DK144690D0 - Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf - Google Patents

Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf

Info

Publication number: DK144690D0
Authority: DK; Denmark
Prior art keywords: heptanic; intermediates; derivatives; acids; procedure
Prior art date: 1988-10-13

Application number

DK144690A

Other languages

English (en)

Other versions

DK144690A (da

DK175073B1 (da

Inventor

Kau-Ming Chen

Prasad Koteswara Kapa

George T Lee

Oljan Repic

Petr Hess

Michel Crevoisier

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-13

Filing date

1990-06-13

Publication date

1990-06-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26945992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK144690(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-06-13 Application filed by Sandoz Ag filed Critical Sandoz Ag

1990-06-13 Publication of DK144690A publication Critical patent/DK144690A/da

1990-06-13 Publication of DK144690D0 publication Critical patent/DK144690D0/da

2004-05-24 Application granted granted Critical

2004-05-24 Publication of DK175073B1 publication Critical patent/DK175073B1/da

Links

239000002253 acid Substances 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
125000004185 ester group Chemical group 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
241000845077 Iare Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000422 delta-lactone group Chemical group 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Obesity (AREA)
Veterinary Medicine (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)

DK199001446A 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf DK175073B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US25747588A	1988-10-13	1988-10-13
US25747588		1988-10-13
US35553189A	1989-05-22	1989-05-22
US35553189		1989-05-22
EP8901201		1989-10-11
PCT/EP1989/001201 WO1990003962A1 (en)	1988-10-13	1989-10-11	Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof

Publications (3)

Publication Number	Publication Date
DK144690A DK144690A (da)	1990-06-13
DK144690D0 true DK144690D0 (da)	1990-06-13
DK175073B1 DK175073B1 (da)	2004-05-24

Family

ID=26945992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK199001446A DK175073B1 (da)	1988-10-13	1990-06-13	Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf

Country Status (24)

Country	Link
EP (2)	EP0363934B1 (da)
JP (1)	JP2853227B2 (da)
KR (1)	KR0162656B1 (da)
AT (1)	ATE99281T1 (da)
AU (1)	AU636122B2 (da)
BG (1)	BG60555B1 (da)
CA (1)	CA2000553C (da)
CZ (1)	CZ283316B6 (da)
DE (1)	DE68911834T2 (da)
DK (1)	DK175073B1 (da)
ES (1)	ES2060712T3 (da)
FI (1)	FI98063C (da)
HK (1)	HK49496A (da)
HU (1)	HU207993B (da)
IE (2)	IE63477B1 (da)
IL (1)	IL91941A (da)
MY (1)	MY105067A (da)
NO (1)	NO174623C (da)
NZ (1)	NZ230973A (da)
RO (1)	RO109732B1 (da)
SG (1)	SG139553A1 (da)
SK (1)	SK579789A3 (da)
WO (1)	WO1990003962A1 (da)
YU (1)	YU48466B (da)

