ATE96421T1 - Therapeutische polyaminamide. - Google Patents
Therapeutische polyaminamide.Info
- Publication number
- ATE96421T1 ATE96421T1 AT89308741T AT89308741T ATE96421T1 AT E96421 T1 ATE96421 T1 AT E96421T1 AT 89308741 T AT89308741 T AT 89308741T AT 89308741 T AT89308741 T AT 89308741T AT E96421 T1 ATE96421 T1 AT E96421T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- different
- cycloalkyl
- optionally
- substituents
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888820442A GB8820442D0 (en) | 1988-08-30 | 1988-08-30 | Therapeutic polyamine amides |
| EP89308741A EP0361687B1 (de) | 1988-08-30 | 1989-08-30 | Therapeutische Polyaminamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE96421T1 true ATE96421T1 (de) | 1993-11-15 |
Family
ID=10642872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89308741T ATE96421T1 (de) | 1988-08-30 | 1989-08-30 | Therapeutische polyaminamide. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5218000A (de) |
| EP (1) | EP0361687B1 (de) |
| JP (1) | JPH03501022A (de) |
| AT (1) | ATE96421T1 (de) |
| AU (1) | AU629856B2 (de) |
| DE (1) | DE68910259T2 (de) |
| DK (1) | DK105290A (de) |
| GB (2) | GB8820442D0 (de) |
| WO (1) | WO1990002114A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770625A (en) * | 1988-02-08 | 1998-06-23 | The Trustees Of Columbia University In The City Of New York | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same |
| US6001824A (en) * | 1988-02-08 | 1999-12-14 | The Trustees Of Columbia University | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same |
| DD298412A5 (de) * | 1989-04-28 | 1992-02-20 | ������@���Kk�� | Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele |
| US5059438A (en) * | 1990-02-05 | 1991-10-22 | Enzytech, Inc. | Compositions and methods for inhibiting browning in foods using resorcinol derivatives |
| US5269987A (en) * | 1992-12-22 | 1993-12-14 | Reedy Michael E | Process for producing alkenyl aromatic foams using a combination of atmospheric and organic gases and foams produced thereby |
| US5998452A (en) * | 1993-06-23 | 1999-12-07 | Chugai Seiyaku Kabushiki Kaisha | Benzene derivatives, compositions and methods for treating ischemic diseases |
| CZ289716B6 (cs) * | 1993-06-23 | 2002-03-13 | Chugai Seiyaku Kabushiki Kaisha | Léčivo pro léčení ischemických chorob, benzenové deriváty a terapeutické prostředky na jejich bázi |
| DE69939784D1 (de) * | 1998-08-06 | 2008-12-04 | Eidgenoess Tech Hochschule | Schmelzverarbeitbares polytetrafluorethylen |
| ES2161594B1 (es) * | 1998-12-17 | 2003-04-01 | Servier Lab | Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
| TW541295B (en) * | 1999-01-05 | 2003-07-11 | Nippon Zoki Pharmaceutical Co | A novel substituted alkylteraamine derivative for use as tachykinin antagonist |
| US6831191B2 (en) | 2001-12-20 | 2004-12-14 | Em Industries | Photo stable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom |
| US6602515B2 (en) | 2001-07-16 | 2003-08-05 | Em Industries | Photo stable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom |
| US7273888B2 (en) | 2001-11-16 | 2007-09-25 | Als Therapy Development Foundation, Inc. | Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis |
| EP1448183A2 (de) * | 2001-11-16 | 2004-08-25 | ALS Therapy Development Foundation, Inc. | Behandlung von neurodegenerativen erkrankungen durch modulieren des polyaminenbiosynthesewegs |
| US6699463B2 (en) | 2002-04-10 | 2004-03-02 | Em Industries | Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom |
| US6936735B2 (en) * | 2002-08-27 | 2005-08-30 | Emd Chemicals, Inc. | Photostable cationic organic sunscreen compounds and compositions obtained therefrom |
| WO2018155260A1 (ja) * | 2017-02-23 | 2018-08-30 | 株式会社Ihi | Ｏｈラジカル検出プローブ、ｏｈラジカル測定装置、および、ｏｈラジカル測定方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB862721A (en) * | 1958-06-23 | 1961-03-15 | Miles Lab | Dialkylaminoethyl derivatives of salicylamides |
| GB879957A (en) * | 1958-09-22 | 1961-10-11 | Ciba Ltd | Improvements relating to the hardening of epoxides |
| US3272861A (en) * | 1961-10-11 | 1966-09-13 | Continental Oil Co | Polyalkylene polyamine derivatives of hydroxybenzoic acid |
| GB1043345A (en) * | 1962-02-28 | 1966-09-21 | Minnesota Mining & Mfg | Phenolic polyamines |
| CH448966A (de) * | 1965-07-13 | 1967-09-15 | Bayer Ag | Verfahren zur Verbesserung der Nassechtheiten von gefärbten textilen Gebilden aus synthetischen Polyamiden |
| US4172094A (en) * | 1976-12-03 | 1979-10-23 | Merck & Co., Inc. | Polyamine compounds |
| US4058624A (en) * | 1976-05-14 | 1977-11-15 | Merck & Co., Inc. | Broad spectrum antibacterial compositions containing tris (hydroxymethyl)-aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines |
| GB8419103D0 (en) * | 1984-07-26 | 1984-08-30 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
| US5047430A (en) * | 1988-04-26 | 1991-09-10 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
-
1988
- 1988-08-30 GB GB888820442A patent/GB8820442D0/en active Pending
-
1989
- 1989-08-30 AT AT89308741T patent/ATE96421T1/de not_active IP Right Cessation
- 1989-08-30 WO PCT/GB1989/001004 patent/WO1990002114A1/en not_active Ceased
- 1989-08-30 DE DE89308741T patent/DE68910259T2/de not_active Expired - Fee Related
- 1989-08-30 JP JP1509210A patent/JPH03501022A/ja active Pending
- 1989-08-30 AU AU41927/89A patent/AU629856B2/en not_active Ceased
- 1989-08-30 GB GB8919563A patent/GB2222590B/en not_active Expired - Lifetime
- 1989-08-30 EP EP89308741A patent/EP0361687B1/de not_active Expired - Lifetime
- 1989-08-30 US US07/473,983 patent/US5218000A/en not_active Expired - Fee Related
-
1990
- 1990-04-27 DK DK105290A patent/DK105290A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB8919563D0 (en) | 1989-10-11 |
| GB2222590B (en) | 1992-07-22 |
| JPH03501022A (ja) | 1991-03-07 |
| EP0361687B1 (de) | 1993-10-27 |
| DK105290D0 (da) | 1990-04-27 |
| DE68910259T2 (de) | 1994-02-24 |
| AU4192789A (en) | 1990-03-23 |
| DK105290A (da) | 1990-04-27 |
| US5218000A (en) | 1993-06-08 |
| EP0361687A1 (de) | 1990-04-04 |
| WO1990002114A1 (en) | 1990-03-08 |
| DE68910259D1 (de) | 1993-12-02 |
| GB2222590A (en) | 1990-03-14 |
| AU629856B2 (en) | 1992-10-15 |
| GB8820442D0 (en) | 1988-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |