ATE80799T1 - Verfahren zur mikroverkapselung eines arzneistoffs, so hergestellter arzneistoff sowie diesen enthaltende arzneimittel. - Google Patents
Verfahren zur mikroverkapselung eines arzneistoffs, so hergestellter arzneistoff sowie diesen enthaltende arzneimittel.Info
- Publication number
- ATE80799T1 ATE80799T1 AT86201400T AT86201400T ATE80799T1 AT E80799 T1 ATE80799 T1 AT E80799T1 AT 86201400 T AT86201400 T AT 86201400T AT 86201400 T AT86201400 T AT 86201400T AT E80799 T1 ATE80799 T1 AT E80799T1
- Authority
- AT
- Austria
- Prior art keywords
- medicinal
- substance
- coating agent
- medicinal substance
- encapsulation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000012907 medicinal substance Substances 0.000 title 2
- 238000005538 encapsulation Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000011248 coating agent Substances 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 239000003094 microcapsule Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Fats And Perfumes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8522009A IT1214629B (it) | 1985-08-29 | 1985-08-29 | Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono |
| EP86201400A EP0212751B1 (de) | 1985-08-29 | 1986-08-08 | Verfahren zur Mikroverkapselung eines Arzneistoffs, so hergestellter Arzneistoff sowie diesen enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE80799T1 true ATE80799T1 (de) | 1992-10-15 |
Family
ID=11190128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86201400T ATE80799T1 (de) | 1985-08-29 | 1986-08-08 | Verfahren zur mikroverkapselung eines arzneistoffs, so hergestellter arzneistoff sowie diesen enthaltende arzneimittel. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4766012A (de) |
| EP (1) | EP0212751B1 (de) |
| JP (1) | JPH0780755B2 (de) |
| AT (1) | ATE80799T1 (de) |
| DE (1) | DE3686796T2 (de) |
| IT (1) | IT1214629B (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63287543A (ja) * | 1987-05-19 | 1988-11-24 | Eisai Co Ltd | マイクロカプセルの製造方法 |
| US4895725A (en) * | 1987-08-24 | 1990-01-23 | Clinical Technologies Associates, Inc. | Microencapsulation of fish oil |
| WO1989003678A1 (en) * | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
| US4916161A (en) * | 1988-10-25 | 1990-04-10 | Bristol-Myers Squibb | Taste-masking pharmaceutical agents |
| JPH0634807B2 (ja) * | 1989-06-08 | 1994-05-11 | 信越化学工業株式会社 | 医薬用硬質カプセルの製造方法 |
| DK0524180T3 (da) * | 1990-04-11 | 1995-09-04 | Upjohn Co | Smagsmaskering af ibuprofen ved fluid bedovertrækning |
| US5578323A (en) * | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
| US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
| US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
| US5443841A (en) * | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
| US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US5714167A (en) * | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| JP3011752B2 (ja) * | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5472712A (en) * | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5792451A (en) * | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5401516A (en) * | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
| US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5709861A (en) * | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AU6819294A (en) * | 1993-04-22 | 1994-11-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| ZA945944B (en) * | 1993-08-13 | 1996-02-08 | Eurand America Inc | Procedure for encapsulating nsaids |
| EP0724433B1 (de) * | 1993-10-22 | 1998-12-30 | Genentech, Inc. | Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe |
| US5512278A (en) * | 1994-01-11 | 1996-04-30 | Phylomed Corporation | Ointment base useful for pharmaceutical preparations |
| US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6090958A (en) * | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5989539A (en) * | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| CN1151836C (zh) * | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
| US5965121A (en) * | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5820881A (en) * | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
