ATE93859T1 - Verfahren zur spaltung racemischer spirohydantoine. - Google Patents

Verfahren zur spaltung racemischer spirohydantoine.

Info

Publication number: ATE93859T1
Authority: AT; Austria
Prior art keywords: spiro; ureido; compound; racemic; dione
Prior art date: 1988-07-27

Application number

AT89307339T

Other languages

English (en)

Inventor

Marcus Brackeen

Harry Ralph Howard Jr

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-27

Filing date

1989-07-19

Publication date

1993-09-15

1989-07-19 Application filed by Pfizer filed Critical Pfizer

1993-09-15 Application granted granted Critical

1993-09-15 Publication of ATE93859T1 publication Critical patent/ATE93859T1/de

Links

125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000003287 optical effect Effects 0.000 abstract 2
-1 spiro-hydantoin compound Chemical class 0.000 abstract 2
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
150000004703 alkoxides Chemical class 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000001469 hydantoins Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
LXANPKRCLVQAOG-NSHDSACASA-N sorbinil Chemical compound C12=CC(F)=CC=C2OCC[C@@]21NC(=O)NC2=O LXANPKRCLVQAOG-NSHDSACASA-N 0.000 abstract 1
229950004311 sorbinil Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)

AT89307339T 1988-07-27 1989-07-19 Verfahren zur spaltung racemischer spirohydantoine. ATE93859T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/224,966 US4952694A (en)	1988-07-27	1988-07-27	Novel resolution process for racemic spiro-hydantoins
EP89307339A EP0352959B1 (de)	1988-07-27	1989-07-19	Verfahren zur Spaltung racemischer Spirohydantoine

Publications (1)

Publication Number	Publication Date
ATE93859T1 true ATE93859T1 (de)	1993-09-15

Family

ID=22842974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89307339T ATE93859T1 (de)	1988-07-27	1989-07-19	Verfahren zur spaltung racemischer spirohydantoine.

Country Status (24)

Country	Link
US (1)	US4952694A (de)
EP (1)	EP0352959B1 (de)
JP (1)	JPH0625152B2 (de)
KR (1)	KR910002839B1 (de)
CN (1)	CN1023645C (de)
AT (1)	ATE93859T1 (de)
DD (1)	DD284020A5 (de)
DE (1)	DE68908812T2 (de)
DK (1)	DK169033B1 (de)
EG (1)	EG18934A (de)
ES (1)	ES2058537T3 (de)
FI (1)	FI893576L (de)
HU (1)	HU204527B (de)
IE (1)	IE892420L (de)
IL (1)	IL91055A0 (de)
MX (1)	MX173143B (de)
MY (1)	MY104136A (de)
NO (1)	NO168773C (de)
NZ (1)	NZ230091A (de)
PL (1)	PL161181B1 (de)
PT (1)	PT91273A (de)
RU (1)	RU1777599C (de)
YU (1)	YU47209B (de)
ZA (1)	ZA895680B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5151544A (en) *	1990-05-25	1992-09-29	Alcon Laboratories, Inc.	Intermediates in the preparation of chiral spirofluorenehydantoins
US5206367A (en) *	1992-02-18	1993-04-27	Pfizer Inc.	Preparation of optically active spiro-hydantoins
US5811605A (en) *	1997-02-19	1998-09-22	Ppg Industries, Inc.	Preparation of 1,2,3,3-tetrachloropropene
WO2009011261A1 (ja)	2007-07-19	2009-01-22	Tokuyama Corporation	ヒダントイン環を有する化合物及びその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4248882A (en) *	1980-02-12	1981-02-03	Pfizer Inc.	Treating diabetes-associated complications with hydantoin amines
ATE23046T1 (de) *	1982-11-10	1986-11-15	Pfizer	Sorbinil durch optische aufspaltung mit aminopinanderivaten.
EP0172719B1 (de) *	1984-08-20	1988-09-21	Pfizer Inc.	Verfahren zur Herstellung asymmetrischer Hydantoine
WO1986002647A1 (en) *	1984-10-30	1986-05-09	Pfizer Inc.	Spiro-heteroazolones for treatment of diabetes complications

