987-10-15 |
| EP0152148A3 (en) | 1987-04-29 |
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