AU2017207862B2 - EGF(A) analogues with fatty acid substituents - Google Patents

EGF(A) analogues with fatty acid substituents Download PDF

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Publication number
AU2017207862B2
AU2017207862B2 AU2017207862A AU2017207862A AU2017207862B2 AU 2017207862 B2 AU2017207862 B2 AU 2017207862B2 AU 2017207862 A AU2017207862 A AU 2017207862A AU 2017207862 A AU2017207862 A AU 2017207862A AU 2017207862 B2 AU2017207862 B2 AU 2017207862B2
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AU
Australia
Prior art keywords
hooc
2xado
egf
gglu
ethoxy
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Ceased
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AU2017207862A
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English (en)
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AU2017207862A1 (en
Inventor
Jianhe Chen
Patrick William Garibay
János Tibor Kodra
Jesper F. Lau
Lars Linderoth
Salka Elbøl RASMUSSEN
Henning THØGERSEN
Birgit Wieczorek
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Novo Nordisk AS
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Novo Nordisk AS
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Publication of AU2017207862B2 publication Critical patent/AU2017207862B2/en
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2017207862A 2016-01-13 2017-01-13 EGF(A) analogues with fatty acid substituents Ceased AU2017207862B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/070791 2016-01-13
CN2016070791 2016-01-13
CN2016076580 2016-03-17
CNPCT/CN2016/076580 2016-03-17
EP16195965 2016-10-27
EP16195965.5 2016-10-27
PCT/EP2017/050668 WO2017121850A1 (en) 2016-01-13 2017-01-13 Egf(a) analogues with fatty acid substituents

Publications (2)

Publication Number Publication Date
AU2017207862A1 AU2017207862A1 (en) 2018-07-05
AU2017207862B2 true AU2017207862B2 (en) 2020-12-17

Family

ID=57868232

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017207862A Ceased AU2017207862B2 (en) 2016-01-13 2017-01-13 EGF(A) analogues with fatty acid substituents

Country Status (26)

Country Link
US (2) US10822385B2 (2)
EP (1) EP3402811B1 (2)
JP (2) JP6797926B2 (2)
KR (1) KR102417487B1 (2)
CN (1) CN108473550B (2)
AU (1) AU2017207862B2 (2)
BR (1) BR112018013820A2 (2)
CA (1) CA3010756A1 (2)
CL (1) CL2018001868A1 (2)
CO (1) CO2018007440A2 (2)
DK (1) DK3402811T3 (2)
ES (1) ES2916998T3 (2)
HR (1) HRP20220720T1 (2)
HU (1) HUE058647T2 (2)
IL (1) IL260043A (2)
LT (1) LT3402811T (2)
MX (1) MX2018008681A (2)
MY (1) MY195199A (2)
PE (1) PE20181376A1 (2)
PH (1) PH12018501502A1 (2)
PL (1) PL3402811T3 (2)
RS (1) RS63298B1 (2)
RU (1) RU2747877C2 (2)
SA (1) SA518391996B1 (2)
SI (1) SI3402811T1 (2)
WO (1) WO2017121850A1 (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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SI3402811T1 (sl) 2016-01-13 2022-06-30 Novo Nordisk A/S Analogi EGF(A) z maščobnokislinskimi substituenti
SI3402782T1 (sl) 2016-01-13 2020-11-30 Grunenthal Gmbh 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati
CA3011176C (en) 2016-01-13 2023-09-19 Grunenthal Gmbh 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
CA3011180A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
SI3402784T1 (sl) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
MA49617A (fr) * 2017-07-19 2020-05-27 Novo Nordisk As Analogues d'egf(a), préparation, formulations et utilisations associées
CA3068956A1 (en) 2017-07-19 2019-01-24 Novo Nordisk A/S Bifunctional compounds
US11358994B2 (en) * 2017-07-27 2022-06-14 Saint Louis University Fatty acid modified human epidermal growth factor
IL279363B2 (en) 2018-06-21 2025-12-01 Merck Sharp & Dohme Pcsk9 antagonist compounds
WO2020070276A1 (en) 2018-10-05 2020-04-09 Novo Nordisk A/S Bifunctional compounds comprising insulin peptides and egf(a) peptides
CA3131997A1 (en) 2019-03-22 2020-10-01 3M Innovative Properties Company Fall-protection system with monitoring system
CN110357969B (zh) * 2019-05-27 2022-03-08 北京志道生物科技有限公司 一种GLP1-EGFa异源二聚体蛋白、功能及方法
AU2020326265A1 (en) 2019-08-07 2022-02-03 Novo Nordisk A/S Solid compositions comprising an EGF(A) derivative and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid
CN114641275A (zh) 2019-11-07 2022-06-17 诺和诺德股份有限公司 包含pcsk9抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物
EP4076492A4 (en) 2019-12-20 2024-01-17 Merck Sharp & Dohme LLC PCSK9 ANTAGONIST COMPOUNDS
JP2024527488A (ja) 2021-07-02 2024-07-25 スリーエム イノベイティブ プロパティズ カンパニー 落下防止安全装置と連動される空中リフト
WO2023012263A1 (en) 2021-08-04 2023-02-09 Novo Nordisk A/S Solid oral peptide formulations

