DK144690A - Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf - Google Patents

Fremgangsmaade til fremstilling af 7-substituerede hept-6-en- og -heptansyrer og derivater og mellemprodukter deraf Download PDF

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Publication number
DK144690A
DK144690A DK144690A DK144690A DK144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A DK 144690 A DK144690 A DK 144690A
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DK
Denmark
Prior art keywords
heptanic
intermediates
derivatives
acids
procedure
Prior art date
Application number
DK144690A
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English (en)
Other versions
DK144690D0 (da
DK175073B1 (da
Inventor
Kau-Ming Chen
Prasad Koteswara Kapa
George T Lee
Oljan Repic
Petr Hess
Michel Crevoisier
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26945992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK144690(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK144690A publication Critical patent/DK144690A/da
Publication of DK144690D0 publication Critical patent/DK144690D0/da
Application granted granted Critical
Publication of DK175073B1 publication Critical patent/DK175073B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK199001446A 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf DK175073B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25747588A 1988-10-13 1988-10-13
US25747588 1988-10-13
US35553189A 1989-05-22 1989-05-22
US35553189 1989-05-22
PCT/EP1989/001201 WO1990003962A1 (en) 1988-10-13 1989-10-11 Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof
EP8901201 1989-10-11

Publications (3)

Publication Number Publication Date
DK144690A true DK144690A (da) 1990-06-13
DK144690D0 DK144690D0 (da) 1990-06-13
DK175073B1 DK175073B1 (da) 2004-05-24

Family

ID=26945992

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001446A DK175073B1 (da) 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf

Country Status (24)

Country Link
EP (2) EP0562643A3 (da)
JP (1) JP2853227B2 (da)
KR (1) KR0162656B1 (da)
AT (1) ATE99281T1 (da)
AU (1) AU636122B2 (da)
BG (1) BG60555B1 (da)
CA (1) CA2000553C (da)
CZ (1) CZ283316B6 (da)
DE (1) DE68911834T2 (da)
DK (1) DK175073B1 (da)
ES (1) ES2060712T3 (da)
FI (1) FI98063C (da)
HK (1) HK49496A (da)
HU (1) HU207993B (da)
IE (2) IE63477B1 (da)
IL (1) IL91941A (da)
MY (1) MY105067A (da)
NO (1) NO174623C (da)
NZ (1) NZ230973A (da)
RO (1) RO109732B1 (da)
SG (1) SG139553A1 (da)
SK (1) SK579789A3 (da)
WO (1) WO1990003962A1 (da)
YU (1) YU48466B (da)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
US5118853A (en) * 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
US5290946A (en) * 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5112819A (en) * 1989-10-10 1992-05-12 Glaxo Group Limited Imidazole derivatives, pharmaceutical compositions and use
DE4424525A1 (de) * 1994-07-12 1995-01-26 Elmar Meyer Dauermagnet-Kolbenmotor
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
PL353199A1 (en) 1999-08-30 2003-11-03 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
CN1217930C (zh) 2000-05-26 2005-09-07 西巴特殊化学品控股有限公司 吲哚衍生物的制备方法和该方法的中间体
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
EP1623976A4 (en) * 2003-04-24 2008-07-30 Daicel Chem METHOD FOR SEPARATING OPTICALLY ACTIVE DIHYDROXYPHIC ACID ESTERS
KR20070092994A (ko) 2003-06-18 2007-09-14 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
US7368581B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
WO2005053683A1 (en) 2003-11-26 2005-06-16 Duke University A method of preventing or treating glaucoma
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2327668T3 (es) 2006-04-20 2009-11-02 F.I.S. Fabbrica Italiana Sintetici S.P.A. Procedimiento para la preparacion de sal sodica de fluvastatina.
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
AU2013214693B2 (en) 2012-02-02 2017-02-23 Kenneth Gek-Jin OOI Improvements in tear film stability
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
WO2025168652A1 (en) 2024-02-05 2025-08-14 Astrazeneca Ab Azd-0780 in combination with a statin for use in lowering ldl-c levels and treating cardiovacular diseases
TW202539678A (zh) 2024-03-20 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202602886A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202602866A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
WO2025238159A1 (en) 2024-05-16 2025-11-20 Astrazeneca Ab Combination therapy comprising azd0780 and ezetimibe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB945536A (en) * 1961-09-08 1964-01-02 Istituto Chemioterapico Method of preparing ª -amino-acroleins
HU204253B (en) * 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
FI860755A0 (fi) * 1984-06-22 1986-02-20 Sandoz Ag Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning.
EP0216785B1 (en) * 1984-12-04 1991-01-30 Sandoz Ag Indene analogs of mevalonolactone and derivatives thereof
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
JPS6322056A (ja) * 1986-04-30 1988-01-29 サンド・アクチエンゲゼルシヤフト オレフイン性化合物の製造法
NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
RO109732B1 (ro) 1995-05-30
YU197389A (en) 1990-12-31
JP2853227B2 (ja) 1999-02-03
ES2060712T3 (es) 1994-12-01
AU636122B2 (en) 1993-04-22
KR900701723A (ko) 1990-12-04
HK49496A (en) 1996-03-29
NO174623B (no) 1994-02-28
SG139553A1 (en) 2008-02-29
IE893277L (en) 1990-04-13
CA2000553A1 (en) 1990-04-13
IE63477B1 (en) 1995-04-19
JPH03501735A (ja) 1991-04-18
CZ579789A3 (en) 1997-11-12
KR0162656B1 (ko) 1999-01-15
FI902935A0 (fi) 1990-06-12
NZ230973A (en) 1993-03-26
FI98063C (fi) 1997-04-10
ATE99281T1 (de) 1994-01-15
NO902598L (no) 1990-08-07
AU4344889A (en) 1990-05-01
HU207993B (en) 1993-07-28
DE68911834D1 (de) 1994-02-10
IL91941A (en) 1994-10-21
EP0363934A1 (en) 1990-04-18
HUT53860A (en) 1990-12-28
NO902598D0 (no) 1990-06-12
HU896048D0 (en) 1990-11-28
BG60555B1 (en) 1995-08-28
YU48466B (sh) 1998-08-14
EP0562643A3 (en) 1994-05-18
DK144690D0 (da) 1990-06-13
EP0562643A2 (en) 1993-09-29
DK175073B1 (da) 2004-05-24
FI98063B (fi) 1996-12-31
CZ283316B6 (cs) 1998-02-18
NO174623C (no) 1994-06-08
CA2000553C (en) 2001-12-04
IL91941A0 (en) 1990-06-10
IE940109L (en) 1990-04-13
BG92179A (bg) 1993-12-24
DE68911834T2 (de) 1994-06-23
WO1990003962A1 (en) 1990-04-19
SK280845B6 (sk) 2000-08-14
SK579789A3 (en) 2000-08-14
EP0363934B1 (en) 1993-12-29
MY105067A (en) 1994-07-30

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