ATE99931T1 - Inhibitoren fuer zellenzuwachs und methoden fuer krebsbehandlung. - Google Patents

Inhibitoren fuer zellenzuwachs und methoden fuer krebsbehandlung.

Info

Publication number: ATE99931T1
Authority: AT; Austria
Prior art keywords: cell growth; methods; cancer treatment; growth inhibitors; inhibitors
Prior art date: 1987-07-28

Application number

AT88908058T

Other languages

English (en)

Inventor

Barry M Markaverich

James H Clark

Rebecca Gregory

Mary Alejandro

Brian S Middleditch

Gregory A Johnson

Rajender Singh Varma

Original Assignee

Baylor College Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-28

Filing date

1988-07-20

Publication date

1994-01-15

1988-07-20 Application filed by Baylor College Medicine filed Critical Baylor College Medicine

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99931T1 publication Critical patent/ATE99931T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
239000003966 growth inhibitor Substances 0.000 title 1
230000010261 cell growth Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1
PDFUCDWETSQSSU-UHFFFAOYSA-N methyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate Chemical compound COC(=O)C(O)CC1=CC=C(O)C=C1 PDFUCDWETSQSSU-UHFFFAOYSA-N 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT88908058T 1987-07-28 1988-07-20 Inhibitoren fuer zellenzuwachs und methoden fuer krebsbehandlung. ATE99931T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7919987A	1987-07-28	1987-07-28
PCT/US1988/002476 WO1989000849A1 (en)	1987-07-28	1988-07-20	Cell growth inhibitors and methods of treating cancer and cell proliferative diseases
EP88908058A EP0374184B1 (de)	1987-07-28	1988-07-20	Inhibitoren für zellenzuwachs und methoden für krebsbehandlung

Publications (1)

Publication Number	Publication Date
ATE99931T1 true ATE99931T1 (de)	1994-01-15

Family

ID=22149049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88908058T ATE99931T1 (de)	1987-07-28	1988-07-20	Inhibitoren fuer zellenzuwachs und methoden fuer krebsbehandlung.

Country Status (8)

Country	Link
US (1)	US5216024A (de)
EP (1)	EP0374184B1 (de)
JP (1)	JPH03501249A (de)
AT (1)	ATE99931T1 (de)
AU (1)	AU625313B2 (de)
CA (1)	CA1332742C (de)
DE (1)	DE3887151T2 (de)
WO (1)	WO1989000849A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4698225A (en) *	1985-04-15	1987-10-06	Morrison David G	Granular binding agent for pellets
US5811447A (en) *	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6306421B1 (en)	1992-09-25	2001-10-23	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US5981568A (en)	1993-01-28	1999-11-09	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en)	1993-01-28	2003-12-16	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
CA2162586C (en) *	1993-05-13	2006-01-03	David J. Grainger	Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
IL112205A0 (en) *	1994-01-06	1995-03-15	Res Dev Foundation	Curcumin, analogues of curcumin and novel uses thereof
EP1129707A3 (de)	1994-08-31	2002-02-27	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Verfahren zur Identifizierung und Behandlung von resistenten Tumoren
US5710179A (en) *	1995-04-05	1998-01-20	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Antitumor agent
US7611533B2 (en)	1995-06-07	2009-11-03	Cook Incorporated	Coated implantable medical device
CA2224874A1 (en) *	1995-06-19	1997-03-13	Ontogen Corporation	Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
GB0505509D0 (en) *	2005-03-17	2005-04-27	Ic Innovations Ltd	Compounds
WO2007026875A1 (ja) *	2005-09-02	2007-03-08	Ube Industries, Ltd.	光学活性（Ｓ又はＲ）－α－ヒドロキシ酸及び光学活性（Ｒ又はＳ）－α－ヒドロキシ酸エステルの製造方法
US20100010002A1 (en) *	2006-09-01	2010-01-14	Piramal Life Sciences Limited	Anticancer use of caffeic acid and its derivatives
CN102697757B (zh) *	2012-05-18	2014-06-04	广州军区广州总医院	对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用
CN113480418B (zh) *	2021-07-13	2022-09-06	上海健康医学院	一种化合物，及其在制备治疗癌症药物方面的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2451149A (en) *	1942-11-16	1948-10-12	Nipa Lab Ltd	Manufacture of materials resistant to or active against microorganisms
GB1438652A (en) *	1972-07-19	1976-06-09	Shell Int Research	Hydroxyl phenyl-substituted ketones and their preparation
US4124724A (en) *	1975-12-08	1978-11-07	Agoro John W	Crystalline caffeic acid derivatives and compositions and method for treating snakebite
NL7804290A (nl) *	1977-05-12	1978-11-14	Henkel Kgaa	Ontsteking vertragend middel voor cosmetische prepara- ten.
GB1591063A (en) *	1977-07-11	1981-06-10	Ici Ltd	Monoalkylation of dihydroxybenzenes
JPS54160740A (en) *	1978-06-09	1979-12-19	Takeda Chem Ind Ltd	Anti-fibrotic agent
US4219569A (en) *	1978-10-10	1980-08-26	The Upjohn Company	Process for treating inflammation
FR2481270A1 (fr) *	1980-04-24	1981-10-30	Roussel Uclaf	Nouveaux derives substitues de l'acide 4-phenyl 4-oxo 2-hydroxy butanoique, procede pour leur preparation et applications comme medicaments
IT1171604B (it) *	1981-10-22	1987-06-10	Roussel Maestretti Spa	Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta' farmacologiche e loro procedimento di preparazione
DE3150233A1 (de) *	1981-12-18	1983-06-30	Basf Ag, 6700 Ludwigshafen	Verfahren zur herstellung von 2-(hydroxiphenoxi)-carbonsaeureestern
JPS59104340A (ja) *	1982-12-07	1984-06-16	Ube Ind Ltd	ベンジルアセトン類の製造方法
GB2141626B (en) *	1983-04-25	1987-01-28	Kao Corp	Cinnamic acid derivatives for lightening melanin pigmentation of skin
JPS60222437A (ja) *	1984-04-17	1985-11-07	Ube Ind Ltd	１−フエニル−２−アルカノン類の製造法
JPS60248645A (ja) *	1984-05-23	1985-12-09	Green Cross Corp:The	カフエ−酸誘導体
EP0163270A3 (de) *	1984-05-23	1989-05-17	Green Cross Corporation	Hemmstoff von Lipoxygenase
JPH0623130B2 (ja) *	1984-07-10	1994-03-30	三井東圧化学株式会社	α−ケト酸の製造方法
IT1190340B (it) *	1986-06-06	1988-02-16	Roussel Maestretti Spa	Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
WO1987007835A1 (fr) *	1986-06-21	1987-12-30	Dainippon Ink And Chemicals, Inc.	Medicament pour le traitement et la prophylaxie de maladies du rein et du foie