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US5290946A (en) *	1988-10-13	1994-03-01	Sandoz Ltd.	Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5118853A (en) *	1988-10-13	1992-06-02	Sandoz Ltd.	Processes for the synthesis of 3-disubstituted aminoacroleins
US5112819A (en) *	1989-10-10	1992-05-12	Glaxo Group Limited	Imidazole derivatives, pharmaceutical compositions and use
DE4424525A1 (de) *	1994-07-12	1995-01-26	Elmar Meyer	Dauermagnet-Kolbenmotor
GT199800127A (es)	1997-08-29	2000-02-01		Combinaciones terapeuticas.
HUP0203326A3 (en)	1999-08-30	2003-04-28	Sanofi Aventis Deutschland	Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001092223A1 (en) *	2000-05-26	2001-12-06	Ciba Specialty Chemicals Holding Inc.	Process for the preparation of indole derivatives and intermediates of the process
US7777006B2 (en)	2002-12-31	2010-08-17	Csl Behring L.L.C.	Method for purification of alpha-1-antitrypsin
WO2004094377A1 (ja) *	2003-04-24	2004-11-04	Daicel Chemical Industries Ltd.	光学活性なジヒドロキシヘプテン酸エステルの分離方法
US7368468B2 (en)	2003-06-18	2008-05-06	Teva Pharmaceutical Industries Ltd.	Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
KR20070094805A (ko)	2003-06-18	2007-09-21	테바 파마슈티컬 인더스트리즈 리미티드	플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
US7368581B2 (en)	2003-06-18	2008-05-06	Teva Pharmaceutical Industries Ltd.	Process for the preparation of fluvastatin sodium crystal from XIV
JP2007512347A (ja)	2003-11-26	2007-05-17	デューク・ユニバーシティー	緑内障を予防するかまたは治療する方法
US7851624B2 (en)	2003-12-24	2010-12-14	Teva Pharamaceutical Industries Ltd.	Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en)	2004-03-16	2006-09-21	Kohn Leonard D	Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ATE431818T1 (de)	2006-04-20	2009-06-15	Italiana Sint Spa	Verfahren zur herstellung von fluvastatin-natrium
SI2373609T1 (sl)	2008-12-19	2013-12-31	Krka, D.D., Novo Mesto	Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (en)	2009-10-29	2011-06-01	KRKA, D.D., Novo Mesto	Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
AU2013214693B2 (en)	2012-02-02	2017-02-23	Kenneth Gek-Jin OOI	Improvements in tear film stability
SG11201507496UA (en)	2013-04-17	2015-11-27	Pfizer	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
US11248001B2 (en)	2019-01-18	2022-02-15	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof
TW202545529A (zh)	2024-02-05	2025-12-01	瑞典商阿斯特捷利康公司	組合療法
TW202602886A (zh)	2024-03-20	2026-01-16	瑞典商阿斯特捷利康公司	Ｐｃｓｋ９抑制劑及其使用方法
TW202539678A (zh)	2024-03-20	2025-10-16	瑞典商阿斯特捷利康公司	Ｐｃｓｋ９抑制劑及其使用方法
TW202602866A (zh)	2024-03-20	2026-01-16	瑞典商阿斯特捷利康公司	Ｐｃｓｋ９抑制劑及其使用方法
WO2025238159A1 (en)	2024-05-16	2025-11-20	Astrazeneca Ab	Combination therapy comprising azd0780 and ezetimibe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB945536A (en) *	1961-09-08	1964-01-02	Istituto Chemioterapico	Method of preparing ª -amino-acroleins
WO1984002131A1 (fr) *	1982-11-22	1984-06-07	Sandoz Ag	Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4571428A (en) *	1983-07-08	1986-02-18	Sandoz, Inc.	6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) *	1984-04-03	1987-03-17	Sandoz Corp.	Preparation of olefinic compounds and intermediates thereof
FI860755A0 (fi) *	1984-06-22	1986-02-20	Sandoz Ag	Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning.
ATE60571T1 (de) *	1984-12-04	1991-02-15	Sandoz Ag	Inden-analoga von mevalonolakton und ihre derivate.
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
JPS6322056A (ja) *	1986-04-30	1988-01-29	サンド・アクチエンゲゼルシヤフト	オレフイン性化合物の製造法
IL83821A0 (en) *	1986-09-10	1988-02-29	Sandoz Ag	Azaindole and indolizine derivatives,their production and pharmaceutical compositions containing them

