JP6797926B2 - 脂肪酸置換基を有するｅｇｆ（ａ）類似体 - Google Patents

脂肪酸置換基を有するｅｇｆ（ａ）類似体 Download PDF

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Publication number: JP6797926B2
Authority: JP; Japan
Prior art keywords: ethoxy; peptide; egf; amino; acetyl
Prior art date: 2016-01-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2018536444A

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English (en)

Japanese (ja)

Other versions

JP2019505521A (ja

JP2019505521A5 (2

Inventor

ジャンヘ・チェン

イェスパー・エフ・ラウ

ヤノス・ティボル・コドラ

ビアギト・ヴィツォレク

ラース・リンデロート

ヘニング・トゥーヤスン

サルカ・エルボル・ラスムセン

パトリック・ウィリアム・ガリバイ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

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Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-01-13

Filing date

2017-01-13

Publication date

2020-12-09

2017-01-13 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2019-02-28 Publication of JP2019505521A publication Critical patent/JP2019505521A/ja

2020-06-18 Publication of JP2019505521A5 publication Critical patent/JP2019505521A5/ja

2020-12-09 Application granted granted Critical

2020-12-09 Publication of JP6797926B2 publication Critical patent/JP6797926B2/ja

Status Active legal-status Critical Current

2037-01-13 Anticipated expiration legal-status Critical

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- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Zoology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Cell Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
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SI3402811T1 (sl)	2016-01-13	2022-06-30	Novo Nordisk A/S	Analogi EGF(A) z maščobnokislinskimi substituenti
SI3402782T1 (sl)	2016-01-13	2020-11-30	Grunenthal Gmbh	8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati
CA3011176C (en)	2016-01-13	2023-09-19	Grunenthal Gmbh	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
CA3011180A1 (en)	2016-01-13	2017-07-20	Grunenthal Gmbh	3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
SI3402784T1 (sl)	2016-01-13	2020-07-31	Gruenenthal Gmbh	Derivati 3-((hetero)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
MA49617A (fr) *	2017-07-19	2020-05-27	Novo Nordisk As	Analogues d'egf(a), préparation, formulations et utilisations associées
CA3068956A1 (en)	2017-07-19	2019-01-24	Novo Nordisk A/S	Bifunctional compounds
US11358994B2 (en) *	2017-07-27	2022-06-14	Saint Louis University	Fatty acid modified human epidermal growth factor
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AU2017207862A1 (en)	2018-07-05
DK3402811T3 (da)	2022-06-13
US20200407409A1 (en)	2020-12-31
PE20181376A1 (es)	2018-09-05
WO2017121850A1 (en)	2017-07-20
PL3402811T3 (pl)	2022-07-11
EP3402811A1 (en)	2018-11-21
JP2019505521A (ja)	2019-02-28
EP3402811B1 (en)	2022-03-30
KR20180100177A (ko)	2018-09-07
RS63298B1 (sr)	2022-07-29
CN108473550B (zh)	2022-11-22
PH12018501502A1 (en)	2019-03-25
US10822385B2 (en)	2020-11-03
US20190016768A1 (en)	2019-01-17
MY195199A (en)	2023-01-11
KR102417487B1 (ko)	2022-07-06
CO2018007440A2 (es)	2018-09-28
RU2018127882A3 (2)	2020-06-19
IL260043A (en)	2018-07-31
RU2018127882A (ru)	2020-02-13
MX2018008681A (es)	2018-09-17
SI3402811T1 (sl)	2022-06-30
SA518391996B1 (ar)	2021-07-14
HRP20220720T1 (hr)	2022-09-30
LT3402811T (lt)	2022-06-10
ES2916998T3 (es)	2022-07-06
HUE058647T2 (hu)	2022-09-28
CA3010756A1 (en)	2017-07-20
BR112018013820A2 (pt)	2018-12-11
RU2747877C2 (ru)	2021-05-17
CL2018001868A1 (es)	2018-08-31
AU2017207862B2 (en)	2020-12-17
JP2021035989A (ja)	2021-03-04

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