DK144690A - Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf - Google Patents

Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf Download PDF

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Publication number
DK144690A
DK144690A DK144690A DK144690A DK144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A
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DK
Denmark
Prior art keywords
heptanic
intermediates
derivatives
acids
procedure
Prior art date
Application number
DK144690A
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English (en)
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DK175073B1 (da
DK144690D0 (da
Inventor
Kau-Ming Chen
Prasad Koteswara Kapa
George T Lee
Oljan Repic
Petr Hess
Michel Crevoisier
Original Assignee
Sandoz Ag
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Publication date
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Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK144690D0 publication Critical patent/DK144690D0/da
Publication of DK144690A publication Critical patent/DK144690A/da
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Publication of DK175073B1 publication Critical patent/DK175073B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK199001446A 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf DK175073B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25747588A 1988-10-13 1988-10-13
US25747588 1988-10-13
US35553189A 1989-05-22 1989-05-22
US35553189 1989-05-22
EP8901201 1989-10-11
PCT/EP1989/001201 WO1990003962A1 (en) 1988-10-13 1989-10-11 Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof

Publications (3)

Publication Number Publication Date
DK144690D0 DK144690D0 (da) 1990-06-13
DK144690A true DK144690A (da) 1990-06-13
DK175073B1 DK175073B1 (da) 2004-05-24

Family

ID=26945992

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001446A DK175073B1 (da) 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf

Country Status (24)

Country Link
EP (2) EP0363934B1 (da)
JP (1) JP2853227B2 (da)
KR (1) KR0162656B1 (da)
AT (1) ATE99281T1 (da)
AU (1) AU636122B2 (da)
BG (1) BG60555B1 (da)
CA (1) CA2000553C (da)
CZ (1) CZ283316B6 (da)
DE (1) DE68911834T2 (da)
DK (1) DK175073B1 (da)
ES (1) ES2060712T3 (da)
FI (1) FI98063C (da)
HK (1) HK49496A (da)
HU (1) HU207993B (da)
IE (2) IE940109L (da)
IL (1) IL91941A (da)
MY (1) MY105067A (da)
NO (1) NO174623C (da)
NZ (1) NZ230973A (da)
RO (1) RO109732B1 (da)
SG (1) SG139553A1 (da)
SK (1) SK280845B6 (da)
WO (1) WO1990003962A1 (da)
YU (1) YU48466B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290946A (en) * 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5118853A (en) * 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
JPH03184961A (ja) * 1989-10-10 1991-08-12 Glaxo Group Ltd 化合物
DE4424525A1 (de) * 1994-07-12 1995-01-26 Elmar Meyer Dauermagnet-Kolbenmotor
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
DK1216038T3 (da) 1999-08-30 2005-12-27 Sanofi Aventis Deutschland Anvendelse af inhibitorer af reninangiotensinsystemet ved forebyggelsen af cardiovaskulære hændelser
CN1217930C (zh) 2000-05-26 2005-09-07 西巴特殊化学品控股有限公司 吲哚衍生物的制备方法和该方法的中间体
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
EP1623976A4 (en) * 2003-04-24 2008-07-30 Daicel Chem METHOD FOR SEPARATING OPTICALLY ACTIVE DIHYDROXYPHIC ACID ESTERS
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
US7368581B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
JP4037898B2 (ja) 2003-06-18 2008-01-23 テバ ファーマシューティカル インダストリーズ リミティド フルバスタチンナトリウム結晶形ｘｉｖ、ｌｘｘｉｉｉ、ｌｘｘｉｘ、ｌｘｘｘ及びｘｘｘｖｉｉ型、それらの調製方法、それらを含有する組成物及びそれらの使用方法
JP2007512347A (ja) 2003-11-26 2007-05-17 デューク・ユニバーシティー 緑内障を予防するかまたは治療する方法
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE431818T1 (de) 2006-04-20 2009-06-15 Italiana Sint Spa Verfahren zur herstellung von fluvastatin-natrium
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
CN104902892A (zh) 2012-02-02 2015-09-09 悉尼大学 泪液膜稳定性的改进
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso
WO2025168652A1 (en) 2024-02-05 2025-08-14 Astrazeneca Ab Azd-0780 in combination with a statin for use in lowering ldl-c levels and treating cardiovacular diseases
TW202602886A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202602866A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202539678A (zh) 2024-03-20 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
WO2025238159A1 (en) 2024-05-16 2025-11-20 Astrazeneca Ab Combination therapy comprising azd0780 and ezetimibe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB945536A (en) * 1961-09-08 1964-01-02 Istituto Chemioterapico Method of preparing ª -amino-acroleins
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
HU204253B (en) * 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
ATE62906T1 (de) * 1984-06-22 1991-05-15 Sandoz Ag Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
ATE60571T1 (de) * 1984-12-04 1991-02-15 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
EP0244364A3 (en) * 1986-04-30 1992-04-01 Sandoz Ag Preparation of olefinic compounds
NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
IE63477B1 (en) 1995-04-19
KR0162656B1 (ko) 1999-01-15
ATE99281T1 (de) 1994-01-15
NO902598D0 (no) 1990-06-12
YU197389A (en) 1990-12-31
IL91941A (en) 1994-10-21
DK175073B1 (da) 2004-05-24
CZ579789A3 (en) 1997-11-12
JP2853227B2 (ja) 1999-02-03
HK49496A (en) 1996-03-29
EP0562643A2 (en) 1993-09-29
MY105067A (en) 1994-07-30
FI98063B (fi) 1996-12-31
KR900701723A (ko) 1990-12-04
JPH03501735A (ja) 1991-04-18
IL91941A0 (en) 1990-06-10
EP0363934A1 (en) 1990-04-18
NO174623C (no) 1994-06-08
NO174623B (no) 1994-02-28
HUT53860A (en) 1990-12-28
DK144690D0 (da) 1990-06-13
DE68911834D1 (de) 1994-02-10
DE68911834T2 (de) 1994-06-23
EP0363934B1 (en) 1993-12-29
SK579789A3 (en) 2000-08-14
CZ283316B6 (cs) 1998-02-18
HU896048D0 (en) 1990-11-28
EP0562643A3 (en) 1994-05-18
SK280845B6 (sk) 2000-08-14
CA2000553C (en) 2001-12-04
IE940109L (en) 1990-04-13
AU4344889A (en) 1990-05-01
IE893277L (en) 1990-04-13
FI902935A0 (fi) 1990-06-12
RO109732B1 (ro) 1995-05-30
BG60555B1 (en) 1995-08-28
CA2000553A1 (en) 1990-04-13
ES2060712T3 (es) 1994-12-01
FI98063C (fi) 1997-04-10
NZ230973A (en) 1993-03-26
BG92179A (bg) 1993-12-24
AU636122B2 (en) 1993-04-22
YU48466B (sh) 1998-08-14
WO1990003962A1 (en) 1990-04-19
NO902598L (no) 1990-08-07
SG139553A1 (en) 2008-02-29
HU207993B (en) 1993-07-28

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