Citations (1)

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JP5721432B2 (ja) 2007-08-15 2015-05-20 ノボ・ノルデイスク・エー／エス アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン
MX2010011499A (es) * 2008-04-23 2010-11-12 Amgen Inc Variantes de proproteina neutralizante de convertasa subtilisina kexina de tipo 9 (pcsk9) y sus usos.
WO2009143633A1 (en) 2008-05-30 2009-12-03 Institut De Recherches Cliniques De Montreal Pcsk9 inhibitors and methods of use thereof
TWI516501B (zh) * 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
CN101993485B (zh) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 促胰岛素分泌肽类似物同源二聚体及其用途
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SI3402811T1 (sl) 2016-01-13 2022-06-30 Novo Nordisk A/S Analogi EGF(A) z maščobnokislinskimi substituenti
CA3068956A1 (en) 2017-07-19 2019-01-24 Novo Nordisk A/S Bifunctional compounds
MA49617A (fr) 2017-07-19 2020-05-27 Novo Nordisk As Analogues d'egf(a), préparation, formulations et utilisations associées

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Also Published As

Publication number Publication date
CN108473550A (zh) 2018-08-31
AU2017207862A1 (en) 2018-07-05
DK3402811T3 (da) 2022-06-13
US20200407409A1 (en) 2020-12-31
JP6797926B2 (ja) 2020-12-09
PE20181376A1 (es) 2018-09-05
WO2017121850A1 (en) 2017-07-20
PL3402811T3 (pl) 2022-07-11
EP3402811A1 (en) 2018-11-21
JP2019505521A (ja) 2019-02-28
EP3402811B1 (en) 2022-03-30
KR20180100177A (ko) 2018-09-07
RS63298B1 (sr) 2022-07-29
CN108473550B (zh) 2022-11-22
PH12018501502A1 (en) 2019-03-25
US10822385B2 (en) 2020-11-03
US20190016768A1 (en) 2019-01-17
MY195199A (en) 2023-01-11
KR102417487B1 (ko) 2022-07-06
CO2018007440A2 (es) 2018-09-28
RU2018127882A3 (2) 2020-06-19
IL260043A (en) 2018-07-31
RU2018127882A (ru) 2020-02-13
MX2018008681A (es) 2018-09-17
SI3402811T1 (sl) 2022-06-30
SA518391996B1 (ar) 2021-07-14
HRP20220720T1 (hr) 2022-09-30
LT3402811T (lt) 2022-06-10
ES2916998T3 (es) 2022-07-06
HUE058647T2 (hu) 2022-09-28
CA3010756A1 (en) 2017-07-20
BR112018013820A2 (pt) 2018-12-11
RU2747877C2 (ru) 2021-05-17
CL2018001868A1 (es) 2018-08-31
JP2021035989A (ja) 2021-03-04

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired