AU603042B2 - Process for the production of o2,2' -anhydro-1-(beta-d- arabinofuranosyl)thymine - Google Patents

Process for the production of o2,2' -anhydro-1-(beta-d- arabinofuranosyl)thymine Download PDF

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Publication number
AU603042B2
AU603042B2 AU38020/89A AU3802089A AU603042B2 AU 603042 B2 AU603042 B2 AU 603042B2 AU 38020/89 A AU38020/89 A AU 38020/89A AU 3802089 A AU3802089 A AU 3802089A AU 603042 B2 AU603042 B2 AU 603042B2
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AU
Australia
Prior art keywords
hydrogen
alkyl
silyl
substituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38020/89A
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English (en)
Other versions
AU3802089A (en
Inventor
Charles William Murtiashaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Publication of AU3802089A publication Critical patent/AU3802089A/en
Application granted granted Critical
Publication of AU603042B2 publication Critical patent/AU603042B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU38020/89A 1988-07-12 1989-07-11 Process for the production of o2,2' -anhydro-1-(beta-d- arabinofuranosyl)thymine Ceased AU603042B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US217906 1988-07-12
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (2)

Publication Number Publication Date
AU3802089A AU3802089A (en) 1990-04-26
AU603042B2 true AU603042B2 (en) 1990-11-01

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38020/89A Ceased AU603042B2 (en) 1988-07-12 1989-07-11 Process for the production of o2,2' -anhydro-1-(beta-d- arabinofuranosyl)thymine

Country Status (21)

Country Link
US (1) US5008384A (de)
EP (1) EP0351126B1 (de)
JP (1) JPH075626B2 (de)
KR (1) KR910008112B1 (de)
CN (1) CN1039423A (de)
AT (1) ATE117314T1 (de)
AU (1) AU603042B2 (de)
CA (1) CA1315776C (de)
DD (2) DD292003A5 (de)
DE (1) DE68920648T2 (de)
DK (1) DK342189A (de)
ES (1) ES2066853T3 (de)
FI (1) FI893364A7 (de)
GR (1) GR3015293T3 (de)
HU (1) HUT50843A (de)
IE (1) IE65735B1 (de)
IL (1) IL90884A0 (de)
NO (1) NO892821L (de)
PT (1) PT91113B (de)
YU (1) YU138789A (de)
ZA (1) ZA895259B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065350B2 (ja) * 1990-11-30 2000-07-17 ヤマサ醤油株式会社 １―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
DE69415506T2 (de) * 1994-05-20 1999-08-12 Council Of Scientific And Industrial Research, New Delhi Verfahren zur Herstellung von Beta-Thymidine
DE60144573D1 (de) 2000-11-29 2011-06-16 Mitsui Chemicals Inc Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin
US6870048B2 (en) * 2001-03-30 2005-03-22 Triangle Pharmaceuticals Process for the preparation of 2'-halo-β-L-arabinofuranosyl nucleosides
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko) 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
WO2005003374A2 (en) 2003-06-30 2005-01-13 Idenix (Cayman) Limited SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES
MX2008011719A (es) 2006-03-15 2008-09-24 Novartis Ag Proceso para preparar derivados de acido b-nucleico e intermediarios de los mismos.
CN102014919B (zh) 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
DE68920648D1 (de) 1995-03-02
CN1039423A (zh) 1990-02-07
DK342189A (da) 1990-01-15
US5008384A (en) 1991-04-16
ES2066853T3 (es) 1995-03-16
HUT50843A (en) 1990-03-28
DE68920648T2 (de) 1995-05-18
IE65735B1 (en) 1995-11-15
NO892821L (no) 1990-01-15
YU138789A (en) 1990-12-31
JPH075626B2 (ja) 1995-01-25
AU3802089A (en) 1990-04-26
ATE117314T1 (de) 1995-02-15
FI893364A7 (fi) 1990-01-13
FI893364A0 (fi) 1989-07-11
EP0351126A3 (en) 1990-10-24
KR910008112B1 (ko) 1991-10-10
DD284024A5 (de) 1990-10-31
CA1315776C (en) 1993-04-06
EP0351126A2 (de) 1990-01-17
PT91113B (pt) 1995-01-31
KR900001704A (ko) 1990-02-27
EP0351126B1 (de) 1995-01-18
DD292003A5 (de) 1991-07-18
PT91113A (pt) 1990-02-08
JPH0259598A (ja) 1990-02-28
IL90884A0 (en) 1990-02-09
ZA895259B (en) 1991-02-27
NO892821D0 (no) 1989-07-07
IE892233L (en) 1990-01-12
GR3015293T3 (en) 1995-06-30
DK342189D0 (da) 1989-07-11

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