1988
- 1988-07-15 US US07/219,680 patent/US5216024A/en not_active Expired - Fee Related
- 1988-07-20 EP EP88908058A patent/EP0374184B1/de not_active Expired - Lifetime
- 1988-07-20 JP JP63506993A patent/JPH03501249A/ja active Pending
- 1988-07-20 AU AU23152/88A patent/AU625313B2/en not_active Ceased
- 1988-07-20 WO PCT/US1988/002476 patent/WO1989000849A1/en not_active Ceased
- 1988-07-20 DE DE3887151T patent/DE3887151T2/de not_active Expired - Fee Related
- 1988-07-20 AT AT88908058T patent/ATE99931T1/de not_active IP Right Cessation
- 1988-07-27 CA CA000573139A patent/CA1332742C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2315288A (en)	1989-03-01
EP0374184B1 (de)	1994-01-12
CA1332742C (en)	1994-10-25
WO1989000849A1 (en)	1989-02-09
AU625313B2 (en)	1992-07-09
DE3887151T2 (de)	1994-06-30
JPH03501249A (ja)	1991-03-22
US5216024A (en)	1993-06-01
DE3887151D1 (de)	1994-02-24
EP0374184A1 (de)	1990-06-27

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE99931T1 (de)	1994-01-15	Inhibitoren fuer zellenzuwachs und methoden fuer krebsbehandlung.
ES2055745T3 (es)	1994-09-01	Compuestos antigestagenicos y antiestrogenos para el tratamiento de tumores hormono-dependientes.
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
NO20003600D0 (no)	2000-07-13	Kaliumkanal inhibitorer
ES2032376T3 (es)	1993-02-16	Procedimiento para preparar 2-sustituidos-(amino-sustituidos)-n-arilalquil-3-(indol-3-il)propanimidas.
BG30015A3 (bg)	1981-03-16	Метод за получаване на трифенилалкенови производни
BR0012243A (pt)	2002-03-26	Triflúor butenos nematocidas
ES8505972A1 (es)	1985-06-16	Un procedimiento para preparar derivados de pirimidina
ATE158288T1 (de)	1997-10-15	Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
NL7503697A (nl)	1975-10-07	Werkwijze voor het verminderen of voorkomen van het ontstaan van aangroeisels aan werkende elektroden.
ATE300541T1 (de)	2005-08-15	Pyrazolopyridinderivate
ES452737A1 (es)	1978-01-01	Un procedimiento para preparar compuestos 2-anol-3-fenilben-zotiofeno.
SG48298A1 (en)	1998-04-17	Saccharin deriatives useful as proteolytic enzymeinhibitors and preparation of
DE60001850D1 (de)	2003-04-30	Chalcon coumarine
AU536920B2 (en)	1984-05-31	Hydroxypropyl-triazole derivatives and their use as antimycotic agents
ES2079068T3 (es)	1996-01-01	2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.
ATE327973T1 (de)	2006-06-15	Polyamin-analoge als cytotoxische wirkstoffe
ES8202015A1 (es)	1981-04-16	Un procedimiento para la preparacion de derivados de penici-lina
IT7827273A0 (it)	1978-09-01	Procedimento per il trattamento superficiale stabilizzante di corpi semiconduttori.
ES2154311T3 (es)	2001-04-01	Quinoxalinas, procedimiento para su preparacion y su utilizacion.
ES2157899T3 (es)	2001-09-01	Derivados de sampangina utiles como agentes antifungicos y antimicobacterianos.
ES491960A0 (es)	1980-12-16	Procedimiento para la obtencion de derivados de sisomicina
ES480112A1 (es)	1980-04-01	Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
BG28056A3 (bg)	1980-02-25	Метод за получаване на 5-амино-1,2,3-тиадиазол
SE7513640L (sv)	1976-06-08	Forfarande for framstellning av 6-metyl-8-(substituerade) metylerogoliner