1988
- 1988-07-27 US US07/224,966 patent/US4952694A/en not_active Expired - Fee Related
1989
- 1989-07-19 EP EP89307339A patent/EP0352959B1/de not_active Expired - Lifetime
- 1989-07-19 DE DE89307339T patent/DE68908812T2/de not_active Expired - Fee Related
- 1989-07-19 AT AT89307339T patent/ATE93859T1/de not_active IP Right Cessation
- 1989-07-19 ES ES89307339T patent/ES2058537T3/es not_active Expired - Lifetime
- 1989-07-20 IL IL91055A patent/IL91055A0/xx not_active IP Right Cessation
- 1989-07-24 MY MYPI89001006A patent/MY104136A/en unknown
- 1989-07-25 PL PL1989280758A patent/PL161181B1/pl unknown
- 1989-07-25 YU YU149189A patent/YU47209B/sh unknown
- 1989-07-25 DD DD89331128A patent/DD284020A5/de not_active IP Right Cessation
- 1989-07-25 PT PT91273A patent/PT91273A/pt not_active Application Discontinuation
- 1989-07-26 DK DK367889A patent/DK169033B1/da not_active IP Right Cessation
- 1989-07-26 HU HU893807A patent/HU204527B/hu not_active IP Right Cessation
- 1989-07-26 KR KR1019890010570A patent/KR910002839B1/ko not_active Expired
- 1989-07-26 NZ NZ230091A patent/NZ230091A/en unknown
- 1989-07-26 ZA ZA895680A patent/ZA895680B/xx unknown
- 1989-07-26 EG EG35689A patent/EG18934A/xx active
- 1989-07-26 FI FI893576A patent/FI893576L/fi not_active Application Discontinuation
- 1989-07-26 RU SU894614599A patent/RU1777599C/ru active
- 1989-07-26 IE IE892420A patent/IE892420L/xx unknown
- 1989-07-26 JP JP1193779A patent/JPH0625152B2/ja not_active Expired - Lifetime
- 1989-07-26 NO NO893053A patent/NO168773C/no unknown
- 1989-07-27 MX MX016955A patent/MX173143B/es unknown
- 1989-07-27 CN CN89107312A patent/CN1023645C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE892420L (en)	1990-01-27
FI893576A0 (fi)	1989-07-26
YU47209B (sh)	1995-01-31
FI893576A7 (fi)	1990-01-28
FI893576L (fi)	1990-01-28
RU1777599C (ru)	1992-11-23
EG18934A (en)	1994-03-30
NO168773C (no)	1992-04-01
DK367889D0 (da)	1989-07-26
KR910002862A (ko)	1991-02-26
PL161181B1 (pl)	1993-05-31
NO168773B (no)	1991-12-23
DE68908812D1 (de)	1993-10-07
ZA895680B (en)	1991-03-27
PT91273A (pt)	1990-02-08
MX173143B (es)	1994-02-02
IL91055A0 (en)	1990-02-09
EP0352959A1 (de)	1990-01-31
JPH0288576A (ja)	1990-03-28
DD284020A5 (de)	1990-10-31
DK169033B1 (da)	1994-08-01
YU149189A (en)	1991-02-28
ES2058537T3 (es)	1994-11-01
HUT56369A (en)	1991-08-28
AU603301B2 (en)	1990-11-08
AU3898889A (en)	1990-02-01
US4952694A (en)	1990-08-28
MY104136A (en)	1994-02-28
EP0352959B1 (de)	1993-09-01
DK367889A (da)	1990-01-29
HU204527B (en)	1992-01-28
CN1040199A (zh)	1990-03-07
JPH0625152B2 (ja)	1994-04-06
KR910002839B1 (ko)	1991-05-06
NO893053D0 (no)	1989-07-26
MX16955A (es)	1993-06-01
NO893053L (no)	1990-01-29
DE68908812T2 (de)	1993-12-09
NZ230091A (en)	1991-01-29
CN1023645C (zh)	1994-02-02

Legal Events

Date	Code	Title	Description
1994-05-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
HUT52162A (en)	1990-06-28	New process for producing optically active
ATE224896T1 (de)	2002-10-15	Verfahren zur herstellung von enantiomerisch reinen imidazol-verbindungen
ES2128959A1 (es)	1999-05-16	Procedimiento de separacion de carbinoles.
ATE93859T1 (de)	1993-09-15	Verfahren zur spaltung racemischer spirohydantoine.
AU2003289250A1 (en)	2004-06-30	Processes for producing (4e)-5-chloro-2-isopropyl-4-pentenoic ester and optically active isomer thereof
AU556793B2 (en)	1986-11-20	Sorbinil and methylsorbinil
DK0556909T3 (da)	1998-08-24	Fremgangsmåde til fremstilling af (R) - og (S) - 1,2-isopropylildenglycol
ATE10623T1 (de)	1984-12-15	Verfahren zur herstellung von l-prolin.