1989
- 1989-10-11 MY MYPI89001403A patent/MY105067A/en unknown
- 1989-10-11 IE IE327789A patent/IE63477B1/en not_active IP Right Cessation
- 1989-10-11 JP JP1510605A patent/JP2853227B2/ja not_active Expired - Lifetime
- 1989-10-11 EP EP89118906A patent/EP0363934B1/en not_active Expired - Lifetime
- 1989-10-11 HU HU896048A patent/HU207993B/hu unknown
- 1989-10-11 EP EP19930106005 patent/EP0562643A3/en not_active Ceased
- 1989-10-11 RO RO145326A patent/RO109732B1/ro unknown
- 1989-10-11 ES ES89118906T patent/ES2060712T3/es not_active Expired - Lifetime
- 1989-10-11 WO PCT/EP1989/001201 patent/WO1990003962A1/en not_active Ceased
- 1989-10-11 IE IE940109A patent/IE940109L/xx unknown
- 1989-10-11 AU AU43448/89A patent/AU636122B2/en not_active Expired
- 1989-10-11 AT AT89118906T patent/ATE99281T1/de not_active IP Right Cessation
- 1989-10-11 YU YU197389A patent/YU48466B/sh unknown
- 1989-10-11 NZ NZ230973A patent/NZ230973A/xx unknown
- 1989-10-11 SG SG200602066-3A patent/SG139553A1/en unknown
- 1989-10-11 DE DE68911834T patent/DE68911834T2/de not_active Expired - Lifetime
- 1989-10-11 IL IL9194189A patent/IL91941A/en not_active IP Right Cessation
- 1989-10-11 KR KR1019900701243A patent/KR0162656B1/ko not_active Expired - Lifetime
- 1989-10-12 CA CA002000553A patent/CA2000553C/en not_active Expired - Lifetime
- 1989-10-12 SK SK5797-89A patent/SK579789A3/sk unknown
- 1989-10-12 CZ CS895797A patent/CZ283316B6/cs not_active IP Right Cessation
1990
- 1990-06-07 BG BG92179A patent/BG60555B1/bg unknown
- 1990-06-12 NO NO902598A patent/NO174623C/no unknown
- 1990-06-12 FI FI902935A patent/FI98063C/fi active IP Right Grant
- 1990-06-13 DK DK199001446A patent/DK175073B1/da not_active IP Right Cessation
1996
- 1996-03-21 HK HK49496A patent/HK49496A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK144690A (da)	1990-06-13
HK49496A (en)	1996-03-29
ES2060712T3 (es)	1994-12-01
FI98063B (fi)	1996-12-31
YU48466B (sh)	1998-08-14
JP2853227B2 (ja)	1999-02-03
HU207993B (en)	1993-07-28
NO174623C (no)	1994-06-08
SG139553A1 (en)	2008-02-29
HU896048D0 (en)	1990-11-28
SK280845B6 (sk)	2000-08-14
RO109732B1 (ro)	1995-05-30
CA2000553C (en)	2001-12-04
DE68911834D1 (de)	1994-02-10
KR0162656B1 (ko)	1999-01-15
SK579789A3 (en)	2000-08-14
EP0562643A2 (en)	1993-09-29
IL91941A (en)	1994-10-21
HUT53860A (en)	1990-12-28
NZ230973A (en)	1993-03-26
FI98063C (fi)	1997-04-10
AU636122B2 (en)	1993-04-22
EP0363934A1 (en)	1990-04-18
NO902598D0 (no)	1990-06-12
IE893277L (en)	1990-04-13
MY105067A (en)	1994-07-30
ATE99281T1 (de)	1994-01-15
YU197389A (en)	1990-12-31
BG92179A (bg)	1993-12-24
NO902598L (no)	1990-08-07
NO174623B (no)	1994-02-28
IE940109L (en)	1990-04-13
JPH03501735A (ja)	1991-04-18
DK175073B1 (da)	2004-05-24
EP0363934B1 (en)	1993-12-29
CA2000553A1 (en)	1990-04-13
IL91941A0 (en)	1990-06-10
EP0562643A3 (en)	1994-05-18
KR900701723A (ko)	1990-12-04
FI902935A0 (fi)	1990-06-12
DE68911834T2 (de)	1994-06-23
CZ283316B6 (cs)	1998-02-18
BG60555B1 (en)	1995-08-28
IE63477B1 (en)	1995-04-19
CZ579789A3 (en)	1997-11-12
WO1990003962A1 (en)	1990-04-19
AU4344889A (en)	1990-05-01

Legal Events

Date	Code	Title	Description
1999-01-18	PUP	Patent expired
2009-10-26	PUP	Patent expired

Publication	Publication Date	Title
DK144690A (da)	1990-06-13	Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf
FI901530A0 (fi)	1990-03-27	Menetelmä immunomoduloivien atsaspiraanien valmistamiseksi
ES2066140T3 (es)	1995-03-01	Derivados de acidos 7-ceto- y 7-hidroxi-androsta-3,5-dieno-3-carboxilicos.
ATE179169T1 (de)	1999-05-15	Prostaglandinanaloge
DK0619305T3 (da)	1997-07-07	Lactonforbindelse og fremgangsmåde til fremstilling deraf
GB1514389A (en)	1978-06-14	Glycerides with antibacterial properties
UA7031A1 (uk)	1995-03-31	Спосіб одержання похідних плевромутіліна або їх гідрохлоридів
ATE60779T1 (de)	1991-02-15	N-glykolylneuraminsaeurederivat.
GR1000469B (el)	1992-07-30	Mεθοδος παρασκευης κινολινοκαρβοξυλικων οξεων.
ES2006361A6 (es)	1989-04-16	Un procedimiento para preparar derivados de insoindolinilo opticamente activos.
DE69313521D1 (de)	1997-10-09	PGE1-Analoge
DK159432C (da)	1991-03-18	Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
BG49274A3 (bg)	1991-09-16	Метод за получаване на естери на l-аминодикарбонова киселина
GB1366182A (en)	1974-09-11	Intermediates useful in the preparation of cephalosporin derivativ es
NO920441L (no)	1993-08-04	Tnf-inhibitorer
GB1507785A (en)	1978-04-19	N-polychloroallyl-amido-thiophosphoric esters
ES8600762A1 (es)	1985-02-16	Un procedimiento para la preparacion de nuevos compuestos de beta-lactama.
DE58909745D1 (de)	1996-11-21	Tetrahydro-4-phenylimino-3-thiophenessigsäuren