| US5750147A (en) * | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| US5824345A (en) * | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
| US5667806A (en) * | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
| US6051258A (en) * | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| GB2320248B (en) * | 1995-09-11 | 1999-04-14 | Emisphere Tech Inc | Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones |
| IL126318A (en) | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
| CA2258264A1 (en) | 1996-06-14 | 1997-12-18 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
| US6479082B1 (en) | 1996-12-23 | 2002-11-12 | Wm. Wrigley, Jr. Co. | Process of increasing flavor release from chewing gum using hydroxypropyl cellulose and product thereof |
| US5990166A (en) * | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5879681A (en) * | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
| US5939381A (en) * | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5804688A (en) * | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6060513A (en) * | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
| US5876710A (en) * | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5962710A (en) * | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
| PT1009387E (pt) | 1997-07-02 | 2006-08-31 | Euro Celtique Sa | Formulacoes estabilizadas de libertacao controlada de tramadol |
| EP1018335B9 (de) * | 1999-01-06 | 2004-03-03 | Tecnimede-Sociedade Tecnico-Medicinal, S.A. | Herstellungsverfahren für granuläre Matrizen durch Polymerausfällung in sauren Lösungen |
| CN1348333A (zh) | 1999-04-01 | 2002-05-08 | Wm.雷格利Jr.公司 | 用于口香糖的风味剂长期持续释放结构 |
| GB9909369D0 (en) | 1999-04-26 | 1999-06-16 | Eurand Int | Method for production of microcapsules |
| DE60128215T2 (de) | 2000-04-20 | 2008-01-10 | Novartis Ag | Beschichtungszusammensetzung zur geschmacksmaskierung |
| US7270937B2 (en) * | 2003-10-17 | 2007-09-18 | Hynix Semiconductor Inc. | Over-coating composition for photoresist and process for forming photoresist pattern using the same |
| ITMI20042356A1 (it) * | 2004-12-10 | 2005-03-10 | Acraf | Composizione farmaceutica orodisperdibile e procedimento per prepararla |
| JP5546129B2 (ja) * | 2005-11-11 | 2014-07-09 | フイルメニツヒ ソシエテ アノニム | フレーバーおよび／またはフレグランスカプセル |
| WO2009064739A1 (en) * | 2007-11-16 | 2009-05-22 | Dow Global Technologies Inc. | Encapsulated low viscosity hydrophobic liquid actives |
| CA2936740C (en) | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| EP4159201A1 (de) | 2021-09-30 | 2023-04-05 | Biomind Labs Inc | Verkapselte mikro- und nanopartikel von dimethyltriptaminen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US28779A (en) * | 1860-06-19 | Improved polish for furniture | ||
| USRE28779E (en) * | 1968-08-03 | 1976-04-20 | Fuji Photo Film Co., Ltd. | Oil-containing microcapsules and method for their production |
| JPS528795B2 (de) * | 1971-12-30 | 1977-03-11 | ||
| JPS5113387A (de) * | 1974-07-24 | 1976-02-02 | Fuji Photo Film Co Ltd | |
| GB1573361A (en) * | 1977-07-04 | 1980-08-20 | Carbon Paper Co Ltd | Metho of making microcapsules |
| IT1148784B (it) * | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| ATE29392T1 (de) * | 1983-06-22 | 1987-09-15 | Univ Ohio State Res Found | Herstellung eines feinteiligen materials und verkapselung. |
-
1985
- 1985-08-29 IT IT8522009A patent/IT1214629B/it active
-
1986
- 1986-08-08 EP EP86201400A patent/EP0212751B1/de not_active Expired - Lifetime
- 1986-08-08 AT AT86201400T patent/ATE80799T1/de not_active IP Right Cessation
- 1986-08-08 DE DE8686201400T patent/DE3686796T2/de not_active Expired - Fee Related
- 1986-08-22 US US06/899,147 patent/US4766012A/en not_active Expired - Lifetime
- 1986-08-28 JP JP61202615A patent/JPH0780755B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0212751B1 (de) | 1992-09-23 |
| JPS62103013A (ja) | 1987-05-13 |
| IT8522009A0 (it) | 1985-08-29 |
| DE3686796D1 (de) | 1992-10-29 |
| JPH0780755B2 (ja) | 1995-08-30 |
| IT1214629B (it) | 1990-01-18 |
| EP0212751A3 (en) | 1987-08-12 |
| EP0212751A2 (de) | 1987-03-04 |
| DE3686796T2 (de) | 1993-03-18 |
| US4766012A (en) | 1988-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| EEWE | Authorization for restitution | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |